Rio De Janeiro City Research Articles

Comparison of identification methods used in Forensic Anthropological services in four distinct institutes in Brazil and the United States

ABSTRACT Identifying unknown deceased individuals, especially those in advanced stages of decomposition, dismemberment, or burning, is a major medico-legal challenge. Forensic anthropologists play a crucial role in these cases due to the numerous characteristics that can be derived from bone remains. Their methods help evaluate the biological profile and individual characteristics, narrowing potential matches. This research investigates the identification methods used by forensic anthropologists in Medicolegal Institutes and Medical Examiner’s Offices in Brazil and the USA. Case reports from forensic anthropology institutes in Vitória, Rio de Janeiro, Porto Velho (Brazil), and New York City (USA) were analysed. In resolved cases, details such as the biological profile, trauma, decomposition extent, and individualization markers were documented. Statistical tests evaluated the association between these variables and identification outcomes. Conventional identification methods included dental analysis, DNA testing, and fingerprint analysis. Additionally, Bayesian methods, visual identification, prosthetics, and X-ray comparison proved useful. This study highlights that forensic anthropologists can employ a variety of methodologies beyond standard practices, enhancing the identification process in complex cases.

Microsporum audouinii: Emergence of an etiological agent of tinea capitis in Rio de Janeiro, Brazil (2012-2019).

The etiology of tinea capitis changes over time, mainly due to trends in migration. We report 19 cases of tinea capitis caused by Microsporum audouinii, an uncommon agent in South America, all of them confirmed by molecular methods. All patients were male. The average age was 6.1 years. Fifteen patients were residents of Rio de Janeiro city and four were from neighboring cities. Among the patients submitted to follow-up, griseofulvin was prescribed for eight of them. Due to medication shortages, terbinafine was prescribed for five patients, needing to be switched in three cases, with a bigger total average time until clinical improvement. The study reaffirms the emergence of a new etiological agent in Rio de Janeiro, Brazil.

EXPERIENCES IN THE AMAZON

The text explores the formation of family and community doctors with a specific focus on acting in rural areas and the health of the indigenous population, a frequently neglected aspect in residency programs in large urban centers. The narrative details an internship at the Macapá Indigenous Health Support House (Casai) and at the base hub of the Manga village, located in Oiapoque, Amapá. During this internship, the resident doctor of the municipality of Rio de Janeiro-RJ had the opportunity to provide medical attention directly to indigenous communities of the villages of Amapá and northern Pará. A central aspect of the text is the importance of exchange between scientific knowledge and traditional indigenous practices. The respect demonstrated by the indigenous population and the credibility attributed to their beliefs were essential to the effectiveness of the care performed. This experience offered the resident significant learning about person -centered medicine, allowing enriching contact with different cultures and traditions. These cultures have unique visions and understandings about the process of getting sick and healing, which contributed to a broader and more integrated understanding of health care. The internship stressed the importance of recognizing and respecting cultural practices in medical practice.

Urban arbovirus exposure in blood donations from an endemic area of Brazil.

In Brazil, urban arboviruses, such as dengue virus (DENV), Zika virus (ZIKV) and chikungunya virus (CHIKV), constitute a major public health problem, and due to their endemicity and asymptomatic cases, they pose a potential threat to blood donations. Rio de Janeiro (RJ), Brazil, has been impacted by extensive DENV epidemics over the last 30 years and, after 2015, by CHIKV and ZIKV. Urban arboviruses DENV, ZIKV and CHIKV were investigated in blood donations (n = 778) at the State Institute of Hematology, HEMORIO (RJ) from 2019 to 2022 by serological and molecular methods. An overall arbovirus exposure was observed in 26.1% of the blood donations. Anti-DENV IgM was detected in 4.0% of samples and two donations were DENV NS1 positive. Positive anti-CHIKV IgM was observed in 4.7% of the donations. Co-detection of anti-CHIKV IgMand anti-DENV IgM was observed in 1.0% of donors, and CHIKV prevalence was 21.3%. All blood donations tested were negative for the DENV, ZIKV and CHIKV RNA. IgM seroprevalence to the arboviruses analyzed here is an indicator of recent infection in asymptomatic donors, showing that the population of blood donors can be a vehicle for new infections, especially during epidemic periods.

