Risk Of Obesity In Adolescents Research Articles

Association between DNA methylation in obesity-related genes and body mass index percentile in adolescents

Childhood obesity remains an epidemic in the U.S. and worldwide. However, little is understood regarding the epigenetic basis of obesity in adolescents. To investigate the cross-sectional association between DNA methylation level in obesity-related genes and body mass index (BMI) percentile, data from 263 adolescents in the population-based Penn State Child Cohort follow-up exam was analysed. Using DNA extracted from peripheral leukocytes, epigenome-wide single nucleotide resolution of DNA methylation in cytosine-phosphate-guanine (CpG) sites and surrounding regions was obtained. We used multivariable-adjusted linear regression models to assess the association between site-specific methylation level and age- and sex-specific BMI percentile. Hypergeometric and permutation tests were used to determine if obesity-related genes were significantly enriched among all intragenic sites that achieved a p < 0.05 throughout the epigenome. Among the 5,669 sites related to BMI percentile with p < 0.05, 28 were identified within obesity-related genes. Obesity-related genes were significantly enriched among 103,466 intragenic sites (Phypergeometric = 0.006; Ppermutation = 0.006). Moreover, increased methylation on one site within SIM1 was significantly related to higher BMI percentile (P = 4.2E-05). If externally validated, our data would suggest that DNA methylation in obesity-related genes may relate to obesity risk in adolescents.

The National After-School Athletics Program Participation as a Tool to Reduce the Risk of Obesity in Adolescents after One Year of Intervention: A Nationwide Study.

Regular exercise during school hours is encouraged; however many children and adolescents fail to meet the recommendations during this time. Extracurricular activities may be a more appealing way for youth to achieve guidelines, and it is recommended that they attend two sessions each week. The aim of the study was to assess the influence of participation in a national physical activity program accompanied by nutritional education for trainers on the risk of obesity and body composition in a nationwide sample of boys and girls, after one year of intervention. The #goathletics Study was conducted in a group of 1014 adolescents aged 12–13: 507 individuals for the Athletics for All program (210 boys, 297 girls) and 507 pair-matched individuals not participating in any physical activity program (matching including: gender, age, city of residence). The body mass (kg), Body Mass Index (BMI) (kg/m2), waist circumference (WC) (cm), waist-to-height ratio (WHtR) (-) and body composition (%) (measured using bioelectrical impedance method) were compared in a gender-related sub-groups using t-Student test (for parametric distributions) or Mann-Whitney U test (for nonparametric distributions) and chi2 test (for the share of sub-groups). After one year of intervention, lower body mass percentile, BMI percentile, WC, WHtR and fat mass share, higher muscle mass share, as well as lower frequency of overweight/obesity and abdominal fat distribution were observed both for boys and girls participating in the physical activity intervention compared to the pair-matched controls. The after-school physical activity program accompanied by nutritional education for trainers may be a highly effective method for reducing the risk of obesity both for boys and girls, as regular participation is ensured.

The Effects of Water Intake, Fruits and Vegetables Consumption, and Socio-Cultural on Obesity among Adolescents

Background: The prevalence of obesity is increasing in the world, especially in Indonesia. Obe­sity can cause health problems, such as hyperinsulinemia, diabetes, cardiovascular disease, hyper­ten­sion, immunological disorders, certain types of cancer, etc. This study aims to analyze the influence of consumption of water, fruit and vegetables and sociocultural views on the risk of obe­si­ty in senior high school adolescents. Subjects and method: This was a cross-sectional study conducted at 25 senior high schools in Banyuwangi, East Java, from March to April 2018. Samples of 225 students were selected using ran­­dom sampling technique. The dependent variable was obesity. The independent variables were con­sumption of water, fruit and vegetables and socio-cultural views. The data were collected using ques­tionnaires and analyzed using multilevel logistic regression. Results: Water consumption (b = -2.67; CI 95% = -3.77 to -1.58; p = <0.001), fruit and vegetables (b = -1.16; CI 95% = -1.88 to -0.44; p = 0.002), activity physical (b = -1.12; 95% CI = -2.08 to -0.15; p = 0.023) and socio-cultural views (b = -1.89; CI 95% = -2.72 to -1.05; p = <0.001) reduce risk of obesity . Genetic factors (b = 3.12; 95% CI = 1.98 to 4.26; p = <0.001) increase the risk of obesity. Senior high school has a contextual effect on the risk of obesity with ICC = 9.89%. Conclusion: The risk of obesity decreases with adequate consumption of water, consumption of enough fruits and vegetables, enough physical activity and living in a society with a socio-cultural outlook with a good diet. The risk of obesity increases with the presence of factors. SMA has a contextual influence on the risk of obesity in adolescents. Keywords: water, fruit and vegetables, socio-cultural views, obesity Correspondence: Nita Aprilia. Masters Program in Public Health, Universitas Sebelas Maret. Jl. Ir.Sutami No. 36 A, Surakarta, Central Java. Email: nitaapriliamelia@gmail.com. Mobile: +6283847987215. Journal of Health Promotion and Behavior (2018), 3(4): 279-289 https://doi.org/10.26911/thejhpb.2018.03.04.08

