Free AccessCommentaryRural residence and adherence to continuous positive airway pressure therapy: have we overcome a barrier? Lucas M. Donovan, MD, MS Lucas M. Donovan, MD, MS Address correspondence to: Lucas M. Donovan, MD, MS, Core Investigator, HSR&D Center of Innovation for Veteran-Centered and Value Driven Care, VA Puget Sound Health Care System, Division of Pulmonary, Critical Care and Sleep Medicine, 1660 South Columbian Way, Seattle, WA 98108; Email: E-mail Address: [email protected] Search for more papers by this author Published Online:April 1, 2022https://doi.org/10.5664/jcsm.9916SectionsPDF ShareShare onFacebookTwitterLinkedInRedditEmail ToolsAdd to favoritesDownload CitationsTrack Citations AboutINTRODUCTIONThe management of obstructive sleep apnea (OSA) presents a major challenge to health systems due to the high prevalence of disease and complexities in service coordination.1,2 These challenges lead to widespread access limitations, which are not distributed equally. Patients in rural areas face particular access barriers due to the urban-based distribution of specialized personnel and equipment.3,4 Reflecting these barriers, patients in rural areas who have symptoms of OSA are less likely to be diagnosed, and those who are able to complete testing tend to be patients with more severe disease.3,5 While there appears to be a relationship between rurality and underdiagnosed OSA, the implications of rural residence on subsequent treatment outcomes are unclear. Specifically, there is a lack of information around the impact of rurality on adherence to continuous positive airway pressure (CPAP) treatment and other treatment outcomes.It is reasonable to suspect that rural residence could impact adherence. CPAP is often challenging to use, but there are actions that providers and health systems can take to support patients. These steps include education, behavioral interventions, and troubleshooting aimed at supporting patients’ self-efficacy and reducing side effects.6 These interventions historically relied on in-person visits with specialists,7–9 complicating access among rural patients. While virtual adherence interventions are increasingly adopted that can reach patients remotely (eg, video-based follow-up, telemonitoring),6,10,11 rural areas often lag behind urban ones in internet connectivity and access.12 Additionally, patients in rural areas also tend to have other risk factors for poor adherence to CPAP, including lower income and fewer years of education.13–16In the present issue of the Journal of Clinical Sleep Medicine, Dr. Corrigan and colleagues present analyses to assess the impact of rurality on adherence to CPAP and improvement in OSA symptoms.17 The authors established a prospective cohort of patients from rural and urban areas who were starting CPAP therapy for the first time from December 2018 to November 2020. To do so, the authors partnered with respiratory homecare providers across the province of Alberta to help identify and recruit eligible patients. Patients consenting to take part in this cohort completed surveys at baseline and after 3 months to assess sleepiness, visit satisfaction, and quality of life. The authors also had access to baseline diagnostic testing results and CPAP usage for each participant. The authors compared CPAP usage and patient-reported outcomes between those defined as rural or urban according to standards defined federally by the Canadian government.18Ultimately, the authors recruited 242 eligible patients, 100 rural and 142 urban patients. Aligning with prior observations, individuals in the rural group had a lower median household income, longer driving distance to a CPAP provider, and experienced longer delays in diagnosis and treatment. Overall, the authors did not detect a difference in adherence between rural and urban patients, and the mean difference in nightly CPAP use for rural vs urban patients was 0.17 hours (95% confidence interval: –0.62 to 0.96). The authors also did not detect differences with regard to improvements in sleepiness or satisfaction. However, the authors did observe a significantly greater improvement in quality of life among rural patients relative to urban: +5.1 EuroQOL-5D visual analog scale score (95% confidence interval: 0.2–10.0).These findings provide some