Risk Reduction Mechanisms Research Articles

Oral contraceptive use is associated with a reduction in the physical size of fallopian tube p53 signatures.

Oral contraceptives reduce ovarian cancer risk, but the mechanism of risk reduction is not understood. We examined whether oral contraceptive pill (OCP) use influences p53 signatures, which are putative early fallopian tube precursors for high-grade serous ovarian carcinomas. For this retrospective cohort (n = 250) of subjects aged over 50 years who had fallopian tubes removed at the time of a benign gynecologic procedure, we used health records to identify 72 patients who used OCPs for at least 5 years and 178 subjects with no history of OCP use. Immunohistochemistry for p53 was performed on all fallopian tube sections, with 8 individuals removed for lack of identifiable tissue. p53 Signatures were identified and stratified based on size. Logistic regressions were run to estimate the association between OCP use and p53 lesion and lesion size. There was no difference in the occurrence of p53 lesions with 20 of 70 of OCP users (28.6%) and 57 of 172 of those with no history of OCP use (33.1%). Subjects who used OCPs were more likely to have a small lesion (OR 1.98, 95% CI 1.03 to 3.83) and had decreased risk of having a medium/large lesion (OR 0.38, 95% CI 0.18 to 0.79). A total of 2 serous tubal intraepithelial lesions and 2 serous tubal intraepithelial carcinomas were identified in OCP-naive patients, whereas none were found in those with a history of OCP use. OCP exposure was associated with a shift toward smaller p53 lesion size but was not found to be associated with a difference in the number of p53 lesions between OCP-exposed and unexposed patients. Future research should examine whether OCP use reduces proliferation and clonal expansion of p53 signature lesions toward higher risk precursors and, eventually, cancer. There were no serous tubal intraepithelial lesions and serous tubal intraepithelial carcinomas in patients with OCP exposure.

New Insights into Aspirin's Anticancer Activity: The Predominant Role of Its Iron-Chelating Antioxidant Metabolites.

Epidemiological studies have suggested that following long-term, low-dose daily aspirin (LTLDA) administration for more than 5 years at 75-100 mg/day, 20-30% of patients (50-80 years old) had a lower risk of developing colorectal cancer (CRC) and about the same proportion in developing iron deficiency anemia (IDA). In cases of IDA, an increase in iron excretion is suspected, which is caused by aspirin chelating metabolites (ACMs): salicylic acid, salicyluric acid, 2,5-dihydroxybenzoic acid, and 2,3-dihydroxybenzoic acid. The ACMs constitute 70% of the administered aspirin dose and have much longer half-lives than aspirin in blood and tissues. The mechanisms of cancer risk reduction in LTLDA users is likely due to the ACM's targeting of iron involved in free radical damage, iron-containing toxins, iron proteins, and associated metabolic pathways such as ferroptosis. The ACMs from non-absorbed aspirin (about 30%) may also mitigate the toxicity of heme and nitroso-heme and other iron toxins from food, which are responsible for the cause of colorectal cancer. The mode of action of aspirin as a chelating antioxidant pro-drug of the ACMs, with continuous presence in LTLDA users, increases the prospect for prophylaxis in cancer and other diseases. It is suggested that the anticancer effects of aspirin depend primarily on the iron-chelating antioxidant activity of the ACMs. The role of aspirin in cancer and other diseases is incomplete without considering its rapid biotransformation and the longer half-life of the ACMs.

Beneficial effects of hydroxychloroquine on blood lipids and glycated haemoglobin: A randomised interventional study in patients with rheumatoid arthritis and systemic lupus erythematosus.

