s1 May 1968Some Aspects of Calcium and Bone Metabolism in Hypothyroidism.B. L. Riggs, M.D., F.A.C.P., J. Jowsey, D.Phil., P. J. Kelly, M.D., J. D. Jones, Ph.D., C. D. Arnaud, M.D.B. L. Riggs, M.D., F.A.C.P.Search for more papers by this author, J. Jowsey, D.Phil.Search for more papers by this author, P. J. Kelly, M.D.Search for more papers by this author, J. D. Jones, Ph.D.Search for more papers by this author, C. D. Arnaud, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-68-5-1190_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe thyroid gland produces two hormones, thyroxine (T4) and thyrocalcitonin (TC), whose absence might produce alterations in calcium metabolism. In hypothyroidism there is a low radiocalcium accretion rate, but no direct data are available in man regarding levels of bone formation and bone resorption. TC is a newly discovered calcium-lowering hormone secreted by the thyroid in response to hypercalcemia. However, its physiologic role in humans is uncertain. Studies of effects of calcium infusion in hypothyroid patients have produced conflicting results. To evaluate the effect of T4, and possibly TC, deficiency in hypothyroidism, rib biopsies from 5 hypothyroid patients were evaluated... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Rochester, Minnesota PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1968Volume 68, Issue 5Page: 1190-1190KeywordsBiopsyBoneBone resorptionCalciumHypercalcemiaHypothyroidismRibsThyroidThyroid hormonesThyroxine Issue Published: 1 May 1968 PDF DownloadLoading ...