Risk Factors For Urolithiasis Research Articles

Bibliometric analysis of the relationship between metabolic study and urolithiasis. A key tool in patient management

Objective: Our objective was doing an analysis of available bibliography to understand tendencies in publications regarding the role of metabolic evaluation in the management of urolithiasis. Materials and Methods: A retrospective bibliometric analysis of the available medical literature ranging from the year 2001 to 2022 was performed on the Web of Science platform. The graph analysis was done using Microsoft Excel and the bibliographic mapping analysis was done on the VOSviewer software. Results: A total of 120 references were found in 63 journals, with a decrease in the rate of publications in the last 5 years. The country, journal, and institution with the largest number of manuscripts were the United States, Journal of Urology, and the University of Bonn, respectively. The author with the largest number of publications was Sarica Kemal. The mapping and analysis of the keyword evolution with respect to the timeline centered on the terms: “prevention”, “metabolic risk factors”, “obesity”, “primary hyperoxaluria”, and “medical management”. Conclusion: Metabolic evaluation is a fundamental tool in the overall approach of these patients. Despite the decrease in the rate of research on the association between metabolic evaluation and urolithiasis in recent years, the importance of a complete assessment of these patients from the first symptomatic episode has been demonstrated, as it helps to determine the risk of recurrence of the disease, and to establish a treatment plan focused on prevention. This first bibliometric analysis on metabolic evaluation and urolithiasis depicts the importance of giving continuity to research on the risk factors of urolithiasis that may be modified and treated.

Genes polymorphism as risk factor of recurrent urolithiasis: a systematic review and meta-analysis

IntroductionUrolithiasis is one of the most prevalent diseases worldwide. Its prevalence is rising, both in developing and developed countries. It is known that genetic factors play big roles in the development of urolithiasis. One of the suspected factors is gene polymorphism. This study aims to find an accurate estimate of the association between genetic polymorphism and the risk of recurrent urolithiasis.MethodsA systematic review and meta-analysis were performed on 12 studies from 3 databases that investigated gene polymorphism as an risk factor of urolithiasis. The review was done using Review Manager® version 5.3.ResultsInsignificant heterogenicity was found in this study. Populations from Asia and the Middle East are more likely to experience recurrent urolithiasis. Additionally, variation in the VDR and urokinase genes, particularly in the Asian population, increases the risk of developing recurrent urolithiasis.ConclusionsGene polymorphisms have significant roles in the development of urolithiasis, especially in the Middle Eastern region.

Association of Chronic Hyperglycemia With the Risk of Urolithiasis.

Background The incidence of urolithiasis is increasing along with elevated rates of chronic hyperglycemia. Therefore, this study aimed to assess the association between high hemoglobin Alc (HbAlc) levels, in the form of type 2 diabetes mellitus (T2DM), and the risk of kidney stone formation among those living in the Eastern Province of Saudi Arabia. Methodology We conducted a cross-sectional study on a total of 501 patients with known cases of urolithiasis who visited King Fahad University Hospital (Khabar, Saudi Arabia). We calculated odds ratios (ORs) of having stones with respect to three parameters, namely, fasting blood glucose level, random blood glucose level, and glycosylated HbA1c testing. Results Of the 501 cases with urinary stones included in this study, the majority (223, 44.5%) were 41-59 years of age, and 350 (69.9%) were males. Our results showed that T2DM was significantly associated with high stone burden, with increased fasting plasma glucose, increased random blood glucose, and increased HbA1c being strong predictors. The significant associations between glycemic control measures and the risk of urolithiasis remained even after adjusting for factors related to insulin resistance. Conclusions According to our results, glycemiccontrol can be an independent risk factor for urolithiasis. This critical finding demonstrates the need for further studies to investigate this particular group of patients.

Univariable and multivariable mendelian randomization study revealed the modifiable risk factors of urolithiasis.