Hydroxychloroquine (HCQ) exerts a large reduction of cardiovascular risk in patients with inflammatory diseases, but the mechanisms are not fully known. The aim of this study was to study potential mechanisms for this. This interventional study (EudraCT 2014-005418-45) in 30 patients (23 with rheumatoid arthritis, 7 with systemic lupus erythematosus) investigates the effects of HCQ on cardiovascular risk factors and arterial stiffness in patients with inflammatory disease. Blood lipids, blood pressure, blood glucose, glycated haemoglobin (HbA1c) and arterial stiffness was assessed at initiation, after four weeks of treatment and after eight weeks of treatment with 200 mg HCQ daily. After four weeks of treatment with HCQ, total cholesterol had decreased from 5.4 mmol/L to 5.1 mmol/L (p<0.001), low-density lipoproteins from 3,0 mmol/L to 2.7 mmol/L (p<0.001) and apolipoprotein B from 0.96 g/L to 0.90 g/L (p<0.01). Those levels remained unchanged after eight weeks of treatment with HCQ. Levels of triglycerides, high-density lipoproteins and apolipoprotein A1 remained unchanged during the study. HbA1c decreased in most patients, especially in patients with high levels at start of HCQ, but increased HbA1c was seen in patients with low levels at start of treatment with HCQ. No significant effect was seen on blood pressure or any measure of arterial stiffness. This study does not identify the mechanisms of cardiovascular risk reduction from HCQ. Arterial stiffness is not affected by HCQ. The impact of HCQ on HbA1c and blood lipids is rapid, but of modest magnitude, and these effects do not fully explain the reduced risk of cardiovascular disease seen in observational studies. The mechanisms of cardiovascular risk reduction from HCQ are yet not completely known.

Adolescent Pornography Exposure, Condom Use, and the Moderating Role of Parental Sexual Health Communication: Replication in a U.S. Probability Sample

ABSTRACT Following calls for an increase in replication studies in communication science as well as multiple other disciplines, the present study provides a direct replication of a pragmatically and theoretically important investigation of U.S. adolescents’ pornography exposure, parent-adolescent sexual health communication, and condomless sex published in this journal. Parent-adolescent sexual health communication has been suggested as a sexual risk-reduction mechanism, but condomless sex among U.S. adolescents is increasing. Simultaneously, pornography remains an extremely popular media genre and condomless sex is the norm in pornographic depictions. The findings of the present study replicated the findings of the original study, with the most notable replicated finding being an interaction between pornography exposure and parent-adolescent sexual health communication on the likelihood of condomless sex. Both in the original and present study, the association between U.S. adolescents’ pornography exposure and likelihood of condomless sex decreased as parental-adolescent sexual health communication increased. Results are discussed in terms of the challenges to examining these particular relationships among U.S. youth and the state of replication in the pornography effects literature.

Impact of Transformational and Relational Leadership Theories and Ethics Towards Climate Change Resilience in Fiji

This analytical essay explores the intricate interplay between leadership theories and the ethical dimensions inherent in addressing climate change, natural disasters, and their impacts on Fiji. Transformational and relational leadership theories are identified as crucial frameworks in shaping ethical attributes within organizations, creating ethical climates that address the implications of climate change and disasters. The challenges posed by natural disasters in Fiji, particularly on the economy, vulnerable sectors, and communities, necessitate effective leadership and ethical approach. This essay delves into multiple leadership theories, examining their relevance and efficacy in the context of Pacific Islands. Authentic leadership, transformational leadership, and culturally sustaining leadership emerge as influential paradigms, contributing to disaster risk reduction, resilience, and coping mechanisms. The Ethical and Effective Leadership (EEL) Model introduces propositions that underscore the impact of leader characteristics, people practices, institutional practices, and contextual factors on organizational outcomes. However, ethical dilemmas surface, as leaders navigate vulnerabilities, resilience, and societal expectations. Crosweller and Tschakert highlight the ethical challenges faced by leaders, particularly in balancing the urgency of climate action with the constraints of neoliberal policies. Complexity of leadership is discussed in disaster risk reduction, including the influence of worldviews and power dynamics within community-led initiatives. In summary, this essay synthesizes various leadership theories, and showcasing their applicability in the Pacific Islands, specifically Fiji, in addressing climate change and disasters. The ethical considerations woven into leadership decisions and actions underscore the need for leaders to navigate complexities, fostering compassion, inclusivity, and preparedness in the face of environmental and societal challenges.

