Rise In New Cases Research Articles

Effect of diabetes mellitus type 2 and sulfonylurea on colorectal cancer development: a case-control study

Background and aimsColorectal cancer (CRC) is a significant global health concern, with studies estimating a rise in new cases to 2.5 million by 2035. Type 2 diabetes (T2D) is also a growing issue, with an estimated 642 million adults affected by 2040. However, the relationship between T2D, its medications, and CRC remains unclear.Materials and methodsThis case-control study includes 810 controls without CRC and 684 cases with CRC admitted to Rasoul-Akram and Firouzgar Hospitals from September 2019 to 2023. Adjusted and unadjusted odds ratios (OR) were calculated to investigate the effect of T2D and sulfonylurea consumption on the chance of CRC development, using univariate and multivariate logistic regression analyses. The relationship between T2D and the clinicopathological features of the tumor was investigated.ResultsThe results show that the effect of T2D on CRC is significant based on unadjusted OR (OR = 1.39, CI = 1.07, 1.81) and insignificant in adjusted OR (OR = 0.67, CI = 0.37, 1.20). The effect of sulfonylurea consumption on CRC was significant in both unadjusted (OR = 2.39, CI = 1.40, 4.09) and adjusted ORs (OR = 2.35, CI = 1.12, 4.91). All analyses related to the relationship between T2D and tumor clinicopathological characteristics were insignificant.ConclusionThis study found an insignificant association between type 2 diabetes and the chance of CRC development in an adjusted state. Sulfonylurea consumption was also associated with a higher chance of CRC development among patients with T2D. These findings have implications for clinical practice and public health strategies in CRC prevention for patients with T2D.

Usability Insights from the BUMPER Cancer Prevention App Pilot Study: A Mixed-Methods Approach

Abstract Introduction As the second leading cause of death in the EU, cancer is expected to see a 55% rise in new cases globally over the next two decades. The European Code Against Cancer (ECAC) and the EU’s Beating Cancer Plan (EBCP) provide resources for understanding and preventing cancer. The BUMPER project aims to develop a cancer prevention App to make the ECAC more accessible to the public. Objectives Understand the factors influencing the use of a cancer prevention app among users with different digital health literacy levels and to evaluate the app’s usability. Methods Mixed-methods approach was used to gather user feedback. FGDs explored user perspectives on app usage, while a cross-sectional survey assessed usability through task completion on an initial app wireframe. The pilot was conducted across seven EU countries in late 2023. Results 77 participants participated in the pilots and FGDs across seven EU countries. The average task completion time was approximately 79 seconds. Participants rated their confidence to complete the tasks at 3.96 and difficulty at 2.28 on a scale of 1 to 5. The average task pass rate was 92.11%. Qualitative findings highlighted the need for evidence-based content, user-friendly design, language accessibility, offline functionality, and data security. Participants also stressed the importance of clear instructions, regular updates, and robust tracking features. Despite some challenges, the app was generally well-received, with users appreciating its educational potential and tracking capabilities. Conclusions The BUMPER project’s pilot study demonstrated the cancer prevention App being developed as a potential tool for cancer education and awareness. Despite navigational and language challenges, the app was favorably received by a diverse user base, underscoring the need for ongoing improvements in user guidance, comprehension, and functionality to enhance accessibility. Key messages • BUMPER project’s cancer prevention app shows promise in pilot study, enhancing cancer education and awareness. • Despite challenges, the app was well-received, highlighting the need for ongoing improvements to enhance accessibility.

RNA Interference Unleashed: Current Perspective of Small Interfering RNA (siRNA) Therapeutics in the Treatment of Neuropathic Pain.

Neuropathic pain (NP) is one of the debilitating pain phenotypes that leads to the progressive degeneration of the central as well as peripheral nervous system. NP is often associated with hyperalgesia, allodynia, paresthesia, tingling, and burning sensations leading to disability, motor dysfunction, and compromised psychological state of the patients. Most of the conventional pharmacological agents are unable to improve the devastating conditions of pain because of their limited efficacy, undesirable side effects, and multifaceted pathophysiology of the diseased condition. A rapid rise in new cases of NP warrants further research for identifying the potential novel therapeutic modalities for treating NP. Recently, small interfering RNA (siRNA) approach has shown therapeutic potential in many disease conditions including NP. Delivery of siRNAs led to potential and selective downregulation of target mRNA and abolished the pain-related behaviors/pathophysiological pain response. The crucial role of siRNA in the treatment of NP by considering all of the pathways associated with NP that could be managed by siRNA therapeutics has been discussed. However, their therapeutic use is limited by several hurdles such as instability in systemic circulation due to their negative charge and membrane impermeability, off-target effects, immunogenicity, and inability to reach the intended site of action. This review also emphasizes several strategies and techniques to overcome these hurdles for translating these therapeutic siRNAs from bench to bedside by opening a new avenue for obtaining a potential therapeutic approach for treating NP.