PO008 Assessment of Cardiovascular Risk In Obese Adolescents Using Tissue Doppler Studies In Egypt

PO008 Assessment of Cardiovascular Risk In Obese Adolescents Using Tissue Doppler Studies In Egypt

Arterial stiffness as a measure of cardiovascular risk in obese adolescents and adolescents with diabetes type 1.

Background Cardiovascular disease (CVD) is the end result of vascular aging and atherosclerosis, having its origins in childhood. The aim of our study was to compare arterial stiffness (AS) and intima-media thickness (IMT) as markers of an early vascular damage between obese adolescents, adolescents with diabetes type 1 (T1D) and lean control subjects. Methods We analyzed AS and IMT in 68 obese adolescents (13.27±2.31 years), 42 adolescents with T1D (14.95±2.35 years) lasting over 5 years and 38 controls (15.02±1.94 years). AS (measured by pulse wave velocity [PWV], arterial compliance [AC] and β-stiffness) and IMT were assessed using an e-tracking ultrasound method. Results A significant difference between the groups was found for AC (p=0.022) and PWV (p=0.010), with the lowest compliance and higher velocities in T1D patients. When corrected for age, the difference in AC among the groups did not reach a statistical difference (p=0.059). Correlation analysis in the obese adolescents showed lower AC in females (p=0.041), with higher systolic blood pressure (SBP) (p=0.032). In T1D adolescents, disease duration was the strongest determinant of AS (AC p=0.028, β p=0.029 and PWV p=0.003), followed by body mass index (BMI; PWV p=0.008; β p=0.033), SBP (AC p<0.001; PWV p=0.023), diastolic BP (AC p=0.049; PWV p=0.048) and HbA1c (PWV p=0.048). No significant correlations were found for AS measures or IMT with sex, age, BMI, Tanner stage or BP levels in controls. Conclusions Early vascular damage is more pronounced in T1D adolescents than in obese or lean adolescents, which may emphasize the impact of hyperglycemia as a major threat for cardiovascular health.

SOSIAL EKONOMI, KONSUMSI FAST FOOD DAN RIWAYAT OBESITAS SEBAGAI FAKTOR RISIKO OBESITAS REMAJA

Obesity is a public health problem that encompasses life cycle including adolescent. Adolescent obesity bring consequences to increase case of obesity in adult and the risk factors for degenerative diseases. This study analyze riskfactor of socio-economic, parents history of obesity, nutrition knowledge and fast food consumption with the prevalence of adolescent obesity. The study was case control study and conducted at several high school in Gorontalo City, with670 adolescent, consisting of 335 case groups and 335 control groups. Data analysis was performed to assess the risk of independent variables of obesity. Low father’s education (OR= 2.724; 95% CI; 1.970 – 3,767), low mother education (OR= 4.727; 95% CI; 3.357 – 6.657), parents history of obesity (OR= 2.016; 95% CI; 1.482 – 2.743), low adolescent knowledge (OR= 6.673; 95% CI; 2.296 – 19.393) and fast food consumption more than 3 times per week (OR= 1.829; 95% CI; 1.337 – 2.502) increasing the risk of adolescent obesity. Mother occupation as a household mother (OR=0.338; 95% CI; 0.224 – 0.468) become protective factor. Pocket money (OR= 1.015; 95% CI; 0.724 – 1.423) was not a risk factor of obesity. Multivariate analysis showed that mothers occupation was dominant factor that infl uence obesity. Parent education, history of obesity, nutrition knowledge and fast food consumption were risk factors for obesity.