Nanoscale zero-valent iron alleviate antibiotic resistance risk during managed aquifer recharge (MAR) by regulating denitrifying bacterial network

The frequent occurrence of antibiotics in reclaimed water is concerning, in the case of managed aquifer recharge (MAR), it inevitably hinders further water purification and accelerates the evolutionary resistance in indigenous bacteria. In this study, we constructed two column reactors and nanoscale zero-valent iron (nZVI) amendment was applied for its effects on water quality variation, microbial community succession, and antibiotic resistance genes (ARGs) dissemination, deciphered the underlying mechanism of resistance risk reduction. Results showed that nZVI was oxidized to iron oxides in the sediment column, and total effluent iron concentration was within permissible limits. nZVI enhanced NO3--N removal by 15.5% through enriching denitrifying bacteria and genes, whereas made no effects on oxacillin (OXA) removal. In addition, nZVI exhibited a pivotal impact on ARGs and plasmids decreasing. Network analysis elucidated that the diversity and richness of ARG host declined with nZVI amendment. Denitrifying bacteria play a key role in suppressing horizontal gene transfer (HGT). The underlying mechanisms of inhibited HGT included the downregulated SOS response, the inhibited Type-Ⅳ secretion system and the weakened driving force. This study afforded vital insights into ARG spread control, providing a reference for future applications of nZVI in MAR.

Sludge-derived biochar: A review on the influence of synthesis conditions on environmental risk reduction and removal mechanism of wastewater pollutants

Sludge-derived biochar: A review on the influence of synthesis conditions on environmental risk reduction and removal mechanism of wastewater pollutants

Disaster Risk Management and Reduction in Niger: A Review of Tools, Structures, and Mechanisms

Niger, a vast landlocked country in the arid Sahel region of West Africa, is constantly faced with disasters, with their attendant loss of human life, material goods, economic damage, and damage to critical infrastructure. However, in terms of disaster risk management and reduction, the country has policies and strategies that are consistent with regional and global disaster risk reduction frameworks and instruments. An analysis carried out based on secondary data collection on disaster risk management and reduction tools, structures, and mechanisms revealed the need to make better use of what already exists by improving overall coordination. This can be achieved by putting in place a strong structure that can drive the mobilization of resources and by placing a strong emphasis on the development of operational tools that focus on prevention rather than emergency response. To achieve this, it is important to review data collection methods by simplifying them using geographical information, which could lead to the collection of relevant and timely data to improve the alert mechanism so that it is as rapid as possible and allows the implementation of preventive actions rather than emergency responses. Improving the GRC framework will also require the implementation of coherent land use and urban development strategies with appropriate building standards, supported by adequate funding mechanisms to build resilient infrastructure. Keywords: Disaster risk management, Prevention, Emergency response, Recovery, Niger.

The social construction of systemic risk: towards an actionable framework for risk governance

