Introduction In cancer patients, trigeminal neuralgia (TN) has been not only observed in its secondary form but also described as one of the common neuropathic pain syndromes related to cancer. Patients with TN experience a marked reduction in quality of life due to the nature and severity of the pain. Although the standard treatment is microvascular decompression, this approach is not always feasible in oncologic patients. Therefore, radiofrequency (RF) guided by tomography has been described as an ablative intervention that allows achieving immediate pain relief in TN. It is of interest to identify the therapeutic response to pain in oncologic patients treated by this procedure. Objective The study aimed to evaluate the effectiveness of percutaneously guided tomography-assisted RF in oncologic patients with TN. Materials and methods We conducted an observational, retrospective, longitudinal, and analytical study. Patients with cancer and TN treated at the Pain Clinic of the National Cancer Institute in Mexico, who underwent RF, were included. A non-probabilistic sampling of consecutive cases was used, and selection criteria were applied. Clinical records were reviewed to measure study variables, including pain by TN before and after the procedure, as well as patient satisfaction. Data were analyzed using descriptive and inferential statistics, employing Student's t-test for related samples, with a significant level set at p ≤ 0.05 to determine statistical significance. The recorded data were analyzed using IBM SPSS Statistics for Windows, V. 26.0 (IBM Corp., Armonk, NY, USA). Results In the sample of 76 subjects (50% women and 50% men) with a mean age of 60.6 years, a variety of oncologic diagnoses were presented, with skin and soft tissue tumors being the most frequent, mainly located at the level of the head and neck. The etiology of TN was secondary in most cases (89.5%), with similar anatomical involvement on both hemifaces (50% left, 50% right). The branches most frequently involved were the maxillary nerve (V2) and mandibular nerve (V3) (39.5%) and V3 alone (22.4%). The most common probable cause was tumor activity (53, 69.7%). Most patients were receiving anticonvulsant treatment (carbamazepine-oxcarbazepine) (58.9%), followed by gabapentinoids (31.5%). Of the 76 patients, only six received computed tomography (CT)-guided RF. No complications associated with RF application were reported. The mean baseline pre-procedure pain (3.8 ± 2.48) and mean baseline post-procedure pain (2.17 ± 1.94) were significantly different in the Wilcoxon signed-rank test (p = 0.043), as were the mean incidental pre-procedure pain (9.0 ± 1.09) and mean incidental post-procedure pain (5.8 ± 2.31) (p = 0.019). Conclusions Our research provides relevant data on the effectiveness of RF in managing TN in oncologic patients, demonstrating a clinically and statistically significant reduction in pain intensity. These findings need to be confirmed through prospective, longitudinal, long-term studies with control groups in a larger number of patients.
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