Risky Decisions Research Articles

Prospect Theory: A Bibliometric and Systematic Review in the Categories of Psychology in Web of Science.

Prospect Theory (PT) is an alternative, dynamic explanation of the phenomenon of risky decision making. This research presents an overview of PT’s history in health fields, including advancements, limitations, and bibliometric data. A systematic and bibliometric review of the scientific literature included in the psychological categories of Web of Science (WoS) was performed following the PRISMA 2020 statement for systematic reviews. A total of 37 studies (10 non-empirical and 27 empirical) were included in the sample. Bibliometric results showed thematic variability and heterogeneity regarding the production, researchers, and methodologies that are used to study PT. The systematic results highlight three main fields of PT research: preventive and screening behaviors, promotion of healthy habits, and COVID-related decision making. Personal and contextual factors which alter the usual pattern specified by PT are also described. To conclude, PT currently has an interdisciplinary character suitable for health promotion, with recent studies broadening its applicability.

Audiovisual time-to-collision estimation for accelerating vehicles: The acoustic signature of electric vehicles impairs pedestrians' judgments

To avoid collisions, pedestrians intending to cross a road need to accurately estimate the time-to-collision (TTC) of an approaching vehicle. For TTC estimation, auditory information can be considered particularly relevant when the approaching vehicle accelerates. The sound of vehicles with internal combustion engine (ICEVs) provides characteristic auditory information about the acceleration state (increasing rotational speed and engine load). However, for electric vehicles (EVs), the acoustic signature during acceleration is less salient. Although the auditory detection of EVs has been studied extensively, there is no research on potential effects of the altered acoustic signature of EVs on TTC estimation. To close this gap, we compared TTC estimates for ICEVs and for EVs with and without activated acoustic vehicle alerting system (AVAS). We implemented a novel interactive audiovisual virtual-reality system for studying the human perception of approaching vehicles. Using acoustic recordings of real vehicles as source signals, the dynamic spatial sound field corresponding to a vehicle approaching in an urban setting is generated based on physical modeling of the sound propagation between vehicle and pedestrian (listener) and is presented via sound field synthesis (higher-order Ambisonics). In addition to the auditory simulations, the scene was visually presented on a head-mounted display with head tracking. Participants estimated the TTC of vehicles that either approached at a constant speed or accelerated positively. In conditions with constant speed, TTC estimates for EVs with and without AVAS were similar to those for ICEVs. In contrast, for accelerating vehicles, there was a substantial effect of the vehicle type on the TTC estimates. For the EVs, the mean TTC estimates showed a significant overestimation. Thus, subjects on average perceived the time of arrival of the EV at their position as longer than it actually was. The extent of overestimation increased with acceleration and presented TTC. This pattern is similar to a first-order TTC estimation representing a failure to consider the acceleration, which is consistently reported in the literature for visual-only presentations of accelerating objects. In comparison, the overestimation of TTC was largely reduced for the accelerating ICEVs. The AVAS somewhat improved the TTC estimates for the accelerating EVs, but without reaching the same level of accuracy as for the ICEVs. In real traffic scenarios, overestimations of the TTC of approaching vehicles might lead to risky road-crossing decisions. Therefore, our finding that pedestrians are significantly less able to use the acoustic information emitted by accelerating EVs for their TTC judgments, compared to accelerating ICEVs, has important implications for road safety and for the design of AVAS technologies.

Taking gambles at face value: Effects of emotional expressions on risky decisions.

Emotional facial expressions are ubiquitous and potent social stimuli that can signal favorable and unfavorable conditions. Previous research demonstrates that emotional expressions influence preference judgments, basic approach-avoidance behaviors, and reward learning. We examined whether emotional expressions can influence decisions such as choices between gambles. Based on theories of affective cue processing, we predicted greater risk taking after positive than negative expressions. This hypothesis was tested in four experiments across tasks that varied in implementation of risks, payoffs, probabilities, and temporal decision requirements. Facial expressions were presented unobtrusively and were uninformative about the choice. In all experiments, the likelihood of a risky choice was greater after exposure to positive versus neutral or negative expressions. Similar effects on risky choice occurred after presentation of different negative expressions (e.g., anger, fear, sadness, and disgust), suggesting involvement of general positive and negative affect systems. These results suggest that incidental emotional cues exert a valence-specific influence of on decisions, which could shape risk-taking behavior in social situations.

Do older adults make more risky decisions in the Hungry Donkey Task or in the Iowa Gambling Task?

