Neurogenic tumors of the lung and interlobar fissures are rare. In a review of the literature the authors could find only 8 complete case reports (3, 4, 7, 13, 14, 17). Seven additional cases with incomplete protocols were also found (2,3, 6, 8, 11, 13). The 2 additional examples to be reported here bring the number to 17. A review of several articles reporting a total of 317 isolated pulmonary masses (1, 2, 6, 8, 12, 15, 16, 18) revealed only 3 neurogenic tumors, of which 1 was malignant (6) and 2 benign (2, 8). Pathology A detailed discussion of the pathology of neurogenic tumors is beyond the scope of this paper. Most authors classify them in two major groups: tumors of the sympathetic nervous system (ganglioneuroma, ganglioneuroblastoma, and neuroblastoma) and tumors of nerve-sheath origin (neurilemmoma, neurofibroma, malignant schwannoma, neurofibrosarcoma) (3). The term “neurinoma” appears occasionally in the literature, supposedly denoting a pure nerve-cell origin with no nerve-sheath elements. Many authors do not include this term in classifications of neurogenic tumors, since practically all of these are of nerve-sheath origin, and neurofibroma is a more applicable designation (3). Benign and malignant variants are present in both groups of neurogenic tumors. It is frequently impossible to differentiate by radiologic or clinical means the benign from the malignant neurogenic tumor. In Kent's series (9), 37 per cent of the tumors were malignant. The following neurogenic tumors have been reported in the literature: 1. Benign neurogenic tumors, arising within lung tissue, 10 cases (2, 3, 5, 7, 8, 13, 14, 17). We add 2 cases. 2. Benign neurogenic tumors arising in the interlobar fissure, 2 cases (3, 4). 3. Malignant neurogenic tumors arising within lung tissue, 3 cases (6, 7, 11). Anatomic Location of Reported Neurogenic Tumors of Lung Of the 9 solitary neurogenic tumors of the lung, 2 were reported as being within the interlobar fissures (3, 4). Of the remaining 7 cases (including the authors'), the tumor was in the right upper lobe in 2 instances (13; Case I, below), in the right middle lobe in 2 instances (5, 7), in the right lower lobe in 2 instances (17; Case II, below), and in the left upper lobe once (7). Tumors were multiple and bilateral in 1 case (14). Clinical Manifestations Of the 10 patients (including the authors') for whom complete case protocols are available, 7 had no clinical manifestations referable to the pulmonary mass. Hemoptysis, left chest pain, dyspnea, and asthmatic attacks were present in 1 case of multiple neurofibromata of the lungs described by Rubin and Aronson (14). In 1 case of primary neurogenic sarcoma of the lung reported by Diveley and Daniel (7), in a forty-eight-year-old white male, the clinical course was suggestive of carcinoma of the lung (45 pounds weight loss, pneumonia-like attacks, fever, productive cough).
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