Urolithiasis is a common urological disease with increasing incidence worldwide, and preventing its risk poses significant challenges. Here, we used Mendelian randomization (MR) framework to genetically assess the causal nature of multifaceted risk factors on urolithiasis. 17 potential risk factors associated with urolithiasis were collected from recently published observational studies, which can be categorized basically into lifestyle factors and circulating biomarkers. The instrumental variables of risk factors were selected from large-scale genome-wide association studies (N ≤ 607,291). Summary-level data on urolithiasis were obtained from UK Biobank (UKB) (3,625 cases and 459,308 noncases) and the FinnGen consortium (5,347 cases and 213,445 noncases). The univariable and multivariable MR analyses were applied to evaluate the causal, independent effect of these potential risk factors upon urolithiasis. Effects from the two consortia were combined by the meta-analysis methods. Higher genetically predicted sex hormone-binding globulin (SHBG, OR, 0.708; 95% CI, 0.555 to 0.903), estradiol (OR, 0.179; 95% CI, 0.042 to 0.751), tea intake (OR, 0.550; 95% CI, 0.345 to 0.878), alcoholic drinks per week (OR, 0.992; 95% CI, 0.987 to 0.997), and some physical activity (e.g., swimming, cycling, keeping fit, and bowling, OR, 0.054; 95% CI, 0.008 to 0.363) were significantly associated with a lower risk of urolithiasis. In the Multivariate Mendelian Randomization (MVMR) analyses, the significant causal associations between estradiol, SHBG, tea intake, and alcoholic drinks per week with urolithiasis were robust even after adjusting for potential confounding variables. However, the previously observed causal association between other exercises and urolithiasis was no longer significant after adjusting for these factors. The univariable and multivariable MR findings highlight the independent and significant roles of estradiol, SHBG, tea intake, and alcoholic drinks per week in the development of urolithiasis, which might provide a deeper insight into urolithiasis risk factors and supply potential preventative strategies.

Urolithiasis in patients with inflammatory bowel disease: A systematic review and meta-analysis of 13,339,065 individuals.

This study aimed to summarize the current literature regarding the prevalence of renal stones in patients with inflammatory bowel disease (IBD). Moreover, we aimed to evaluate the risk factors of urolithiasis in patients with IBD and the difference between patients with IBD and healthy controls in terms of urinary profile. On February 23, 2022, a computerized search was conducted on PubMed, OVID via MEDLINE, Web of Science, and Scopus using relevant keywords. Three independent reviewers performed 2-stage screening and data extraction. The National Institutes of Health tools were employed for quality assessment. Review Manager 5.4 software was used to calculate the mean difference (MD) between IBD patients and non-IBD in terms of urine profile using the Inverse-variance model and to estimate the odds ratio of reported risk factors for renal stones with the Generic Inverse-Variance model. Thirty-two articles (n = 13,339,065 patients) were included. The overall prevalence of renal stones in patients with IBD was 6.3%, 95% Confidence interval (4.8%-8.3%). The prevalence of urolithiasis was more common in Chron's disease vs Ulcerative colitis (7.9% vs 5.6%) and in old studies (1964-2009) than in more recent studies (2010-2022) (7.3% vs 5.2%), respectively. Compared to non-IBD patients, patients with IBD were associated with significantly lower urine volume (MD = -518.84 mL/day, P < .00001), calcium 24-hour urine (MD = -28.46 mg/day, P < .0001), citrate 24-hour urine (MD = -144.35 mg/day, P < .00001), sodium 24-hour urine (MD = -23.72 mg/day, P = .04), and magnesium 24-hour urine (MD = -33.25 mg/day, P < .00001). The overall prevalence of renal stones in patients with IBD was comparable to the general population. Patients with Chron's disease were associated with a higher prevalence of urolithiasis compared to Ulcerative colitis. Drugs that induce renal calculi should be stopped in high-risk patients.

Prevalence and associated risk factors of urolithiasis in India, a systematic review

Introduction and Aim: In India approximately two million persons are affected by urolithiasis per year and some areas of India have been named as a stone belt. This article reviews information regarding associated risk factors of urolithiasis from Indian perspectives. Methods: The studies were retrieved from eight electronic databases. All the cases of an adult above the age of 18 with urolithiasis were included in this review. The studies conducted in different states of India on human subjects and published between 2010 -2017, which are available in electronic media were included. The quality of studies was assessed by the help of Joanna Briggs Institute Checklist for Systematic Reviews and Research Syntheses. A narrative approach was adopted to analyze the data. Results: The risk factors identified were, less frequency of urination /day, consumption of red meat once a month or more, higher consumption of calcium, sodium, magnesium and phosphorus, high intake of coffee, tea, and sugar, working in high temperatures, lack of physical activity, obesity, and ground water consumption. Habits like smoking and alcohol consumption. Some of the disease conditions like urinary tract infection, renal cyst, horseshoe kidney, atrophic kidney, benign prostatic hyperplasia. Conclusion: The urolithiasis among adults is a public health problem and calls for appropriate action against this.