The Epidemiology of Syphilis and Co-infection with HIV in a Tertiary Care Center in Lebanon: A Retrospective Review

Introduction: Syphilis is an ancient STI causing a new worldwide outbreak in general and in Lebanon specifically. Methods: We conducted a retrospective chart review to assess the rate of syphilis increase in an infectious diseases clinic in Lebanon from 2006 to 2023. We studied the epidemiology of these cases, stage and treatment response and their association to HIV infection and its control. Results: There was an 862% increase in syphilis cases from 2006 to 2019.Most of our cases were middle aged men living with HIV. Most of them had well-controlled HIV infection with good CD4 counts. Most of the diagnosed cases of syphilis were primary and secondary, responding to penicillin G. Discussion: Our data mostly parallels international data, except for gender distribution. Despite successful treatment of most cases in our clinic, the alarming rise of new cases highlights the urgent need for public health measures to mitigate this epidemic. Conclusion: Inclusive awareness is needed to stop syphilis spread in Lebanon, and more screening is key in identifying new cases early for a successful eradication.

Diagnostic correlation between plain radiographic and histopathology reports among patients with long bones tumours treated at a Tertiary Hospital in Tanzania

Background: Bone tumours are significant global health concern, with a rising number of new cases being diagnosed each year. The incidence of bone tumours has shown a significant increase in recent years, as evidenced by a 50% rise in new cases in 2020 alone. Early and accurate diagnosis is crucial for effective treatment and improved patient outcomes. The diagnosis of primary bone tumours is based on clinical, radiological and histopathological findings. Objective: This study aimed to determine the diagnostic correlation between plain radiographic and histopathological reports in diagnosing long bone tumours. Methods: A cross-sectional study was conducted between 2018 and 2021. Participants who underwent a histological examination for long bone tumours and met the inclusion criteria were enrolled. Relevant information was obtained from patient records then sensitivity, specificity, and accuracy of the plain radiograph were calculated with histopathology serving as the gold standard. Results: The study included 83 participants, the majority were aged 30 years old or younger. Forty six percent of the cases were malignant tumours while benign were 54%. Osteosarcoma was found to be the most common tumour type both by radiological and histological diagnosis and femur was the most commonly affected bone. Plain radiograph was found to have a sensitivity of 92.1%, specificity of 73.3% and accuracy of 82%. Conclusion: This study found a strong diagnostic correlation between plain radiographic and histopathology reports in patients with long bone tumours. This suggests that plain radiography can serve as a useful screening tool for long bone tumours in resource-limited settings, allowing for early and accurate preliminary diagnoses.

Predicting Number of Accumulative Cases of Covid-19 Using the Iteration Method

The COVID-19 pandemic, first identified in Wuhan, China in December 2019, has rapidly spread to various countries, including India and Indonesia. This study utilizes data from the cumulative cases in India and Indonesia, espand specific provinces within Indonesia, such as DKI Jakarta and Gorontalo, spanning a period of approximately two years. The proposed method incorporates factors such as expected recovery and mortality rates to determine the maximum daily growth, which deviates from exponential growth and tends towards stability or decline. RStudio software was employed to estimate future trends based on the current available data. The results indicate that Indonesia, Jakarta, and Gorontalo exhibit a sloping average growth rate over the past 30 days, while India demonstrates linear movement compared to the previous period. A 20% increase in growth rate in Jakarta leads to a significant rise in new cases compared to the other regions. Conversely, a 0% growth rate reduction in India and Gorontalo results in a notable deviation of cumulative case numbers from the actual data. This method can be applied to analyze similar problems if in the future there is another spread of pandemic diseases.Keywords: COVID-19, Iteration Method, Exponential Growth, Gorontalo and DKI Jakarta.

