Risk Of Depression In Adolescents Research Articles

S-ketamine alleviates depression-like behavior and hippocampal neuroplasticity in the offspring of mice that experience prenatal stress

Prenatal stress exerts long-term impact on neurodevelopment in the offspring, with consequences such as increasing the offspring’s risk of depression in adolescence and early adulthood. S-ketamine can produce rapid and robust antidepressant effects, but it is not clear yet whether and how S-ketamine alleviates depression in prenatally stressed offspring. The current study incestigated the preliminary anti-depression mechanism of S-ketamine in prenatally stressed offspring, particularly with regard to neuroplasticity. The pregnant females were given chronic unpredictable mild stress on the 7th-20th day of pregnancy and their male offspring were intraperitoneally injected with a single dose of S-ketamine (10 mg/kg) on postnatal day 42. Our findings showed that S-ketamine treatment counteracted the development of depression-like behaviors in prenatally stressed offspring. At the cellular level, S-ketamine markedly enhanced neuroplasticity in the CA1 hippocampus: Golgi-Cox staining showed that S-ketamine alleviated the reduction of neuronal complexity and dendritic spine density; Transmission electron microscopy indicated that S-ketamine reversed synaptic morphology alterations. At the molecular level, by western blot and RT-PCR we detected that S-ketamine significantly upregulated the expression of BDNF and PSD95 and activated AKT and mTOR in the hippocampus. In conclusion, prenatal stress induced by chronic unpredictable mild stress leads to depressive-like behaviors and hippocampal neuroplasticity impairments in male offspring. S-ketamine can produce antidepressant effects by enhancing hippocampal neuroplasticity via the BDNF/AKT/mTOR signaling pathway.

Parenting strategies to support adolescent mental health during a pandemic: A Delphi consensus study

BackgroundThe COVID-19 pandemic has had ongoing detrimental effects on mental health, especially for young people. Parents can play a crucial role in the prevention of youth depression and anxiety disorders. While parenting guidelines for reducing the risk of adolescent depression and anxiety have been developed, they needed to be adapted for the unique challenges brought by a pandemic. MethodThis study employed the Delphi methodology to establish expert consensus on parenting strategies that are important for preventing adolescent depression or anxiety disorders during a pandemic. Through a literature search and panel recommendations, we identified 304 parenting recommendations. These were presented to an international panel of 35 experts in parenting and youth mental health, who rated the importance of these recommendations in preventing adolescent depression and anxiety over three survey rounds. ResultsThere were 167 parenting strategies endorsed as important or essential in reducing adolescents' risk of developing depression or anxiety disorders during a pandemic by ≥90% of the panel. These strategies were written into a set of specific and actionable guidelines for parenting through the pandemic, and made freely available online for parents. ConclusionsThis study adapted an original set of parenting guidelines for the COVID-19 pandemic, supported by research evidence and/or international experts, which can be promoted in Western English-speaking communities to help parents protect their adolescents from depression and anxiety disorders during pandemic and post-pandemic times.

90 The association between risk of depression and combined vigorous physical activity and screen time behaviours in French-speaking Belgian adolescents