Pon1 and Sult1a1 Polymorphisms and Breast Cancer Among Young Women in Brazil.

Purpose: To investigate the association of genetic polymorphisms Gln192Arg and Leu55Met of Paraoxonase 1 (PON1) gene, and Arg213His of Sulfotransferase 1A1 (SUT1A1) gene with occurrence of breast cancer among young women living in Rio de Janeiro city. Methods: This is a hospital-based case-control study including 265 women aged 18-35 years, diagnosed with breast cancer at National Cancer Institute; and 277 controls in the same age group selected among women patients and companions of three general hospitals from Rio de Janeiro public health network. Polymorphisms genotyping was performed using the PCR-RFLP technique. Results: For PON1 gene, breast cancer women had a greater chance of being homozygote for Leu55Met polymorphism (ORadjusted = 1.42, 95% CI= 0.67-3.00, recessive model) and a lower chance of having at least one allele of Gln192Arg polymorphism (ORadjusted = 0.75, 95% CI = 0.50-1.13, dominant model), but without statistical significance. Accordingly, frequency of the haplotype Met55/Arg192 was lower among breast cancer women, but no statistically significant association was observed (ORadjusted = 0.85; 95% CI = 0.48-1.51). SULT1A1 His/His genotype was significantly associated with a protective effect for breast cancer (OR adjusted = 0.51, 95% CI = 0.28-0.91, recessive model). Conclusion: Arg213His polymorphism of SUT1A1 gene showed a protective effect against breast cancer among Brazilian young women. More studies with different designs are needed to understand the role of PON1 and SULT1A1 polymorphisms in breast cancer development in young Brazilian women.

Human mobility patterns in Brazil to inform sampling sites for early pathogen detection and routes of spread: a network modelling and validation study

Detecting and foreseeing pathogen dispersion is crucial in preventing widespread disease transmission. Human mobility is a fundamental issue in human transmission of infectious agents. Through a mobility data-driven approach, we aimed to identify municipalities in Brazil that could comprise an advanced sentinel network, allowing for early detection of circulating pathogens and their associated transmission routes. In this modelling and validation study, we compiled a comprehensive dataset on intercity mobility spanning air, road, and waterway transport from the Brazilian Institute of Geography and Statistics (2016 data), National Transport Confederation (2022), and National Civil Aviation Agency (2017-23). We constructed a graph-based representation of Brazil's mobility network. The Ford-Fulkerson algorithm was used to rank the 5570 Brazilian cities according to their suitability as sentinel locations, allowing us to predict the most suitable locations for early detection and to track the most likely trajectory of a newly emerged pathogen. We also obtained SARS-CoV-2 genetic data from Brazilian municipalities during the early stage (Feb 25-April 30, 2020) of the virus's introduction and the gamma (P.1) variant emergence in Manaus (Jan 6-March 1, 2021), for the purposes of model validation. We found that flights alone transported 79·9 million (95% CI 58·3-101·4 million) passengers annually within Brazil during 2017-22, with seasonal peaks occurring in late spring and summer, and road and river networks had a maximum capacity of 78·3 million passengers weekly in 2016. By analysing the 7 746 479 most probable paths originating from source nodes, we found that 3857 cities fully cover the mobility pattern of all 5570 cities in Brazil, 557 (10·0%) of which cover 6 313 380 (81·5%) of the mobility patterns in our study. By strategically incorporating mobility patterns into Brazil's existing influenza-like illness surveillance network (ie, by switching the location of 111 of 199 sentinel sites to different municipalities), our model predicted that mobility coverage would have a 33·6% improvement from 4 059 155 (52·4%) mobility patterns to 5 422 535 (70·0%) without expanding the number of sentinel sites. Our findings are validated with genomic data collected during the SARS-CoV-2 pandemic period. Our model accurately mapped 22 (51%) of 43 clade 1-affected cities and 28 (60%) of 47 clade 2-affected cities spread from São Paulo city, and 20 (49%) of 41 clade 1-affected cities and 28 (58%) of 48 clade 2-affected cities spread from Rio de Janeiro city, Feb 25-April 30, 2020. Additionally, 224 (73%) of the 307 suggested early-detection locations for pathogens emerging in Manaus corresponded with the first cities affected by the transmission of the gamma variant, Jan 6-16, 2021. By providing essential clues for effective pathogen surveillance, our results have the potential to inform public health policy and improve future pandemic response efforts. Our results unlock the potential of designing country-wide clinical sample collection networks with mobility data-informed approaches, an innovative practice that can improve current surveillance systems. Rockefeller Foundation.