The Impact of COVID-19 on the Psychological Well-Being of Surgeons in Pakistan: A Multicenter Cross-Sectional Study.

IntroductionThe severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic left a profound and pervasive impact on the healthcare infrastructure on a global scale. Since its onset, the pattern of reported cases and its associated mortality had shown variability with intermittent peaks causing a significant effect on the psychological well-being of the surgeons of Pakistan. The aim of this study was to assess the effects of the COVID-19 pandemic on the mental well-being of surgeons in Pakistan.MethodsThis multicenter cross-sectional study was carried out to assess the impact of COVID-19 on the psychological well-being of surgeons in Pakistan. The validated Self-Reporting Questionnaire-20 (SRQ-20) tool was circulated electronically via Google Forms (Google, Inc., Mountain View, CA, USA) in the practicing surgical fraternity across all five regions of Pakistan, i.e., Sindh, Punjab, Baluchistan, Khyber Pakhtunkhwa (KPK), and Azad Jammu and Kashmir (AJK).ResultsThis study showed that the female gender, having fewer years of working experience, non-satisfaction with the available personal protective equipment (PPE), and working in the public sector were the factors affecting the psychological well-being of surgeons during the pandemic.ConclusionConsidering the continuous rise in new cases during the ongoing pandemic, the mental health of surgeons working in low- and middle-income countries (LMIC) such as Pakistan has been significantly affected. There is an undeniable need to pay close attention to their psychological well-being. Measures need to be undertaken to ensure their physical and mental health and wellness.

Hepatitis C Vaccination: Where We Are and Where We Need to Be

The hepatitis C virus (HCV) is a common cause of chronic liver disease and liver cancer worldwide. Despite advances in curative therapies for HCV, the incidence of new infections is not decreasing at the expected rate to hit the World Health Organization (WHO) target for the elimination of HCV by 2030. In fact, there are still more new cases of infection in the United States and worldwide than are being cured. The reasons for the rise in new cases include poor access to care and the opioid epidemic. The clinical burden of HCV requires a multimodal approach to eradicating the infection. Vaccination would be an excellent tool to prevent incidence of new infections; however, the genetic diversity of HCV and its ability to generate quasispecies within an infected host make creating a broadly reactive vaccine difficult. Multiple vaccine candidates have been identified, but to date, there has not been a target that has led to a broadly reactive vaccine, though several of the candidates are promising. Additionally, the virus is very difficult to culture and testing candidates in humans or chimpanzees is ethically challenging. Despite the multiple barriers to creating a vaccine, vaccination still represents an important tool in the fight against HCV.

An insight into cytotoxic activity of flavonoids and sesquiterpenoids from selected plants of Asteraceae species.

Cancer continues to be a disease that is difficult to cure and the current therapeutic regimen is associated with severe side effects and the issue of emerging drug resistance. According to the World Health Organization fact sheet 2017, cancer is the second major cause of morbidity and death and a 70% rise in new cases is expected over the next 20years. The quest for new anticancer chemical entities is a thrust area identified by many government agencies and industry research and development groups. Nature-derived entities have played a very important role in therapeutics especially cancer Asteraceae is a large family consisting of around 1700 genera and more than 24,000species. Several genera belonging to this family have ethnopharmacological uses such as cytotoxicity, antidiabetic, hepatoprotective and antioxidant. This review highlights the cytotoxic potential of structurally novel flavonoids and sesquiterpenes isolated from some selected species of Asteraceae plants native to Asia, Europe, parts of Africa and America. The existing literature suggests that sesquiterpenes and flavonoids from various species of Asteraceae represent a viable class of secondary metabolites with strong cytotoxic potential. These have demonstrated potent activity in cell cycle arrest, inhibition of neoangiogenesis and induction of apoptosis. The sesquiterpenoids exhibiting potent cytotoxic activity were found to contain an α- methylene-butyrolactone conjugated with an exomethylene group and the flavonoids obtained from various plant species of Blumea suggest that a dihydroxy ring system present in structure is essential for activity. Most of the published literature contains in vitro data of extracts/secondary metabolites with very few in vivo studies. Additionally, there is dearth of knowledge on mechanisms of cytotoxic activity and molecular targets impacted by the active secondary metabolites. This review hopes to fuel interest in researchers to take up detailed investigations on these scaffolds that could contribute significantly as potential leads in anticancer drug development.