reassurance that patients in rural areas can achieve comparable outcomes with CPAP. However, we must consider several factors before generalizing these results to other rural settings and populations. First, the authors’ analyses only include patients consenting to a research study. Those consenting for research studies often differ from those who do not consent.19,20 Importantly, the characteristics where research participants often differ from nonparticipants (higher income, greater education) are themselves associated with greater adherence.15 Second, the authors’ reported overall adherence appears to be lower than other cohorts,11,21 raising concerns that floor effects may have masked a true effect between urban and rural individuals. Finally, the nature of care delivery for this sample may not be generalizable to what is currently done in other settings. While all sleep testing was interpreted by sleep specialists, it is notable that only 8% of individuals in this study followed the specialist pathway. In other words, 92% of patients received OSA-related counseling and CPAP instruction from respiratory homecare providers without interacting with a specialist. Many health systems, particularly those in the United States, rely much more heavily on specialist consultation.22 As specialists are more likely to be isolated to urban areas,3,4,17 it is possible that a more specialist-dependent model could lead to worse adherence for patients in rural areas.Patients in rural areas face numerous barriers that limit access to services. However, the findings of Dr. Corrigan and colleagues provide some reassurance that these barriers do not necessarily translate to lower success with CPAP. Their results should give us some hope that barriers are not insurmountable. While causation cannot be directly inferred, it is important to contextualize these findings in the setting of modern technologies and systems of care that promote geographic reach.23 Innovations in remote care (eg, telemonitoring) emerged after decades of work and reinforce that, with concerted effort, creativity, and research, our field can adapt pathways to overcome access barriers. We should keep this in mind as we strive for equitable delivery of care in other areas, including addressing persistent racial, ethnic, and socioeconomic disparities in adherence.24,25DISCLOSURE STATEMENTDr. Donovan received support during the period of this work from VA Health Services Research & Development CDA 18-187 and IIR 20-240. The views expressed in this article are those of the author and do not necessarily represent the views of the US Department of Veterans Affairs. The author reports no conflicts of interest.REFERENCES1. Pack AI. Sleep-disordered breathing: access is the issue. Am J Respir Crit Care Med. 2004;169(6):666–667. CrossrefGoogle Scholar2. Benjafield AV, Ayas NT, Eastwood PR, et al.. Estimation of the global prevalence and burden of obstructive sleep apnoea: a literature-based analysis. Lancet Respir Med. 2019;7(8):687–698. CrossrefGoogle Scholar3. Allen AJMH, Amram O, Tavakoli H, Almeida FR, Hamoda M, Ayas NT. Relationship between travel time from home to a regional sleep apnea clinic in British Columbia, Canada, and the severity of obstructive sleep. Ann Am Thorac Soc. 2016;13(5):719–723. CrossrefGoogle Scholar4. Kirsh S, Su GL, Sales A, Jain R. Access to outpatient specialty care: solutions from an integrated health care system. Am J Med Qual. 2015;30(1):88–90. CrossrefGoogle Scholar5. Spagnuolo CM, McIsaac M, Dosman J, Karunanayake C, Pahwa P, Pickett W. Distance to specialist medical care and diagnosis of obstructive sleep apnea in rural Saskatchewan. Can Respir J. 2019;2019:1683124. CrossrefGoogle Scholar6. Patil SP, Ayappa IA, Caples SM, Kimoff RJ, Patel SR, Harrod CG. Treatment of adult obstructive sleep apnea with positive airway pressure: an American Academy of Sleep Medicine systematic review, meta-analysis, and GRADE assessment. J Clin Sleep Med. 2019;15(2):301–334. LinkGoogle Scholar7. Aloia MS, Di Dio L, Ilniczky N, Perlis ML, Greenblatt DW, Giles DE. Improving compliance with nasal CPAP and vigilance in older adults with OAHS. Sleep Breath. 2001;5(1):13–21. CrossrefGoogle Scholar8. Aloia MS, Arnedt JT, Strand M, Millman RP, Borrelli B. Motivational enhancement to improve adherence to positive airway pressure in patients with obstructive sleep apnea: a randomized controlled trial. Sleep. 