SARS-CoV-2 transmission in a highly vulnerable population of Brazil: a household cohort study

Household transmission studies seek to understand the transmission dynamics of a pathogen by estimating the risk of infection from household contacts and community exposures. We estimated within/extra-household SARS-CoV-2 infection risk and associated factors in a household cohort study in one of the most vulnerable neighbourhoods in Rio de Janeiro city. Individuals ≥1 years-old with suspected or confirmed COVID-19 in the past 30 days (index cases) and household members aged ≥1 year were enrolled and followed at 14 and 28 days (study period November/2020-December/2021). RT-PCR testing, COVID-19 symptoms, and SARS-CoV-2 serologies were ascertained in all visits. Chain binomial household transmission models were fitted using data from 2024 individuals (593 households). Extra-household infection risk was 74.2% (95% credible interval [CrI] 70.3-77.8), while within-household infection risk was 11.4% (95% CrI 5.7-17.2). Participants reporting having received two doses of a COVID-19 vaccine had lower extra-household (68.9%, 95% CrI 57.3-77.6) and within-household (4.1%, 95% CrI 0.4-16.6) infection risk. Within-household infection risk was higher among participants aged 10-19 years, from overcrowded households, and with low family income. Contrastingly, extra-household infection risk was higher among participants aged 20-29 years, unemployed, and public transportation users. Our study provides important insights into COVID-19 household/community transmission in a vulnerable population that resided in overcrowded households and who struggled to adhere to lockdown policies and social distancing measures. The high extra-household infection risk highlights the extreme social vulnerability of this population. Prioritising vaccination of the most socially vulnerable could protect these individuals and reduce widespread community transmission. Fundação Oswaldo Cruz, CNPq, FAPERJ, Royal Society, Instituto Serrapilheira, FAPESP.

PSYCHIATRIC DEINSTITUTIONALIZATION IN BRAZIL

The Brazilian Psychiatric Reform is a movement that seeks to transform the mental health care model, promoting the deinstitutionalization and social inclusion of people with mental disorders. In this context, Therapeutic Residences represent an alternative to psychiatric institutionalization, offering residential support for individuals who face these disorders and need family or community support, aiming for their social reintegration. This experience report seeks, therefore, to share the experience of a team from the Family Health Strategy in the city of Rio de Janeiro-RJ after one year of monitoring residents of a Therapeutic Residence.

Sustainable Rainwater Management With the Use of Compensatory Urban Drainage Techniques: Case Study on The Maracanã Campus of the University of the State of Rio De Janeiro (UERJ)

Objective: The objective of this study is to evaluate the hydrological impact of using different compensatory techniques on the conventional urban drainage system in an intramural contribution basin to the Maracanã Campus of the State University of Rio de Janeiro (UERJ), located in the Maracanã neighborhood, in the city from Rio de Janeiro-RJ. Theoretical Framework: A bibliographical review was prepared with an approach to the urbanization process associated with urban drainage infrastructures, as well as the use of compensatory techniques to control urban flooding. Method: Rainfall and hydrological data, demand and consumption of non-potable water in the building, sizing of the microdrainage network and compensatory techniques and calculation of the runoff buffered by the techniques were obtained. Results and Discussion: The results obtained revealed that the hydrological impact of using compensatory techniques designed on the drainage network designed in the Maracanã Campus basin, which discharges a flow of 2,041.66 Lts/s, would have a reduction in the flow of around 19%, using only around 14% of the Campus area is a contribution area for techniques. Research Implications: The research brings a scientific contribution based on the analysis of the implementation of compensatory techniques on the microdrainage network as an alternative to be evaluated by municipal managers as a solution to be integrated into the infrastructure development of cities, in order to make them more resilient in terms of to intense rainfall events. Originality/Value: The study showed, based on the results obtained, the efficiency in the use of compensatory urban drainage techniques, with discussion in the scientific community to develop further studies in the context of water resources management.

