Reverse Trajectory Research Articles

Impact of capitation on physicians’ behavior among patients with hypertension: an interrupted time series study in rural China

ObjectiveThe purpose of this study is to explore the change in physicians’ hypertension treatment behavior before and after the reform of the capitation in county medical community.MethodsSpanning from January 2014 to December 2019, monthly data of outpatient and inpatient were gathered before and after the implementation of the reform in April 2015. We employed interrupted time series analysis method to scrutinize the instantaneous level and slope changes in the indicators associated with physicians’ behavior.ResultsSeveral indicators related to physicians’ behavior demonstrated enhancement. After the reform, medical cost per visit for inpatient exhibited a reverse trajectory (-53.545, 95%CI: -78.620 to -28.470, p < 0.01). The rate of change in outpatient drug combination decelerated (0.320, 95%CI: 0.149 to 0.491, p < 0.01). The ratio of infusion declined for both outpatient and inpatient cases (-0.107, 95%CI: -0.209 to -0.004, p < 0.1; -0.843, 95%CI: -1.154 to -0.532, p < 0.01). However, the results revealed that overall medical cost per visit and drug proportion for outpatient care continued their initial upward trend. After the reform, the decline of drug proportion for outpatient care was less pronounced compared to the period prior to the reform, and length of stay also had a similar trend.ConclusionTo some extent, capitation under the county medical community encourages physicians to control the cost and adopt a more standardized diagnosis and treatment behavior. This study provides evidence to consider the impact of policy changes on physicians’ behavior when designing payment methods and healthcare systems aimed at promoting PHC.

Expressway ETC Transaction Data Anomaly Detection Based on TL-XGBoost

China’s widely adopted expressway ETC system provides a feasible foundation for realizing co-operative vehicle–infrastructure integration, and the accuracy of ETC data, which forms the basis of this scheme, will directly affect the safety of driving. Therefore, this study focuses on the abnormal data in an expressway ETC system. This study combines road network topology data and capture data to mine the abnormal patterns of ETC data, and it designs an abnormal identification model for expressway transaction data based on TL-XGBoost. This model categorizes expressway ETC abnormal data into four distinct classes: missing detections, opposite lane detection, duplicated detection and reverse trajectory detection. ETC transaction data from a southeastern Chinese province were used for experimentation. The results validate the model’s effectiveness, achieving an accuracy of 98.14%, a precision of 97.59%, a recall of 95.44%, and an F1-score of 96.49%. Furthermore, this study conducts an analysis and offers insights into the potential causes of anomalies in expressway ETC data.

Variation characteristics, source analysis, and health risk assessment of carbonyl compounds in Zhangjiajie National Forest Park, China

This study presents a comprehensive analysis of carbonyls in the atmosphere of Zhangjiajie Forest from May 2016 to January 2017 following the Environmental Protection Agency (EPA) TO-11 A guidelines, including pollution characteristics, human health risks, and sources. The dominant carbonyl compounds were formaldehyde, acetaldehyde, and acetone, with average concentrations of 5.94, 1.48, and 4.24 μg/m3, respectively. A seasonal variation was observed in the total carbonyl compound concentrations in the order summer > autumn > spring > winter. The diurnal patterns showed that the concentration of the main carbonyl compounds peaked in the afternoon. The ratios of formaldehyde/acetaldehyde (C1/C2) and acetaldehyde/propionaldehyde (C2/C3) ranged from 2.82 to 5.66 and 0.76–3.14; this indicates that compared with anthropogenic sources, volatile organic compounds emitted from natural sources contributed more significantly to atmospheric carbonyl compounds in the Zhangjiajie Forest. Correlation analysis of the three main carbonyl compounds with common air pollutants revealed that formaldehyde and acetaldehyde have similar secondary sources for photochemical reactions. In autumn and winter, acetaldehyde and acetone were affected by fuel combustion and vehicle exhaust emissions. Reverse trajectory, potential source contribution function, and concentration-weighted trajectory analyses revealed that carbonyl compounds in the atmosphere of Zhangjiajie Forest were mainly polluted locally in spring and autumn and influenced by the urban air mass from the northeast in summer and winter. The health risk assessment showed that the lifetime carcinogenic risk of formaldehyde and acetaldehyde exceeded the acceptable level and that long-term exposure to this concentration poses serious carcinogenic risks. The findings of this study shed light on the characteristics of atmospheric carbonyl compound pollution in subtropical forest areas, and provide scientific basis for formulating pollution control measures.

