Review Committee Research Articles

Savolitinib in patients in China with locally advanced or metastatic treatment-naive non-small-cell lung cancer harbouring MET exon 14 skipping mutations: results from a single-arm, multicohort, multicentre, open-label, phase 3b confirmatory study

Savolitinib has been approved in China for advanced or metastatic non-small-cell lung cancer (NSCLC) with MET exon 14 (METex14) skipping alterations in previously treated patients and those unable to receive platinum-based chemotherapy. We report results from a treatment-naive cohort of a phase 3b study that was designed to evaluate the efficacy and safety of savolitinib in locally advanced or metastatic METex14-mutated NSCLC. This single-arm, multicohort, multicentre, open-label, phase 3b study was done at 48 hospitals in China in adult (≥18 years) patients with locally advanced or metastatic METex14-mutated NSCLC who had not received previous systemic antitumour therapy. Patients with a bodyweight of 50 kg or more and those with a bodyweight of less than 50 kg received savolitinib once daily at 600 mg or 400 mg, respectively, in 21-day cycles. The primary endpoint was objective response rate assessed by independent review committee (IRC) per Response Evaluation Criteria in Solid Tumours, version 1.1. The full analysis set comprised all patients who received at least one dose of study medication, which was used to assess the efficacy endpoints and baseline and safety data. This study is registered with ClinicalTrials.gov (NCT04923945) and is closed to accrual. Between Aug 31, 2021, and Oct 20, 2023, 125 treatment-naive patients were assessed for eligibility, of whom 87 were enrolled and received savolitinib. The median age of patients was 70·0 years (IQR 65·2-75·8) and 51 (59%) of 87 patients were male and 36 (41%) were female. In the full analysis set, the IRC-assessed objective response rate was 62% (95% CI 51-72) and the investigator-assessed objective response rate was 60% (49-70), showing a high concordance rate (84%). Treatment-related adverse events were reported in 85 (98%) of 87 patients, with peripheral oedema (54 [62%]) being the most common. Two of these treatment-related adverse events led to death (cardiac failure n=1, unknown reasons n=1). Savolitinib showed manageable toxicity and promising efficacy in treatment-naive patients with advanced or metastatic METex14-mutated NSCLC. HUTCHMED and AstraZeneca.

The Study on the Chinese Environmental Audit Tool (C-EAT) for Long-Term Care Facilities.

Objective: The aim of this study was to translate the Australian Environmental Assessment Tool (EAT) into Chinese and identify culturally specific characteristics in the Chinese context for adaptation. Background: In the context of dementia-specific care, the design of the environment is considered an influential factor in supporting and maintaining skills. However, despite the increasing number of individuals with dementia in China, there is currently no valid instrument available to systematically assess the quality of the physical environment in long-term care facilities (LTCFs). Methods: This study utilized a mixed-method procedure consisting of seven steps, including translation and adaptation. The study involved focus groups comprising an expert panel (n = 17) and potential users (n = 64) of the newly developed tool. Cross-cultural adaptation was performed through Chinese literature review and literature quality appraisal, field study, and expert committee review. Results: The final version of the China Environmental Assessment Tool (C-EAT) consisted of 10 key design principles and 64 items. The C-EAT was tested in four LTCFs in China and underwent two rounds of review by an expert panel. Conclusions: The C-EAT was deemed a suitable tool for assessing the environment and enhancing the living environments for individuals with dementia in LTCFs in China. In future research, field tests will be conducted to validate the C-EAT scale and modify the EAT-HC to enhance its applicability in China.

Comparison of axillary Exclusion versus No Exclusion on seroma formation after Modified Radical Mastectomy.