Geodiversity as a Tool to Integrate Geographical Science and School Geography in Elementary Education in Rio de Janeiro City

O artigo aborda Geodiversidade, com o objetivo de integrar a Ciência Geográfica e a Geografia Escolar, aplicada em uma escola primária do Rio de Janeiro. Para alcançar esse objetivo, consideramos as regras da Base Nacional Comum Curricular (BNCC). Além disso, conceitos relacionados à Geodiversidade e Geoeducação são também discutidos com os estudantes, para que possam aplicar à geoeducação. Um Laboratório de Solos foi criado na Escola Municipal Marília de Dirceu, com recursos da FAPERJ, com o objetivo de levar os alunos para aulas práticas. Uma pequena aula de campo foi feita com os alunos, para ensiná-los a identificar diferentes paisagens urbanas, próximas da escola. Além dos solos, durante o projeto, os estudantes aprenderam sobre rochas, e como associá-las com a Geodiversidade do Rio de Janeiro, evidenciando aprendizagem significativa a partir do contato com atividades científicas e práticas.

Golden lion tamarin metapopulation dynamics five years after heavy losses to yellow fever.

The golden lion tamarin (GLT) is an Endangered primate endemic to Brazil's lowland Atlantic Forest. After centuries of deforestation and capture for the pet trade, only a few hundred individuals survived, all in isolated forest fragments 85 km from Rio de Janeiro city. Intensive conservation actions, including reintroduction of zoo-born tamarins, increased numbers to about 3700 in 2014. The most severe yellow fever epidemic/epizootic in Brazil in 80 years reduced two of the largest GLT populations by over 90%. Herein we report the results of a 2023 survey of GLTs designed to examine the dynamics of population recovery following yellow fever. Results indicate that populations hard hit by yellow fever are recovering due in part to immigration from adjacent forest fragments. No local extirpations were observed. About 4800 GLTs live in the survey area. This represents a 31% increase since the baseline survey completed in 2014. Two factors explain most of the increase: four large areas that had no GLTs or very low-density populations in 2014 are now at moderate density (three areas) or low density (one area), explaining 71% of overall increase since 2014. Increase in forest area within our survey area may explain up to 16% of the increase in GLT numbers since 2014. Results of computer simulations suggest that strengthening forest connectivity will facilitate metapopulation resilience in the face of mortality factors such as yellow fever.

The cost of genetic diagnosis of suspected hereditary pediatric cataracts with whole-exome sequencing from a middle-income country perspective: a mixed costing analysis

Up to 25% of pediatric cataract cases are inherited. There is sparse information in the literature regarding the cost of whole-exome sequencing (WES) for suspected hereditary pediatric cataracts. Molecular diagnosis of suspected hereditary pediatric cataracts is important for comprehensive genetic counseling. We performed a partial economic evaluation with a mixed costing analysis, using reimbursement data and microcosting approach with a bottom-up technique to estimate the cost of using WES for genetic diagnosis of suspected hereditary pediatric cataracts from the perspective of the Brazilian governmental health care system. One hundred and ten participants from twenty-nine families in Rio de Janeiro (RJ) were included. Costs of consumables, staff and equipment were calculated. Two scenarios were created: (1) The reference scenario included patients from RJ with suspected hereditary pediatric cataracts plus two family members. (2) The alternative scenario considered other genetic diseases, resulting in 5,280 exams per month. Sensitivity analysis was also performed. In the reference scenario, the total cost per exam was 700.09 United States dollars (USD), and in the alternative scenario, the total cost was 559.23 USD. The cost of WES alone was 527.85 USD in the reference scenario and 386.98 USD in the alternative scenario. Sensitivity analysis revealed that the largest costs were associated with consumables in both scenarios. Economic evaluations can help inform policy decisions, especially in middle-income countries such as Brazil.

Mpox outbreak in Rio de Janeiro, Brazil: A translational approach.

