Nanofluid, a colloidal suspension of nonmetallic or metallic nanoparticles into conventional base fluid and used for heat transfer characteristics enhancement for many industrial applications. Cleanrooms are essential at various industries for controlling airborne contamination and environmental parameters. In this article, heat transfer properties of nanofluid (Al2O3 + water) at various nanoparticle concentrations (1%, 2%, and 3%) on a prototype cleanroom air handling chiller unit was investigated experimentally in laminar flow zone. Thermal conductivity ratio, Nusselt number, Peclet number, and pressure drop were obtained for above nanoparticle concentrations. Experimental investigations indicate the heat transfer properties improvement in a prototype cleanroom air handling chiller unit by using nanoparticle at base fluid. Experimental investigation on varying Al2O3 + water nanofluid concentrations in a cleanroom air handling chiller unit heat exchanger revealed a notable increase in heat transfer by reducing nanoparticle size from 50 to 10 nm and increasing concentration from 1% to 3% volume, resulting in a 17.70% rise in thermal conductivity ratio and a significant 9.23% increase in Nusselt number at higher Peclet numbers. However, this improvement in heat transfer was accompanied by a substantial 72.5% increase in pressure drops, particularly with increased Reynolds number and particle concentration. Manipulating nanoparticle characteristics resulted in substantial improvements in Nusselt number across a wide range of Reynolds numbers, with smaller particle sizes and higher volume concentrations yielding more significant heat transfer improvements. The novelty of this research lies in its investigation of the influence of variable Al2O3 + water nanofluid concentrations, encompassing different nanoparticle sizes, and volume concentrations, on dimensionless heat transfer parameters within a cleanroom air handling unit, offering valuable insights into optimizing heat transfer efficiency in a controlled and critical environment, addressing a significant research gap in the field.
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