You have accessJournal of UrologyStone Disease: Epidemiology & Evaluation II1 Apr 2016PD47-02 GLOBAL TRENDS IN UROLITHIASIS MORBIDITY AND MORTALITY FROM 1990-2010 David Bayne, Tom Chi, Catherine Harris, and Anobel Odisho David BayneDavid Bayne More articles by this author , Tom ChiTom Chi More articles by this author , Catherine HarrisCatherine Harris More articles by this author , and Anobel OdishoAnobel Odisho More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2016.02.2690AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES The sequelae of untreated urolithiasis include infection, renal failure, and death. We sought to determine global trends in urolithiasis morbidity and mortality and evaluate potential risk factors. METHODS Age-adjusted sex-specific mortality rates (deaths per 100,000 people) and disease burden (Years Lost due to Disability, YLD) for 187 countries were obtained from the 2010 Global Burden of Disease Project for 1990, 2005, and 2010. Countries were classified into income groups and geographic regions based on World Bank categorizations. Gross Domestic Product (GDP) per capita, Human Development Index (HDI), Gini Index, Body Mass Index (BMI), and climate data (mean annual temperature) were obtained from the World Bank, United Nations Development Programme, and World Health Organization. RESULTS Between 1990 and 2010, population weighted global mortality from urolithiasis decreased from 0.51 to 0.37 per 100,000 people. Mortality rates decreased by 2%, 19%, 59%, and 52% for low, lower-middle, middle, and high income countries, respectively. YLD decreased in low and lower-middle income countries (13%, 15% respectively) but increased in upper middle and high income countries (5%, 6% respectively). Similar trends were found across regional country groupings, with Europe/Central Asia and East Asia/Pacific showing the largest decrease in mortality rate, while only South Asia and Sub-Saharan Africa experienced a decrease in YLD (Table 1). Multivariate analysis controlling for climate, BMI, HDI, GDP, and inequality (Gini), showed that increased mean annual temperature, increased GDP, and increasing inequality were associated with increasing mortality rate, and increased HDI was associated with decreased mortality rate. BMI had no impact. CONCLUSIONS Although urolithiasis mortality has declined over time, lower income countries suffer higher mortality rates compared to higher income countries. However, higher income countries suffer from increased disability due to urolithiasis. More work is necessary to better understand risk factors of urolithiasis and how to minimize the global burden of urolithiasis. © 2016FiguresReferencesRelatedDetails Volume 195Issue 4SApril 2016Page: e1170-e1171 Advertisement Copyright & Permissions© 2016MetricsAuthor Information David Bayne More articles by this author Tom Chi More articles by this author Catherine Harris More articles by this author Anobel Odisho More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...