Insights into risk factors for urolithiasis: a mendelian randomization study

BackgroundRisk factors for urolithiasis have not been identified. Here, we aimed to identify potentially causal risk factors driving the risk of urolithiasis.MethodsTwo sets of instrumental variables were used for analysis, derived from publicly available databases. Summary-level statistical data for urolithiasis were obtained from the MRC-IEU Consortium and UK biobank (Neale Lab). Mendelian randomization (MR) was conducted to identify causal risk of urolithiasis. Finally, the results of the two databases were combined and a meta-analysis was performed.ResultsIn the MRC-IEU consortium, the odds of urolithiasis increased per 1-SD increase of body mass index (BMI) (OR = 1.0016, 95% CI:1.0004–1.0029, p = 0.010), triglycerides (OR = 1.0016, 95% CI:1.0003–1.0029, p = 0.017), adiponectin (OR = 1.0027, 95% CI:1.0003–1.0050, p = 0.024), and body fat percentage (OR = 1.008, 95% CI:1.0001–1.0161, p = 0.047). In addition, alcohol intake also increased the incidence of urolithiasis (OR = 1.0030, 95% CI:1.0009–1.0051, p = 0.005). In the UK biobank, the odds of urolithiasis increased per 1-SD increase of waist circumference (OR = 1.0215, 95% CI:1.0061–1.0372, p = 0.008) and body fat percentage (OR = 1.0239, 95% CI:1.0043–1.0440, p = 0.020). Surprisingly, we found that the risk of urolithiasis decreased with increasing hip circumference (OR = 0.9954, 95% CI:0.9915–0.9992, p = 0.017). In a meta-analysis of MR results, higher BMI (OR = 1.0016, 95% CI:1.0004–1.0027, p = 0.009), waist circumference (OR = 1.0073, 95% CI:1.0020–1.0126, p = 0.007), adiponectin (OR = 1.0026, 95% CI:1.0008–1.0043, p = 0.004), triglycerides (OR = 1.0015, 95% CI:1.0004–1.0026, p = 0.008) and body fat percentage (OR = 1.0104, 95% CI:1.0030–1.0178, p = 0.006) increased the risk of urolithiasis. Furthermore, alcohol intake also increased the incidence of urolithiasis (OR = 1.0033, 95% CI:1.0012–1.0053, p = 0.002).ConclusionsOur MR study found that higher BMI, triglycerides, waist circumference, adiponectin, body fat percentage, and alcohol intake increased the risk of urolithiasis.

Factors Associated With Urolithiasis: A Hospital-Based Case-Control Study.

Urolithiasis is a common preventable ailment. Previous studies showed that there are a lot of factors, such as dietary, health and environmental factors, which are likely to develop this condition. Only a few research have been conducted on urolithiasis in the UAE. Therefore, our study aimed to identify the factors associated with urolithiasis in the country, identify the symptoms of urolithiasis among the cases and identify the most common diagnostic methods. It was a case-control study design. The study population was adults above 18 years attending a tertiary care centre. Those who have confirmed diagnosis of urolithiasis and gave informed consent were considered cases and those who have not confirmed diagnosis of urolithiasis as controls. Patients with renal, bladder or urinary tract impairment or anomaly were excluded from the study. Ethical approval was obtained for the study. Crude odds ratio (OR) showed that age, gender, past treatment for urinary stones, and lifestyle factors such as diet and smoking are risk factors while exercising is a protective factor. Age-adjusted OR found that past treatment for the urinary disease (OR=10.4), consumption of oily food (OR=11.5), consumption of fast food (OR=11.0)and consumption of energy drinks (OR=5.9) were the significant risk factors for urolithiasis. We found that past urinary disease treatment and diet are vital in developing urinary stones. Higher consumption of salty, oily, sugary and protein foods increases the odds of urinary diseases. Public awareness programs are essential to educating people about urolithiasis risk factors and preventive measures.