ABSTRACT The Iowa Gambling Task (IGT) and the Hungry Donkey Task (HDT) are well-known tasks employed to assess decisions under ambiguity. Although the two tasks are equal in terms of wins and losses, they differ in terms of the recipient: while in the IGT participants make decisions for themselves, in the HDT decisions are made to help a hungry donkey. Decisions for themselves versus another one in a situation of ambiguity are particularly important in the field of aging because of older adults’ changes in motivational and other-oriented behavior. The present study aimed to test whether older adults make different decisions under ambiguity for themselves than for another one (i.e., the hungry donkey) as compared to younger adults. Forty-five young adults (M = 23.31; SD = 1.58) and 45 older adults (M = 72.47; SD = 5.49) performed the IGT and the HDT. In addition, participants performed tasks on working memory, set-shifting, and inhibition. Results showed age-related differences in the HDT but not in the IGT. Older adults, compared to younger adults, made disadvantageous decisions to help the hungry donkey as compared to themselves. Interestingly, this pattern of results is not explained by the age-related decline in cognitive functioning. The findings seem to suggest that older adults’ decisions made under the condition of ambiguity are affected by motivational and emotional changes associated with aging.

New Evidence on National Culture and Corporate Financing: Does Institutional Quality Matter?

The purpose of this paper is twofold. First, to examine the dynamic impact of national culture on corporate financing in the context of seven Asian countries using a two-step GMM model, and second, to assess the moderating role of institutional quality on the relationship between culture and corporate financing. To achieve these objectives, a unique sample of seven Asian countries from the period of 2002 to 2018 was employed. The empirical results reveal that firms operating in countries that encourage individualism, masculinity, and uncertainty avoidance tend to use higher leverage in their operations. Individualism encourages autonomy in decision making and managers from such cultures engage in more risky decisions, while masculinity focuses on competition and suggests that males have a higher tendency for risk preference than females when undertaking financial decisions. In addition, firms from high uncertainty avoidance societies are more driven to engage in the use of leverage to obtain benefits via tax saving, whereas firms in higher power distance countries are less reliant on leverage. Our findings are consistent with our expectations, as well as supporting the existing literature on the issue. Further, the positive culture–leverage nexus is significantly and positively moderated by institutional quality. The findings are robust to alternative procedures (i.e., alternative proxies for culture and corporate financing, reduced sample size, and alternative estimation model), contribute to the existing literature, and have implications for potential policymakers.

No evidence for a causal effect of exogenous testosterone on risky decision-making in women: An experiment and meta-analysis.

No evidence for a causal effect of exogenous testosterone on risky decision-making in women: An experiment and meta-analysis.

1.15 Profiles of HIV-Related Knowledge and Neurocognitive Factors in At-Risk Adolescents

Risky decisions in youth can increase the risk for substance use as well as acquisition of sexually transmitted diseases, including HIV. Understanding how HIV/AIDS-related knowledge and perceptions and neurocognitive factors underlying risky decision making combine within distinct risk profiles may help identify youth for tailored prevention strategies. Latent profile analysis (LPA) was used to explore profiles among 124 youth at elevated risk for substance use disorder, ages 11 to 13 years (32.2% girls, 65.3% boys; 32.3% African American, 58.1% White, 9.7% Multiracial).

Brain mechanisms underlying the influence of emotions on spatial decision-making: An EEG study.

It is common for people to make bad decisions because of their emotions in life. When these decisions are important, such as aeronautical decisions and driving decisions, the mistakes of decisions can cause irreversible damage. Therefore, it is important to explore how emotions influence decision-making, so as to avoid the negative influence of emotions on decision-making as much as possible. Although existing researchers have found some mechanisms of emotion's influence on decision-making, only a few studies focused on the influence of emotions on decision-making based on electroencephalography (EEG). In addition, most of them were focused on risky and uncertain decision-making. We designed a novel experimental task to explore the influence of emotion on spatial decision-making and recorded subjective data, decision-making behavioral data, and EEG data. By analyzing these data, we came to three conclusions. Firstly, we observed three similar event-related potentials (ERP) microstates in the decision-making process under different emotions by microstate analysis. Additionally, the prefrontal, parietal and occipital lobes played key roles in decision-making. Secondly, we found that the P2 component of the prefrontal lobe presented the influence of different emotions on decision-making by ERP analysis. Among them, positive emotion evoked the largest P2 amplitude compared to negative emotions and no stimuli. Thirdly, we found some graph metrics that were significantly associated with decision accuracy by effective connectivity analysis combined with graph theoretic analysis. In consequence, the finding of our study may shed more light on the brain mechanisms underlying the influence of emotions on spatial decision-making, thereby providing a basis for avoiding decision-making accidents caused by emotions and realizing better decision-making.

