Introduction: Cone beam computed tomography (CBCT) was introduced and became more common based on its low cost, fast image procedure rate and low radiation dose compared to CT. This imaging modality improved diagnostic and treatment-planning procedures by providing three-dimensional information with greatly reduced level of radiation dose compared to 2D dental imaging modalities for investigation of maxillofacial skeleton, dentition and the relationship of anatomical structures. However, CBCT is associated with multiple artifacts like. Extinction artifacts, beam hardening artifacts, partial volume effect, aliasing artifacts, ring artifacts and motion artifacts (misalignment artifacts), Noise and scatter. All of them leads to image quality reduction and have capability of Mistakenly considering as a pathological lesion. This study aimed to investigate Cone Beam Computed Tomography artifacts and their reduction procedures. Materials and Methods: A systematic search of the literature published from 2000 to 2017 in the PubMed, scopus and web of science databases was performed. The following key words combined in different ways: cone beam computed tomography, CBCT Artifacts and artifact reduction. Results: Artifact is caused by several factors containing reconstruction parameters like small field of views (FOVs), presence of metal objects, patient movement, etc. Artifact reduction methods can have divided into two categorize preprocessing in the projection domain and post processing in the image domain. Limitation of field of view, modification of patient head position or separating dental arches for scatter reduction, Application of high KVP in order to beam hardening reduction, iterative method and projection modification method for metal artifacts are recommended. In addition, Filtration, interpolation, iterative reconstruction and filtering algorithms, application of the smaller voxel size and respiratory gating are other suggested items for artifact reduction in CBCT. Conclusion: Multiple artifacts accompany CBCT imaging procedures. There for With the aim of improving the quality of the CBCT images; reducing the artifact caused scatter photons , various software-based and hardware-based correction methods are recommended .