Review Of Procedures Research Articles

A Systematic Review of Health-Related Quality of Life in Women with HER2-Positive Metastatic Breast Cancer Treated with Trastuzumab.

Many trials of human epidermal growth factor receptor 2 (HER2)-positive metastatic breast cancer treatment with trastuzumab have provided evidence of improved clinical outcomes. This systematic review examined how a regimen that includes trastuzumab affects patients' health-related quality of life (HRQoL) during and after treatment. A systematic search for articles published up to February 2023 without restrictions of language or publication year was performed using the Pubmed, Embase, and Scopus databases. We included studies of women aged >18 years with metastatic HER2-positive breast cancer treated with a trastuzumab-containing regimen. We assessed the quality of the studies using the Cochrane Risk of Bias (RoB) tool (2.0) for randomized controlled trials (RCTs) and the Risk Of Bias In Non-randomised Studies-of Interventions (ROBINS-I) tool for cross-sectional studies. We used Microsoft Excel to extract and synthesize data, and documented the review procedure following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. In total, eight studies compared 1104 trastuzumab-treated patients and 1003 non-trastuzumab-treated patients. Most studies were RCTs (n=7) and one was a prospective observational study. All the included studies used the EORTC-QLQ-C30, EORTC-QLQ-BR23, FACT-B, or FACT-G questionnaires. During treatment, patients taking regimens that included trastuzumab showed clinical improvement in HRQoL, social functioning, and role functioning. After the treatment, patients' HRQoL profiles in the trastuzumab and chemotherapy arms were similar. However, trastuzumab (versus chemotherapy) treatment led to clinically improved functional status, role and physical functioning, and fatigue. The quality assessment revealed some concerns in most RCTs, with the risk of bias being high in two studies, low in one study, and moderate in the cross-sectional study. Trastuzumab-containing regimens administered to HER2-positive breast cancer patients at the metastatic stage evidenced beneficial effects on total HRQoL during and after treatment. Upon therapy cessation, patients' HRQoL scores for both interventions improved. Nevertheless, HRQoL profiles of patients treated with trastuzumab were more favorable, particularly for functional status, role functioning, physical well-being, and fatigue. This review was registered in PROSPERO (registration number: CRD42021259826).

Impacts of Climate Change Scenarios on the Corn and Soybean Double-Cropping System in Brazil

Brazil is one of the main producing and exporting countries of corn and soybean and a continental country with climatic diversity that allows the cultivation of these crops in various agricultural systems. Double cropping is a widely adopted system throughout the national territory, where it is possible to cultivate soybeans at the beginning of the growing season, followed by corn in succession, in the same growing season. The present study aims to systematize the scientific knowledge about the impacts of future climate change scenarios on yield and on the double-cropping system of soybean + corn in Brazil. Systematic review procedures were adopted. The soybean yield is projected to increase in all regions of Brazil under all climate scenarios. Corn yields under future climate scenarios are projected to decline, with the subtropical climate region being less affected than the northern regions. The double-cropping systems of soybean + corn tend to present increasing climate risks in tropical climate regions. Climate change scenarios point to a delay in the start of the rainy season that will delay the sowing of soybeans, consequently delaying the sowing of corn in succession, resulting in fewer rainy days to complete its cycle.

Application of Rodenticides for the Control of Zoonotic Cutaneous Leishmaniasis in Iran: A Systematic Review of the Literature

Introduction: Rodent control programs have a long history of controlling zoonotic cutaneous leishmaniasis (ZCL) in Iran. The present systematic review reports the effect of rodenticides in reducing ZCL in Iran. Materials and Methods: Various electronic databases were explored for reliable research using appropriate keywords between January 1970 and September 2023. Relevant studies were included based on the inclusion criteria. All articles identified from the systematic search were added into Endnote X9 (Clarivate Analytics) and duplicate articles were removed. This study followed standard procedures for systematic reviews and reported results according to systematic reviews guidelines. Results: Overall, 637 documents were identified after screening based on the PRISMA checklist, and finally, 13 papers were included in this systematic review. The findings indicated that most of studies used zinc phosphide (2.5%) and Klerat® mixed with wheat grains in rodents control programs in Iran. The results showed that rodent control programs were implemented in five provinces of Iran, including Esfahan, Yazd, Semana, Golestan, Kermanshah, and Fars, with the highest number of studies in Esfahan province. According to results, the incidence rate of ZCL significantly reduced after rodenticide implementation. Conclusion: This review study provides a better understanding of rodent control programs trends as a promising and practical approach to reducing ZCL incidence in Iran over the past 50 years and can serve as a reference for planning future control and research programs.

