Background Road traffic accidents are a severe health concern in Ethiopia. This study aims to examine the primary contributing variables of road traffic accidents in Ethiopia, North Gondar Zone, under 24 administrative wereda’s. Methods This study utilized secondary data collected from both the werda-level and North Gondar central-level offices within the study areas. The sector police typically submit reports to the zonal-level offices annually. Information regarding crashes, fatalities, and injuries during the study period was extracted from these police reports. The research focused on analyzing the frequency and severity of traffic accidents attributed to various factors of drivers, vehicles, road conditions, pedestrians, and environmental influences. Results In a sample of 603 aggregate road traffic accidents, the data reveals that the majority of damage results are attributed to young drivers, accounting for 58% of the cases, with junior grade level drivers contributing 29.4%. Driving without a license was a significant factor, representing 87%, while accidents involving recruited driver stood at 63.2%. Vehicles with small to articulated trucks contributing to 39%. Mechanical failures were prevalent, with an unknown diagnosis rate of 48.3%. Vehicles in service for 2-5 years accounted for 29.4%. Road surface conditions were 46%, while rural roads saw a higher percentage at 51.2%. Weather conditions played a role also influential, as dry asphalt and gravel roads under main access ownership were linked to of accident, with 91.2% occurring during visible daylight hours between 8:00-12:00 and 15:00-17:00. The victims were predominantly farmers at 49.6%, followed by students at 23%. Conclusions To reduce road traffic accidents in the study area, it is essential to manage causative factors such as driver and road users, vehicles, roads, pedestrians, and environmental behaviors. The study suggests the development of a successful, up-to-date traffic accident database system regionally within respective offices.