Median sternotomy remains the most frequent access in cardiac surgery, while postoperative sternomediastinitis is one of the most serious complications of transsternal access. The article analyzes the preoperative factors for the development of complications, including concomitant pathology, constitutional features, bad habits, length of hospital stay, and urgency of the operation. It was also noted that intraoperative factors consist of technical errors in the operation, intraoperative features of the course of surgical intervention, the nature of the choice of shunt during myocardial vascularization and the completion of the operation. Postoperative risk factors include the management of the postoperative period in cardiac patients, that can lead to complications. The analysis of preventive measures taken by cardiac surgeons in the development of complications is presented.