Abstract Purpose While there is a clear consensus on the positive effect of physical activity on reducing the risk of depression, the literature on the association between screen time and risk of depression is rather conflicting. Also, no clear consensus has been reached on whether being sufficiently active could alleviate the negative effects of being sedentary on mental health. The purpose of this study was to investigate the association of combined vigorous physical activity (VPA) and screen time (ST) behaviours with the risk of depression (RD) in Belgian adolescents. Methods The analysis used data collected through self-reported questionnaires from 8412 adolescents aged 10 to 20 included in the 2022 “Health Behaviour in School-aged Children” (HBSC) study in French-speaking schools. RD was measured using the World Health Organisation Five Well-being Index (WHO-5), with scores ≤28/100 indicating RD. VPA and ST behaviours were identified by combining data on ST (TV, video games and internet use) and VPA in three categories: (1) low ST (total weekly ST < 4hours/day), independently of VPA; (2) high VPA-high ST (VPA≥3 times/week and total weekly ST ≥ 4hours/day) and (3) low VPA-high ST (VPA<3 times/week and total weekly ST ≥ 4hours/day). The association between RD and VPA-ST behaviours was measured using adjusted binary logistic regression. Results In 2022, 15.4% had low ST, 40.6% high VPA-high ST, and 44.0% low VPA-high ST behaviours. Moreover, 13.2% were at risk of depression. This prevalence was eight times higher in low VPA-high ST (62.9%) and four times higher in high VPA-high ST (29.5%) than in low ST (7.6%) adolescents. After adjusting for sociodemographic characteristics, body mass index and sleep duration, adolescents with low VPA-high ST behaviours were more likely to be at risk of depression (aOR=1.17, 95%CI: 1.31-2.35) compared to those with low ST, but this was not the case for those who had high VPA-high ST (aOR=1.18, 95%CI: 0.81-1.71). Conclusion These findings suggest that having either low ST or sufficient VPA may be protective for RD in adolescents. With ST increasing and PA remaining low in French-speaking Belgian adolescents, health promotion initiatives should continue to promote both PA and the reduction of sedentary behaviours in adolescents.

Longitudinal pathways from harsh parenting to adolescent depression via internal working models: The moderating role of adolescent trait mindfulness

Theoretical and empirical research indicates that insecure attachment with parents may function as a mediator between aversive parenting and adolescent depression. However, no longitudinal research has differentiated the roles of internal representations of parental attachment, especially the roles of the two internal working models (i.e., the self-model and the other model) in the longitudinal relation from harsh parenting to adolescent depression and whether adolescent mindfulness can play a moderating role in such relationships. Six hundred and forty-five school children completed a paper-and-pencil questionnaire in school three times with two eight-month intervals (338 girls and 307 boys, mean age = 13.45), and data on harsh parenting, internal working models, and depression were collected at three time points, and mindfulness were collected only at Time 1. Results demonstrated that among adolescents low in mindfulness, harsh parenting could undermine positivity of the self-model, which could further elevate the risk of adolescent depression. In comparison, these predictive relations did not exist among highly mindful adolescents. To our knowledge, this study is the first one to differentiate the roles of the two elements of internal working models in a longitudinal research design, which highlights the significant role of the impaired self-model in the development of adolescent depression in the context of aversive parenting.

Exploring the relationship between sleep patterns and depression among Chinese middle school students: a focus on sleep quality vs. sleep duration.

This study aims to explore the relationship between sleep patterns and depressive symptoms among adolescents, examining variations in depressive symptoms across different sleep qualities, durations, and habits. A cross-sectional survey was conducted, gathering data from 8,775 Chinese adolescents on their demographics, lifestyle habits, sleep quality and duration, and depressive symptoms. The association between sleep parameters and depressive symptoms was analyzed using multivariate logistic regression. The findings reveal a significant correlation between sleep quality/duration and depressive symptoms. Specifically, adolescents with poor sleep quality had higher depressive scores (mean score = 14.62, standard deviation = 5.71), significantly exceeding those with better sleep quality (mean score = 11.54, standard deviation = 4.69). Adolescents with shorter sleep duration also showed significantly higher depressive scores than those with moderate sleep duration. Importantly, adolescents experiencing both poor sleep quality and shorter sleep duration were at a significantly increased risk of depressive symptoms (OR = 4.04, 95% CI: 3.53-4.62, P < 0.001). Further analysis indicated that older age and lower family economic status were independent predictors of a higher risk of adolescent depression (OR = 1.22, 95% CI: 1.08-1.38, P = 0.001), whereas factors such as gender, ethnicity, residence, being an only child, and parental education levels were not statistically significant. Among Chinese adolescents, poor sleep quality and shorter sleep duration are independent predictors of higher depressive symptom scores. Adolescents experiencing both of these conditions simultaneously have a significantly increased risk of depressive symptoms. Furthermore, older age and lower family economic status are also significantly related to an increased risk of depression in adolescents. These findings emphasize the importance of improving sleep quality and optimizing sleep duration for the prevention of adolescent depression. They also suggest the need for a comprehensive approach that addresses the multifaceted factors influencing adolescent mental health, including sleep patterns and socioeconomic disparities.