Comparative analysis of COVID-19 case fatality rate between two waves in Nepal.

The first COVID‐19 case in Nepal was reported on January 23, 2020. Then infection, then, started to spread gradually, and October marked the most devastating increase in COVID‐19 cases of the year 2020. Compared with the October 2020 peak in Nepal, the May 2021 peak of COVID‐19 observed 2‐ and 10‐fold rise in new cases and deaths per day, respectively. Given that this surprising increase in the death rate was not observed in other countries, this study analyzed the COVID‐19 case fatality rates between the two peaks in Nepal. We found an increase in death rates among younger adults and people without comorbidities.

The Agglutinin of Common Nettle (Urtica dioica L.) Plant Effects on Gene Expression Related to Apoptosis of Human Acute Myeloid Leukemia Cell Line

Treatment of acute myeloid leukemia (AML) requires new drugs as result of a rise in new cases and high disease relapse. Plant lectins with the ability to bind carbohydrates on the cell surface have the potential to treat cancer. Urtica dioica L. agglutinin (UDA) is a low weight lectin with anti-benign prostatic hyperplasia (BPH) impact. Here, we examine the impact of UDA on HL-60 cell line. Cytotoxicity and cytostatic effects were assessed in HL-60 cells treated with UDA and vincristine (positive control). The effects of the lectin on cell cycle phases and cell death mechanism were surveyed by propidium iodide (PI) staining and annexin V/PI, respectively. The activation status of the apoptosis pathway was determined by western blotting. Finally, the expression levels of 84 genes were examined by the Human cancer drug target gene PCR array kit. The results indicated that the increase in UDA concentration inhibited the proliferation of HL-60 cells as well as apoptosis induction. Cell cycle analysis showed that the number of sub G1 cells increased essentially. Experimental observations showed that UDA can induce cell apoptosis through a caspase 9-dependent pathway. The expression changes of 21 genes confirmed the apoptotic events in HL-60 cells treated with UDA. In this, we have presented the first investigation on the cytotoxic and apoptotic effects of a lectin isolated from rhizomes and roots of Urtica dioica L. on human AML cells. Generally, the results suggest that UDA may have therapeutic value for leukemia and would be studied further as a new drug for AML later on.

SARS-CoV-2 superspreading in cities vs the countryside.

The first wave of the COVID‐19 pandemic was characterized by an initial rapid rise in new cases followed by a peak and a more erratic behaviour that varies between regions. This is not easy to reproduce with traditional SIR models, which predict a more symmetric epidemic. Here, we argue that superspreaders and population heterogeneity would predict such behaviour even in the absence of restrictions on social life. We present an agent‐based lattice model of a disease spreading in a heterogeneous population. We predict that an epidemic driven by superspreaders will spread rapidly in cities, but not in the countryside where the sparse population limits the maximal number of secondary infections. This suggests that mitigation strategies should include restrictions on venues where people meet a large number of strangers. Furthermore, mitigating the epidemic in cities and in the countryside may require different levels of restrictions.

Information disorders during the COVID-19 infodemic: The case of Italian Facebook

The recent COVID-19 pandemic came alongside with an “infodemic”, with online social media flooded by often unreliable information associating the medical emergency with popular subjects of disinformation. In Italy, one of the first European countries suffering a rise in new cases and dealing with a total lockdown, controversial topics such as migrant flows and the 5G technology were often associated online with the origin and diffusion of the virus. In this work we analyze COVID-19 related conversations on the Italian Facebook, collecting over 1.5M posts shared by nearly 80k public pages and groups for a period of four months since January 2020. On the one hand, our findings suggest that well-known unreliable sources had a limited exposure, and that discussions over controversial topics did not spark a comparable engagement with respect to institutional and scientific communication. On the other hand, however, we realize that dis- and counter-information induced a polarization of (clusters of) groups and pages, wherein conversations were characterized by a topical lexicon, by a great diffusion of user generated content, and by link-sharing patterns that seem ascribable to coordinated propaganda. As revealed by the URL-sharing diffusion network showing a “small-world” effect, users were easily exposed to harmful propaganda as well as to verified information on the virus, exalting the role of public figures and mainstream media, as well as of Facebook groups, in shaping the public opinion.