Protocol for a Meta-Review on Education Meta-Analyses: Exploring Methodological Quality and Potential Significance for Research Use in Practice

This protocol presents the planned methods and procedures for a meta-review that explores the methodological quality of education meta-analyses and their potential significance for research use. An ever-increasing number of meta-analyses are published every year while at the same time new approaches to enhance the validity and reproducibility of systematic reviews are in constant development. We aim to conduct a meta-review to examine the current practices of education meta-analyses in terms of review procedures, meta-analysis methods, and strategies for making meta-analyses useful for non-research audiences. We will focus on meta-analyses including randomized controlled trials and quasi-experimental designs on the effects of K-12 school-based academic interventions on student academic achievement. A comprehensive search will be conducted to retrieve all studies that potentially meet our criteria. Study features will be coded to evaluate three main dimensions: the quality of the review process, which includes the practices used at each systematic review stage (e.g., search procedure, selection, and critical appraisal); the quality of the meta-analysis methods, including the methods used for synthesizing the results, exploring heterogeneity and additional analyses, such as publication bias assessment; the significance for research use, which includes evaluating the ways authors present findings to increase accessibility and relevance for practitioners (e.g., stakeholder engagement in the process, reporting of results). We will identify strengths and weaknesses of current meta-analysis practices and compare them across time, publication outlet, and funding status.

Utilizing ASReview in screening primary studies for meta-research in SLA: A step-by-step tutorial

Meta-research, including meta-analyses and systematic methodological reviews, has proven to be a useful tool for obtaining a comprehensive understanding of research questions by numerically summarizing data and methodological features in a given literature. As part of the review procedure, researchers select primary studies to be included in their analysis. However, this process is resource-intensive and prone to human error. In this tutorial, we introduce a practical application of artificial intelligence (AI), known as ASReview, that can facilitate the screening process. Using a simulated data set derived from a published meta-analysis, we offer step-by-step guidance on how to incorporate the tool into the screening process. We cover the essential steps, including the preparation of the data set, the import of the data set, the labeling of the study as relevant or irrelevant (for inclusion or not), as well as the saving of the results for the researcher's record and sharing for transparency in the spirit of open science. In addition, the tutorial addresses essential factors to consider in the AI-aided screening process, such as stopping rules. We acknowledge potential limitations of the tool and provide a couple of alternatives for interested readers. Our overall goal is to contribute to advancing and promoting meta-research in SLA by facilitating the screening process in the era of AI.

Harnessing Disruptive Technologies for Agricultural Revolution: A Systematic Literature Review on Impact and Sustainability

This literature review employs the Scientific Procedures and Rationales for Systematic Literature Reviews (SPAR-4-SLR) framework to comprehensively analyze the impact of disruptive technologies on the agricultural sector, often characterized as the Agriculture Revolution. The review's primary focus lies on understanding how disruptive technologies influence business model transformation, enhance operational efficiency, promote sustainability, and mitigate supply chain disruptions within the agricultural domain. By systematically reviewing existing research, this study seeks to consolidate knowledge, identify research gaps, and provide valuable insights for the future development of agriculture in the era of disruptive technologies.

Future Research Prospects of Floriculture Industry from Management Perspective: A Bibliometric Analysis Using the SPAR-4-SLR Approach

Floriculture as a branch of the horticulture industry is still at a developing stage that needs to be assessed for further orientation in the areas of management, business and economics. The commercialization of ornamental plants and cut flowers is of recent origin in developing economies which have high growth potential, both in domestic and international markets. The study highlights the evolution of the floriculture industry having a management perspective and paving the way for future research directions. The paper conducts a bibliometric analysis and rigorous systematic review of 126 papers published in peer-reviewed journals related to the floriculture industry using the Scientific Procedures and Rationales for Systematic Literature Reviews (SPAR-4-SLR) protocol. The Biblioshiny function of R software and VOS viewer is used for the analysis. The intellectual structure of the floriculture literature is presented through bibliographic coupling and thematic cluster analysis. The findings indicate considerable opportunities for further investigations in the field of floriculture focusing on the inclusion of sustainability practices, the evolution and role of women farmers and entrepreneurs, and supply chain management of floriculture products.

Mechanical Thrombectomy for Aseptic, Atraumatic, Medically Refractory Cerebral Venous Sinus Thrombosis: aSystematic Review.

