Risk Of Primary Lung Cancer Research Articles

Lys751Gln polymorphism in the DNA repair gene XPD and risk of primary lung cancer

a Department of Internal Medicine, School of Medicine, Kyungpook National Uni ersity Hospital, Samduk 2ga 50, Taegu 700-412, South Korea b Cancer Research Institute, School of Medicine, Kyungpook National Uni ersity, Dong In 2Ga 101, Taegu 700-422, South Korea c Department of Biochemistry, School of Medicine, Kyungpook National Uni ersity, Dong In 2Ga 101, Taegu 700-422, South Korea d Department of Thoracic Surgery, School of Medicine, Kyungpook National Uni ersity Hospital, Samduk 2ga 50, Taegu 700-412, South Korea e Department of Internal Medicine, School of Medicine, Keimyung Uni ersity, Dongsan Dong 194, Taegu 700-712, South Korea f Department of Pre enti e Medicine, School of Medicine, Kyungpook National Uni ersity, Dong In 2Ga 101, Taegu 700-422, South Korea

Current applications of imaging procedures in the patient with lung cancer

The primary role of imaging procedures in the patient with lung cancer should be focused on staging and follow-up challenges. The role of imaging procedures in the detection of the patient at risk for primary lung cancer remains limited and cannot be recommended at present. There is no significant difference between the yield of CT and MR in this patient group, with the possible exception of a more specific role for MR when questions are raised concerning hilar lymph node involvement and mediastinal compartmental invasion. The main role of cross-sectional imaging techniques should be in the avoidance of unnecessary surgical procedures, identifying the unresectable patient prior to exploratory thoracotomy. It should be emphasized that all radiographic abnormalities are non-specific and must be histologically verified before presuming that an abnormal lymph node or large adrenal gland contains metastatic lung cancer.

Fluoroscopic radiation and risk of primary lung cancer following pneumothorax therapy of tuberculosis.

STEINITZ has reported a remarkable epidemiological study in Israel which indicated that persons with a tuberculosis history, active or arrested, showed a five to ten-fold increase in the risk of subsequent development of primary lung cancer1. Steinitz was, of course, acutely aware of the excessive risk of lung cancer in cigarette smokers and gave careful attention to this variable. Recently, she has also indicated that there is no reason to believe that persons with a past history of tuberculosis smoked cigarettes more than did those in the general population sample (personal communication). It therefore seems that by some mechanism other than cigarette smoking a record of extensive therapy of tuberculosis implies a high risk of primary lung cancer. The magnitude of excess risk of lung cancer in tuberculous persons is comparable with that for cigarette smoking in non-tuberculous persons. Is tuberculosis per se responsible for the observed excessive risk of future primary lung cancer ? We think not. We propose that frequent nuoroscopies of the chest, associated with the past extensive use of pneumothorax collapse therapy, is the aetiological factor responsible.