Developmental risk sensitivity theory: the effects of socio-economic status on children's risky gain and loss decisions.

Evolutionary developmental theories propose that early environments shape human risk preferences. Developmental risk sensitivity theory (D-RST) focuses on the plasticity of risk preferences during childhood and makes predictions about the effect of reward size based on a child's social environment. By contrast, prospect theory predicts risk aversion for gains and risk seeking for losses regardless of environment or status. We presented 4 to 10-year-olds (n = 194) with a set of trials in which they chose between a certain amount and a chance to receive more or nothing. Two trials were equal expected value choices that differed by stake size and two were unequal expected value choices. Children either received gain trials or loss trials. Social environment was assessed using socio-economic status (SES) and subjective social status. Results confirmed the predictions of D-RST for gains based on SES. Children from lower-SES families differentiated between the high- and low-value trials and made more risky decisions for the high-value reward compared with higher-SES children. Children from higher-SES families were more risk averse for both trial types. Decisions for loss trials did not conform completely to either theory. We discuss the results in relation to evolutionary developmental theories.

Diversity in boardroom and debt financing: A case from China.

The study aims to explore the role of gender diversity in debt financing choices among Chinese listed firms. The study used the Chinese listed firm's data from 1991 to 2022 from the Chinese Stock Market return. The study used the fixed effect regression analysis and revealed that gender diversity positively affects debt financing among Chinese firms. Additionally, mass theory results suggested that at least three females on the board significantly influence firms. It served as the voice of gender diversity to influence the board's decisions regarding debt financing. The study has several theoretical and practical implications. This study will enlighten the Chinese boardroom dynamics by reassuring them to add more females to diversity policies. It will benefit future studies on boardroom activities and debt financing in emerging economies. It will be practical guidance for the Chinese policymakers, governing authorities, and corporate executives. The study stresses the need for significant diversity on the board rather than one female presence on the board. Secondly, this study contradicts the stereotype perception that females are not making risky decisions.

Videogaming Frequency and Executive Skills in Young Adults.

Many studies have shown that “action” videogames (VG) training can improve various cognitive aspects (such as attention, enumeration skill, problem solving, vigilance, inhibitory control and decision making). Unfortunately, independently by VG genre, little research has been conducted on the relevance of videogaming frequency to modulate cognitive performance. In the present study, we investigated the differences between two groups of young adults (Experienced Gamers and Casual Gamers, respectively, EGs and CGs) in some attentional and executive abilities. To this end, 19 EGs (age 23.21 ± 1.68 years; gaming frequency 46.42 ± 11.15 h/week) and 19 CGs (age 23.10 ± 2.28 years; gaming frequency 1.31 ± 1.76 h/week) were selected and asked to complete a computer-based and customized version of an executive battery (i.e., Attention Network Task, Game of Dice task, Go/NoGo task and Task Switching). The results showed better basic attentional abilities and alertness level (i.e., as indicated by faster reaction times (RTs) and greater accuracy) in EGs compared to CGs. Moreover, EGs showed a more efficient decision making than CGs, particularly evident in risky decisions. Taken together, such results show that an executive functioning improvement can be observed as a consequence of continuous and constant exposure to VG, independently by the specific genre played. These data can be a useful starting point to develop new and innovative executive training protocols, based and inspired to videogames to be applied in clinical populations suffering, for example, from dysexecutive impairment.

Predicting Risky Decision Making (Odds Selection) in Regular Soccer Gamblers from Nigeria using Cognitive Tasks Combined with Non-Cognitive Measures.