Identifying the risk of depression in a large sample of adolescents: An artificial neural network based on random forest.

This study aims to develop an artificial neural network (ANN) prediction model incorporating random forest (RF) screening ability for predicting the risk of depression in adolescents and identifies key risk factors to provide a new approach for primary care screening of depression among adolescents. The data were from a large cross-sectional study conducted in China from July to September 2021, enrolling 8635 adolescents aged 10-17 with their parents. We used the Patient health questionnaire (PHQ-9) to rate adolescent depression symptoms, using scales and single-item questions to collect demographic information and other variables. Initial model variables screening used the RF importance assessment, followed by building prediction model using the screened variables through the ANN. The rate of depression symptoms in adolescents was 24.6%, and the depression risk prediction model was built based on 70% of the training set and 30% of the test set. Ten variables were included in the final prediction model with a model accuracy of 85.03%, AUC of 0.892, specificity of 89.79%, and sensitivity of 70.81%. The top 10 significant factors of depression risk were adolescent rumination, adolescent self-esteem, adolescent mobile phone addiction, peer victimization, care in parenting styles, overprotection in parenting styles, academic pressure, conflict in parent-child relationship, parental rumination, and relationship between parents. The ANN model based on the RF effectively identifies depression risk in adolescents and provides a methodological reference for large-scale primary screening. Cross-sectional studies and single-item scales limit further improvements in model accuracy.

Inflammation and immune system pathways as biological signatures of adolescent depression—the IDEA-RiSCo study

The biological mechanisms underlying the onset of major depressive disorder (MDD) have predominantly been studied in adult populations from high-income countries, despite the onset of depression typically occurring in adolescence and the majority of the world’s adolescents living in low- and middle-income countries (LMIC). Taking advantage of a unique adolescent sample in an LMIC (Brazil), this study aimed to identify biological pathways characterizing the presence and increased risk of depression in adolescence, and sex-specific differences in such biological signatures. We collected blood samples from a risk-stratified cohort of 150 Brazilian adolescents (aged 14–16 years old) comprising 50 adolescents with MDD, 50 adolescents at high risk of developing MDD but without current MDD, and 50 adolescents at low risk of developing MDD and without MDD (25 females and 25 males in each group). We conducted RNA-Seq and pathway analysis on whole blood. Inflammatory-related biological pathways, such as role of hypercytokinemia/hyperchemokinemia in the pathogenesis of influenza (z-score = 3.464, p < 0.001), interferon signaling (z-score = 2.464, p < 0.001), interferon alpha/beta signaling (z-score = 3.873, p < 0.001), and complement signaling (z-score = 2, p = 0.002) were upregulated in adolescents with MDD compared with adolescents without MDD independently from their level of risk. The up-regulation of such inflammation-related pathways was observed in females but not in males. Inflammatory-related pathways involved in the production of cytokines and in interferon and complement signaling were identified as key indicators of adolescent depression, and this effect was present only in females.

Prenatal maternal Inflammation, childhood cognition and adolescent depressive symptoms

