Rise In Serum Creatinine Level Research Articles

The Role of Ultrasound in the Diagnosis of Kidney Allograft Rejection

Seventeen nephrectomized dogs underwent kidney transplantation from unrelated donors. Routine immunosuppressive therapy was administered. Serial ultrasound studies and biopsies and complete pathological examinations were performed and compared. A number of sonographic changes were observed within the renal parenchyma during rejection, some of which were present before a significant rise in serum creatinine levels. The medulla became enlarged due to edema, followed by growth of the rest of the kidney and thickening of the cortex. The cortical echoes became more sparsely distributed and either increased or decreased in amplitude; distribution was generalized or localized. During rejection, the corticomedullary boundary became indistinct. Later, a decrease in the renal sinus echoes was also noted. In 2 cases, perirenal fluid collections occurred as the result of renal rupture.

Bilateral Ureteral Obstruction Simulating Recurrent Acute Renal Failure

A patient with two closely spaced episodes of anuria and rising serum creatinine levels experienced spontaneous remission on both occasions without the use of ureteral catheterization even though bilateral ureteral obstruction was the cause of the anuria.

KIDNEY PRESERVATION FOR TRANSPORTATION

SUMMARY To determine whether kidneys could be uniformly preserved by simple means for transport, hypothermia was evaluated for short periods up to 16 hr. With attention to certain details, it was shown that hypothermia alone was sufficient to prevent any significant rise in serum creatinine levels after kidneys stored for 8 hr were reimplanted into nephrectomized dogs. With 12 hr of storage, only a small rise (highest mean serum creatinine of 2.8 mg%) occurred. Thirteen kidneys were transported by air as far as 2600 miles and were allografted. With the exception of one technical failure, all functioned well until rejection. The technique was used to harvest and transport 3 human kidneys as far as 400 miles with good results.

KIDNEY PRESERVATION FOR TRANSPORTATION

SUMMARY To determine whether kidneys could be uniformly preserved by simple means for transport, hypothermia was evaluated for short periods up to 16 hr. With attention to certain details, it was shown that hypothermia alone was sufficient to prevent any significant rise in serum creatinine levels after kidneys stored for 8 hr were reimplanted into nephrectomized dogs. With 12 hr of storage, only a small rise (highest mean serum creatinine of 2.8 mg%) occurred. Thirteen kidneys were transported by air as far as 2600 miles and were allografted. With the exception of one technical failure, all functioned well until rejection. The technique was used to harvest and transport 3 human kidneys as far as 400 miles with good results.