Acceleration of BMI in Early Childhood and Risk of Sustained Obesity

BackgroundThe dynamics of body-mass index (BMI) in children from birth to adolescence are unclear, and whether susceptibility for the development of sustained obesity occurs at a specific age in children is important to determine.MethodsTo assess the age at onset of obesity, we performed prospective and retrospective analyses of the course of BMI over time in a population-based sample of 51,505 children for whom sequential anthropometric data were available during childhood (0 to 14 years of age) and adolescence (15 to 18 years of age). In addition, we assessed the dynamics of annual BMI increments, defined as the change in BMI standard-deviation score per year, during childhood in 34,196 children.ResultsIn retrospective analyses, we found that most of the adolescents with normal weight had always had a normal weight throughout childhood. Approximately half (53%) of the obese adolescents had been overweight or obese from 5 years of age onward, and the BMI standard-deviation score further increased with age. In prospective analyses, we found that almost 90% of the children who were obese at 3 years of age were overweight or obese in adolescence. Among the adolescents who were obese, the greatest acceleration in annual BMI increments had occurred between 2 and 6 years of age, with a further rise in BMI percentile thereafter. High acceleration in annual BMI increments during the preschool years (but not during the school years) was associated with a risk of overweight or obesity in adolescence that was 1.4 times as high as the risk among children who had had stable BMI. The rate of overweight or obesity in adolescence was higher among children who had been large for gestational age at birth (43.7%) than among those who had been at an appropriate weight for gestational age (28.4%) or small for gestational age (27.2%), which corresponded to a risk of adolescent obesity that was 1.55 times as high among those who had been large for gestational age as among the other groups.ConclusionsAmong obese adolescents, the most rapid weight gain had occurred between 2 and 6 years of age; most children who were obese at that age were obese in adolescence. (Funded by the German Research Council for the Clinical Research Center “Obesity Mechanisms” and others; ClinicalTrials.gov number, NCT03072537.)

Stratified Multilevel Logistic Regression Modeling for Risk Factors of Adolescent Obesity in Tennessee

Background: US adolescent obesity rates have quadrupled over the past 3 decades. Research examining complex factors associated with obesity is limited. Objectives: The purpose of this study was to utilize a representative sample of students (grades 6 - 8) in Tennessee to determine the co-occurrence of risk behaviors with adolescent obesity prevalence and to analyze variations by strata. Patients and Methods: The 2010 youth risk behavior survey dataset was used to examine associations of obesity with variables related to sample demographics, risk and protective behaviors, and region. Hierarchical logistic regression analyses stratified by demographics and region were conducted to evaluate variation in obesity risk occurring on three hierarchical levels: class, school and district. Results: The sample consisted of 60715 subjects. The overall obesity rate was 22%. High prevalence of obesity existed in males, non-white race, those ever smoked and was positively correlated with age. Across three state regions, race, gender, and specific behaviors (smoking, weight misperception, disordered eating, +3 hours TV viewing, and no sports team participation) persisted as significant predictors of adolescent obesity, although variations by region and demographics were observed. Multilevel analyses indicate that < 1%, 0 - 1.97% and 4.03 - 13.06% of the variation in obesity was associated with district, school and class differences, respectively, when stratifying the sample by demographic characteristics or region. Conclusions: Uniform school-based prevention efforts targeting adolescent obesity risk may have limited impact if they fail to respond to geographical and demographic nuances that hierarchal modeling can detect. Study results reveal that stratified hierarchical analytic approaches to examine adolescent obesity risk have tremendous potential to elucidate significant prevention insights.

Gender, stressful life events and interactions with sleep: a systematic review of determinants of adiposity in young people

ObjectivesOverweight and obesity among young people are high and rising. Social stressors and sleep are independently associated with obesity, but are rarely studied together or examined for gender-specific effects. The...