BackgroundAccumulating evidence indicates that higher prenatal maternal inflammation is associated with increased depression risk in adolescent and adult-aged offspring. Prenatal maternal inflammation (PNMI) may increase the likelihood for offspring to have lower cognitive performance, which, in turn, may heighten risk for depression onset. Therefore, this study explored the potential mediating role of childhood cognitive performance in the relationship between PNMI and adolescent depressive symptoms in offspring. MethodsParticipants included 696 mother-offspring dyads from the Child Health and Development Studies (CHDS) cohort. Biomarkers of maternal inflammation [interleukin (IL)-6, IL-8, IL-1 receptor antagonist (IL-1RA) and soluble TNF receptor-II (sTNF-RII)] were assayed from first (T1) and second trimester (T2) sera. Childhood (ages 9–11) cognitive performance was assessed via standardized Peabody Picture Vocabulary Test (PPVT), a measure of receptive vocabulary correlated with general intelligence. Adolescent (ages 15–17) depressive symptoms were assessed via self-report. ResultsThere were no significant associations between T1 biomarkers and childhood PPVT or adolescent depressive symptoms. Higher T2 IL1-RA was directly associated with lower childhood PPVT (b = -0.21, SE = 0.08, t = -2.55, p = 0.01), but not with adolescent depressive symptoms. T2 IL-6 was not directly associated with childhood PPVT, but higher T2 IL-6 was directly associated at borderline significance with greater depressive symptoms in adolescence (b = 0.05, SE = 0.03, t = 1.96, p = 0.05). Lower childhood PPVT predicted significantly higher adolescent depressive symptoms (b = -0.07, SE = 0.02, t = -2.99, p < 0.01). There was a significant indirect effect of T2 IL-1RA on adolescent depressive symptoms via childhood PPVT (b = 0.03, 95 % CI = 0.002–0.03) indicating a partially mediated effect. No significant associations were found with T2 sTNF-RII nor IL-8. ConclusionsLower childhood cognitive performance, such as that indicated by a lower PPVT score, represents a potential mechanism through which prenatal maternal inflammation contributes to adolescent depression risk in offspring.

The mediation and interaction effects of Internet addiction in the association between family functioning and depressive symptoms among adolescents: A four-way decomposition

IntroductionPrevious studies have demonstrated that both family dysfunction and internet addiction (IA) are associated with a higher risk of adolescent depression. However, no study has yet investigated the mechanisms involved. This study aims to explore the mediation and interaction roles of internet addiction (IA) between family functioning and depressive symptoms among adolescents in rural China. MethodsA multi-stage, stratified cluster, and random sampling was conducted among 3343 adolescents in rural China from October 27 to November 6, 2020. Depressive symptoms, IA, and family functioning were assessed using the Epidemiologic Studies Depression Scale (CESD), the Internet Addiction Test (IAT), and the Family Adaptation Partnership Growth Affection and Resolve Index (APGAR), respectively. Correlation analysis was performed by binary logistic regression. The study employed a four-way decomposition method to explore the potential mechanisms of family functioning on depressive symptoms. ResultsThe results indicated that family functioning and IA were associated with adolescents' depressive symptoms. The interaction between family functioning and IA accounted for 74 % of the association between family functioning and depression symptoms, while direct effects accounted for 24 %. The “proportion eliminated” (76.11 %) was substantially larger than “proportion mediated” (7.36 %). LimitationsThe cross-sectional design limited to identify the causal relationship among the variables. ConclusionsWe found that family dysfunction synergizes with IA to contribute to the high risk of adolescent depression. Prioritizing at preventing IA in adolescence could be an effective way to mitigate the adverse effects of family dysfunction on depression.

Emerging Risk of Adolescent Depression and Suicide Detected Through Pediatric Primary Care Screening.

The goal of the current study was to document patterns of stability and change in adolescent depression and suicide risk detected via universal depression screening in pediatric primary care and to determine who may go on to experience emerging risk. Retrospective electronic health record information (sociodemographic data and depression screening results for 2 timepoints) was extracted for adolescents aged 12-17 who attended well-visits between November 15, 2017, and February 1, 2020, in a large pediatric primary care network. A total of 27,335 adolescents with 2 completed depression screeners were included in the current study. While most adolescents remained at low risk for depression and suicide across the 2 timepoints, others experienced emerging risk (i.e., low risk at time 1 but elevated risk at time 2), decreasing risk (i.e., high risk at time 1 but low risk at time 2) or stable high risk for depression or suicide. Odds of experiencing emerging depression and suicide risk were higher among adolescents who were female (compared to males), Black (compared to White), and had Medicaid insurance (compared to private insurance). Odds of experiencing emerging depression risk were also higher among older adolescents (compared to younger adolescents) as well as adolescents who identified as Hispanic/Latino (compared to non-Hispanic/Latino). Findings can inform symptom monitoring and opportunities for prevention in primary care.