Cerebral venous sinus thrombosis (CVST) follows asevere clinical course in 13.5% of cases. Practice guidelines recommend endovascular therapy (EVT); no randomised control trials (RCTs) exist comparing EVTs. To determine whether specific EVTs are superior to alternatives. CENTRAL, Medline, Embase, five other databases and four clinical trials registers. Grey literature searches, reference checking, citation searching, and author contact. All CVST cases treated with mechanical thrombectomy (MT) were includible. Paediatric, and trauma-related or infection-related thromboses were excluded. Standard Cochrane review procedures. Primary outcome measures; clinical efficacy (modified Rankin Score, mRS), technical efficacy (recanalisation), and clinical safety (procedure-related complications and death). Subgroup analyses were performed, comparing outcome measures between demographic groups, clinico-radiological severity, interventional strategies, and degrees of recanalisation. In this study 124 papers were included (n = 486). All patients underwent MT, with 69.5% of patients receiving concomitant chemolysis. New/expanding intracerebral haemorrhage (ICH) occurred in 5.1%; non-haemorrhagic complications in 1.4%; 10.7% died. Predictors of poor efficacy included age ≥ 55years, altered mental status (AMS), Glasgow Coma Scale (GCS) < 8. Predictive of poor safety outcomes included pre-existing ICH, deep system thrombosis, and AMS. Complete recanalisation was associated with improved clinical efficacy and safety outcomes. The review is based on case reports/series, increasing bias-risk. Myriad of potentially includible studies were necessarily excluded due to lack of requisite details. Predictors of poor outcomes with medical therapy predict poor outcomes with MT; these measures should not dictate candidacy. Complete recanalisation predicts favorable clinical and safety outcomes. Local chemolysis is safe, improves recanalisation, and should be recommended, provided there is no contraindication. Clot maceration strategies and stent-retriever thrombectomy are associated with superior clinical efficacy and safety endpoints, as compared with balloon angioplasty and rheolysis.

Effects of Self-Management Interventions on Challenging Behavior: A Systematic Review and Meta-Analysis

Purpose: The systematic review and meta-analysis evaluated the effectiveness of self-management interventions on classroom behaviors and academic outcomes. Methods: Review procedures followed Campbell Collaboration guidelines to search, select, and extract data from published and unpublished studies employing an experimental/quasi-experimental comparison group or single-case experimental design assessing the effects of a self-management intervention in schools. Seventy-five single-case design studies (236 participants; 456 effects) and 4 comparison group studies (422 participants; 11 effects) were included. Results: Single-case results indicated self-management interventions positively impacted challenging behaviors (LRRi = 0.69 [0.59, 0.78]) and academic outcomes (LRRi = 0.58 [0.41, 0.76]). A significant main effect for improving challenging behaviors was revealed in group design studies ( g = 0.63 [0.08, 1.17]). Discussion: Limitations, including methodological shortcomings in the single-group design studies and the small number of comparison group studies, should be considered when interpreting findings. Implications for practice and future research are discussed.

Onsite serious adverse events reporting: Seven-year experience of the institutional ethics committee of a tertiary care hospital.

Over the years, Indian regulations have undergone numerous amendments, including stringent reporting deadlines, relatedness requirements, and compensation obligations for serious adverse event (SAE). A historic change, new drugs and trial rules-2019, was proposed on March 19, 2019. The purpose of the study was to ascertain whether various stakeholders were reporting in accordance with the evolving SAE criteria. Data were retrieved after the Ethics Committee's approval between August 2014 and December 2021. Data gathered before March 19, 2019, were categorized as "BEFORE" data, while the remaining data were categorized as "AFTER." Utilizing causality, on-site SAE reporting, and the ethics committee review procedure, we evaluated the compliance. The data were evaluated using descriptive statistics, and the Chi-square or Mann-Whitney tests were used to compare the "BEFORE" and "AFTER" groups. A total of 77 SAEs were reported in 26 clinical trials, where most clinical trials were phase III. Endocrine projects made up 9/26 (34.61%). In the cardiology studies, the greatest SAE distribution was 21 SAEs/89 participants (23.59%) with approximately 48% of these being vascular. The "AFTER" group noticed a decrease in the total number and length of SAE subcommittee meetings. In the "AFTER" group, there was a significantly higher median number of agenda items/meetings (8 [4.5-10.75]) (P < 0.0001). The median interval between the onset of SAE and the first reporting date, however, was just 1 day (interquartile range: 1-5 days). In nondeath SAEs, there was no significant difference in the compensation paid. In the "AFTER" group, there were no discrepancies in reporting SAE. There is acceptable adherence to SAE reporting criteria.

Emergency Approval Mechanisms for Human Vaccines in India.