Psychological Prophylaxis of Eхogenous Constitutional Obesity of Adolescents with Social Psychological Factors, Taken into Account

Aim - psychological prevention of development of exogenous-constitutional obesity on the basis of the definition of early diagnostic socio-psychological criteria for the risk of obesity in adolescents. Materials and methods. The study was conducted on the basis of the Department of Endocrinology of the Children's City Clinical Hospital No. 1. The sample of the study consisted of 40 adolescents, 20 of whom had a diagnosis of "Exogenous-constitutional obesity", grade 3-4 (the clinical group), while the other 20 adolescents had normal weight (the control group). The following psychodiagnostic methods were used in the study: the test of character accentuation by K. Leonhard, S. Schmieschek, the Dutch food questionnaire, the test "Adolescents about Parents" (ADOR), the method of directed retrospective analysis on "My Relations with Food" topic by V.I. Shebanova. Results. Adolescents with obesity are characterized by high sensitivity, empathy, a tendency for prolonged experience of grievances, suspicion, mistrust, emotional discomfort. In the families of adolescents with obesity, there is a cult of food, which negatively affects the formation of eating behavior. Adolescents with obesity are prone to emotionally dependent eating behavior. The social-psychological risk factors for obesity in adolescents are stuck and emotional character accentuations, low level of restrictive eating behavior, lack of intimacy with the mother, mother’s hostility and domination. Conclusion. Knowledge of the identified factors allows to predict the risk of obesity in adolescents at the early stage of weight gain and to carry out its timely prevention by correcting the characterological features, parent-child relationships and eating style in the family.

Intermittent nocturnal hypoxia and metabolic risk in obese adolescents with obstructive sleep apnea.

There is conflicting data regarding the independent associations of obstructive sleep apnea (OSA) with metabolic risk in obese youth. Previous studies have not consistently addressed central adiposity, specifically elevated waist to height ratio (WHtR), which is associated with metabolic risk independent of body mass index. The objective of this study was to determine the independent effects of the obstructive apnea-hypopnea index (OAHI) and associated indices of nocturnal hypoxia on metabolic function in obese youth after adjusting for WHtR. Subjects had standardized anthropometric measurements. Fasting blood included insulin, glucose, glycated hemoglobin, alanine transferase, and aspartate transaminase. Insulin resistance was quantified with the homeostatic model assessment. Overnight polysomnography determined the OAHI and nocturnal oxygenation indices. Of the 75 recruited subjects, 23% were diagnosed with OSA. Adjusting for age, gender, and WHtR in multivariable linear regression models, a higher oxygen desaturation index was associated with a higher fasting insulin (coefficient [standard error] = 48.076 [11.255], p < 0.001), higher glycated hemoglobin (coefficient [standard error] = 0.097 [0.041], p = 0.02), higher insulin resistance (coefficient [standard error] = 1.516 [0.364], p < 0.001), elevated alanine transferase (coefficient [standard error] = 11.631 [2.770], p < 0.001), and aspartate transaminase (coefficient [standard error] = 4.880 [1.444], p = 0.001). However, there were no significant associations between OAHI, glucose metabolism, and liver enzymes. Intermittent nocturnal hypoxia rather than the OAHI was associated with metabolic risk in obese youth after adjusting for WHtR. Measures of abdominal adiposity such as WHtR should be considered in future studies that evaluate the impact of OSA on metabolic health.

The Distribution of Weight Status according to Familial Socioeconomic Status in Korean Adolescents: The Twelfth Korea Youth Risk Behavior Web-based Survey, 2016

Background: The influence of socioeconomic status (SES) on weight status varies depending on the countries' levels of social and economic development. There are many studies on a risk of adolescent obesity according to familial SES in Korea. However, it is not clarified what effects familial SES has...

Oxidized and electronegative low-density lipoprotein as potential biomarkers of cardiovascular risk in obese adolescents

OBJECTIVES:To evaluate biomarkers associated with early cardiometabolic risk in obese adolescents.METHODS:This cross-sectional study included 137 adolescents of both sexes aged 10 to 19 years divided into a normal weight group (NW) (n=69) and an obese group (OB) (n=68).RESULTS:As expected, obesity showed positive associations with homeostatic model assessment for insulin resistance (HOMA-IR), triacylglycerol, insulin, plasma levels of non-esterified fatty acids, and cholesterol ester transfer protein activity and negative associations with plasma antioxidant levels. Plasma oxidized low-density lipoprotein (oxLDL) and electronegative low-density lipoprotein [LDL(-)] levels were significantly higher in the OB group. Higher tertiles of oxLDL were associated with increased values of body mass index; waist circumference; fatty mass percentage (%FM); and the atherogenic lipids non-high-density-lipoprotein cholesterol (non-HDL-C), low-density lipoprotein cholesterol (LDL-C), apolipoprotein B and triacylglycerol. Higher tertiles of LDL(-) were robustly associated with body mass index and waist circumference. Logistic regression models (odds ratios) confirmed that increased values of lipids and apolipoprotein B were associated with increased risk of oxLDL. For LDL(-), these associations were not significant, suggesting that another mechanism is involved in generating this particle in obese adolescents.CONCLUSIONS:Obese adolescents showed increased plasma LDL(-) and oxLDL, and obese girls had more LDL(-) than obese boys. Therefore, oxLDL is strongly and independently associated with classical cardiovascular risk factors, while increased levels of LDL(-) were influenced by body mass index, waist circumference and demographic parameters in obese adolescents.