Analysis of the Relationship between Parenting Style and the Risk of Depression in Teenager

Background : Depression is an emotional state usually characterized by extreme sadness, feelings of worthlessness and guilt. Depression in adolescents requires support from parents for adolescents to be able to overcome it as well. Parents with a democratic parenting style will make the child's personality self-controlled and good with his friends. Purpose : This study was to analyze the relationship between parenting style and the risk of depression. Methods : This study used a descriptive analysis research design with a cross sectional approach. The sample in this study was 102 students grade 11 and data analysis used the chi square test. Results : The results of the analysis showed that the relationship between parenting style and the risk of depression was found to be p = 0.000 (p &lt;0.05). Based on the results of the analysis in this study, it can be concluded that there is a significant relationship between parenting style and the risk of depression in adolescents

Relationship between Parent-child Communication, Adolescent Emotional Adjustment and Depression Symptoms

This paper aims to explore the relationship between parent-child communication and adolescent emotional adjustment and depressive symptoms, so as to provide theoretical support and practical guidance for family education and mental health intervention. Studies have shown that good parent-child communication has a positive impact on adolescents' emotional adjustment ability, which can reduce the risk of depressive symptoms. It is found that there is a significant positive correlation between parent-child communication and adolescent emotional adjustment. This means that in the family environment, good parent-child communication is helpful to improve teenagers' emotional adjustment ability and help them better cope with negative emotions. The improvement of emotional adjustment ability can make teenagers keep calm and control their emotions in the face of difficulties, so as to solve problems better. In addition, the study also found that there is a negative correlation between parent-child communication and depressive symptoms, and there is a significant negative correlation between adolescent emotional adjustment and depressive symptoms. This means that good parent-child communication can reduce the risk of adolescent depression. In the face of stress and difficulties, good parent-child communication can help teenagers gain emotional support and understanding, thus reducing the possibility of depressive symptoms.

The Effects of Early-Life Stress on Liver Transcriptomics and the Protective Role of EPA in a Mouse Model of Early-Life-Stress-Induced Adolescent Depression.

Early-life stress (ELS) was found to increase the risk of adolescent depression, and clinical evidence indicated that eicosapentaenoic acid (EPA) was decreased in patients with adolescent depression, but the underlying mechanisms are unclear. Here, we utilized an ELS model of maternal separation with early weaning to explore the protective role of EPA in adolescent depression. We found that that ELS induced depression-like behavior rather than anxiety-like behavior in adolescent mice. RNA-sequencing results showed that ELS changed the transcription pattern in the liver, including 863 upregulated genes and 971 downregulated genes, especially those related to the biosynthesis of unsaturated fatty acids metabolism in the liver. Moreover, ELS decreased the expression of the rate-limiting enzymes, fatty acid desaturases 1/2 (FADS1/2), involved in the biosynthesis of EPA in the liver. Additionally, ELS reduced the levels of EPA in the liver, serum, and hippocampus, and EPA administration improved depression-like behavior-induced by ELS. Our results provide transcriptomic evidence that ELS increases the risk of adolescent depression by reducing the synthesis of unsaturated fatty acids in the liver, especially EPA, and suggest that supplementation with EPA should be investigated as a potential treatment for adolescent depression.

