This work reports the facile fabrication of reduced graphene oxide (rGO) based metallic (R) (copper (Cu), silver (Ag), gold (Au) and trimetallic (Tm)) nanocomposites or metal organic frameworks (MOFs) using glucose as a reducing and stabilizing agent in an eco-friendly and low-cost method. The morphology, physicochemical properties and size of different nanocomposites were determined by Scanning Electron Microscopy (SEM), UV–Visible spectroscopy, Transmission electron Microscopy (TEM), Cyclic voltametry and Raman spectra, respectively. In comparative experimental investigations, antioxidant behavior of rGO, RNPs (metallic nanoparticles: AuNPs, CuNPs, AgNPs, TmNPs (trimetallic NPs), rGO-RNPs (rGOCuNPs, rGO-AgNPs, rGO-AuNPs, and rGO-TmNPs or Au@Ag@Cu decorated rGO) was explored for the first time. The antioxidant behavior was estimated by radical scavenging assays viz. total antioxidant, ferric power reducing and hydrogen peroxide assay. Interestingly, antioxidant properties of rGO-RNPs nanocomposite (R-Cu/Au/Ag/Tm)) were found to be arranged in the descending order of AA (ascorbic acid)>rGO-TmNPs > TmNPs >rGOCuNPs > rGO-AgNPs > rGO-AuNPs >AgNPs > CuNPs > AuNPs for total antioxidant assay. In similar way order or arrangmet was rGO-TmNPs > rGO-AgNPs > rGO-AuNPs > AuNPs > TmNPs > rGOCuNPs > AA >AgNPs > CuNPs for hydrogen peroxide scavenging method. And order of arrangment was found to be rGO-TmNPs-GO > rGOCuNPs > rGO-AgNPs > rGO-AuNPs > CuNPs > AgNPs > AuNPs> TmNPs > AA using ferric reducing power assay. These findings indicated that TmNPs decorated rGO showed the best antioxidant capabilities among rGO, RNPs and rGO-RNPs nanocomposites. Furthermore, electrochemical assessment of kinetic parameters (such as peak separation potential, peak current, diffusion coefficient, k°, Ψ, concentration of ionic species etc.) estimated using cyclic voltammetry provided insight towards favourable drift obsereved in all these parameters, that appear to be contributing towards improved conducting behavior. This behavior could also have emerged from improving the disorder in sp2/sp3 carbon of rGO and metal nanoparticles, thereby improving the stability and favorable ease in transfer of electrons between metal NPs and rGO surface. Since these metallic RNPs were found to be uniformly distributed onto rGO surface, this synergistic amalgamation of rGO and multi-metallic nanoparticles possess great potential for low cost, eco-friendly opportunities to tap various environmental and industrial applications. Further investigations to assess catalytic applications, clinical diagnostics and antimicrobial activity estimations are under way.