Effects of Promoting Long-term, Exclusive Breastfeeding on Adolescent Adiposity, Blood Pressure, and Growth Trajectories

Evidence that breastfeeding reduces child obesity risk and lowers blood pressure (BP) is based on potentially confounded observational studies. To investigate the effects of a breastfeeding promotion intervention on adiposity and BP at age 16 years and on longitudinal growth trajectories from birth. Cluster-randomized Promotion of Breastfeeding Intervention Trial. Belarusian maternity hospitals and affiliated polyclinics (the clusters) were allocated into intervention (n = 16) or control arms (n = 15) in 1996 and 1997. The trial participants were 17 046 breastfeeding mother-infant pairs; of these, 13 557 children (79.5%) were followed up at 16 years of age between September 2012 and July 2015. Breastfeeding promotion, modeled on the Baby-Friendly Hospital Initiative. Body mass index (BMI, calculated as weight in kilograms divided by height in meters squared); fat and fat-free mass indices and percentage of body fat from bioimpedance; waist circumference; overweight and obesity; height; BP; and longitudinal growth trajectories. The primary analysis was modified intention-to-treat (without imputation for losses to follow-up) accounting for within-clinic clustering. We examined 13 557 children at a median age of 16.2 years (48.5% were girls). The intervention substantially increased breastfeeding duration and exclusivity compared with the control arm (exclusively breastfed: 45% vs 6% at 3 months, respectively). Mean differences at 16 years between intervention and control groups were 0.21 (95% CI, 0.06-0.36) for BMI; 0.21 kg/m2 (95% CI, -0.03 to 0.44) for fat mass index; 0.00 kg/m2 (95% CI, -0.21 to 0.22) for fat-free mass index; 0.71% (95% CI, -0.32 to 1.74) for percentage body fat; -0.73 cm (-2.48 to 1.02) for waist circumference; 0.05 cm (95% CI, -0.85 to 0.94) for height; -0.54 mm Hg (95% CI, -2.40 to 1.31) for systolic BP; and 0.71 mm Hg (95% CI, -0.68 to 2.10) for diastolic BP. The odds ratio for overweight/obesity (BMI ≥85th percentile vs <85th percentile) was 1.14 (95% CI, 1.02-1.28) and the odds ratio for obesity (BMI ≥95th percentile vs <95th percentile) was 1.09 (95% CI, 0.92-1.29). The intervention resulted in a more rapid rate of gain in postinfancy height (1 to 2.8 years), weight (2.8 to 14.5 years), and BMI (2.8 to 8.5 years) compared with the control arm. The intervention had little effect on BMI z score changes after 8.5 years. A randomized intervention that increased the duration and exclusivity of breastfeeding was not associated with lowered adolescent obesity risk or BP. On the contrary, the prevalence of overweight/obesity was higher in the intervention arm. All mothers initiated breastfeeding, so findings may not apply to comparisons of the effects of breastfeeding vs formula feeding. isrctn.org: ISRCTN37687716; and clinicaltrials.gov: NCT01561612.

Birth weight, biological maturation and obesity in adolescents: a mediation analysis.

This study was aimed to investigate associations between birth weight and multiple adiposity indicators in youth, and to examine potential mediating effects by biological maturation. This was a school-based study involving 981 Brazilian adolescents aged between 10 and 17 years. Birth weight was reported retrospectively by mothers. Maturation was estimated by age of peak height velocity. Adiposity indicators included body mass index (BMI), waist circumference and percent body fat estimated from triceps and subscapular skinfolds. Multilevel mediation analyses were performed using the Sobel test, adjusted for chronological age, gestational age, cardiorespiratory fitness and socio-economic status. Except for body fat in girls, biological maturation partly or fully mediated (P<0.05) positive relationships between birth weight with all other obesity indicators in both sexes with their respective values of indirect effects with 95% confidence intervals: BMI [boys: 0.44 (0.06-0.82); girls: 0.38 (0.13-0.64)], waist circumference [boys: 1.14 (0.22-2.05); girls: 0.87 (0.26-1.48)] and body fat [boys: 0.60 (0.13-1.07)]. To conclude, birth weight is associated with elevated obesity risk in adolescence and biological maturation seems to at least partly mediate this relationship.