Impact of Sodium-Glucose Cotransporter-2 Inhibitors on Urolithiasis

Urolithiasis is a common disease with an estimated global prevalence of up to 15% and a recurrence rate of up to 50%. Diabetes mellitus has been implicated as a risk factor for urolithiasis.1 The mechanism underlying the increased risk of urolithiasis in patients with diabetes mellitus may involve high uric acid excretion, impaired ammoniagenesis, and a subsequent decrease in urinary pH levels resulting from insulin resistance. Sodium-glucose cotransporter-2 (SGLT2) inhibitors have diuretic and anti-inflammatory effects.

Role, importance and assessment of dietary habits in urolithiasis patient.

Urolithiasis, which prevalence is increasing, poses a risk for chronic kidney disease in patients. Dietary habits play a significant role in stone formation, growth and recurrence. Also, comorbidities and lifestyle changes are among the factors affecting stone formation. The next step should be to detect metabolic disorders, if any, with analyzes to be made after a detailed anamnesis, and to arrange the necessary treatment. Insufficient fluid intake is considered to be the main dietary risk factor for urolithiasis. A daily fluid intake of 2.5-3.0 L/day or diuresis of 2.0-2.5 L/day is recommended to prevent recurrence of kidney stones. Not all beverages are beneficial, and some may even increase the risk of stone formation. Dietary management, vitamins and supplements, physical activity are important components in reducing the risk of recurrent urolithiasis. A detailed dietary assessment is recommended as dietary habits affect the faith of the disease. In this review we evaluated the dietary approach of urolithiasis patients with and without comorbidities, the recommended daily fluid intake, vitamin supplementation, and relation of the urolithiasis with physical activity.

Prevalence of Urolithiasis in a China Hospital: A Cross-Sectional Study.

This study aimed to investigate the prevalence of urolithiasis and its association with systemic diseases among inpatients in a top hospital of China. This cross-sectional study included all inpatients in Peking Union Medical College Hospital (PUMCH) from 1 January 2017 to 31 December 2017. Patients were divided in two groups, the urolithiasis group and non-urolithiasis group. Subgroup analysis according to payment type (General or VIP ward), hospitalization department (surgical or not) and age was performed with patients in the urolithiasis group. Additionally, Univariable and multivariable regression analyses were performed to determine factors associated with urolithiasis prevalence. 69518 hospitalized cases were included in this study. The age was 53.40 ± 15.05 and 48.00 ± 18.12 years, and the male-to-female ratio was 1.7:1 and 0.55:1 in the urolithiasis and non-urolithiasis groups, respectively (p < 0.01). Among all patients, urolithiasis had a prevalence of 1.78%. The rate depending on payment type (5.73% versus 9.05%, p < 0.01) and hospitalization department (56.37% versus 70.91%, p < 0.01) were significantly lower in urolithiasis group compared to the non-urolithiasis. Urolithiasis rate also showed age differences. Female was independent protective factor of urolithiasis, while age, hospitalization in the non-surgical department and payment type of general ward were risk factors of urolithiasis (all p < 0.01). Gender, age, hospitalization in the non-surgical department and the socioeconomic status, specifically, the payment type of general ward, are independently associated with urolithiasis.

The relationship between the stone's composition and the biochemical parameters of blood and urine in patients with urolithiasis

Urolithiasis is the most painful and frequent urological disease of the urinary tract. This study is the first in Morocco that aimed to determine the relationship between the urinary stone's composition and the biochemical analysis of blood and daily urine.A total of 154 urinary stones from lithiasis patients was collected between December 2009 and July 2015 at the Hassan II University Hospital in Fez-Morocco. The stones were analysed morphologically and chemically, blood and urine biochemical parameters were established and the relationship between these latter and the stones composition was determined.The stones analysis shows that more than 63% of stones are calcium oxalate, infection stones were more common in patients under 16 years of age. Twenty-two percent of patients had a higher creatinine level and 13% of them had hypercalciuria. However, uric acid stone (UA) patient's group were older than those of whewellite (Wh) group (p = 0.004). The blood creatinine level was significantly high in the UA and weddellite (Wd) groups (p = 0.032), and a significant difference between the two groups, Wh and Wd, for the Calciuria/Creatininuria ratio (p = 0.032). The Principal Component Analysis (PCA) showed a correlation between 24-hour uricuria, 24-hour urine, 24-hour diuresis, 24-hour creatinine, and natriuresis on the one hand, and with calciuria, 24-hour calciuria and BMI on the other hand.These results show the probable effect of different biochemical parameters of urine and blood in certain stones types formation, and presents a contribution to understand the urolithiasis risk factors in order to limit the recurrence of kidney stones and long-term complications

Extreme temperature exposure and urolithiasis: A time series analysis in Ganzhou, China.