The coronavirus disease 2019 (COVID-19) pandemic highlighted the world's level of preparedness in managing public health emergencies (PHEs). It revealed the critical need for timely medical therapeutics, especially vaccines. To expedite response, many nations, including India, adopted emergency approval mechanisms and offered new ways of review, such as the rolling review along with the accelerated review procedure. This response resulted in reallocating internal resources and adopting new policies and measures, such as integrating digital technology with regulatory submissions and flexibility in statistical approaches. The present review focuses on the utilization of the New Drugs and Clinical Trials Rules 2019 for granting emergency approval to COVID-19 vaccines by the Drug Controller General of India (DCGI) and explores the legislative basis for such authorization during the PHE. The review aims to elucidate key intricacies and challenges inherent in the existing 'emergency use' framework within the Indian regulatory landscape. It assesses three critical facets of the 'emergency use' paradigm: the definition of the term, establishment of a transparent decision-making process, and formulation of rules governing termination or expiration of the emergency status. It makes policy recommendations regarding the 'emergency use' framework to respond to new, emerging, or re-emerging public health threats of the future.

Retraction Note: Visiting the Sick in Hospitalized Children with Neurological Disorders

RetractionAn investigation by the publisher found a number of articles, including this one, published in Journal of Pediatric Neurology on September 28, 2022 (DOI: 10.1055/s-0042-1756449), with a number of concerns, including but not limited to undeclared conflicts of interest and manipulated peer review procedures. As a result, the publisher has retracted and removed this article.

Retraction Note: Use of Ruqyah in Patients with Neuropsychiatric Disorders

RetractionAn investigation by the publisher found a number of articles, including this one, published in Journal of Pediatric Neurology on October 11, 2022 (DOI: 10.1055/s-0042-1757622), with a number of concerns, including but not limited to undeclared conflicts of interest and manipulated peer review procedures. As a result, the publisher has retracted and removed this article.

Retraction Note: The Miracle of Ibrahim's (Alayhi As-Salam) “The Fire that Does Not Burn”: Lessons to Today's Health Professionals

RetractionAn investigation by the publisher found a number of articles, including this one, published in Journal of Pediatric Neurology on February 06, 2023 (DOI: 10.1055/s-0043-1761484), with a number of concerns, including but not limited to undeclared conflicts of interest and manipulated peer review procedures. As a result, the publisher has retracted and removed this article.

Retraction Note: The Effects of Quran Recitation on Sedation and Pain in Children

RetractionAn investigation by the publisher found a number of articles, including this one, published in Journal of Pediatric Intensive Care on January 13, 2023 (DOI: 10.1055/s-0042-1760632), with a number of concerns, including but not limited to undeclared conflicts of interest and manipulated peer review procedures. As a result, the publisher has retracted and removed this article.

Retraction Note: Epilepsy and the Quran Recitation as a Meditation

RetractionAn investigation by the publisher found a number of articles, including this one, published in Journal of Pediatric Epilepsy in Volume 12, Number 02, 63-64, in June 2023 (DOI: 10.1055/s-0042-1756438), with a number of concerns, including but not limited to undeclared conflicts of interest and manipulated peer review procedures. As a result, the publisher has retracted and removed this article.

Retraction Note: Salvation of the Prophet Yunus (Alayhi As-Salam), Swallowed by the Big Fish: A Message for Today's Physicians

RetractionAn investigation by the publisher found a number of articles, including this one, published in Journal of Pediatric Neurology on January 03, 2023 (DOI: 10.1055/s-0042-1760195), with a number of concerns, including but not limited to undeclared conflicts of interest and manipulated peer review procedures. As a result, the publisher has retracted and removed this article.

Retraction Note: Importance of Religious Coping in Bereaved Parents after the Death of a Child with Genetic Disorder.

An investigation by the publisher found a number of articles, including this one, published in Journal of Pediatric Genetics in Volume 12, Number 02, 95-96, in June 2023 (DOI: 10.1055/s-0042-1759781), with a number of concerns, including but not limited to undeclared conflicts of interest and manipulated peer review procedures. As a result, the publisher has retracted and removed this article.

Retraction Note: A Spiritual Prescription for Patients with Stroke

RetractionAn investigation by the publisher found a number of articles, including this one, published in Journal of Pediatric Neurology on September 15, 2022 (DOI: 10.1055/s-0042-1756448), with a number of concerns, including but not limited to undeclared conflicts of interest and manipulated peer review procedures. As a result, the publisher has retracted and removed this article.

Retraction Note: Patients' Supernatural Beliefs on Cause of Multiple Sclerosis

RetractionAn investigation by the publisher found a number of articles, including this one, published in Journal of Pediatric Neurology on April 17, 2023 (DOI: 10.1055/s-0043-57006), with a number of concerns, including but not limited to undeclared conflicts of interest and manipulated peer review procedures. As a result, the publisher has retracted and removed this article.