Training Primary Care Providers in the Use of Motivational Interviewing for Youth Behavior Change.

Adolescent obesity is a global epidemic. Motivational interviewing (MI) is a promising strategy to address adolescent obesity risk behaviors. However, primary care providers (PCPs) tend to express discomfort with learning and adopting MI practices and with addressing patient weight issues. PCP proficiency in using MI to discuss body mass index, health screening results, and nutrition and physical activity behaviors after receiving training and coaching from an MI expert and practicing the technique was evaluated. We hypothesized that comfort with MI would increase consistently over time. Self-assessment surveys in MI proficiency were administered to PCPs after every youth participant MI session. MI comfort as determined by proficiency was categorized into low, medium, and high comfort according to survey Likert scale responses. Data were analyzed using analysis of variance (ANOVA) and Fisher's exact tests. Two hundred twenty-seven youth were seen for MI-based discussions by 4 PCPs. Two hundred twenty-six surveys had complete data for analysis. As anticipated, overall PCPs reported significantly more comfort with MI from the first to the final MI session over a 2- to 3-month period (p< .001). Comfort scores did not increase linearly over time for all PCPs. Despite standard training practices, overall MI proficiency as measured by comfort scores varied by PCP (p< .01). This type of MI training program should be considered for clinical nurses and nurse practitioners during their nursing education training to facilitate their ability to consistently and effectively support youth behavior change for conditions such as obesity (ClinicalTrials.gov Number NCT02502383).

Cardiometabolic risk markers, adipocyte fatty acid binding protein (aFABP) and the impact of high-intensity interval training (HIIT) in obese adolescents

ObjectiveThe impact of high-intensity interval training (HIIT) as well as the association between the adipocyte fatty binding protein (aFABP) and cardiometabolic risk factors in overweight adolescents was investigated. MethodsTwenty-eight adolescents (13–18years; BMI≥90th percentile according to German reference values) were offered HIIT twice weekly for 6months. At baseline and after program completion, anthropometric, clinical and metabolic characteristics were assessed and a fasting blood sample was obtained. Leptin, adiponectin, visfatin and aFABP were measured using commercially available kits. DNA methylation at RALBP1 was assessed using pyrosequencing. Descriptive statistics, Pearson's correlation and linear models were calculated. ResultsMean age at start of the program was 15.5±1.4years (53.5% females) and 20/28 (71%) provided follow-up data. At baseline, aFABP was correlated with BMI-SDS (0.48 [0.13,0.72]; p=0.0095), waist-to-height-ratio (0.63 [0.33,0.81], p=0.00036) and body fat content (0.55 [0.21, 0.77]; p=0.0031). Certain markers of metabolic risk were significantly correlated with aFABP (HOMA-IR 0.52 [0.19, 0.75], p=0.0044; γGT 0.48 [0.13, 0.73], p=0.0091; uric acid 0.46 [0.11, 0.71] p=0.013; HDL-C -0.39 [−0.66, −0.01] p=0.043; triglycerides 0.38 [0.01, 0.66], p=0.047). With the exception of triglycerides, these associations vanished after adjusting for BMI-SDS. aFABP did not depend on sex, age or pubertal stage in obese adolescents. After the HIIT program, small but significant reductions were observed in waist-to-height-ratio, (0.013 [0.0025, 0.024]; p=0.023), skin-fold based body fat content (2.0% [0.6, 3.5]; p=0.011), and standard deviation score of systolic blood pressure (0.69 [0.26 to 1.1]; p=0.0036). No changes were observed in adipokines or epigenetic markers following the program. ConclusionHIIT may have beneficial effects on body composition and cardiometabolic health in overweight adolescents. Like in adults, aFABP seems to be associated with markers of metabolic risk in obese adolescents.

Adolescent obesity in contextual settings: a scoping study of multilevel and hierarchical examinations.