New Training Method for Non-Dominant Hand Pitching Motion Based on Reversal Trajectory of Dominant Hand Pitching Motion Using AR and Vibration

New Training Method for Non-Dominant Hand Pitching Motion Based on Reversal Trajectory of Dominant Hand Pitching Motion Using AR and Vibration

Concepts Relevant for the Kinetic Analysis of Reversible Reaction Systems.

The net rate of a reversible chemical reaction is the difference between unidirectional rates of traversal along forward and reverse reaction paths. In a multistep reaction sequence, the forward and reverse trajectories, in general, are not the microscopic reverse of one another; rather, each unidirectional route is comprised of distinct rate-controlling steps, intermediates, and transition states. Consequently, traditional descriptors of rate (e.g., reaction orders) do not reflect intrinsic kinetic information but instead conflate unidirectional contributions determined by (i) the microscopic occurrence of forward/reverse reactions (i.e., unidirectional kinetics) and (ii) the reversibility of reaction (i.e., nonequilibrium thermodynamics). This review aims to provide a comprehensive resource of analytical and conceptual tools which deconvolute the contributions of reaction kinetics and thermodynamics to disambiguate unidirectional reaction trajectories and precisely identify rate- and reversibility-controlling molecular species and steps in reversible reaction systems. The extrication of mechanistic and kinetic information from bidirectional reactions is accomplished through equation-based formalisms (e.g., De Donder relations) grounded in principles of thermodynamics and interpreted in the context of theories of chemical kinetics developed in the past 25 years. The aggregate of mathematical formalisms detailed herein is general to thermochemical and electrochemical reactions and encapsulates a diverse body of scientific literature encompassing chemical physics, thermodynamics, chemical kinetics, catalysis, and kinetic modeling.

Heredity of clusters in liquid Ta rapid solidification process and its correlation with local symmetry

Metallic glass (MG) has received intensive attention in the fields of amorphous physics and materials science, owing to its excellent mechanical properties, good corrosion resistance, and large elastic deformation limit. Comparing with traditional oxide glass, the limited glass-forming ability (GFA) seriously restricts the application of MG in engineering. Therefore, the GFA has been a hot scientific issue in the field of amorphous material research. Recently, scientists have fully realized that GFA is closely related to the local atomic structure in liquid as well as its evolution features. Since the MG is called the “freezing” liquid, exploring the correlation of local atomic structures between liquid phase and solid phase under rapid solidification conditions is helpful in understanding the microstructural mechanism of GFA. Therefore, the rapid solidification process of liquid Ta is investigated via molecular dynamics simulation. The pair correlation function (PDF), the largest standard cluster (LSC), and the reverse atomic trajectory tracking methods are used to characterize and analyze the microstructure and its evolution during the rapid solicitation of liquid Ta. The results show that the local atomic configurations of the rapidly solidified Ta are various Kasper clusters as well as their distorted configurations, among of which [1/444, 10/555, 2/666] deformed icosahedron (or Z13 cluster) accounts for the highest proportion. The trend of hereditary ability of clusters revealed by the onset temperature of continuous heredity is consistent well with that by the fraction of staged heredity. The geometric symmetry of clusters can be quantitatively characterized by using the local symmetry parameter (LSP). The hereditary ability of clusters is closely related to their LSP. The local five-fold symmetry is beneficial to enhancing hereditary ability, while local four- and six-fold symmetry are disadvantageous for that. The probability of clusters with the same LSC index emerging in the energy range follows the Gaussian distribution, and the expected average atomic potential energy &lt;inline-formula&gt;&lt;tex-math id="M3"&gt;\begin{document}$ {E}_{\rm exp}^{j} $\end{document}&lt;/tex-math&gt;&lt;alternatives&gt;&lt;graphic xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="24-20231153_M3.jpg"/&gt;&lt;graphic xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="24-20231153_M3.png"/&gt;&lt;/alternatives&gt;&lt;/inline-formula&gt; is almost linearly related to the LSP, and &lt;inline-formula&gt;&lt;tex-math id="M4"&gt;\begin{document}$ {E}_{\rm exp}^{j} $\end{document}&lt;/tex-math&gt;&lt;alternatives&gt;&lt;graphic xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="24-20231153_M4.jpg"/&gt;&lt;graphic xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="24-20231153_M4.png"/&gt;&lt;/alternatives&gt;&lt;/inline-formula&gt; decreases with the increase of LSP&lt;sub&gt;5&lt;/sub&gt;. The high local five-fold symmetry reduces the average atomic potential energy of LSC, thereby enhancing its configurational heredity. These findings have guiding significance in improving GFA through regulating the local symmetry of liquid monatomic metals or alloys.