As real time soccer gambling is becoming a game of choice for many Nigerian youths, there is need to examine some predictive factors that could account for risky decision making in the population. We combined some cognitive tasks (memory, concentration, executive function and problem solving) and non-cognitive measures (time taken to complete a bet, years of gambling and addiction tendency measures) to derive a more parsimonious model of predicting risky decision making in this population. Twenty-eight undergraduate students that endorsed regular involvement (at least once a week) in soccer betting and were willing to come to the psychology lab for testing were recruited. Four neuropsychological measures (Craft Story 21: Immediate and delayed, Number Span Test: Forward and backward, Trail Making Test: A&B, Tower of Hannoi and a gambling questionnaire (Gamblers Anonymous Questionnaire) were used for the study. Study design was correlational and linear regression (step wise method) was used for data analysis. Step wise regression statistics yielded nine possible model combinations with high predictive strengths. Overall, model 9 (with adjusted R2 = 0.57) that has 6 measures including one from non-cognitive and 5 from cognitive measures was adjudged to be most parsimonious putting into consideration its predictive strength and number of tasks required. The tasks in our most parsimonious model were: time taken to complete a bet (non-cognitive), Craft Story 21: immediate (cognitive: memory), Number Span Forward: Total correct and longest correct (cognitive: concentration), Trail Making Test: B (cognitive: executive function) and Tower of Hannoi: Time taken to complete (cognitive: problem solving). Pearson product moment correlation between the predictor variables and the dependent variable (number of odds selected) showed inverse correlation of Craft Story Immediate, Number Span total correct and Number span longest correct suggesting strong divergence of these variables to odd selection. Time taken to complete bet, Trail Making Test: B and time taken to complete Tower of Hannoi respectively had positive correlations with number of odds selected. Our results suggest that multiple domains of cognitive abilities and time taken to complete a bet are important for predicting gamblers at risk for poor decision making. It further suggests that use of single task for a particular cognitive domain could be sufficient in predicting persons at risk for decision making. Overall, our study suggests that risky decision making in real time sports betting could be predicted using fewer neuropsychological tasks measuring wider domains of brain behaviour and a non-cognitive measure.

Sure-thing vs. probabilistic charitable giving: Experimental evidence on the role of individual differences in risky and ambiguous charitable decision-making.

Charities differ, among other things, alongside the likelihood that their interventions succeed and produce the desired outcomes and alongside the extent that such likelihood can even be articulated numerically. In this paper, we investigate what best explains charitable giving behaviour regarding charities that have interventions that will succeed with a quantifiable and high probability (sure-thing charities) and charities that have interventions that only have a small and hard to quantify probability of bringing about the desired end (probabilistic charities). We study individual differences in risk/ambiguity attitudes, empathy, numeracy, optimism, and donor type (warm glow vs. pure altruistic donor type) as potential predictors of this choice. We conduct a money incentivised, pre-registered experiment on Prolific on a representative UK sample (n = 1,506) to investigate participant choices (i) between these two types of charities and (ii) about one randomly selected charity. Overall, we find little to no evidence that individual differences predict choices regarding decisions about sure-thing and probabilistic charities, with the exception that a purely altruistic donor type predicts donations to probabilistic charities when participants were presented with a randomly selected charity in (ii). Conducting exploratory equivalence tests, we find that the data provide robust evidence in favour of the absence of an effect (or a negligibly small effect) where we fail to reject the null. This is corroborated by exploratory Bayesian analyses. We take this paper to be contributing to the literature on charitable giving via this comprehensive null-result in pursuit of contributing to a cumulative science.

Comparing Decision Trees and Association Rules for Stock Market Expectations in BIST100 and BIST30

With the increased financial fragility, methods have been needed to predict financial data effectively. In this study, two leading data mining technologies, classification analysis and association rule mining, are implemented for modeling potentially successful and risky stocks on the BIST 30 index and BIST 100 Index based on the key variables of index name, index value, and stock price. Classification and Regression Tree (CART) is used for classification, and Apriori is applied for association analysis. The study data set covered monthly closing values during 2013-2019. The Apriori algorithm also obtained almost all of the classification rules generated with the CART algorithm. Validated by two promising data mining techniques, proposed rules guide decision-makers in their investment decisions. By providing early warning signals of risky stocks, these rules can be used to minimize risk levels and protect decision-makers from making risky decisions.

The Effects of Citalopram and Thalamic Dopamine D2/3 Receptor Availability on Decision-Making and Loss Aversion in Alcohol Dependence.