Objective: To determine the effectiveness of axillary exclusion technique versus no axillary exclusion in Modified Radical Mastectomy in terms of mean drain output. Study Design: Randomized Control Trial. Setting: Department of Surgery, Allied Hospital Faisalabad Pakistan. Period: 8th August, 2018 to 8th February, 2019. Methods: A request for authorization was made to the Hospital Ethical Review Committee. The research had 60 individuals in all who were admitted. General Surgery Department from outside the Allied Hospital in Faisalabad. For the sixty patients receiving modified radical mastectomy, written informed consent was obtained. A computer-generated database of random numbers was used to split them into two equal groups of thirty patients each at random. Following a modified radical mastectomy, group A received axillary exclusion, but group B did not. Total volume of accumulated fluid) following a modified radical mastectomy. After surgery, until the drain was removed, the total quantity of fluid collection in the drainage bag was recorded and compared across groups. Data was input into a template form. Results: In our study, the mean + SD was determined as 43.73+5.64 years in Group B. Of the two groups, 63.33% (n=19) in Group A and 70% (n=21) in Group B were between 41 and 70 years old, while 36.67% (n=11) in Group A and 30% (n=9) in Group B were between 20 and 40 years old. (First Table-I). Following a modified radical mastectomy with drainage, axillary exclusion procedures were compared with no exclusion, and the results indicated that the mean total drainage output (+SD) in Group B was 642.1 ml (+117.06). (Table-II). The total volume of seroma fluid drained between the two groups was significantly lower, as indicated by the p value of ˂0.001. Conclusion: In comparison to individuals who do not undergo axillary exclusion, we find that axillary exclusion procedures considerably reduce drainage expense in patients undergoing modified radical mastectomy.

Differentiating Ischemic Hepatitis from Acetaminophen Overdose in Acute Liver Failure: Role of Acetaminophen Adducts-Ischemic Hepatitis vs Acetaminophen Overdose.

Acetaminophen (APAP) hepatotoxicity and ischemic hepatic injury (IH) demonstrate remarkably similar biochemical patterns. Deciding between these two etiologies in the setting of acute liver failure (ALF) can be challenging. We reviewed all cases in the Acute Liver Failure Study Group (ALFSG) registry where these diagnoses were considered, to determine reasons for, and frequency of, difficulties making these diagnoses. We hypothesized that the newly developed APAP-CYS adduct assay could help in discerning the correct diagnosis. Among 3364 patients with ALF or acute liver injury (ALI: INR ≥ 2.0 but without encephalopathy) between 1998 and 2019, 1952 (58%) received a final diagnosis of either APAP (1681) or IH (271). We utilized a review committee of senior hepatologists as well as the APAP-CYS assay (where sera were available), measuring the presence of toxic by-products of APAP injury to optimize adjudication. With these methods, a total of 575 adduct positive APAP cases included 488 recognized APAP, as well as an additional 87 patients previously diagnosed as other etiologies. Nine cases initially attributed to IH were deemed combination APAP-IH injuries. Conversely, 215 of the 280 IH subjects tested for adducts disclosed 173 confirmed as IH with adduct testing below the toxicity threshold, while 9 cases were revised from APAP to the IH-APAP combination phenotype, where both hypotension and APAP likely played a role. Discerning APAP from IH can be difficult-in rare cases, combined injury is observed (18/1952). APAP-CYS testing resulted in revising the diagnosis in 14.6% of cases.

Combination of exhaled breath condensate samples with lipoarabinomannan point of care assay for pulmonary tuberculosis (TB) diagnosis: protocol for a diagnostic accuracy study

IntroductionThe WHO estimates a gap of about 30% between the incident (10.6 million) and notified (7.5 million) cases of tuberculosis (TB). Combined with the growing recognition in prevalence surveys of...

Preface

Dear Distinguished Authors and Guests, 2024 9th International Conference on Mechanical Structures and Smart Materials (ICMSSM 2024) was held on June 15-16, 2024 in Beijing, China. The conference program covered invited, oral presentation session and poster session from scientists working in similar areas to establish platforms for collaborative research projects in this field. The conference aimed to bring together leaders from mechanical structures and smart materials to exchange and share their experiences, present research results, explore collaborations and to spark new ideas, with the purpose of developing new projects and exploiting new technology in this field. We hope that the conference has resulted in significant contribution to the knowledge on mechanical structures and smart materials. To this end, this book contains the papers presented at ICMSSM 2024. All papers were accepted through a peer-review process conducted by the conference program committee and international reviewers. Finally, we would like to thank all authors and participants of ICMSSM 2024 for their contributions to making this conference a success. We look forward to your participation in the 10th ICMSSM in 2025. With our warmest regards, The Committee of ICMSSM 2024 List of Committee Members are available in this Pdf.

2024 Conference Committee and Abstract Reviewers

2024 Conference Committee and Abstract Reviewers

Comparison of drug-eluting bead with conventional transcatheter arterial chemoembolization for hepatocellular carcinoma with portal vein tumor thrombus: a randomized clinical trial.