THE TRAJECTORY OF COLONIZATION OF SERVICE PEOPLE IN THE COMFLUENTS OF THE PSLA RIVER AFTER THE CONSTRUCTION OF THE BELGOROD LINE

The article is devoted to the analysis of archival materials and other narrative sources, on the basis of which the places of outflow during the settlement of service military people from the middle of the XVII-th century at Oboyansky and Sudzhansky counties are established. The authors consider the entire process mentioned above for each migration category separately. Researchers determine the percentage of the forced settlementers who didn't come and the importance of their institute of guarantee, among the unauthorized migrants – their social composition and the presence of fellow countrymen among them, and among the local population – the role of their influence on the entire settlement process. As a result, the authors found that both of these counties were populated mainly by the surrounding trajectory and had many boyar children who wanted to have estates in the rear. Even in these counties, the northern trajectory of settlement ceases to dominate, from which, in both of them, its western direction prevailed over the eastern one. By the way, the latest presence was a characteristic feature of the Oboyan county, due to the forced settlement of the Karpov city. The peculiarity of the Sudzhansky county was in the initial presence of the local population, as well as in close proximity to the ukrainians from the Sumy Sloboda Regiment. The authors note that, basically, common features in the settlement of Sudzhansky and Oboyansky counties determined their proximity, as well as their location on the same river system. Moreover, the settlement of one county smoothly flowed into another. After all, the active colonization of the tributaries of the Psel river by service military people took place alternately from east to west during the strengthening of the rear of the Belgorod line. By the way, it was moving towards the Ukrainian colonization, which proceeded along the reverse trajectory from west to east. They met on the territory of the Sudzhansky county. In addition to this conclusion, the authors established that geography of settlement in the study area was an avalanche-like, due to the fact that over time, the exit points of the northern trajectory shifted south.

Геохимическая активность снега и послойная изменчивость изотопного состава кислорода (δ18О) в снежной толще в условиях разной запыленности приземной атмосферы

The layered distribution of the isotopic composition (18O) in the snow mass under conditions of different dust pollution of the near-surface atmosphere was studied on the territory of two scientific test sites of the IAO SB RAS: the Fonovaya observatory and the suburban BEK test site (Tomsk). Interlayer differences in isotopic characteristics and the activity of snow chemical reactions were evaluated in conjunction with the analysis of the dispersed composition of the precipitated aerosol substance, the radiation transparency of snow in the UV range, and taking into account reverse trajectories of air mass transfer. Interlayer fluctuations in 18O values were established, the variability of which increased in layers confined to the thermal diffusion geochemical barrier. We suggested that due to the geochemical activity of snow and its ultraviolet transparency, as well as the presence of iron-containing dust-aerosol particles in the snow mass, conditions arose that initiated photoactivated snow-chemical reactions. Their occurrence may be accompanied by free radical oxidation of the precipitated aerosol matter and the formation of stable photoreaction products, which may be evidenced by the established post-sedimentary interlayer differences in the isotope stratification of the snow mass.

