Objective: The healthcare industry is undergoing a transformative phase marked by rising costs and a shortage of healthcare professionals, necessitating the adoption of information technology-based solutions (Shaheen, 2021). Methods: This study explores the integration of artificial intelligence (AI) in addressing these challenges and enhancing healthcare systems. Using a systematic literature review, we examined the role of AI in overcoming issues such as limited access, high costs, inefficiencies, and an aging population (Greenberg et al., 2020; Maphumulo & Bhengu, 2019). Our analysis focused on applications of AI in drug discovery, clinical trials, and patient care, including intelligent care systems and healthcare robotics (Chan et al., 2019; Vaishya et al., 2020). Results: The findings suggest that AI significantly accelerates drug discovery, streamlines clinical trials, and improves patient outcomes through advanced diagnostics and treatment support (DĂaz et al., 2019; Woo, 2019). AI has proven particularly effective during the COVID-19 pandemic, where it aided in diagnosis, contact tracing, and treatment decision-making, highlighting its potential to address existing vulnerabilities in healthcare systems (Pavli et al., 2021). Conclusion: AI offers a paradigm shift in healthcare by providing clinicians with real-time access to robust clinical evidence and best practices, reducing reliance on anecdotal experience and cognitive biases (McNeill & Walton, 2002; Shaheen, 2021a). By harnessing the power of AI, healthcare systems can improve efficiency, reduce costs, and enhance patient outcomes, marking a significant step towards a more efficient, effective, and equitable healthcare system (Mayorga-Ruiz et al., 2019; Luengo-Oroz et al., 2020).