According to modern scientific literature, specific dermatoglyphic signs can be diagnostic markers of a person’s mental state. The purpose of the work is to identify the association of dermatoglyphic indicators with personality characteristics of practically healthy men of Ukraine. From the data bank of the materials of the research center of National Pirogov Memorial Medical University, Vinnytsya were taken the primary dermatoglyphic and questionnaires indicators of personality characteristics of 92 practically healthy men in the third generation residents of Vinnitsya, Khmelnytsky, part of Ternopil and Zhytomyr regions. Processing of dermatoglyphs was performed according to the method of Cummins H. and Midlo Ch. (1961) in the statement by Gladkova T.D. (1966). For objective evaluation of personality traits of practically healthy men, a number of leading indicators were determined, which included a number of properties of temperament (according to Eysenck), anxiety (according to Spielberger), accentuated personality traits (according to Shmishek), motivational orientation of personality (by Rotter), as well as the peculiarities of psycho-emotional organization of personality, aggressiveness, the level of distribution of asthenic and depressive personality manifestations (by the color test of Luscher), which were determined on the basis of personal use personality questionnaires and test methods. Factor analysis was performed in the “Statistica 6.1” license package. The main factors that indicate the association of personality traits of practically healthy men with some dermatoglyphic indicators are identified: “ridge count of fingers” (dispersion ratio – 13.22%) and “the magnitude of the angle atd” (dispersion ratio – 10.66%). Analysis of the obtained relationships of the interdependence of indicators of personality characteristics with dermatoglyphic indicators showed that with increasing indicators of ridge counts of the fingers and the delta index the degree of probability of growth of indicators of neuroticism according to Eysenck, situational and personal anxiety according to Spielberger, the accentuation of the character of the emotional and arousing types by Shmishek, subjective control in the field of health and illness according to Rotter, black and gray color by Luscher decreases, and the indicators of the accentuation of the character of the anxious and demonstrative types by Shmishek, the overall internality of the level of subjective control in the field of educational (professional) relations according to Rotter, blue and blue-green color by Luscher – is increasing. As the magnitude of the angle atd increases on both hands, the degree of likelihood of growth of neuroticism according to Eysenck, situational and personal anxiety according to Spielberger, accentuation of the character of the emotional, anxious and arousing types by Shmishek, blue color by Luscher increase, and indicators of accentuation of the character of the demonstrative type according to Shmishek, the general internality of the level of subjective control, in the field of educational (professional) relations and in the field of health and illness according to Rotter, blue-green, black and gray color according to Luscher – decrease. The use of factor analysis has allowed to determine the most significant correlation of indicators of personality characteristics with dermatoglyphic indicators.