This study uses Landsat Thematic Mapper (TM), Shuttle Radar Topography Mission (SRTM) Digital Elevation Model (DEM), and aeromagnetic data to examine possible reactivation of the Ediacaran, NE-trending Ad Damm Fault Zone (AFZ) and the Fatima Fault Zone (FFZ) in the western Arabian Shield. Reactivation is by latest Paleogene to Neogene and Quaternary structures of the Red Sea. The AFZ is the tectonic boundary between the Tonian Jeddah terrane in the northwest and the Asir terrane to the southeast of the Arabian Shield. The AFZ and FFZ coincide with possible onshore continuation of a transform fault that separates the sea floor spreading segment of the Red Sea in the south from its transitional segment to the north. It has been suggested that the AFZ is a candidate for the formation of a future onshore transform fault that would result in an eastward jump of the Red Sea sea floor spreading center onto the Arabian Shield. The future spreading center will follow the latest Neogene to Quaternary volcanic rocks (Harrat) that are exposed on the eastern side of the Red Sea. The Landsat TM image and the SRTM DEM show that the AFZ dissects the Red Sea topographic escarpment, and both the AFZ and FFZ control paleo-drainage system (wadis). The aeromagnetic data show that there is a ∼100 km wide zone between the AFZ and FFZ dominated by NE-trending short wavelength magnetic anomalies, possibly related to regional tectonic fabric. Additionally, the aeromagnetic data show that both fault zones dissect NW-trending short wavelength magnetic anomalies, interpreted as latest Paleogene to earliest Neogene dike swarms associated with the opening of the Red Sea. This dissection also includes possible Red Sea related narrow marginal grabens and horsts that were formed onshore and offshore parallel to the Red Sea shoreline. Red Sea-related structure might have reactivated the AFZ and FFZ.