Ambient temperature change is a risk factor for urolithiasis that cannot be ignored. The association between temperature and urolithiasis varies from region to region. Our study aimed to analyze the impact of extremely high and low temperatures on the number of inpatients for urolithiasis and their lag effect in Ganzhou City, China. We collected the daily number of inpatients with urolithiasis in Ganzhou from 2018 to 2019 and the meteorological data for the same period. The exposure-response relationship between the daily mean temperature and the number of inpatients with urolithiasis was studied by the distributed lag non-linear model (DLNM). The effect of extreme temperatures was also analyzed. A stratification analysis was performed for different gender and age groups. There were 38,184 hospitalizations for urolithiasis from 2018 to 2019 in Ganzhou. The exposure-response curve between the daily mean temperature and the number of inpatients with urolithiasis in Ganzhou was non-linear and had an observed lag effect. The warm effects (30.4°C) were presented at lag 2 and lag 5-lag 9 days, and the cold effects (2.9°C) were presented at lag 8 and lag 3-lag 4 days. The maximum cumulative warm effects were at lag 0-10 days (cumulative relative risk, CRR = 2.379, 95% CI: 1.771, 3.196), and the maximum cumulative cold effects were at lag 0-5 (CRR = 1.182, 95% CI: 1.054, 1.326). Men and people between the ages of 21 and 40 were more susceptible to the extreme temperatures that cause urolithiasis. Extreme temperature was correlated with a high risk of urolithiasis hospitalizations, and the warm effects had a longer duration than the cold effects. Preventing urolithiasis and protecting vulnerable people is critical in extreme temperature environments.

Effect of Two Different Dietary Weight Loss Strategies on Risk Factors for Urinary Stone Formation and Cardiometabolic Risk Profile in Overweight Women

Overweight has been suggested to increase the risk of kidney stone formation. Although weight reduction might affect risk factors for urolithiasis, findings on the impact of different dietary weight loss strategies are limited. This randomized, controlled study evaluated the effect of a conventional energy-restricted modified diet with (MR group) or without meal replacement (C group) on risk factors for stone formation in overweight women without a history of urolithiasis. Of 105 participants, 78 were included into the per-protocol analysis. Anthropometric, clinical, biochemical, and 24 h urinary parameters were collected at baseline and after 12 weeks. Although both dietary interventions resulted in a significant weight reduction, relative weight loss and rate of responders were higher in the MR group. Weight loss improved cardiometabolic risk profile in both groups. Unfortunately, the benefit of decreased GPT activity in the C group was offset by a significant increase in homocysteine and a decline in GFR. While the relative supersaturation of calcium oxalate decreased significantly in both groups, a significant decline in serum uric acid concentration and relative supersaturation of uric acid was observed only in the MR group. Finally, the energy-restricted modified diet with meal replacement showed significant advantages over the energy-restricted modified diet alone.

Quantification of Visceral Adipose Tissue (VAT) and Subcutaneous Adipose Tissue (SAT) Based on CT Scan Tissue Segmentation Associated with Urolithiasis Recurrence

Introduction: The aim of this study is to applied CT scan-based tissue segmentation to measure visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) volumes. Then, the ratio of both fat tissue volumes was calculated to get two more parameters: visceral fat volume ratio (VFVR) and subcutaneous fat volume ratio (SFVR). After that, the relationship between these factors and urolithiasis recurrence was examined using correlation analysis. Other parameters, which are the patient’s age and gender, were also tested for correlation analysis with urolithiasis recurrence. Finally, logistic regression analysis was performed to find the association between urolithiasis recurrence and the parameters (age, gender, VAT volume, SAT volume, VFVR and SFVR). Methods: This study was a retrospective cross-sectional study design using the images collected from CT Urology cases in the year 2019. The patients selected have a history of stone removal in 2014. The application used for CT tissue segmentation is 3D Slicer. Results: Urolithiasis recurrence shows medium and high degree of positive correlation with total fat volume, VAT volume, and VFVR (correlation coefficient, cc = 0.254, p = 0.023), (cc = 0.390, p&lt; 0.001) and (cc = 0.688, p&lt; 0.001), respectively and high degree of negative correlation with SFVR (cc = -0.688, p&lt; 0.001). However, using logistic regression analysis, only VAT volume was significantly associated with urolithiasis recurrence (OR 1.11, 95% CI 1.01-1.22, p= 0.03), while the total fat volume, VFVR, and SFVR are not significant. Conclusion: CT scan-based tissue segmentation has a huge impact on fat volume quantification. This study confirms that VAT volume was strongly correlated with urolithiasis recurrence, indicating that VAT volume plays a more important role than SAT volume, total fat volume, VFVR and SFVR in the production of urinary stone. Thus, VAT volume can be further considered as a new independent risk factor for urolithiasis.