The impact of improved spatial and temporal resolution of reanalysis data on Lagrangian studies of the tropical tropopause layer

Abstract. Lagrangian trajectories are frequently used to trace air parcels from the troposphere to the stratosphere through the tropical tropopause layer (TTL), and the coldest temperatures of these trajectories have been used to reconstruct water vapor variability in the lower stratosphere, where water vapor's radiative impact on Earth's surface is strongest. As such, the ability of these trajectories to accurately capture temperatures encountered by parcels in the TTL is crucial to water vapor reconstructions and calculations of water vapor's radiative forcing. A potential source of error for trajectory calculations is the resolution of the input data. Here, we explore how improving the spatial and temporal resolution of model input data impacts the temperatures measured by Lagrangian trajectories that cross the TTL during boreal winter using ERA5 reanalysis data. We do so by comparing the temperature distribution of trajectories computed with data downsampled in either space or time to those computed with ERA5's maximum resolution. We find that improvements in temporal resolution from 6 to 3 and 1 h lower the cold point temperature distribution, with the mean cold point temperature decreasing from 185.9 to 185.0 and 184.5 K for reverse trajectories initialized at the end of February for each year from 2010 to 2019, while improvements to vertical resolution from that of MERRA2 data (the GEOS5 model grid) to full ERA5 resolution also lower the distribution but are of secondary importance, and improvements in horizontal resolution from 1∘ × 1∘ to 0.5∘ × 0.5∘ or 0.25∘ × 0.25∘ have negligible impacts to trajectory cold points. We suggest that this is caused by excess vertical dispersion near the tropopause when temporal resolution is degraded, which allows trajectories to cross the TTL without passing through the coldest regions, and by undersampling of the four-dimensional temperature field when either temporal or vertical resolution is reduced.

One Voice Many Languages, Colonial Radio in India

Languages knit people together, but at All India Radio we witness the reverse trajectory. Radio's first 20 years, 1927–47, coinciding with the last 20 of British rule, saw the subcontinent's kaleidoscopic linguistic profile creating havoc. Three emotive stumbling blocks emerged, affecting radio: did a nation need a single language or was a multilingual state sustainable; could an alien language gain acceptance; and could there be consensus on a language imposed for institutional convenience. With heavy dependence on English, the dominant language of broadcast, station directors, had the authority to allocate rest of the time to prevailing languages, juggling diverse vernaculars. Complications surfaced at most stations, but most prominent at northern stations where language from being socio-cultural indicators became religious pointers, Hindi associated with Hindus and Urdu with Muslims. All India Radio adopted Hindustani, the confluence of both for practical reasons; instead of two languages, it was easier to cater in just one. This espousal led to heated disputes, with Hindi supporters alleging that radio's Hindustani leaned heavily towards Arabic, and the Urdu clique seeing a definite predisposition towards Sanskrit. The epicentre of controversy were the news programmes. The radio policy of British India was generally to be cautious and to avoid needless controversy.

Positioning Algorithm of MEMS Pipeline Inertial Locator Based on Dead Reckoning and Information Multiplexing

High-precision mapping and positioning of urban underground pipelines are the basic requirements of urban digital construction. Aiming at the above problems, a dead reckoning algorithm based on the starting point and ending point correction and forward and reverse solution information reuse is proposed. This paper firstly establishes a dead reckoning system model consisting of a microelectromechanical system (MEMS) inertial measurement unit (IMU) and an odometer and analyzes the propagation mechanism of dead reckoning errors. The algorithm constructs the trajectory correction matrix by using the position information of the starting point and the ending point of the short-distance underground pipeline and then uses the trajectory correction matrix to correct the trajectory position information obtained by forward and reverse dead reckoning. Finally, the corrected forward and reverse trajectory position information is fused and averaged to achieve high-precision mapping and positioning of underground pipelines. The simulation results of the 100 m pipeline show that the maximum positioning error of the proposed algorithm for straight pipelines is within 5 cm, and the maximum positioning error for 90° curved pipelines is within 20 cm. The algorithm effectively solves the problem of a rapid accumulation of errors over time in the process of dead reckoning, which greatly improves the positioning accuracy.

