Water inrush in coal mine could be considered as one of the major threats to the security of miners. Thus, it is necessary to forecast the risk of water inrush to ensure the safety of mine production. The mechanism of water inrush and the related factors, such as geological structures, mining pressure, water pressure and water resisting layer are analyzed. The water inrush prediction model was proposed and applied to DongShan coal mine based on GIS and multi-information. Compared with the water inrush status of DongShan coal mine, the results obtained from the water inrush prediction model are satisfied.