PurposeThis paper explores the building blocks of risk governance systems that are equipped to manage systemic risk in the 21st century. Whilst approaches to risk governance have been evolving for more than a decade, recent disasters have shown that conventional risk management solutions need to be complemented with a multidimensional risk approach to govern complex risks and prevent major, often simultaneous, crises with cascading and knock-on effects on multiple, interrelated systems at scale. The paper explores which risk governance innovations will be essential to provide the enabling environment for sustainable development that is resilient to interrelated shocks and risks.Design/methodology/approachThis interdisciplinary literature review-based thought piece highlights how systemic risk is socially constructed and identifies guiding principles for systemic risk governance that could be actionable by and provide entry points for local and national governments, civil society and the private sector. particularly in low- and middle-income countries (LMIC), in a way that is relevant to the achievement of the 2030 Agenda for Sustainable Development. This considers preparedness, response and resilience, but more importantly prospective and corrective risk control and reduction strategies and mechanisms. Only when systemic risk is framed in a way that is relevant to the political agendas of countries will it be possible to begin a dialogue for its governance.FindingsThe paper identifies opportunities at the global, national and local levels, which together draw up a viable framework for systemic risk governance that (1) embraces the governance of sustainability and resilience through a strengthened holistic governance framework for social, economic, territorial and environmental development; (2) improves managing conventional risk to ultimately manage systemic risks; (3) fosters the understanding of vulnerability and exposure to gain insight into systemic risk; (4) places a greater focus on prospective risk management; (5) manages systemic risk in local infrastructure systems, supply chains and ecosystems; (6) shifts the focus from protecting privatized gains to managing socialized risk.Originality/valueThe choices and actions that societies take on the path of their development are contributing intentionally or unintentionally to the construction of systemic risks, which result in knock-on effects among interconnected social, environmental, political and economic systems. These risks are manifesting in major crises with cascading effects and a real potential to undermine the achievement of the SDGs, as COVID-19 is a stark reminder of. This paper offers the contours of a new risk governance paradigm that is able to navigate the new normal in a post-COVID world and is equipped to manage systemic risk.

An analysis of social vulnerability in a multi-hazard urban context for improving disaster risk reduction policies: The case of Sancaktepe, İstanbul

An analysis of social vulnerability in a multi-hazard urban context for improving disaster risk reduction policies: The case of Sancaktepe, İstanbul

Overcoming Namibia’s worst drought in the last 40 years: Ethnographic insights from Okakarara constituency

In 2019, Namibia experienced one of the worst droughts in recent decades, significantly affecting its agricultural economy, especially the livestock production sector. In this context, there is limited literature about how pastoral farmers in the country’s communal agricultural areas navigated this severe dryness. This paper addresses this knowledge gap by introducing a case study involving Ovaherero pastoralists in the Okakarara constituency. Following a mixed-method approach, it describes the practices implemented by local households to keep their cattle herds alive, the challenges they experienced thereby, and the strategies used for recovering their livestock losses. The study reveals that essential drought-coping practices, such as livestock mobility along with various long-term risk reduction mechanisms, such as reservation of emergency pastures, and social institutions of exchange, are limited in the communities described in this research. The paper discusses the main reasons for these conditions and their implications for local farmers, considering that more frequent droughts of similar severity are projected for the coming years in the region.

Nuts and Cardiovascular Disease Outcomes: A Review of the Evidence and Future Directions.

Nuts are nutrient-rich foods that contain many bioactive compounds that are beneficial for cardiovascular health. Higher consumption of nuts has been associated with a reduced risk of several cardiovascular diseases (CVD) in prospective cohort studies, including a 19% and 25% lower risk of CVD incidence and mortality, respectively, and a 24% and 27% lower risk of coronary heart disease incidence and mortality, respectively. An 18% lower risk of stroke mortality, a 15% lower risk of atrial fibrillation, and a 19% lower risk of total mortality have also been observed. The role of nuts in stroke incidence, stroke subtypes, peripheral arterial disease and heart failure has been less consistent. This narrative review summarizes recommendations for nuts by clinical practice guidelines and governmental organizations, epidemiological evidence for nuts and CVD outcomes, nut-containing dietary patterns, potential mechanisms of nuts and CVD risk reduction, and future research directions, such as the use of biomarkers to help better assess nut intake. Although there are still some uncertainties around nuts and CVD prevention which require further research, as summarized in this review, there is a substantial amount of evidence that supports that consuming nuts will have a positive impact on primary and secondary prevention of CVD.