Multilevel/hierarchical obesity studies analyze adolescent and family, neighbourhood and social settings' characteristics to generate data needed to design prevention interventions. This scoping study summarizes such studies' characteristics and key findings to provide information to decision makers, which allows them to quickly grasp the state of the evidence and potential policy implications for adolescent obesity prevention. PubMed, CINAHLplus, PsychINFO and Sociological Abstracts were searched for peer-reviewed studies spanning 1 January 2000-31 August 2014. Inclusion criteria included (i) outcome weight status, physical activity and weight status, or physical activity alone if the aim was obesity prevention; (ii) 12- to 19-year-old participants in a cross-sectional study, a separate analysis in a cross-sectional study or a longitudinal follow-up. Nineteen studies were published in the United States of America; four in Canada; two in Spain, China and Vietnam, respectively; and one in Germany. Self-efficacy, parental physical activity support, perceived neighbourhood support, social cohesion and access to recreational facilities were associated with increased activity levels; neighbourhood physical disorder and perceived lack of safety associated with reduced physical activity levels. Overweight or obesity was associated with sugar-sweetened beverage intake and household availability thereof; reduced odds were reported with fruit and vegetable intake and household availability of these, daily breakfast and family meal frequency. Potential adolescent obesity risk regulators may be found at the individual, family or social contextual levels.

Is Neck Circumference a Marker for Cardiovascular Risk in Obese Adolescents?

Background: Weight excess has become a public health problem worldwide, reaching about 200 million children, of whom 40 to 50 million are obese. Obesity in childhood is associated with increased blood pressure (BP), high triglycerides, low HDL-cholesterol and abnormal glucose metabolism. Visceral fat is a stronger predictor of metabolic dysfunction and cardiovascular risk than total body adiposity. Assessment of neck circumference (NC) is an easy method, which can serve as screening to identify individuals with weight excess. Our study aim was to examine associations between NC with BP values, lipid profile, blood glucose and fasting insulin in obese adolescents and verify the reproducibility of measurements of NC. Methods: 82 adolescents aged 10 to 17 years were included in the study, being 43 (22 boys and 21 girls) with obesity and 39 with normal weight (20 boys and 19 girls). Results: Significant associations were observed between NC and BMI, BP, HDL cholesterol, insulin and HOMA-IR. Disagreement between both observers for NC was observed in 5.2% of the sample, only concerning obese individuals. Conclusion: Our findings strengthen the knowledge about the potential value of NC as a tool for identifying patients at risk for hypertension, insulin resistance, and obesity. However as with the waist circumference it may be flawed in obese individuals.

Associations Between Depression and Obesity in Parents and Their Late-Adolescent Offspring: A Community-Based Study.

Major depressive disorder (MDD) and obesity are associated within individuals, but little is known about the association between MDD and obesity within families. We hypothesized that parental MDD would predict increased risk for adolescent obesity and that parental obesity would predict increased risk for adolescent MDD. Participants were drawn from the community-based Minnesota Twin Family Study (N = 7307; 17 years old: n = 3774). Parents and their 17-year-old offspring were assessed for MDD using a structured diagnostic interview, and direct assessments of height and weight were conducted (and diagnoses of obesity were derived from these measurements). Parental MDD was associated with offspring obesity (odds ratio [OR] = 1.74, 95% confidence interval [CI] = 1.24-2.46). ORs representing the risk associated with maternal and paternal MDD were similar (OR = 1.42, 95% CI = 1.02-1.92; OR = 1.40, 95% CI = 0.88-2.20, respectively). This parental effect remained significant when adjusting for parental obesity and offspring MDD (OR = 1.67, 95% CI = 1.18-2.37). Maternal obesity was associated with increased risk for MDD in offspring (OR = 1.32, 95% CI = 1.06-1.64), but paternal obesity was associated with decreased risk for MDD among offspring (OR = 0.70, 95% CI = 0.54-0.91). These effects remained significant when adjusting for parental MDD and offspring obesity (OR = 1.36, 95% CI = 1.07-1.73; OR = 0.65, CI = 0.49-0.87, respectively). There were no differences in these findings by offspring sex (p values for all tests of a sex interaction term > .374). We found general support for hypothesized cross-disorder associations between MDD and obesity in parents and offspring, suggesting that a shared etiology may underlie these associations. Contrary to prediction, paternal obesity was associated with decreased risk for offspring MDD, a finding that requires further investigation.