Selective serotonin reuptake inhibitors (SSRIs) are commonly prescribed for patients who misuse alcohol, especially in the context of comorbid depressive symptoms. Deficits in impulse control and decision-making are linked to routine alcohol consumption and alcohol dependence. The goal of this study was to determine the effects of a single dose of citalopram on measures of impulsivity, decision-making, and/or brain dopamine receptor availability in alcohol-dependent individuals. A double-blind, placebo-controlled, within-subject, outpatient study was conducted with active alcohol-dependent (DSM-IV-TR criteria) participants (n = 12) and matched healthy controls (n = 13). Serial doses of both citalopram (40 mg) and saline were administered intravenously before laboratory tests of decision-making (Balloon Analogue Risk Task, delay discounting task, and Loss Aversion Gambling Task) and positron emission tomography with [18F]-fallypride to measure dopamine D2/3 receptor availability, separated by at least one week. Alcohol-dependent participants demonstrated greater loss aversion than healthy controls, but there were no group differences in risk taking on the Balloon Analogue Risk Task. Citalopram increased delay discounting across groups, with no group difference in the effect. There were no effects of citalopram on risk taking on the Balloon Analogue Risk Task. PET showed a negative correlation between thalamic dopamine D2/3 receptor availability and loss aversion across groups. The effect of citalopram to decrease the valuation of monetary reward as a function of delay raises the possibility that SSRIs can influence risky decision-making in clinical populations. In addition, these results suggest that altered thalamic dopamine signaling may play an important role in disproportionately valuing losses in patients with Alcohol Use Disorder. This trial is registered under ClinicalTrials.gov registration NCT01657760.

Learning and memory : neurosciences perspectives

Learning is the process of acquiring new or modifyingexisting knowledge, skills, behaviors or preferences (Schachter et al., 2010)
 
 
 Memory is the faculty of encoding, storing and retreiving information (Squire, 2009)
 
 Basic forms of learning were demonstrated at earlier and earlier stages of development, including in utero (Blumberg et al., 2010, Kail and Spear, 1984)
 
 There are multiple brain learning/memory systems, age-specific ecological adaptions, and acquisition-vs.-expression of learning (Krasnegor et al., 1986, Shair et al., 1991, Spear and Campbell, 1979). 
 
 
 Rats show “infantile amnesia” (Campbell and Campbell, 1962, Campbell and Spear, 1972). The discovery that rodents show poor long-term memory for experiences occurring in infancy suggested that the human phenomenon has a biological basis. 
 
 The neurobiology of learning and memory during adolescence showed specific sex/gender effects (Spear, 2009, Raznahan 2019).
 
 There is a strong relationship between neurobiological and behavioral changes specifically during the adolescent period: alterations in fronto-striatal systems during adolescence impact risky decision making and vulnerability to social pressures, which may ultimately provide a framework for the development of reward-related learning abilities (DePasque & Galvan 2017).
 
 Involvement of NMDA glutamate receptors in impairments in fearextinction during adolescence, and how the role of NMDA receptorsmay differ during this stage of development compared to adults and juveniles (Baker and Richardson 2017). 
 
 The maturation of cortical noradrenergic systems contributes to executive function (Mokler and colleagues 2017). 
 
 

Preliminary evidence that misalignment between sleep and circadian timing alters risk-taking preferences.

Decision-making has been shown to suffer when circadian preference is misaligned with time of assessment; however, little is known about how misalignment between sleep timing and the central circadian clock impacts decision-making. This study captured naturally occurring variation in circadian alignment (i.e., alignment of sleep-wake timing with the central circadian clock) to examine if greater misalignment predicts worse decision-making. Over the course of 2 weeks, 32 late adolescent drinkers (aged 18-22 years; 61% female; 69% White) continuously wore actigraphs and completed two overnight in-laboratory visits (Thursday and Sunday) in which both dim-light melatonin onset (DLMO) and behavioural decision-making (risk taking, framing, and strategic reasoning tasks) were assessed. Sleep-wake timing was assessed by actigraphic midsleep from the 2 nights prior to each in-laboratory visit. Alignment was operationalised as the phase angle (interval) between average DLMO and average midsleep. Multilevel modelling was used to predict performance on decision-making tasks from circadian alignment during each in-laboratory visit; non-linear associations were also examined. Shorter DLMO-midsleep phase angle predicted greater risk-taking under conditions of potential loss (B=-0.11, p=0.06), but less risk-taking under conditions of potential reward (B=0.14, p=0.03) in a curvilinear fashion. Misalignment did not predict outcomes in the framing and strategic reasoning tasks. Findings suggest that shorter alignment in timing of sleep with the central circadian clock (e.g., phase-delayed misalignment) may impact risky decision-making, further extending accumulating evidence that sleep/circadian factors are tied to risk-taking. Future studies will need to replicate findings and experimentally probe whether manipulating alignment influences decision-making.

Effort-based decision making in response to high-dose androgens: role of dopamine receptors.