Prevalence and Risk Factors of Urolithiasis Among the Population of Hail, Saudi Arabia

BackgroundUrolithiasis is the formation of calculi in the urinary system. It is a public health concern worldwide that can lead to serious long-term consequences. Age, gender, dietary habits, and physical activity levels are all factors that increase the risk of urolithiasis formation. Furthermore, the presence of comorbid medical conditions such as diabetes and hypertension are other major risk factors. Among the most prominent determinants that raise the likelihood of acquiring urolithiasis is exposure to high temperatures, especially in middle-aged men. Consequently, Saudi residents are two and a half times more prone than the global average to develop urolithiasis, especially those in the Kingdom’s hottest regions.MethodologyThis cross-sectional study assessed the self-reported prevalence and non-nutritional risk factors of urolithiasis among the population of Hail, Saudi Arabia, through an electronic questionnaire. The questionnaire contained 16 questions divided into three categories. Participants’ permission was obtained before completing the questionnaire. The Statistical Package for Social Sciences (SPSS) version 22 (IBM Corp., Armonk, NY, USA) was used to analyze the data.ResultsOf the 1150 participants with a mean age of 26.3 ± 12.8 years old, nearly half were males (50.9%). Urolithiasis was detected among 158 (13.7%) participants. The following factors showed significant relation with having urolithiasis: increased age, male gender, a low level of education, diabetes, hypertension, and hyperthyroidism. A family history of renal stones was also associated with double the risk of having urolithiasis.ConclusionThe results showed a high prevalence of urolithiasis in the Hail region, with many risk factors associated with it. It is important to support and promote awareness campaigns that address the critical risk factors of urolithiasis. Further studies should be conducted to arrive at a better understanding of the association between non-nutritional risk factors and developing urolithiasis.

Upper urolithiasis in cats with chronic kidney disease: prevalence and investigation of serum and urinary calcium concentrations.

This study aimed to define the prevalence of upper urolithiasis in cats with chronic kidney disease (CKD) in a referral population, and to compare urinary calcium:creatinine ratio (UCa:Cr), and total and ionised calcium between cats with CKD with and without upper urolithiasis. The medical records of cats diagnosed with CKD were reviewed for signalment, body weight, diet and prevalence of upper urolithiasis. Cats with preserved urine samples were further classified into two groups: urolithiasis group (upper urolithiasis identified by abdominal ultrasonography) and control group (CKD of unknown origin). Serum biochemical analysis, CKD stage, blood gas analysis, urine specific gravity and UCa:Cr were compared between groups using a two-sample t-test or Mann-Whitney U-test for continuous variable and a χ2 test or Fisher's exact test for categorical variables. Multivariable binary logistic regression analysis was used to identify risk factors. Among the 140 cats with CKD, the prevalence of upper urolithiasis was 73%. Fifty cats (5, 29 and 16 cats with CKD stages 1, 2 and 3, respectively) with urine samples met the inclusion criteria and were included in the analysis. Among cats with CKD, being purebred (odds ratio [OR] = 81.56; P = 0.03) and being fed dry food only (OR = 25.06; P = 0.001) were identified as independent upper urolithiasis risk factors; those with upper urolithiasis were more likely to be exclusively fed with urine-acidifying food (P <0.001) and have increased serum ionised calcium (iCa) (P = 0.044), fractional excretion of calcium (P = 0.45) and UCa:Cr (P = 0.005) than cats with CKD without upper urolithiasis. Cats with CKD that were purebred, fed dry food and fed urine-acidifying food only often had upper urolithiasis. A higher UCa:Cr may be a result of increased serum iCa and may cause upper urolithiasis.