Mpox is a zoonotic disease historically reported in Africa. Since 2003, limited outbreaks have occurred outside Africa. In 2022, the global spread of cases with sustained interhuman transmission and unusual disease features raised public health concerns. We explore the mpox outbreak in Rio de Janeiro (RJ) state, Brazil, in an observational study of mpox-suspected cases from June to December 2022. Data collection relied on a public healthcare notification form. Diagnosis was determined by MPXV-PCR. In 46 confirmed cases, anti-OPXV IgG was determined by ELISA, and seven MPXV genomes were sequenced. A total of 3095 cases were included, 816 (26.3%) with positive MPXV-PCR results. Most positive cases were men in their 30 s and MSM. A total of 285 (34.9%) MPXV-PCR+ patients live with HIV. Eight were coinfected with varicella-zoster virus. Anogenital lesions and adenomegaly were associated with the diagnosis of mpox. Females and individuals under 18 represented 9.4% and 5.4% of all confirmed cases, respectively, showing higher PCR cycle threshold (Ct) values and fewer anogenital lesions compared to adult men. Anti-OPXV IgG was detected in 29/46 (63.0%) patients. All analyzed sequences belonged to clade IIb. In RJ state, mpox presented a diverse clinical picture, represented mainly by mild cases with low complication rates and prominent genital involvement. The incidence in females and children was higher than usually reported. The observation of a bimodal distribution of Ct values, with few positive results, may suggest the need to review the diagnostic criteria in these groups.

Biological patterns of reproduction of the Brazilian sardine Sardinella brasiliensis in the purse seine fishery of Southwest Atlantic Ocean: A long-term assessment

Recent estimates of the size at first maturity (L50) of Sardinella brasiliensis showed contradictory results with a decreasing in the fish stock biomass encompassed by increasing values of L50. The methodological approach used hereby allowed to separate sardines classified in the virginal maturity stage from those categorized in the recovery stage, and ready for one next spawning event. This study evaluated the hypothesis of the existence of separated stocks experiencing distinct environmental conditions and fishing pressures which may have altered L50 estimates using a robust dataset based on biological samples collected along the entire species distribution area in the southeast-south Brazilian coast [Rio de Janeiro (RJ), São Paulo (SP), Paraná (PR), Santa Catarina (SC) and Rio Grande do Sul (RS)] between 2000 and 2018. A reclassification of the gonadal maturity stages provided a more realistic estimate of L50. Combining biological, reproductive, fishing data and the mean temperature of the catch (MTC), the leave-one-out classification correctly re-assigned individuals with an overall accuracy of 85% [100% (RJ), 45% (SP), 99% (PR), 99% (SC) and 82% (RS)]. The connectivity between the local populations of S. brasiliensis off RJ (23°S) and the southern populations is limited, contrasting to spatial structured semi-discrete population-units found between SP and RS (24°S-30°S). The northern extreme population-unit (RJ, 22°S-23°S) showed an expressive reduction of L50, and a negative correlation was detected between the increasing MTC values and the abundance of early maturing individuals and recruits of the species. Stock specific L50 estimates seemed to act as indicators of long term environmental fluctuations.

Use of antimicrobials in pediatric wards of five Brazilian hospitals

The use of antimicrobials (AMs) in pediatric infections is common practice and use may be inappropriate leading to antimicrobial resistance. Off-label AM use is also common in this group and can result in drug-related problems. There is lack of DUR data in Brazil and in Latin America, specially for AM pediatric use. The aim of this study was to describe the utilization of AMs in hospitalized children in five hospitals in Brazil. We conducted an observational study of the utilization of AMs in pediatric wards in hospitals in the states of Ceará (CE), Sergipe (SE), Rio de Janeiro (RJ), Rio Grande do Sul (RS) and the Federal District (DF). Data derived from patient medical records and prescriptions were collected over a six-month period in each hospital. The number of AMs used by each patient was recorded, and AM use was assessed using Days of therapy (DOT) and Length of therapy (LOT) per 1000 patient days according to different patient characteristics. Off-label (OL) use was described according to age. The study analyzed data from 1020 patients. The sex and age distributions were similar across the five hospitals. However, differences were found for comorbidities, history of ICU admission and length of hospital stay. The most common diseases were respiratory tract infections. There were wide variations in DOT/1000PD (278–517) and LOT/1000PD (265–390). AM utilization was highest in the hospital in SE. The consumption of second-generation penicillins and cephalosporins was high. The prevalence of OL use of AMs was higher for patients in the RJ hospital, in infants, in patients who underwent prolonged hospital stays, and in patients who used multiple AMs. The AM that showed the highest prevalence of OL use was azithromycin, in both oral and parenteral formulations. Overall AM use was high and showed differences in each setting, possibly influenced by local characteristics and by prescribing standards adopted by pediatricians.