Drug-eluting bead transarterial chemoembolization (DEB-TACE) has shown efficacy for treating hepatocellular carcinoma (HCC) with portal vein tumor thrombus (PVTT). However, whether DEB-TACE is superior to conventional TACE (cTACE) remains unclear. This randomized controlled trial aimed to compare the efficacy and safety of DEB-TACE versus cTACE in treating HCC with PVTT. The study was conducted at a tertiary care center in Southeast China. HCC patients with PVTT were randomized at a 1:1 ratio into the DEB-TACE or cTACE groups. The primary endpoint was progression-free survival (PFS), and the secondary endpoints were overall survival (OS) and the incidence of adverse events (AEs). An independent review committee assessed the radiologic response according to the modified Response Evaluation Criteria in Solid Tumors (mRECIST). AEs were assessed by the Common Terminology Criteria for Adverse Events (CTCAE) version 4.0. Systemic therapies were not restricted. Between September 2018 and July 2020, 163 patients were randomized to undergo DEB-TACE ( n =82) or cTACE ( n =81). Nine patients were excluded, and 154 patients were included in the final analysis; the median age was 55 years (range, 24-78years), and 140 (90.9%) were male. The median PFS in the DEB-TACE group was 6.0 months (95% CI, 5.0-10.0) versus 4.0 months (95% CI, 3.0-5.0) in the cTACE group (hazard ratio, 0.63; 95% CI, 0.42-0.95; P =0.027). The DEB-TACE group showed a higher response rate [51 (66.2%) vs. 36 (46.8%); P =0.0015] and a longer median OS [12.0 months (95% CI, 9.0-16.0) vs. 8.0 months (95% CI, 7.0-11.0), P =0.039] than the cTACE group. Multivariate analysis showed that the treatment group, ALBI score, distant metastasis and additional TKIs were the four independent prognostic factors correlated with PFS. In addition, the treatment group, PVTT group and combination with surgery were independently associated with OS. AEs were similar in the two groups, and postembolization syndrome was the most frequent AE. DEB-TACE is superior to cTACE in treating HCC patients with PVTT, demonstrating improved PFS and OS with an acceptable safety profile, and may thus emerge as a promising treatment strategy for HCC patients with PVTT. Chinese Clinical Trial Registry ChiCTR1800018035.

Alternative payment models in Dutch hospital care: what works, how, why and under what circumstances? Protocol for a realist evaluation study

IntroductionThe predominant provider payment models in healthcare, particularly fee-for-service, hinder the delivery of high-value care and can encourage healthcare providers to prioritise the volume of care over the value of...

The Relationship between Pediatric Medical Training and Neonatal Care in the Delivery Room and Beyond.

The modern neonate differs greatly from newborns cared for a half-century ago, when the neonatal-perinatal medicine certification examination was first offered by the American Board of Pediatrics. Delivery room resuscitation and neonatal care are constantly evolving, as is the neonatal workforce. Similarly, the Accreditation Council for Graduate Medical Education review committees revise the requirements for graduate medical education programs every 10 years, and the modern pediatric medical trainee is also constantly evolving. Delivery room resuscitation, neonatal care, and pediatric residency training are codependent; changes in one affect the other and subsequently influence neonatal outcomes. In this educational perspective, we explore this relationship and outline strategies to mitigate the impact of decreased residency training in neonatal-perinatal medicine.

Frequency & Predictors of Depression in Patients of Chronic Heart Failure with Reduced Ejection Fraction (HFrEF)

Background: Clinically significant depression is estimated to occur in a significant portion of chronic heart failure (CHF) patients and increases sharply with increase in heart failure severity. However, the frequency and predictors of depression in this group of patients are underreported. This study was designed to assess frequency & predictors of depression in patients of chronic heart failure with reduced ejection fraction (HFrEF). Methods: This cross-sectional analytical study was performed in the department of Cardiology, Dhaka Medical College Hospital, Dhaka, during the period from October’2018 to Septemeber’2019. One hundred and fifty-two CHF patients with reduced ejection fraction (<40%) either admitted in the department of Cardiology or attended Cardiology OPD, Dhaka Medical College Hospital (DMCH), Dhaka who fulfilled the selection criteria were included into the study. A translated and validated Patient Health Questionnaire (PHQ-9) in Bengali was used to assess depression level in CHF patients in this study. Informed written consent was taken from each patient. Approval for the study was taken from Ethical Review Committee (ERC) of Dhaka Medical College before commencement of the study. After compiling data from all participants, statistical analyses were performed using the Statistical Package for Social Science (SPSS), version 22.0 for windows. Results: Mean age of the patients was 58.68±9.40 years, ranging from 36 to 75 years. Male predominance was noted (72% vs 28%). Overall, frequency of depression was 56%. Among the depressed patients (n=85), majority (40%) had minimal depression while 27%, 19% and 14% had mild, moderate and severe depression. respectively. Among the different risk factors, DM and sedentary lifestyle were significantly associated with depression (p<0.05). Age >65 years, sedentary lifestyle, and H/O past MI were independently associated with depression among chronic HErEF patients. Widowed patients, diabetes, hospital readmission in last 2 months before study inclusion and NYHA class III/IV were also significantly associated with depression among patients with chronic HFrEF (p<0.05). Conclusion: More than half of the patients with chronic HFrEF had concurrent depression of varied severity. Proper care of depression along with HF may improve the survival and quality of life of these patients. Bangladesh Heart Journal 2024; 39(2): 74–84

