Objectives: To determine the rate of uterine cancer in reproductive- age Hispanic women compared to non-Hispanic White women and assess trends in obesity associated with uterine cancer in the United States (US). Methods: Data were obtained from the United States Cancer Statistics (USCS) database and the Behavioral Risk Factors Surveillance System (BRFSS) survey from 2001-2018. Obesity-related cancers as classified by the Centers for Disease Control and Prevention (CDC) were described using SEER*Stata. The average annual percent change (AAPC) was calculated using Joinpoint regression. Incidence rates and demographic factors, including age (divided into 5-10 year age groups), sex, and race, were reported. Reproductive age was defined as women under 50 years, whereas young reproductive age was defined as 18-40 years. Results: Over the 17-year study period, 843,116 patients were diagnosed with uterine cancer, with reproductive-age women accounting for 12.7% of cases. In 2018, Hispanic women aged 35-39 years had the highest incidence of uterine cancer among young reproductive- age women at 13.9 (per 100,000), a rate which was 49% higher than White women (9.3 per 100,000). Incidence increased annually at a rate of 4.0 to 4.5% in Hispanic women versus only 1.5 to 2.3% in White women, a nearly two-fold higher rate in this young cohort (25-39 years old). The intersection of young (35-39 years old) Hispanic women residing in the West had an incidence of 14.93 compared to 6.61 (per 100,000) for White women (1.5-fold higher rate), with corresponding annual rates of increase of 5.24% and 1.48%, respectively. Using a predictive model with the current rate of increase, we demonstrated that the incidence of uterine cancer in young (35-39 year old) Hispanic women in the West will be three times that of White women in the next five years (22.4 vs 7.4 per 100,000 by the year 2026). Using the BRFSS survey, Hispanic women aged 35-44 years reported an obesity rate of 30.1% in the year 2018. In a trend analysis from 2001 to 2018, the rate of obesity in Hispanic women rose by 1 .4% annually. Conclusions: The incidence of uterine cancer is rising rapidly in young reproductive-age Hispanic women compared to White women. These results may have public health implications towards the prevention and early detection of uterine cancer in this high-risk population. Objectives: To determine the rate of uterine cancer in reproductive- age Hispanic women compared to non-Hispanic White women and assess trends in obesity associated with uterine cancer in the United States (US). Methods: Data were obtained from the United States Cancer Statistics (USCS) database and the Behavioral Risk Factors Surveillance System (BRFSS) survey from 2001-2018. Obesity-related cancers as classified by the Centers for Disease Control and Prevention (CDC) were described using SEER*Stata. The average annual percent change (AAPC) was calculated using Joinpoint regression. Incidence rates and demographic factors, including age (divided into 5-10 year age groups), sex, and race, were reported. Reproductive age was defined as women under 50 years, whereas young reproductive age was defined as 18-40 years. Results: Over the 17-year study period, 843,116 patients were diagnosed with uterine cancer, with reproductive-age women accounting for 12.7% of cases. In 2018, Hispanic women aged 35-39 years had the highest incidence of uterine cancer among young reproductive- age women at 13.9 (per 100,000), a rate which was 49% higher than White women (9.3 per 100,000). Incidence increased annually at a rate of 4.0 to 4.5% in Hispanic women versus only 1.5 to 2.3% in White women, a nearly two-fold higher rate in this young cohort (25-39 years old). The intersection of young (35-39 years old) Hispanic women residing in the West had an incidence of 14.93 compared to 6.61 (per 100,000) for White women (1.5-fold higher rate), with corresponding annual rates of increase of 5.24% and 1.48%, respectively. Using a predictive model with the current rate of increase, we demonstrated that the incidence of uterine cancer in young (35-39 year old) Hispanic women in the West will be three times that of White women in the next five years (22.4 vs 7.4 per 100,000 by the year 2026). Using the BRFSS survey, Hispanic women aged 35-44 years reported an obesity rate of 30.1% in the year 2018. In a trend analysis from 2001 to 2018, the rate of obesity in Hispanic women rose by 1 .4% annually. Conclusions: The incidence of uterine cancer is rising rapidly in young reproductive-age Hispanic women compared to White women. These results may have public health implications towards the prevention and early detection of uterine cancer in this high-risk population.
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