Introduction One of the risks of using endonasal tubes (ET) is the appearance of pressure ulcers (PU). Objective To ascertain the proportion of patients with nasal PU, study the risk factors of appearance, and find predictive variables. Material and methods A six-month prospective, observational study of intensive care unit patients with ET. Variables Variable response: “ the appearance of pu as a result of the use of ET”. Explanatory variables: age, duration of stay, length of time with ET, gender, sedation, norepinephrine perfusion, mechanical ventilation, anemia, nutritional state. Analysis multivariate statistical techniques (multiple logistical regression). Statistics program g-stat 2.0. Significance level p < 0.05. Results Sample of 48 patients. Proportion of patients with PU: 29.2%. Those patients with PU had similar ages, duration of stay and longer length of time with ET. Results of the Logistic Regression model: only the variable “time with ET” was statistically significant (p = 0.03; odds ratio: 1.047). Conclusions The length of time the patient is using an ET influences the appearance of nasal PU (risk increases 1.047 for each day with ET). None of the variables dealt with could be used as a predictive factor in the appearance of PU.