Recommendation for the practice of total intravenous anesthesia.

This Recommendation was developed by the Japanese Society of Intravenous Anesthesia Recommendation Making Working Group (JSIVA-WG) to promote the safe and effective practice of total intravenous anesthesia (TIVA), tailored to the current situation in Japan. It presents a policy validated by the members of JSIVA-WG and a review committee for practical anesthesia management. Anesthesiologists should acquire and maintain the necessary knowledge and skills to be able to administer TIVA properly. A secure venous access is critically important for TIVA. To visualize and understand the pharmacokinetics of intravenous anesthetics, use of real-time pharmacokinetic simulations is strongly recommended. Syringe pumps are essential for the infusion of intravenous anesthetics, which should be prepared according to the rules of each individual anesthesia department, particularly with regard to dilution. Syringes should be clearly labeled with content and drug concentration. Whenmanaging TIVA, particularly with the use of muscle relaxants, monitoring processed electroencephalogram (EEG) is advisable. However, the depth of sedation/anesthesia must be assessed comprehensively using various parameters, rather than simply relying on a single EEG index. TIVA should be swiftly changed to an alternative method that includes inhalation anesthesia if necessary. Use of antagonists at emergence may be associated with re-sedation risk. Casual administration of antagonists and sending patients back to surgical wards without careful observation are not acceptable.

Development of the Brazilian version of the Performance of Upper Limb scale for children and adolescents with Duchenne muscular dystrophy

BackgroundDuchenne muscular dystrophy (DMD) is one of the most common and disabling childhood genetic diseases. The course of DMD involves progressive muscular degeneration and weakness, leading to functional decline. The Performance of the Upper Limb scale (PUL) is a specific instrument designed to assess the upper limb function of patients with DMD. ObjectiveTo adapt the PUL cross-culturally to Brazilian Portuguese (PUL-Br) and assess the convergent validity, structural validity, inter-rater reliability, and internal consistency for Brazilian patients with DMD MethodsThe cross-cultural adaptation involved six steps: translation to Brazilian Portuguese, Brazilian Portuguese translation synthesis, back-translation to English, back-translation synthesis, an expert committee review, and a pre-final version test (n = 12). The convergent validity of the PUL-Br was evaluated by examining its correlation to the Motor Function Measure scale (MFM) using 30 patients with DMD. Confirmatory factor analysis was conducted to assess structural validity. Intraclass correlation coefficient (ICC) verified the PUL-Br interrater reliability. Cronbach's alpha was calculated to verify internal consistency. ResultsThe PUL was cross-culturally adapted to Brazilian Portuguese. A strong and positive correlation was found between the PUL-Br total score and the total score on the MFM (r = 0.83; 95% CI: 0.67, 0.91). The PUL-Br showed a satisfactory fit of the data to the three-factor model, excellent inter-rater reliability (ICC: 0.94), and good internal consistency (Cronbach's: 0.91). ConclusionThe PUL-Br is valid and reliable for assessing the upper limb function of Brazilian patients with DMD.

Systematic scoping review of cluster randomised trials conducted exclusively in low-income and middle-income countries between 2017 and 2022

ObjectiveCluster randomised trials (CRTs) are used for evaluating health-related interventions in low-income and middle-income countries (LMICs) but raise complex ethical issues. To inform the development of future ethics guidance, we...

