Road pavement damage affects driving comfort markedly, threatens driving safety, and may even cause traffic accidents. The traffic management department conventionally captures pavement damage information mainly using manual and vehicle-mounted equipment, which is not conducive to the detection of large-scale road pavement distress. Street-view images can provide full-view images of urban roads where the data is updated regularly by navigation map service companies, making it possible to rapidly detect pavement damage in urban areas. This paper presents a new pavement damage detection approach that is built upon an improved YOLOv5 network and street-view images. The proposed model can deal with a large-scale detection layer to improve the detection precision of large distress targets, achieving thus both cross-layer and cross-scale feature fusion by using the Generalized Feature Pyramid Network (Generalized-FPN) structure. The improved network also involves a diagonal Intersection over Union loss for regression calculation of the boundary box and builds the decoupled Head structure to achieve the decoupling detection of prediction and regression. As a result, the fusion of the weak feature information in feature layers is enhanced at different spatial scales, a more suitable method is achieved for pavement damage detection in the complex context of multi-scale street-view images, and the accuracy of the modified network is much improved in the detection of pavement distress from street-view imagery. Furthermore, We created a large image sample set for model training and testing, and a total of 156,304 street-view images, obtained from Fengtai District, Beijing, China was used for demonstrating the usefulness of the proposed network. The findings indicated that the proposed approach could effectively achieve pavement damage detection of urban roads from street-view images, with a precision average of 79.8% on the test samples. Moreover, the developed model was applied for pavement damage detection for all the roads in Fengtai District, Beijing, indicating that our method can offer viable damage data for road maintenance planning.