The floodplain wetlands of northern Victoria are crucial for conservation of biodiversity and the livelihoods of people. Extensive ecosystem degradation and recent extreme floods and droughts have highlighted the urgent need for more sustainable management. We draw on expertise in ecology, hydrology, climatology and governance to synthesise key knowledge and options for enhanced conservation of the floodplains. A key finding is the need for more flexible mechanisms for delivering water to the diverse array of wetlands. A key option is ‘relaxing constraints’ that involves agreements with selected landholders to enable pulses of environmental water to fill river channels and safely spill onto low-lying floodplain wetlands. This should improve conservation of biodiversity, better manage flood risk and support a diverse range of local agricultural and recreational industries. These options may aid Victorians to find better ways of managing the rich lands, waters and biota of the floodplains in the southern part of the Murray–Darling Basin.