Risk Factors For Psoriatic Arthritis Research Articles

SAT0300 Nail psoriasis per se does not predict psoriatic arthritis: Analysis of risk factors in a cohort of italian psoriatic patients

BackgroundNail psoriasis is acknowledged to be associated with Psoriatic Arthritis (PsA). Onycho-Psoriasis (ONPS), however, is extremely common in psoriatic population and correlate poorly with skin involvement. Further, not all clinical...

AB0572 Additional risk for cardiovascular comorbidities in patients with psoriatic arthropathy

BackgroundCardiovascular(CV) comorbidities are an important issue of inflammatory arthritis (1.2), given that mortality increases with the severity form of the disease(3). CV risk factors and metabolic factors were present more...

Variants in linkage disequilibrium with the late cornified envelope gene cluster deletion are associated with susceptibility to psoriatic arthritis

ObjectiveA common deletion mapping to the psoriasis susceptibility locus 4 on chromosome 1q21, encompassing two genes of the late cornified envelope (LCE) gene cluster, has been associated with an increased...

Obesity in Early Adulthood as a Risk Factor for Psoriatic Arthritis

To study whether obesity increases the risk of psoriatic arthritis (PsA), given that obesity is a risk factor for psoriasis and is associated with more severe disease. Case series. We used Cox regression analysis to study the relationship between obesity and PsA while controlling for age at psoriasis onset, current body mass index (BMI), sex, family history of psoriasis, worst-ever body surface area (BSA) involvement, Koebner phenomenon, and nail involvement. Dermatology clinics at the University of Utah School of Medicine. Patients Volunteer sample of patients with dermatologist-diagnosed psoriasis enrolled in the Utah Psoriasis Initiative from November 2002 to October 2008 (943 subjects; 50.2% women, 49.8% men). Physician diagnosis of PsA from self-report questionnaire. In our subjects, we found that BMI at age 18 years was predictive of PsA (odds ratio [OR], 1.06) (P < .01) over and above control variables. Other variables that were predictors of PsA included younger age at psoriasis onset (odds ratio [OR], 0.98) (P < .01), female sex (OR, 1.45) (P = .01), higher worst-ever BSA involvement with psoriasis (OR, 1.01) (P = .04), Koebner phenomenon (OR, 1.59) (P < .01), and nail involvement (OR, 1.76) (P < .01). Current BMI and family history of psoriasis were not significant predictors of PsA. This study suggests that obesity at age 18 years increases the risk of developing PsA. Adiposity is associated with higher levels of inflammatory cytokines known to be associated with psoriasis. This inflammatory milieu could increase the risk of PsA in predisposed subjects. Prevention and early treatment of obesity may decrease the risk of PsA.