Anabolic-androgenic steroids (AAS) are performance-enhancing drugs used by both world-class and rank-and-file athletes. AAS abuse has been linked with risky decision-making, ranging from drunk driving to abusing multiple drugs. Our lab uses operant behavior in rats to test the effects of AAS (testosterone) on decision making. In our previous study, testosterone caused rats to work harder for food reward during an effort discounting (ED) task. ED is sensitive to dopamine in the nucleus accumbens, and AAS alter accumbens dopamine receptor expression. Accordingly, we determined if testosterone increases response to dopamine receptor antagonists during ED. Rats were treated chronically with high-dose testosterone (7.5 mg/kg; n = 9) or vehicle (n = 9). We measured baseline preference for the large reward in an ED task, where rats choose between a small easy reward (one lever press for one sugar pellet) and a large difficult reward (2, 5, 10, or 15 presses for three pellets). Preference for the large reward was measured after administration of D1-like (SCH23390, 0.01 mg/kg) or D2-like (eticlopride, 0.06 mg/kg) receptor antagonists. At baseline, testosterone- and vehicle-treated rats showed similar preference for the large reward lever (FR5, testosterone: 68.6 ± 9.7% and vehicle: 85.7 ± 2.5%). SCH23390 reduced large reward preference significantly in both groups (FR5, testosterone: 41.3 ± 9.2%; vehicle: 49.1 ± 8.2%; F(1,16) = 17.7; P < 0.05). Eticlopride decreased large reward preference in both groups, but more strongly in testosterone-treated rats (FR5: testosterone: 37.0 ± 9.7%; vehicle: 56.3 ± 7.8%; F(1,16) = 35.3; P < 0.05). Testosterone increases response to dopamine D2-like receptor blockade, and this contributes to previously observed changes in decision-making behaviors.

Hair cortisol as a biomarker of chronic stress in preadolescents: influence of school context and bullying

ABSTRACT Bullying has been identified as the most common form of aggression and a major source of stress among children and adolescents. The main objective of this study was to analyze the association that school context in general and bullying in particular might have with hair cortisol concentration (HCC), examining the effect of executive function and sex on this association. The study included 659 11-year-old preadolescents from the cohorts of Gipuzkoa and Sabadell of the INMA (INfancia y Medio Ambiente-Children and Environment) project. We gathered information about school-related factors (bullying, school environment, problems with peers and academic performance) and executive function (risky decision-making). Hair samples were collected to measure cortisol concentrations and Structural Equation Modeling was used to examine associations between school-related factors, executive function and HCC. Results showed that being involved as a bully/victim was related to higher HCC and, higher HCC was associated with poorer executive function. This study may contribute to a better understanding of the consequences that chronic exposure to a stressful factors may have on preadolescents’ health and developmental outcomes. Besides, our results are relevant for designing programs for prevention and intervention, which could modify individual physiological responses to stress and reduce the effects of stress on the health.

Persistent Ventral Anterior Cingulate Cortex and Resolved Amygdala Hyper-responses to Negative Outcomes After Depression Remission: A Combined Cross-sectional and Longitudinal Study

BackgroundMajor depressive disorder (MDD) is a highly prevalent mood disorder affecting more than 300 million people worldwide. Biased processing of negative information and neural hyper-responses to negative events are hallmarks of depression. This study combined cross-sectional and longitudinal experiments to explore both persistent and resolved neural hyper-responses to negative outcomes from risky decision making in patients with current MDD (cMDD) and remitted MDD (rMDD). MethodsA total of 264 subjects participated in the cross-sectional study, including 117 patients with medication-naïve, first-episode current depression; 45 patients with rMDD with only 1 episode of depression; and 102 healthy control subjects. Participants completed a modified balloon analog risk task during functional magnetic resonance imaging. In the longitudinal arm of the study, 42 patients with cMDD were followed and 26 patients with rMDD were studied again after 8 weeks of antidepressant treatment. ResultsPatients with cMDD showed hyper-responses to loss outcomes in multiple limbic regions including the amygdala and ventral anterior cingulate cortex (vACC). Amygdala but not vACC hyperactivity correlated with depression scores in patients with cMDD. Furthermore, amygdala hyperactivity resolved while vACC hyperactivity persisted in patients with rMDD in both cross-sectional and longitudinal studies. ConclusionsThese findings provide consistent evidence supporting differential patterns of amygdala and vACC hyper-responses to negative outcomes during depression remission. Amygdala hyperactivity may be a symptomatic and state-dependent marker of depressive neural responses, while vACC hyperactivity may reflect a persistent and state-independent effect of depression on brain function. These findings offer new insights into the neural underpinnings of depression remission and prevention of depression recurrence.