Cesarean Section under General Anesthesia over 10 Years at Tertiary Care Center: A Descriptive Cross-sectional Study

Introduction: The global surge in cesarean deliveries necessitates safe anesthetic practices to optimize outcomes. While the neuraxial block is the preferred method, specific conditions warrant general anesthesia. This study is aimed to determine the prevalence of cesarean sections under general anesthesia at a tertiary care center. Methods: A descriptive cross-sectional study was conducted on cesarean sections performed between April 14, 2013, and April 13, 2023, at a tertiary care center. Ethical approval was obtained from the Institutional Review Committee (Reference number: 20092023/01). Total sampling was done. Data for the past ten years were manually collected from hospital records using a self-structured proforma and analyzed using Microsoft Excel 2018 and IBM SPSS version 26. The point estimate and 95% confidence interval were calculated for the study. Results: In this study, there were 216 (2.98%) (95% CI: 2.59-3.38%) cesarean sections under general anesthesia in 10 years. Notably, among them, there were 103 (47.69%) primigravida, nullipara 130 (60.19%), 135 (62.50%) with no living children, and 161 (74.54%) without any past abortions. In most cases, 182 (84.26%) were emergency procedures and 34 (15.74%) were elective. Fetal bradycardia with distress was the primary indication observed in 121 (56.02%) cases, followed by 32 (14.81%) maternal requests. Additionally, twenty-one cases were found initially planned as cesarean sections under subarachnoid block but were converted to general anesthesia. The prevalence in this study was found within the recommended limits.Conclusions: The findings highlight that the majority of these procedures were emergency cases, predominantly due to fetal distress, with a notable proportion involving primigravida and nulliparous women.

Characterization of Etiology and Pattern of Dental Extraction among Patients Presenting to Dental Department of a Tertiary Care Centre: A Descriptive Cross-sectional Study

Introduction: Dental extraction is a common curative treatment against pain provided to the patients. A limited number of scientific literature are available that characterizes the reasons for teeth extractions in Nepalese population. The aim of this study is to find out the causes for dental extraction in patients and explore the relationships between demographic variables and loss of teeth in the Nepalese population.Methods: This is a descriptive cross-sectional study performed to assess the predictors and reasons for permanent tooth extraction among the Nepalese patients who visited dental department in a tertiary health care center from 18th June 2022 to 17th June 2023. Ethical approval was obtained from the Institutional Review Committee (Approval No: 52/22). Demographic details were recorded, diagnosis established and the teeth in question were extracted. Descriptive statistical analysis was performed.Results: A total of 465 (42.66%) permanent teeth were extracted from the 1090 patients, out of which 198 (18.16%) were male and 267 (24.49%) were female patients between the age of 10 years to 70 years. Among all the participants, 726 (66.60%) patients were educated while 364 (33.40%) were uneducated, 165 (15.13%) extraction were done due to peridontal disease and 213 (19.54%) of extraction was done due to endodontic disease.Conclusions: Endodontic and periodontal diseases were the most common causes of dental extraction. Permanent molars and incisors were extracted the most.

군인의 죽음과 관련된 몇 가지 법적 과제

The death of a soldier signifies a profound sacrifice and dedication to the national community, and as such, it should be properly honored. It also reflects the values upheld by the nation. This article addresses various legal issues related to the death of soldiers, including distinctions between combat-related deaths, duty-related deaths, and other categories under the Military Personnel Act, as well as decisions regarding national merit and compensation under the National Merit Act and the Veterans' Compensation Act. Recently, the revision of the Military Court Act transferred the authority to investigate military deaths from the military to the National Police Agency, which is a positive development. However, considering that approximately 60-80% of recent military deaths are suicides, these cases often lack criminal allegations and are quickly concluded, potentially leading to inadequate investigations of significant unit-related factors. This highlights a limitation of the current system. The article also discusses issues such as the categorization of duty-related deaths, conflicts or inconsistencies between the National Merit Act and the Veterans' Compensation Act Enforcement Decree, among others. It is essential to establish a state agency independent of the military to investigate not only the deaths of soldiers but also the related unit-level factors. This is crucial to prevent the recurrence of similar incidents. The Military Human Rights Protection Officer, who also serves as a standing commissioner of the National Human Rights Commission, could fulfill this role. Additionally, this agency should have the authority to review decisions regarding death classifications if objections are raised by the bereaved families. Currently, the Central Military Merit Review Committee, which operates under the Ministry of National Defense, is responsible for re-investigating the causes of death. This could be seen as a conflict of interest, as it involves self-judgment. To address this, it may be beneficial for a newly established Military Human Rights Supervisory Body to assume the final responsibility for re-investigations and death classification judgments. In summary, this new body should be responsible for 1) the protection of and policy development regarding military human rights, 2) the investigation of military death cases based on complaints from bereaved families or ex officio, and 3) the re-investigation and review of death classifications upon objections from the bereaved.

