Risk Of Adenoma Recurrence Research Articles

DNA aneuploidy in colorectal adenomas is associated with an increased risk of adenoma recurrence: [formula omitted], M.S. Baker, M.J. Flaherty, Z. Feng, T.J. Ylvisaker, A.D. Feld, A.R. Kristal. Cancer Prevention Research Program, Fred Hutchinson Cancer Research Center; Group Health Cooperative of Puget Sound; and Depts. Medicine, Epidemiology & Pathology, University of Washington; Seattle, WA

DNA aneuploidy in colorectal adenomas is associated with an increased risk of adenoma recurrence: [formula omitted], M.S. Baker, M.J. Flaherty, Z. Feng, T.J. Ylvisaker, A.D. Feld, A.R. Kristal. Cancer Prevention Research Program, Fred Hutchinson Cancer Research Center; Group Health Cooperative of Puget Sound; and Depts. Medicine, Epidemiology & Pathology, University of Washington; Seattle, WA

Cigarette smoking and other behavioral risk factors for recurrence of colorectal adenomatous polyps (New York City, NY, USA).

Adenomatous polyps (hereinafter referred to as adenomas) are known precursors of colorectal cancer. Cigarette smoking has been associated with adenomas but not with colorectal cancer, while alcohol and fat intake have been associated with both adenomas and cancer in some studies. Approximately 30 percent of patients with resected adenomas develop another adenoma within three years. This case-control study explores the association of cigarette smoking with adenoma recurrence. Between April 1986 and March 1988, we administered a questionnaire to colonoscoped patients aged 35 to 84 years in three New York City (NY, USA) practices. We compared 186 recurrent polyp cases (130 males, 56 females) and 330 controls (187 males, 143 females) who had a history of polypectomy but normal follow-up colonoscopy, by cigarette-smoking pack-years adjusted for possible confounders. Risk for a metachronous or recurrent adenoma was significantly greater in the highest quartile of smokers than in never-smokers among both men (odds ratio [OR] = 1.8, 95 percent confidence interval [CI] = 1.0-3.4) and women (OR = 3.6, CI = 1.7-7.6). Adjustment for time since smoking cessation reduced risk only slightly, as did adjustment for dietary fat intake, which itself remained significant. No association was found between alcohol intake and risk of recurrence. Cigarette smokers appear to have an elevated risk of adenoma recurrence that is not eliminated entirely by smoking cessation. Intervention trials that use adenoma recurrence as an endpoint should take smoking into account.

The remaining colon after radical surgery for colorectal cancer. The first three years of a prospective study.

This study investigates the possible gain and limitation by performing colonoscopy and double-contrast enema immediately after, and every six months after, radical surgery for colorectal cancer. It was possible to perform a complete colonoscopy within three months of surgery in 80 per cent of the 239 patients and at the follow-up time in 90 per cent. Incompleteness was related to insufficient bowel preparation, narrow anastomosis, and long transverse colon. Five patients had synchronous cancers, and 64 had adenomas at the time of surgery. The risk of recurrent adenomas in the latter was higher (17/64) than in those without adenomas (15/175). The adenomas were located above the rectum in 57 of 80 patients who had polypectomy. Four patients with metachronous cancer and one of five patients with local recurrence had another radical operation, while this was possible in none of 40 patients with recurrence diagnosed by other means than colonoscopy and enema. Radical colorectal surgery should be followed by colonoscopy and double-contrast enema, but how often and for how long remains to be established.