Digitalization as a factor in the development of innovative technologies in the fuel and energy complex of Russia

The purpose of this study is to identify the main trends in the use of digitalization achievements in the fuel and energy complex of Russia and ways to stimulate innovative technologies by reducing the risks of “digital” projects in modern conditions. The object of research is the role of digitalization in the development of innovative technologies. The subject of the study is the specific features of the introduction of digitalization to stimulate the innovative development of the fuel and energy complex of Russia. To achieve the goal, the following tasks are set: 1) to analyze the fundamental trends in the use of digitalization achievements in the fuel and energy complex of Russia; 2) to identify the results of the introduction of modern digital technologies and the role of digitalization in the innovative development of the fuel and energy complex of Russia in modern conditions. The mechanism of risk reduction in the implementation of “digital” projects to stimulate innovation in the fuel and energy complex of Russia is proposed.

Діагностика розвитку управління ризиками телекомунікаційних підприємств

The article provides an in-depth diagnosis of the development of risk management of telecommunications enterprises, taking into account the existing level of organization of risk management and the level of the enterprises’ economic stability in the context of digitalization of business processes. Thus, the imperatives for diagnosing the efficiency of risk management development are substantiated; a typology of clusters of telecommunication enterprises has been formed to determine the level of development of risk management; a system of indicators for assessing the level of organization of risk management of telecommunication enterprises and for determining the level of economic stability of the enterprise, taking into account risk factors, is proposed. Based on the proposed scientific-methodological approach, the coefficients of efficiency of risk management development are calculated and the level of efficiency is determined. It is found that the leading telecommunication enterprises of Ukraine, namely, PJSC «Kyivstar», PJSC «VF Ukraine», LLC «lifesell» and PJSC «Ukrtelecom» have a fairly high (above average or average) level of risk management development. The highest level of risk management development and the least «radical» focus of changes in risk management strategy is provided by Kyivstar PJSC. This enterprise has a progressive level of organization of risk management and the highest level of economic stability among the studied enterprises. PJSC «VF Ukraine» (2nd place after PJSC «Kyivstar») and LLC «lifesell» (respectively – 3rd place) have a sufficiently high (on the scale of «above average») level of risk management development. It is determined that at the present stage these enterprises have a standard, with elements of progressive, level of development of risk management and are sufficiently prepared for the use of innovative risk reduction mechanisms.

Community-based fire management in Bolivia: integrating people, knowledge and good practices

Fire has always been part of the dynamics of Bolivia’s forest landscapes. However, the increasing frequency and intensity of large fires is threatening the sustainability of ecosystems and the livelihoods of vulnerable communities, mainly in the Chiquitania region of Santa Cruz Department. Local communities are assuming an active and responsible role in fire management. However, stronger partnerships and technical assistance are still required to consolidate good practices, mainly those related to the use of and access to information and communication technologies. This presents an opportunity to target digital inclusion policies that provide incentives to local communities to strengthen early warning and risk-reduction mechanisms.

Abstract 12741: Effect of One Year of Exercise Training on Left Ventricular Relaxation in Patients With Stage B Heart Failure