Migratory behaviour of Brown planthopper, Nilaparvata lugens (Stål) (Hemiptera: Delphacidae), in India as inferred from genetic diversity and reverse trajectory analysis.

The online version contains supplementary material available at 10.1007/s13205-022-03337-6.

Asymmetrical forward and reverse developmental trajectories determine molecular programs of B cell antigen receptor editing.

During B lymphopoiesis, B cell progenitors progress through alternating and mutually exclusive stages of clonal expansion and immunoglobulin (Ig) gene rearrangements. Great diversity is generated through the stochastic recombination of Ig gene segments encoding heavy and light chain variable domains. However, this commonly generates autoreactivity. Receptor editing is the predominant tolerance mechanism for self-reactive B cells in the bone marrow (BM). B cell receptor editing rescues autoreactive B cells from negative selection through renewed light chain recombination first at Igκ then Igλ loci. Receptor editing depends on BM microenvironment cues and key transcription factors such as NF-κB, FOXO, and E2A. The specific BM factor required for receptor editing is unknown. Furthermore, how transcription factors coordinate these developmental programs to promote usage of the λ chain remains poorly defined. Therefore, we used two mouse models that recapitulate pathways by which Igλ light chain-positive B cells develop. The first has deleted J kappa (Jκ) genes and hence models Igλ expression resulting from failed Igκ recombination (Igκdel). The second models autoreactivity by ubiquitous expression of a single-chain chimeric anti-Igκ antibody (κ-mac). Here, we demonstrated that autoreactive B cells transit asymmetric forward and reverse developmental trajectories. This imparted a unique epigenetic landscape on small pre-B cells, which opened chromatin to transcription factors essential for Igλ recombination. The consequences of this asymmetric developmental path were both amplified and complemented by CXCR4 signaling. These findings reveal how intrinsic molecular programs integrate with extrinsic signals to drive receptor editing.

Extended Intraoperative Longitudinal 3-Dimensional Cone Beam Computed Tomography Imaging With a Continuous Multi-Turn Reverse Helical Scan.

Cone beam computed tomography (CBCT) imaging is becoming an indispensable intraoperative tool; however, the current field of view prevents visualization of long anatomical sites, limiting clinical utility. Here, we demonstrate the longitudinal extension of the intraoperative CBCT field of view using a multi-turn reverse helical scan and assess potential clinical utility in interventional procedures. A fixed-room robotic CBCT imaging system, with additional real-time control, was used to implement a multi-turn reverse helical scan. The scan consists of C-arm rotation, through a series of clockwise and anticlockwise rotations, combined with simultaneous programmed table translation. The motion properties and geometric accuracy of the multi-turn reverse helical imaging trajectory were examined using a simple geometric phantom. To assess potential clinical utility, a pedicle screw posterior fixation procedure in the thoracic spine from T1 to T12 was performed on an ovine cadaver. The multi-turn reverse helical scan was used to provide postoperative assessment of the screw insertion via cortical breach grading and mean screw angle error measurements (axial and sagittal) from 2 observers. For all screw angle measurements, the intraclass correlation coefficient was calculated to determine observer reliability. The multi-turn reverse helical scans took 100 seconds to complete and increased the longitudinal coverage by 370% from 17 cm to 80 cm. Geometric accuracy was examined by comparing the measured to actual dimensions (0.2 ± 0.1 mm) and angles (0.2 ± 0.1 degrees) of a simple geometric phantom, indicating that the multi-turn reverse helical scan provided submillimeter and degree accuracy with no distortion. During the pedicle screw procedure in an ovine cadaver, the multi-turn reverse helical scan identified 4 cortical breaches, confirmed via the postoperative CT scan. Directly comparing the screw insertion angles (n = 22) measured in the postoperative multi-turn reverse helical and CT scans revealed an average difference of 3.3 ± 2.6 degrees in axial angle and 1.9 ± 1.5 degrees in the sagittal angle from 2 expert observers. The intraclass correlation coefficient was above 0.900 for all measurements (axial and sagittal) across all scan types (conventional CT, multi-turn reverse helical, and conventional CBCT), indicating excellent reliability between observers. Extended longitudinal field-of-view intraoperative 3-dimensional imaging with a multi-turn reverse helical scan is feasible on a clinical robotic CBCT imaging system, enabling long anatomical sites to be visualized in a single image, including in the presence of metal hardware.

