Surgical treatment of the morbidly obese has assumed an increasingly important role in both the academic and community setting, while postoperative pulmonary embolism remains a devastating complication. Since the overall incidence remains low, the role for vena cava filter placement in this group is not yet well defined. In addition, the technical challenges and techniques for insertion have not been well-described. We present our experience with filter placement among patients with gastric bypass and the evolution of technique to facilitate safe placement in this group. From 1995 to August 2003, 586 patients underwent gastric bypass for morbid obesity. Review of registries and records from this period was accomplished to identify patients at MUSC who underwent both the gastric bypass and placement of an inferior vena cava filter. 12 patients were identified by this method. Technical challenges with venous access and imaging are described. 6 patients were identified as potential high risk for thromboembolic complications and had a filter placed preoperatively with a mean postoperative stay of 5.3 days. The 6 patients who required filter placement in the postoperative period as part of the management of postoperative complications had a mean hospital stay of 24.5 days. There were no long-term complications associated with filter placement at a mean follow-up interval of 19 months. Inferior vena cava filter placement is not only feasible and safe for the morbidly obese individual undergoing gastric bypass, but should be strongly considered for patients with risk factors for thromboembolic complications or who experience postoperative complications requiring ICU stay or prolonged immobility.