Современный взгляд на скрининг мочекаменной болезни

Introduction. TUrolithiasis is a widespread disease. In 2019 year 889,891 cases of this disease detected in Russia, and the increase in morbidity since 2005 was 35.5%. The share of urolithiasis accounts for up to 50-60% of patients in urological hospitals, often hospitalized for emergency indications. At the same time, there are no specialized questionnaires aimed at identifying risk factors for urolithiasis. The purpose of the work: to study the use of questionnaires for the timely detection of urinary tract stones. Materials and methods. Based on the men's health cabinet of the City hospital No. 1» Cheboksary (Republic of Chuvashia) in 2020-2021, a survey of 700 men aged 40 to 80 years conducted. To form risk groups, a specially designed questionnaire used to identify stones of the urinary system. According to the sum of the Questionnaire scores, 2 groups of patients were formed: low risk (0-1 point) and high risk (2-8 points). To validate the Questionnaire, all respondents, regardless of the amount of points, underwent ultrasound of the kidneys and bladder, and patients with detected stones larger than 3 mm and MSCT. Statistical processing of the received material carried out using the computer program Statistics 10.0 and the Microsoft Excel application software package. Results. According to the sum of the Questionnaire scores, 2 groups of patients were formed: low risk (0-1 point) and high risk (2-8 points). Out of 700 respondents, 54 respondents with kidney stones identified: 11 in the low-risk group and 43 in the high-risk group. The total prevalence of urolithiasis in the studied population was 7.7%. With an increase for points, a progressive increase in the average size of concretions from 3.1 mm to 29 mm noted. The developed method of screening urolithiasis by means of a questionnaire has good indicators of sensitivity and specificity: 76.63% and 98.30%, respectively. Conclusion. Urolithiasis screening based on a combined approach using questionnaires and ultrasound can become a simple and affordable method for active detection of urolithiasis, formation and stratification of risk groups. Further research is required to objectify the data.

Bariatric Surgery and Risk of Urolithiasis: A Review

Obesity is a global epidemic for which dietary and lifestyle modifications alone are ineffective treatment strategies. Subsequently, more patients are opting for bariatric surgery, which has better success rates in weight loss and improvement of obesity-related comorbidities. These procedures involve anatomic alterations of the gastrointestinal tract resulting in either restriction of intake or malabsorption of nutrients. While obesity itself is an independent risk factor for urolithiasis, bariatric surgery may also adversely affect stone risk. Restrictive procedures appear to have the lowest risk, whereas malabsorptive procedures are associated with the highest risks of stone formation. Stone prevention strategies including dietary manipulation are critical in the management of the patients who have had bariatric surgery.

The role of reactive oxygen species derived from different NADPH oxidase isoforms and mitochondria in oxalate-induced oxidative stress and cell injury

Hyperoxaluria is a risk factor for urolithiasis and can cause renal epithelial cell injury secondary to oxidative stress. Reactive oxygen species (ROS) produced during cell damage originate from different sources and play different roles. Here, we explored the potential sources of ROS production and investigated the role of ROS from various sources in oxalate-induced oxidative stress and cell injury in normal rat kidney-52 epithelial (NRK-52E) cells. Oxalate-induced injury was assessed by lactate dehydrogenase (LDH) release experiments. 2,7-dichlorodihydrofluorescein diacetate and mitoSOX Red were used to determine the intracellular and mitochondrial ROS (mtROS) production, respectively. The expression level of Nox4, Nox2, and p22 protein was detected by Western blotting to observe the effect of oxalate on nicotinamide adenine dinucleotide phosphate oxidase (NADPH) oxidase (Nox). Furthermore, a specific NADPH oxidase subtype inhibitor and targeted mitochondrial antioxidants were used to preliminarily identify the role of ROS from different sources in renal tubular epithelial cell injury induced by oxalate. We found that oxalate inhibited cell viability, induced LDH release, and prompted intracellular and mitochondrial ROS (mtROS) production. Oxalate also decreased the protein expression level of Nox4 and increased the protein expression level of p22. Mitochondria were also a source of ROS production. In addition, Nox2 inhibitor or mtROS scavenging prevented oxalate-induced cell injury, reversed by an inhibitor of Nox4/1. We concluded that ROS from different sources might play different roles in oxalate-induced renal tubular epithelial cell injury. We also identified new potential targets for preventing or alleviating oxalate-induced renal tubular epithelial cell injury.Graphic abstract