Dissipative (Water – Iron (II, III) Oxide – MWCNT) hybrid nanofluid dynamics over a flat plate at varied Lorentz forces, volume fraction, and activation energy are unknown when quadratic thermal radiation is taken into account. Paper's novelty is addressing this gap, which is to examine the impact of activation energy on the hybrid nanofluid flow by a flat plate with viscous dissipation and magnetic field. Nonlinear ordinary differential equations are constructed from flow-driven equations, and the MATLAB bvp4c solver is used to solve them. Entropy generation increases as the volume fraction of nanoparticles increases, and the rate of mass transfer decreases as the activation energy parameter increases are the major findings of this study. As thermal radiation and Eckert number increase, observed an increase in the fluid temperature. Increasing the volume fraction of nanoparticles causes a rise in shear stress, while increasing the magnetic field parameter decreases it. It is noticed that, when magnetic field parameter () takes input in the range , skin friction coefficient decreases at a rate of 1.10078 per unit value of magnetic field parameter. It is detected that, when Eckert number increases, Nusselt number decreases. The decrement rates are observed as 0.02457 when Eckert number takes input in the range . It is discovered that the mass transfer rate decreases at a rate of 0.08123 when activation energy parameter takes input in the range .