CYTOTOXICITY OF ALOE VERA EXTRACT ON CHRONIC MYELOID LEUKEMIA CELLS; IN VITRO STUDY ON CYTOTOXICITY ON HL-60 CELLS

Aloe vera has been traditionally used for its various therapeutic properties, but its potential anticancer effects have not been thoroughly explored. Understanding its efficacy against leukemia could significantly impact care recommendations for leukemia patients. Objective: This in-vitro study aims to establish the anti-cancerous effects of Aloe vera on the Human Leukemia HL-60 cell line. Methods: Following approval from the Ethical Review Committee, this study involved culturing the HL-60 cell line and treating it with increasing concentrations of Aloe vera extract to determine the half-maximal inhibitory concentration (IC50). The MTT assay was employed to assess cell viability, and the absorbance was measured using an ELISA reader. Gene expression levels of pro-apoptotic biomarkers, Caspase-3 and Caspase-9, were also quantified to gauge apoptosis induction. Results: Aloe vera demonstrated a relatively low IC50 value of 13.1 µM in the HL-60 cell line, indicating potent cytotoxicity. Notably, pro-apoptotic biomarkers were highly expressed, with Caspase-3 and Caspase-9 recording gene expression levels of 11.1 and 13.7, respectively. Conclusion: Aloe vera exhibited significant pro-apoptotic effects against the leukemia HL-60 cell line, suggesting its potential as an anti-cancer agent. Further in-vivo and clinical studies are warranted to elucidate the specific pathways through which Aloe vera exerts these effects and to validate its use in clinical settings.

Multidrug Resistance Gram-negative Bacteria in Intensive Care Unit of Tertiary Care Hospital: A Descriptive Cross-sectional Study

Introduction: Antimicrobial resistance is global health problem, amongst major causes for mortality. It is one of the hinderance for achievement of Sustainable Goal 3 (Good health and well-being) of WHO. Multidrug resistant gram negative bacteria are major threat to humanity especially patients admitted in intensive care unit. This is associated with to treatment failure and mortality of the patients in intensive care unit. Therefore, this study was conducted to find out the prevalence of Multidrug resistant gram negative bacteria in intensive care unit of tertiary care center. Methods: A descriptive cross-sectional study was conducted in the Department of Microbiology of a tertiary care hospital from February, 2020 till August, 2021 for 18 months after obtaining ethical approval from the Institutional Review Committee (Reference Number: 246). All the samples from Intensive Care Unit were processed following standard methodology. Only Gram-negative bacteria isolated from samples were included in the study. Convenience sampling method was used. The point estimated was calculated at 95% Confidence Interval. Data was entered in Microsoft Excel 2016 and analysis was done using IBM SPSS Statistics version 16.0.Results: Out of 500 samples only 380 showed growth of gram negative bacteria. The prevalence Multi Drug Resistance was 83.15%. The prevalence of multidrug resistant was notably higher among Acinetobacter spp (100%) followed by Non fermenter (95%) and Escherichia coli (87.1%). Multidrug resistant isolates were least resistant towards carbapenem group of antibiotics.Conclusions: The prevalence of Multidrug resistant gram negative bacteria was found to be lower than in the study conducted in similar setting.

Hypertensive Retinopathy among Hypertensive Patients in a Tertiary Care Centre: A Descriptive Cross-sectional Study

Introduction: Hypertension manifests in the eyes as retinopathy, choroidopathy, and optic neuropathy of which retinopathy can be used as a predictor for systemic morbidities and mortalities. The study aims to determine the prevalence of hypertensive retinopathy among hypertensive patients visiting the outpatient Department of Ophthalmology in a tertiary care center.Methods: A descriptive cross-sectional study was conducted among hypertensive patients from 4th April to 19th November 2023 after obtaining ethical approval from the Institutional Review Committee (Reference number: 2079/80/96). A Convenience sampling method was used. The Point estimate was calculated at a 95% Confidence Interval. Results: Among 161 hypertensive patients, hypertensive retinopathy was present in 70 (43.48%) (35.82-51.14, 95% Confidence Interval). Grade I hypertensive retinopathy accounted for 35 (50%) followed by Grade II HR in 17 (24.29%), Grade III HR in 14 (20%) and Grade IV HR in 4 (5.71%) in the study participants.Conclusions: The prevalence of hypertensive retinopathy was found to be higher than other studies done in similar settings.