You have accessJournal of UrologyCME1 Apr 2023MP30-12 HIGHER TESTOSTERONE SERUM LEVELS ARE ASSOCIATED WITH A HIGHER CHILDBIRTH IN PATIENTS TREATED FOR TESTICULAR CANCER Cosimo De Nunzio, Riccardo Lombardo, Antonio Nacchia, Giorgio Guarnotta, Aldo Brassetti, Gabriele Tuderti, Antonio Luigi Pastore, Yazan Al Sahli, Giuseppe Simone, Antonio Carbone, and Andrea Tubaro Cosimo De NunzioCosimo De Nunzio More articles by this author , Riccardo LombardoRiccardo Lombardo More articles by this author , Antonio NacchiaAntonio Nacchia More articles by this author , Giorgio GuarnottaGiorgio Guarnotta More articles by this author , Aldo BrassettiAldo Brassetti More articles by this author , Gabriele TudertiGabriele Tuderti More articles by this author , Antonio Luigi PastoreAntonio Luigi Pastore More articles by this author , Yazan Al SahliYazan Al Sahli More articles by this author , Giuseppe SimoneGiuseppe Simone More articles by this author , Antonio CarboneAntonio Carbone More articles by this author , and Andrea TubaroAndrea Tubaro More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000003258.12AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Aim of our study was to assess fertility of patients treated with orchifunicolectomy for testicular cancer. METHODS: A retrospective analysis of patients undergoing orchifunicolectomy for testicular cancer was conducted in three centers from 2000 to 2019. Demographic, clinical and histological characteristics of the patients were recorded. Adjuvant treatments were recorded. Number of pregnancies, number of children, cryopreservation, in vitro fertilization were recorded as well as post-operative testosterone serum level. Risk factors for pregnancy were evaluated. Univariate and multivariate analysis were performed to evaluate factors influencing pregnancy rates. RESULTS: Overall 271 patients were enrolled with a median age of 31 (25/35) years and a median BMI of 25 (23/28 Kg/m2). Overall 187 of 271 (69%) presented a seminoma, 61 of 271 (22%) presented advanced stage (≥pT2), 4 of 271 (1%) presented metastasis, 13 of 271 (5%) underwent lymphadenectomy. 112 of 271 (41%) underwent adjuvant chemotherapy and 35 of 271 (13%) underwent adjuvant radiotherapy. 71 of 271 (26%) patients had at least one child, 165 of 271 (60%) performed cryopreservation, 9 of 271 (3%) performed fertilization in vitro and out of them 8 of 9 (89%) had at least one child. Patients with at least one child presented higher levels of testosterone and performed more often in vitro fertilization (Table). On multivariate analysis testosterone levels (OR=1,94; 95% CI: 1,35-2,80, p=0,001) were associated with a higher probability of having a child after testicular cancer surgery. Table 1. Patients characteristics according to Child status CONCLUSIONS: In our experience, patients undergoing testicular cancer surgery have 25% probability of having a child. Higher testosterone levels increase the probability of having a child in patients treated for testicular cancer. Source of Funding: No one © 2023 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 209Issue Supplement 4April 2023Page: e395 Advertisement Copyright & Permissions© 2023 by American Urological Association Education and Research, Inc.MetricsAuthor Information Cosimo De Nunzio More articles by this author Riccardo Lombardo More articles by this author Antonio Nacchia More articles by this author Giorgio Guarnotta More articles by this author Aldo Brassetti More articles by this author Gabriele Tuderti More articles by this author Antonio Luigi Pastore More articles by this author Yazan Al Sahli More articles by this author Giuseppe Simone More articles by this author Antonio Carbone More articles by this author Andrea Tubaro More articles by this author Expand All Advertisement PDF downloadLoading ...