Introduction: Left ventricular hypertrophy (LVH) is a risk factor for developing heart failure (HF). Exercise training decreases LV stiffness in individuals with LVH, but the effects of exercise training on LV relaxation in these individuals are unknown. Methods: Patients with LVH (&gt; 11 mm) and elevated cardiac biomarkers (N-terminal pro- B-type natriuretic peptide [&gt;40 pg/mL] or high-sensitivity troponin T [&gt;0.6 pg/mL]) were randomized 2:1 to 1 year of monitored exercise training 4-5 days a week, including high intensity intervals, and 1-2 days of strength training or an attention control. Isovolumetric relaxation time (IVRT) was measured with pulse wave Doppler echocardiography and pulmonary capillary wedge pressure (PCWP) was consecutively measured with right heart catheterization before and after intervention. LV relaxation time constant, Tau, was estimated by Tau = IVRT / (Ln End-systolic pressure (ESP) - Ln PCWP) (Figure). Maximal oxygen uptake (VO 2 Max; Douglas bags) was measured with an incremental treadmill test. LV Stiffness was significantly improved in exercise arm, previously reported. Results: Thirty-one participants completed the study (Control: n=11, 51±6 years, 55% men, Exercise: n=20 53±6, 65% men). VO 2 Max increased by 18.2% in the exercise arm (2.2±0.6 L/min to 2.5±0.6, but not in controls; group x time p&lt;0.001). Exercise training did not change Tau (exercise 38.2±6.5 to 39.8±8.7 ms) compared to control(40.3 ± 5.9 to 39.2±6.8 ms, group x time p = 0.84, Figure ). Exercise training resulted in no significant changes in IVRT (p = 0.35), SBP (p=0.89) or PCWP (p=0.69). Conclusions: In patients with LVH at risk for HF, one year of high intensity exercise training did not improve LV relaxation despite significant improvement in ventricular stiffness and exercise capacity. These results suggest the primary mechanism for HF risk reduction with exercise training is by lowering LV stiffness, and not necessarily altering LV relaxation.

Perception towards preeclampsia and perceived barriers to early health-seeking among pregnant women in selected Hospitals of South Gondar Zone, Northwest Ethiopia: A qualitative study

BackgroundPreeclampsia is one of the top maternal morbidity and mortality that disproportionately affects pregnant women in low and middle-income countries where access and quality of health services are limited. People in different areas perceive preeclampsia differently which directly or indirectly affects the timing and place of heath seeking. Positive perception about perceived causes, perceived complications, and prevention of preeclampsia is central for the prediction and early diagnosis of the disease. However, little is known about the perception of pregnant women towards preeclampsia in Ethiopia. This study aimed to assess the perception towards preeclampsia and perceived barriers to early health-seeking among pregnant women in selected Hospitals of South Gondar Zone, Northwest Ethiopia.MethodsA qualitative study using phenomenological approach was implemented among 20 purposively selected pregnant women who visited health facilities for antenatal care service in four selected Hospitals of the South Gondar Zone of the Amhara Region. Data were collected through an in-depth interview (IDI) using a semi-structured interview guide from January to February 2020. Thematic analysis was executed using Open Code Software version 4.03.ResultsThe majority of the participants believed preeclampsia as a pregnancy-specific hypertensive disease and mainly associated it with overweight and nutritional problems. With regards to the perceived severity, the study participants agreed that preeclampsia can lead women to death. Personal delay, lack of awareness about the disease, transport problem, and low socioeconomic condition were perceived as the major reasons for the delay to early health-seeking (the 1st and the 2nd delay). While poor service provision and long waiting times were the barriers to receive services at the health facility level (the 3rd delay).ConclusionThe majority of the participants believed preeclampsia as a pregnancy-specific hypertensive disease and mainly associated it with overweight and nutritional problems. The finding of this study implied that awareness creation about the danger of hypertension during pregnancy and its risk reduction mechanisms shall be emphasized. The care provision at health facilities shall be improved by decreasing long waiting time which discourages service utilizations aside from improving early seeking behavior of pregnant women through different interventions.

External and Domestic Drivers of Nuclear Trilemma in Southern Asia: China, India, and Pakistan

ABSTRACT This paper discusses both the external and domestic drivers of the nuclear trilemma in Southern Asia that involves China, India and Pakistan. It seeks to untangle the complexity of the dyad and the triangular nature of the relationships between the three countries and highlights major differences as well as similarities in the nuclear dynamics. It identifies and examines the internal dynamics of the China–India and India–Pakistan conflicts and explores how domestic drivers such as nationalism, public opinions, and civil–military relations either mitigate or exacerbate nuclear risks in a region marked by perennial disputes, emerging rivalry, and long-standing extra-regional interferences. Against these backgrounds, the paper addresses the central theme of the nuclear trilemma between China, India, and Pakistan by looking at causes of instability, risks of conflicts and escalation to nuclear use, and prospects of restraint and risk reduction, including the development and implementation of confidence-building measures and nuclear risk reduction mechanisms.