Offline: Europe and COVID-19—struggling with tragedy

The Institute for Health Metrics and Evaluation (IHME) at the University of Washington, Seattle, USA, publishes weekly reports on progress to control the COVID-19 pandemic in Europe. They make grim reading. The latest iteration, dated Nov 19, predicts that daily deaths from COVID-19 will continue to rise in the coming weeks, reaching a peak of over 7000 deaths per day around mid-January. Hospitals will be stretched to breaking point from December through to the end of February. COVID-19 is currently the second leading cause of death in the region—29 858 weekly deaths (ischaemic heart disease killed 44 253 people across Europe during the same period). The effective reproduction number, R, remains above 1 in most countries. There is still a large susceptible population—IHME estimates that only 7% of Europeans have been infected with the coronavirus so far. European publics remain resistant to public health advice. Mask use is less than 50% in Sweden, Norway, Denmark, Finland, the Netherlands, Belarus, Bulgaria, Croatia, and Latvia. Europe is struggling with tragedy. But the crisis Europe faces is not only about health—it is about politics too. There is a sense of desperation among political leaders. One example: Belgium. This country is the headquarters to the EU and North Atlantic Treaty Organization. It is the symbolic heart of Europe. But of equal symbolic significance, Belgium has now risen to the top of the Johns Hopkins Coronavirus Resource Center's mortality league table. The country has suffered 133 deaths from COVID-19 per 100 000 population (for comparison, the US figure is 77). This ruinous situation has plunged Belgian politicians into despair. Belgium's parliament has established a Special Commission to examine the origins of the pandemic and to understand better how to manage it. I took part in one evidence session they held last week. A dozen or so politicians met virtually and raised questions that uncovered fear and bewilderment about how they have reached this point of breakdown. “What do you think European countries should do to prepare for the next pandemic?” “Do you consider that the reaction by the WHO and the recommendations that it disseminated during the initial months of the crisis were sufficient and appropriate?” “Could the alarm have been raised earlier?” “Was there a tendency to play down the epidemiological situation?” This urgent search for answers led parliamentarians to look for someone to blame. “Did European leaders overestimate or underestimate the outbreak of this virus?” “In your opinion, where and when did things go wrong in Belgium?” The first case of COVID-19 in Belgium was reported on Feb 4 and the first death took place on March 11. A lockdown was instituted on March 18 and lasted until May 4. The virus surged back. A second lockdown was imposed on Nov 2 and will last at least until Dec 13. Clues to explain the high mortality in Belgium are evident. Political chaos as competing party factions sought power. A breakdown in trust between government and the people. Poor coordination between regions. But the responsibility does not only lie at the national level. I voted against Brexit. I hope that one day a new generation of more internationalist political leaders will inspire public support for rejoining the EU. In solidarity, therefore, we should ask: when facing the greatest peacetime threat in its history, why didn't the EU do more to ensure collaboration, learning, and collective action among countries? The European Centre for Disease Prevention and Control (ECDC), based in Stockholm, Sweden, is the agency dedicated to supporting national governments on health issues. COVID-19 tested its competence. And, sad to say, the ECDC stumbled. It was unable to coordinate country action. It could not convene national leaders to synchronise responses. It was too silent, too invisible, and too weak. When it did speak, it was ignored. The scenarios set out by IHME are not without hope. The rate of rise of new cases across Europe is slowing. Expanding mask use from the current average of 67% to 95% could avert 221 000 deaths by March 1, 2021. Improvements in clinical care have reduced infection fatality rates by 30%. But the coming winter will be hard. Those dark nights will leave ample time for European leaders to reflect on the gap between the ideal of Europe and its reality.

Outbreak Prediction of COVID-19 for Dense and Populated Countries Using Machine Learning.

The Coronavirus Disease-2019 (COVID-19) pandemic persists to have a mortifying impact on the health and well-being of the global population. A continued rise in the number of patients testing positive for COVID-19 has created a lot of stress on governing bodies across the globe and they are finding it difficult to tackle the situation. We have developed an outbreak prediction system for COVID-19 for the top 10 highly and densely populated countries. The proposed prediction models forecast the count of new cases likely to arise for successive 5 days using 9 different machine learning algorithms. A set of models for predicting the rise in new cases, having an average accuracy of 87.9% ± 3.9% was developed for 10 high population and high density countries. The highest accuracy of 99.93% was achieved for Ethiopia using Auto-Regressive Moving Average (ARMA) averaged over the next 5 days. The proposed prediction models used by us can help stakeholders to be prepared in advance for any sudden rise in outbreak to ensure optimal management of available resources.

