Implant-supported fixed prosthesis is a treatment option to restore missing teeth. Occasionally, it is necessary to connect teeth and implants as abutments for these restorations. Whether such restorations can be recommended is a matter of debate. This in vivo study measured strains involved in connecting implants to a natural tooth and compared rigid and nonrigid tooth/implant connections. A patient was treated with mandibular unilateral fixed prosthesis supported by two implants and one proximal tooth. Strain gauges were cemented to the experimental framework restoration. Recordings were obtained from the restorations while the patient bit on a wooden stick on the day of placement and after 2 weeks in function, using both rigid and nonrigid attachment connections. A significant difference was found in horizontal deformation of the tooth/crown between day 1 and 2 weeks later. Vertical deformations were smaller than horizontal ones. After applying biting forces, horizontal and vertical deformations were maintained. Strain recorded in a clinical setting revealed mostly horizontal strains generated in a combined tooth/implant device. These strains were maintained after a 2-week recording. Within the limitation of this study, combined tooth/implant restorations could be a potential complication and could cause an intrusion of a natural abutment regardless of the type of connection (rigid or nonrigid).