2013;36(11):1655–1662. CrossrefGoogle Scholar9. Richards D, Bartlett DJ, Wong K, Malouff J, Grunstein RR. Increased adherence to CPAP with a group cognitive behavioral treatment intervention: a randomized trial. Sleep. 2007;30(5):635–640. CrossrefGoogle Scholar10. Hoy CJ, Vennelle M, Kingshott RN, Engleman HM, Douglas NJ. Can intensive support improve continuous positive airway pressure use in patients with the sleep apnea/hypopnea syndrome? Am J Respir Crit Care Med. 1999;159(4 Pt 1):1096–1100. CrossrefGoogle Scholar11. Hwang D, Chang JW, Benjafield AV, et al.. Effect of telemedicine education and telemonitoring on CPAP adherence: The Tele-OSA Randomized Trial. Am J Respir Crit Care Med. 2017. Google Scholar12. Pew Research Center. For 24% of rural Americans, high-speed internet is a major problem. https://www.pewresearch.org/fact-tank/2018/09/10/about-a-quarter-of-rural-americans-say-access-to-high-speed-internet-is-a-major-problem/. Accessed January 28, 2022. Google Scholar13. Semega J, Kollar M, Shrider EA, Creamer JF. Income and Poverty in the United States. 2019: 88; revised September 2021. https://www.census.gov/content/dam/Census/library/publications/2020/demo/p60-270.pdf. Accessed February 3, 2022. Google Scholar14. USDA Economic Research Service. Rural Education. https://www.ers.usda.gov/topics/rural-economy-population/employment-education/rural-education/ Accessed January 27, 2022. Google Scholar15. Palm A, Grote L, Theorell-Haglöw J, et al.. Socioeconomic factors and adherence to CPAP: the population-based course of disease in patients reported to the Swedish CPAP Oxygen and Ventilator Registry Study. Chest. 2021;160(4): 1481–1491. CrossrefGoogle Scholar16. Platt AB, Kuna ST, Field SH, et al.. Adherence to sleep apnea therapy and use of lipid-lowering drugs: a study of the healthy-user effect. Chest. 2010;137(1):102–108. CrossrefGoogle Scholar17. Corrigan J, Tsai WH, Ip-Buting A, et al.. Treatment outcomes among rural and urban patients with obstructive sleep apnea: a prospective cohort study. J Clin Sleep Med. 2022;18(4):1013–1020. LinkGoogle Scholar18. Statistics Canada. Population Centre and Rural Area Classification 2016. 2017. https://www.statcan.gc.ca/en/subjects/standard/pcrac/2016/index. Accessed January 25, 2022. Google Scholar19. Jordan S, Watkins A, Storey M, et al.. Volunteer bias in recruitment, retention, and blood sample donation in a randomised controlled trial involving mothers and their children at six months and two years: a longitudinal analysis. PLoS One. 2013;8(7):e67912. CrossrefGoogle Scholar20. Ganguli M, Lytle ME, Reynolds MD, Dodge HH. Random versus volunteer selection for a community-based study. J Gerontol A Biol Sci Med Sci. 1998;53(1):M39–M46. CrossrefGoogle Scholar21. Drager LF, Brunoni AR, Jenner R, Lorenzi-Filho G, Benseñor IM, Lotufo PA. Effects of CPAP on body weight in patients with obstructive sleep apnoea: a meta-analysis of randomised trials. Thorax. 2015;70(3):258–264. CrossrefGoogle Scholar22. Watson NF, Rosen IM, Chervin RD; Board of Directors of the American Academy of Sleep Medicine. The past is prologue: the future of sleep medicine. J Clin Sleep Med. 2017;13(1):127–135. LinkGoogle Scholar23. Shamim-Uzzaman QA, Bae CJ, Ehsan Z, et al.. The use of telemedicine for the diagnosis and treatment of sleep disorders: an American Academy of Sleep Medicine update. J Clin Sleep Med. 2021;17(5):1103–1107. LinkGoogle Scholar24. Billings ME, Cohen RT, Baldwin CM, et al.. Disparities in sleep health and potential intervention models: a focused review. Chest. 2021;159(3):1232–1240. CrossrefGoogle Scholar25. Borker PV, Carmona E, Essien UR, et al.. Neighborhoods with greater prevalence of minority residents have lower continuous positive airway pressure adherence. Am J Respir Crit Care Med. 2021;204(3):339–346. CrossrefGoogle Scholar Next article FiguresReferencesRelatedDetails Volume 18 • Issue 4 • April 1, 2022ISSN (print): 1550-9389ISSN (online): 1550-9397Frequency: Monthly Metrics History Submitted for publicationJanuary 31, 2022Submitted in final revised formJanuary 31, 2022Accepted for publicationJanuary 31, 2022Published onlineApril 1, 2022 Information© 2022 American Academy of Sleep MedicinePDF download