Neural activation to peer acceptance and rejection in relation to concurrent and prospective depression risk in adolescent and pre-adolescent girls

Neurobiological sensitivity to peer interactions is a proposed marker of risk for adolescent depression. We investigated neural response to peer rejection and acceptance in relation to concurrent and prospective depression risk in adolescent and pre-adolescent girls. Participants were 76 girls (Mage=13, 45% racial/ethnic minorities) varying in depression risk: 22 with current major depressive disorder (MDD), 30 at High Risk for MDD based on parental history, and 24 at Low Risk with no psychiatric history. Girls participated in the Chatroom-Interact task—involving rejection and acceptance feedback from fictitious peers—while undergoing functional magnetic resonance neuroimaging. Activation in response to peer rejection and acceptance was extracted from regions of interest. Depressive symptoms were assessed at 6- and 12-month follow-up. Girls with MDD showed blunted left subgenual anterior cingulate response to acceptance versus girls in High and Low Risk groups. Girls in the High Risk group showed greater right temporo-parietal junction (rTPJ) and right anterior insula (AI) activation to both acceptance and rejection versus girls in the MDD (rTPJ) and Low Risk (rTPJ, AI) groups. Greater rTPJ response to rejection was associated with fewer depressive symptoms at 12-months and mediated the association between High Risk group status and 12-month depressive symptoms; greater rTPJ response to acceptance mediated the association between High Risk and increased 12-month depressive symptoms. Our finding of associations between altered neural response to peer interactions and concurrent and prospective depression risk/resilience highlights the importance of neural underpinnings of social cognition as risk and compensatory adaptations along the pathway to depression.

Effects of Family Relations Towards Risk of Depression in Adolescents

AbstractIntroductions: In these days, with depression in adolescents levels getting higher in amounts, it should be assessed whether their relationships with their families have an effect on their risk of depression. This study aims to find out the effect of family relations on the risk of depression. Methods: Literature from PubMed that was published in 2015-2019 was searched using specific keywords. Then these literatures were filtered according to the inclusion and exclusion criteria of the variables used within the studies and then the results of the research were put in a table and the individual results are compared. Results: Four studies were conducted with similar independent and dependent variables to be then assessed and the results were that different family relations refer to different depressive tendencies. Conclusions: This study shows that there are effects to be had from family relations towards the risk of depression in adolescents.

Analysis of Adolescent Depression Risk Factors During the Third Year of COVID-19 Pandemic in Surabaya

Background: The COVID-19 pandemic has caused changes such as isolation and contact restrictions. Adolescents are vulnerable to these changes because social contact is very important for their development. Research is needed on risk factors for adolescent mental health disorders especially depression during a pandemic to help deal with psychological conditions during and after an outbreak. Objective: To analyse the relationship between risk factors and adolescent depression during the third year of COVID-19 pandemic in Surabaya. Methods: This study used an observational analytic cross-sectional study design with an accidental sampling technique. The sample population is students of a junior high school in Surabaya grade 7 and 8. Depression is the dependent variable measured using the DASS-42 score using only the depression item. The independent variables consist of risk factors which are measured using a questionnaire. Statistical data were analysed using the Chi-square test. Result: Total respondents in this study is 121 students. A total of 22.3% students experienced depression. There was a correlation between gender (p=0.009), family history of COVID-19 infection (p=0.041), and parental education (p=0.055) on depression in adolescents. Conclusion: Gender, family history of COVID-19 infection, and parental education have a relationship with depression in adolescents during the COVID-19 pandemic in Surabaya.

Feeling unloved is the most robust sign of adolescent depression linking to family communication patterns.

Using network analysis, this study investigated how family communication patterns (Conversation and Conformity) were related to and predictive of adolescent overall depression severity and specific symptoms. A community sample of adolescents (10-17 years, n=1327) completed the Children's Depression Inventory and the Revised Family Communication Pattern Instrument. Depressive symptoms were also re-assessed 6months later. Results showed that Conversation orientation protected against, whereas Conformity orientation increased the risk of adolescent depression. Family communication particularly influenced the child's feeling of being unloved, and feeling unloved was the only symptom prospectively predicted by two communication orientations at baseline. These findings revealed the path linking family factors to adolescent depression and may have implications for future family-based interventions.

Predicting adolescent depression and anxiety from multi-wave longitudinal data using machine learning.

