This study aimed to investigate the direct association between domestic violence and the indirect association of exposure through pregnancy, delivery, and neonatal risk factors with severe maternal morbidity (SMM). The target population of this case-control study included all women who gave birth in the hospitals of the Torbat Heidarieh University of Medical Science from June 2018 to May 2020. A total of 123 mothers with SMM according to the World Health Organization criteria were selected as cases, and 127 mothers who did not meet the World Health Organization criteria were included in the control group. Data were analyzed using Stata 14 and mediation packages with a counterfactual approach. The odds ratio of the pure direct effect of physical violence on SMM through pregnancy and neonatal risk factors is 2.26 and 2.29, respectively. The odds ratio of the pure direct effect of social violence on SMM through pregnancy, delivery, and neonatal risk factors was 2.54, 2.67, and 2.57, respectively, and that for economic violence through neonatal risk factors was 1.99. Additionally, the interaction between physical and social violence and pregnancy risk factors increased the risk of severe maternal morbidity by 394.6% and 360%, respectively. Domestic violence against women is directly associated with severe maternal morbidity. Physical and social violence showed a significant interaction with severe maternal morbidity. A preventive program for domestic violence should be considered an effective intervention to prevent severe maternal morbidity and improve the health of mothers by implementing control strategies.
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