Colorectal tumor is the second cause of neoplastic mortality in males after lung cancer, and ranks the same in female after breast cancer. Among screening procedures conventional colonoscopy is considered the best available method, however it is invasive, it's associated with procedural risks, usually needs conscious sedation or even deep sedation. The E-Worm is a new medical device for the diagnostic colonoscopy, it is the result of an italian academic research in the field of robotic biomimetics, it moves like a worm using two specific clampers for adhesion with intestinal mucosa. The light sources (LEDS) and the videocamera are inserted in the head of the E-Worm. This allows a live vision on the screen of the workstation like a normal colonoscope. The unique locomotion system with outstanding flexibility, able to follow every type of tree-dimensional shape, gives a new opportunity for a painless colonoscopy procedure. The flexibility together with the low force required to move the probe reduces the risk of any perforation. The Authors present their fist experience in performing colonoscopies using this new colonoscope. From December 2007 to November 2008 we performed 37 colonoscopies with the E-Worm. Patients were prepared with PEG as conventional colonoscopy. Cecal intubation was possible in 15 cases (40%), ileal exploration was performed in 1 patient with crohn's disease (2%). The right colon was reached in other 7 patients (19%). No patients needed sedation. No complications occurred. Pathologies were found in 19 pts (51%). Evaluating the first 20 pts with the last 17 we saw an increase of cecal intubation rate from 35% to 48%. In spite of a lower definition resolution of endoscopic picture, the diagnostic yield was good, comparable to conventional colonoscopy. Our preliminary experience demonstrates that this new colonoscope allows good diagnostic procedures without any need of sedation. In our opinion the low cecal intubation rate could be related to the learning curve.