Guidance on the Clinical Management of Electronic Cigarette or Vaping-Associated Lung Injury.

In the summer of 2019, there was a rise in clusters of adolescents and young adults in the United States reporting to emergency departments with acute respiratory distress related to use of e-cigarette (electronic cigarette) or vaping. The number of patients with e-cigarette or vaping-associated lung injury continued to rise through the summer before peaking in September 2019. Through the efforts of state and federal public health agencies, officials were able to define the condition, identify the relationship of the respiratory injury to tetrahydrocannabinol-containing products, and stem the rise in new cases. In this report, we present a comprehensive review of the clinical characteristics and features of patients with e-cigarette or vaping-associated lung injury and guidelines for patient care and management to inform and navigate clinicians who may encounter these patients in their clinical practice.

Response to COVID-19 Infection in Hemodialysis Patients: An Australian Perspective.

The first reported case of coronavirus disease 2019 (COVID-19) infection in Australia (population 26 million) occurred on January 24th, 2020 in a returned traveler from Wuhan, China (1) followed by a rapid rise in new cases (Figure 1). The Australian government activated the Health Sector Emergency Response Plan for Novel Coronavirus (2) in late February, with subsequent implementation of strict social distancing measures and closure of international boarders in late March (Figure 1). We describe the response taken by the Australian and New Zealand Society of Nephrology (ANZSN) to prepare for the potential exponential increase in case load that was seen in other countries, such as Italy, the United Kingdom, and the United States. Figure 1. Daily coronavirus disease 2019 (COVID-19) infection numbers in Austraia January 24th to June 8th, 2020 showing peak cases mid to late March. Blue and red arrows illustrate timing of Australian Government and Australian and New Zealand Society of Nephrology (ANZSN) initiatives in relation to daily COVID-19 infection numbers. On March 4th, 2020, the ANZSN Council canvassed members to determine if any had commenced preparations for the COVID-19 infection. It became clear that no coordinated approach to this infection had been instigated. As such, the ANZSN Council held a members-only virtual meeting (the COVID-19 Forum) to gauge the preparedness of society members and obtain guidance on further actions. The first COVID-19 Forum was held on March 18th at a time when daily case numbers were rapidly escalating (Figure 1). It was clear at this meeting that the society and its members were not prepared for the COVID-19 infection. This directed the ANZSN Council to create a COVID-19 Working Group (WG) comprising nephrologists and renal nursing and patient advocacy experts with geographic representation across Australia and New Zealand. Specifically, the WG performed three broad functions—monitor and remain informed …

PREPAREDNESS AND RESPONSE OF PAKISTAN FOR CORONAVIRUS DISEASE 2019: GAPS AND CHALLENGES

PREPAREDNESS AND RESPONSE OF PAKISTAN FOR CORONAVIRUS DISEASE 2019: GAPS AND CHALLENGES

Understanding the Impact of COVID-19 Intervention Policies on the Labor Market of the Hospitality and Retail Industries

Using new high-frequency data that covers a representative sample of small business owners, we investigate the effects of the COVID-19 pandemic and the resulting state policies on the retail, hospitality, food, and accommodation sectors. First, we find that business closure policies are associated with a 20-30% reduction of non-salaried workers in the hospitality industry and a 10-20% decline for the retail sector from March-April of 2020. Second, business reopening policies play a statistically significant role in reviving the labor market, though at a slower pace. Third, considerable differences exist in the impact of policies on the labor market by state. Fourth, the rise of new cases on a daily basis is associated with the continued deterioration of the labor market. We use these results to provide policy and managerial recommendations for restoring the labor market and curbing the transmission of COVID-19.

S&P 500 Index and COVID-19

In this paper, I study the impact of the COVID-19 on S&P 500 index using daily data from January 1, 2020, to May 12, 2020. The result shows that the number of confirmed cases, the number of deaths, and the number of recovery cases are the main parameters that affect the S&P 500 index. The first corona case in the USA is found on January 21, 2020. During March, the S&P 500 price fell by almost 31% and reached $2,237.40. The result shows that as the number of daily cases increases, it severely affects the S&P 500 index. But, as the number of deaths increases, the S&P 500 index's reduction is more severe with the rise of new cases. However, there is a little bit of positive effect of the new recovery cases on the S&P 500 Index.