Maturity of e-government in Brazilian municipalities: analysis of the dissemination of information and knowledge about the Covid-19 pandemic to Society

Electronic government (e-gov) is a reality already experienced by citizens and organizations of different countries around the world. Governments of different levels can provide information and knowledge available through electronic channels in order to provide a better relationship between their institutions and society. This research aims to identify and classify the maturity of electronic portals of municipal governments in the five largest cities in Brazil regarding the dissemination of information and knowledge about the Covid-19 pandemic to society, classifying them according to the stages of maturity of electronic government proposed by Lechakoski and Tsunoda (2015). To acchieve this goal, a descriptive research of multiple cases was carried out, with the application of a documentary research protocol on the websites of the following Brazilian municipal governments: São Paulo (SP), Rio de Janeiro (RJ), Salvador (BA), Belo Horizonte (MG) and Fortaleza (CE). The results showed that the municipalities of São Paulo (SP) and Rio de Janeiro (RJ) showed greater compliance with the criteria analyzed in the model considered, being classified in the 'integrated' stage, the most developed level. The municipalities of Salvador, Belo Horizonte, and Fortaleza were classified in the transactional stage.

Unravelling COVID-19 waves in Rio de Janeiro city: Qualitative insights from nonlinear dynamic analysis

Since the COVID-19 pandemic was first reported in 2019, it has rapidly spread around the world. Many countries implemented several measures to try to control the virus spreading. The healthcare system and consequently the general quality of life population in the cities have all been significantly impacted by the Coronavirus pandemic. The different waves of contagious were responsible for the increase in the number of cases that, unfortunately, many times lead to death. In this paper, we aim to characterize the dynamics of the six waves of cases and deaths caused by COVID-19 in Rio de Janeiro city using techniques such as the Poincaré plot, approximate entropy, second-order difference plot, and central tendency measures. Our results reveal that by examining the structure and patterns of the time series, using a set of non-linear techniques we can gain a better understanding of the role of multiple waves of COVID-19, also, we can identify underlying dynamics of disease spreading and extract meaningful information about the dynamical behavior of epidemiological time series. Such findings can help to closely approximate the dynamics of virus spread and obtain a correlation between the different stages of the disease, allowing us to identify and categorize the stages due to different virus variants that are reflected in the time series.

Evaluation of tourist carrying capacity to support recreational beaches management

The overexploitation of sandy beaches by tourism reduces ecological integrity, rendering natural conditions unsatisfactory for the needs of the population and resulting in negative socio-economic impacts. In this context, the assessment of tourist carrying capacity aims to support beach management from a social, environmental, and economic perspective. The objective of this study was to estimate the tourist carrying capacity at nine beaches in the states of Rio de Janeiro (RJ) and Espírito Santo (ES), southeastern Brazil. The physical carrying capacity was calculated based on the available space for recreation in scenarios of one user per 5 m2 and 10 m2. Subsequently, limiting environmental factors for recreational use such as sunlight, precipitation, strong winds, tidal range, and temperature were considered, supporting the calculation of the tourist carrying capacity. For the calculation, management conditions (infrastructure and services) were estimated based on the scoring of 69 indicators, included in the international beach quality program called Blue Flag and in the main instrument for coastal management in Brazil, the Orla Project. At RJ beaches, the carrying capacity was not exceeded in the scenario of one user per 10 m2, except in the central region with a higher tourist appeal. In ES state, the results indicated overload for all beaches in the central southern region; for example, one received six times more users than its tourist capacity. Overall, the highest percentages of management capacity were recorded at beaches with Blue Flag certification. The beaches that require the most improvements in coastal management are those located in regions with lower Human Development Index (HDI) and farther from major urban centers. The results suggest priority management actions and guide efforts towards potential beach certification. The management of services, infrastructure, and overload highlights the need for preventive measures to avoid the tourism paradox, including loss of environmental quality and revenue. Moreover, the flexibility of this evaluation tool allows for its application in beaches of any country. The integration of tourist carrying capacity and assessment of the coastal scenario provides a more comprehensive and effective framework for the sustainable management of beaches.

