A computerized system using concepts of profiling and problem orientation will be described and examples of its use demonstrated. The system contains or accesses files on employee demography, job history, and current task lists, inventory of workplace risks categorized as physical, chemical, and functional, a master chemical inventory, and individual exposure records. By using Systemized Nomenclature of Medicine codes, a complete medical file catalogs all physiological and pathological variables, disease states, and functional responses. Profiling exposures and medical conditions enhances inquiry of the large data base that is accumulated.