This study leveraged machine learning to evaluate the contribution of information from multiple developmental stages to prospective prediction of depression and anxiety in mid-adolescence. A community sample (N = 374; 53.5% male) of children and their families completed tri-annual assessments across ages 3-15. The feature set included several important risk factors spanning psychopathology, temperament/personality, family environment, life stress, interpersonal relationships, neurocognitive, hormonal, and neural functioning, and parental psychopathology and personality. We used canonical correlation analysis (CCA) to reduce the large feature set to a lower dimensional space while preserving the longitudinal structure of the data. Ablation analysis was conducted to evaluate the relative contributions to prediction of information gathered at different developmental periods and relative to previous disorder status (i.e. age 12 depression or anxiety) and demographics (sex, race, ethnicity). CCA components from individual waves predicted age 15 disorder status better than chance across ages 3, 6, 9, and 12 for anxiety and 9 and 12 for depression. Only the components from age 12 for depression, and ages 9 and 12 for anxiety, improved prediction over prior disorder status and demographics. These findings suggest that screening for risk of adolescent depression can be successful as early as age 9, while screening for risk of adolescent anxiety can be successful as early as age 3. Assessing additional risk factors at age 12 for depression, and going back to age 9 for anxiety, can improve screening for risk at age 15 beyond knowing standard demographics and disorder history.

RPS6KA5 methylation predict response to 6-week treatment for adolescent MDD patients

ObjectiveWe aimed to investigate the effect of differentially methylated genes and chronic childhood stress on the development of depressive symptoms in Chinese adolescents, as well as to test whether methylation at baseline can be used as a predictor of remission at follow-up after six weeks of treatment.MethodsAfter recruiting 87 MDD patients and 53 healthy controls, we compared demographic and baseline clinical characteristics. The Childhood Chronic Stress Questionnaire was used to assess stress caused by early-life events. MDD patients underwent six weeks of treatment, and response to treatment was assessed using the Beck Depression Inventory-II. In addition, four MDD patients and five controls were randomly chosen for genome-wide methylation analysis.ResultsThe gene RPS6KA5 showed significant methylation differences between the two groups. Severity of chronic childhood stress was significantly associated with increased risk of depression in adolescents, but not with treatment response. Baseline RPS6KA5 methylation can predict remission after six weeks of treatment. We did not observe any interaction between RPS6KA5 methylation and chronic childhood stress.ConclusionsOur results suggest that RPS6KA5 methylation can be used as a predictor of response to treatment in adolescent MDD patients. Here we offer new evidence for the role of epigenetics in early response to treatment of depression.Trial registrationChiCTR, ChiCTR2000033402, 31/05/2020, http://www.chictr.org.cn/index.aspx

The mediating role of self-esteem in the association between physical fitness and risk of depression in adolescents: DADOS Study

ABSTRACT Background: Previous literature showed an inverse association between physical fitness and risk of depression in adolescents, but the mechanisms involved in this association remain unclear. Aims: The primary aim of the study was to test the mediating role of self-esteem on the association between physical fitness components and risk of depression. The secondary aim was to investigate sex differences in these mediation models. Methods: A total of 225 participants (44% girls), aged 13.9 ± 0.3 years, from the DADOS (Deporte, ADOlescencia y Salud) study were included in the analyses. The results presented in this study belong to baseline data obtained between February and May of 2015. ALPHA-Fitness Test-Battery was used to evaluate physical fitness components. The Spanish version of the Behaviour Assessment System for Children-3 questionnaire was used to asses self-esteem and risk of depression. Boot-strapped mediation procedures were performed and indirect effects (IE) with confidence intervals (CI) not including zero were considered statistically significant. Results: Self-esteem was revealed as a mediator in the association between cardiorespiratory fitness and risk of depression (IE = −0.059; 95% CI = −0.098 to −0.015) and in the association between speed-agility and risk of depression (IE = −1.800; 95% CI = −3.117 to –0.623). Stratified mediation analyses by sex showed similar results in girls, but self-esteem did not act as a mediator in boys. Conclusion: Our findings indicate that high levels of cardiorespiratory fitness and speed-agility may improve self-esteem, which could have positive effects in mental health by reducing risk of depression in adolescents, especially in girls.