Museums Institutions as A Proposal for Regional, Economic and Social Development: The Museu do Amanhã

Objective: To carry out this study, the objective was to address the main impacts of the Museu do Amanhã on regional development since its inauguration on 2015, in the port region of the city of Rio de Janeiro-RJ. Theoretical reference: As defined in Article 1 of Federal Law 11.904, and in accordance with the guidelines of the International Council of Museums (ICOM), museums are non-profit institutions that work at the service of societies (2009). However, museums are also importante cultural facilities that can be well used according to urban and regional strategic planning to revitalize certain areas. Likewise, museums can make theis contribution based on impacts generated by the greather flow of people in the region with increased tourism, which can result in significant regional, economic and social development. Method: This study is based on exploratory and descriptive research dealing with the impacts of the Museu do Amanhã on regionaldevelopment, based on bibliographic sources and data and whose analysis method applied was a qualitative approach to analyze the proposed phenomenon. Results and conclusion: The current analysis leads to the conclusion that the Museu do Amanhã brought significant regional impacts, both economic and social and cultural. However, from bibliographical sources of the time, it was observed that there are signs of gentrifyng action in the processo f revitalization of the region where the museum was built, which cannot, under any circumstances, be related to the real purposes of a museum institution. And this is because museums have as their mission the purpose of working for the promotion of humanity and the establishment of peace. At the same time, museums are also strategic instruments for urban and regional planning and this contexto opens up countless analyzes and discussions. Implications of the research: This study presents important questions focused on the relationship between musems and urban and regional planning, opening up new research and proposing further discussions and analyzes on the topic. Originality/value: The field of museology is quite comprehensive, and its multidisciplinar and interdisciplinar character must also be taken into account. Even so, mosto f the time research is carried out that delas more with the activities carried out within museums such as conservation, research, exhibition and educational action, but there are other ways of thinking about a museum for society and regarding this there are still manygaps that nees be filled. One possibility on this path is precisely to carry out research with proposals that recognize museums in another way, for example, as strategic instruments for urban and regional planning.

Chemical Profile of Drug Infused Papers Seized in Rio de Janeiro (Brazil) Prisons During the COVID-19 Lockdown

Coronavirus disease (COVID-19) pandemic affected several business segments due to the lockdown period, including the illicit drug market. As Brazil usually imports new psychoactive substances (NPS), it was expected that their traffic would change during the pandemic. This study aimed to characterize NPS infused in pieces of paper seized inside prisons in the State of Rio de Janeiro (RJ), Brazil, during the COVID-19 pandemic by gas chromatography coupled with mass spectrometry, attenuated total reflectance-Fourier transform infrared spectroscopy, and high-resolution mass spectrometry. All samples were identified as synthetic cannabinoid receptor agonists, with indole-indazole structures. It was the first record of methyl (2S)-3,3-dimethyl-2-(1-(pent-4-en-1-yl)- 1H-indazole-3-carboxamido) butanoate (MDMB-4en-PINACA), N-[(2S)-1-amino-3,3-dimethyl1-oxobutan-2-yl]-1-butylindazole-3-carboxamide (ADB-BUTINACA), and N-(1-adamantyl)- 1-(4-fluorobutyl)indazole-3-carboxamide (4F-ABUTINACA) in RJ, demonstrating that new NPS still arrived despite the lockdown. The integration of the data obtained via this study enabled the unequivocal identification of NPS even in the absence of standard reference materials, which is a common drawback faced by forensic laboratories in the analysis of NPS.