Objective: Autosomal polycystic kidney disease (APKD) is a common hereditary renal disease with an incidence of 1/1.000 people, it's associated with development of hypertension and chronic kidney disease (CKD), both important cardiovascular risk factors (CRF). We considered this study to see the relationship between hypertension, CRF and CKD in APKD. Methods: The study was conducted in the Guadalajara's Hospital during 2009. Recording was made for sex, weight, height, BMI, CRF, target organ damage (TOD) (myocardial infarction, heart failure, coronary ischemia, stroke and CKD (GFR < 60 ml/min/1, 73m2), comorbidity (Charlson Index). The statistical analysis was carried out by percentages, qualitative variables by chi square and quantitative by Student t test. A p value <0.05 was considered statistically significant. Results: There have been 56 patients with APKD, hypertension was confirmed in 32 (57.1%), 55.4% women, BMI was 27.02 ± 4.08, mean age was 52.82 ± 18.91 and CKD in 9 (16.1%), 16.1% had TOD. The presence of hypertension was related to age >55 years in males and >65 in women (p = 0.009), but there were no significant differences in other CRF such as dyslipidemia, smoking, impaired fasting glucose, dyslipidemia, obesity, diabetes mellitus or metabolic syndrome, although hypertensive patients had more CKD this was not significant (p = 0.063). On the other hand the risk of TOD (p = 0.036, OR: 7.6 [95% CI 0,88–66,2]), age (p:0.007, 95% CI −23.3 to −3.8) and Charlson I. (p = 0.0001, 95% CI −2.50 to −1.01) was higher in hypertensive patients. (Table 01 and 02).Conclusions: We note a high prevalence of hypertension in patients with APKD. The hypertension in patients with APKD is associated with the presence of TOD, more comorbidity and age, and it's important that eight of nine patients with CKD were hypertensive. Further studies should be conducted to determine the actual role of APKD in the presence of reno-cardiovascular damage, on the other side as there is no specific treatment for APKD, it's important an adequate control of hypertension.