ВИКОРИСТАННЯ РИНКОВИХ ДЖЕРЕЛ ФІНАНСУВАННЯ ДЕФІЦИТУ ДЕРЖАВНОГО БЮДЖЕТУ В УКРАЇНІ

Adopting a budget with a deficit in the modern world is not considered a negative phenomenon. However, it is imperative to identify sources of funding for such a deficit. In this regard, the use of market sources of financing the state budget deficit is the most optimal. The purpose of the article is to reveal the theoretical provisions and practice of financing the state budget deficit of Ukraine with the help of market sources. The article solves the following tasks: determining the place of financing the budget deficit in the process of equalization using different sources; characterization of existing sources of financing the budget deficit, and establishing criteria for classifying them as "market"; analysis of statistics on the preconditions for the state budget deficit in Ukraine; assessment of the use of market sources of financing the state budget deficit of Ukraine and the consequences of such financing. The existing sources of financing the state budget deficit are considered, among which: deficit financing emission, tax sources, budget sequestration, sale of budget assets, internal state loans, external state loans, free assistance. Market features identify the sources related to the use of debt financing instruments of the budget deficit, namely internal and external government loans. The advantages of using market sources of financing the state budget deficit are determined, namely: non-inflationary nature, efficiency of coverage, possibility to choose the most optimal offers on the market, wide opportunities for diversification, large base of risk reduction mechanisms, high liquidity. An assessment of the market sources use in terms of the state budget deficit financing in Ukraine allowed us to establish that external financing, which carries the greatest burden on the budget, accounts for the majority. In the structure of external financing, the largest share belongs to loans received by Ukraine from international financial institutions. Sold foreign government bonds also account for a large share of external debt. The domestic market for deficit financing is realized through the sale of domestic bonds. The increase in domestic and external debts poses a threat to Ukraine's debt security, which was analyzed using a number of indicators.

Occurrence of polycyclic aromatic compounds and interdomain microbial communities in oilfield soils

Soil polycyclic aromatic compound (PAC) pollution as a result of petroleum exploitation has caused serious environmental problems. The unclear assembly and functional patterns of microorganisms in oilfield soils limits the understanding of microbial mechanisms for PAC elimination and health risk reduction. This study investigated the polycyclic aromatic hydrocarbons (PAHs) and substituted PAHs (SPAHs) occurrence, and their impact on the bacteria-archaea-fungi community diversity, co-occurrence network and functionality in the soil of an abandoned oilfield. The results showed that the PAC content in the oilfield ranged from 3429.03μgkg-1 to 6070.89μgkg-1, and risk assessment results suggested a potential cancer risk to children and adults. High molecular weight PAHs (98.9%) and SPAHs (1.0%) contributed to 99.9% of the toxic equivalent concentration. For microbial analysis, the abundantly detected degraders and unigenes indicated the microbial potential to mitigate pollutants and reduce health risks. Microbial abundance and diversity were found to be negatively correlated with health risk. The co-occurrence network analysis revealed nonrandom assembly patterns of the interdomain microbial communities, and species in the network exhibited strong positive connections (59%). The network demonstrated strong ecological linkages and was divided into five smaller coherent modules, in which the functional microbes were mainly involved in organic substance and mineral component degradation, biological electron transfer and nutrient cycle processes. The keystone species for maintaining microbial ecological functions included Marinobacter of bacteria and Neocosmospora of fungi. Additionally, benzo [g,h,i]pyrene, dibenz [a,h]anthracene, indeno [1,2,3-cd]perylene and total phosphorus were the key environmental factors driving the assembly and functional patterns of microbial communities under pollution stress. This work improves the knowledge of the functional pattern and environmental adaptation mechanisms of interdomain microbes, and provides valuable guidance for the further bioremediation of PAC-contaminated soils in oilfields.