Reverse trajectory analysis of the hydrogen negative ion beam in a prototype accelerator for ITER

Reverse calculation of negative ion trajectory based on the measured beam emittance has been performed for the first time in multi-stage accelerator in order to reconstruct negative ion profile near meniscus, which has been a long-term issue for negative ion sources. According to reverse calculation, negative ions are mainly extracted from the periphery of extraction area, and the particles extracted from the aperture edge is lost on acceleration grids. By taking into account the lost component with reconstructed negative ion profile, the negative ion trajectory became consistent with observed beam traces on the acceleration grids. This result can be applied directly to the design of ITER accelerator as well as the other Cs-seeded negative ion sources.

Bidirectional Data-Driven Trajectory Prediction for Intelligent Maritime Traffic

Intelligent maritime transportation is one of the most promising enabling technologies for promoting trade efficiency and releasing the physical labor force. The trajectory prediction method is the foundation to guarantee collision avoidance and route optimization for ship transportation. This article proposes a bidirectional data-driven trajectory prediction method based on Automatic Identification System (AIS) spatio-temporal data to improve the accuracy of ship trajectory prediction and reduce the risk of accidents. Our study constructs an encoder-decoder network driven by a forward and reverse comprehensive historical trajectory and then fuses the characteristics of the sub-network to predict the ship trajectory. The AIS historical trajectory data of US West Coast ships are employed to investigate the feasibility of the proposed method. Compared with the current methods, the proposed approach lessens the prediction error by studying the comprehensive historical trajectory, and 60.28% has reduced the average prediction error. The ocean and port trajectory data are analyzed in maritime transportation before and after COVID-19. The prediction error in the port area is reduced by 95.17% than the data before the epidemic. Our work helps the prediction of maritime ship trajectory, provides valuable services for maritime safety, and performs detailed insights for the analysis of trade conditions in different sea areas before and after the epidemic.

Single controller design based on integrated trajectory for three-link vertical underactuated manipulators with first active joint

For a three-link vertical underactuated manipulator with first active joint, few methods can swing its endpoint up from the vertical downward equilibrium point and stabilise it at the vertical upward equilibrium point. This paper proposes a single controller design method based on integrated trajectory to realise the above control objective effectively. To obtain the trajectories of each link from the starting states to ending states, we first plan a forward and a reverse trajectory with adjustable parameters for the active link, where the forward trajectory is from the starting states to intermediate states and the reverse one is from the ending states to intermediate states. Based on the system coupling characteristic, the adjustable parameters are optimised by the intelligent optimisation algorithm, so getting the trajectories of the passive links from the starting states to ending states. To ensure that the system with the gravity can remain at the ending states, we plan the constant trajectory for each link. Then, we integrate the optimised forward trajectory, the optimised reverse trajectory and the constant trajectory of each link into the continuous trajectory. Next, according to the integrated trajectory, we construct a linear time-varying error system, and design the single controller to make the system follow the integrated trajectory. Thus, the swing-up and stable control of the system is realised. Finally, simulation results demonstrate the validity of the control method.

Quality of Life in Young Adults With Cerebral Palsy: A Longitudinal Analysis of the SPARCLE Study.

Introduction: While most people with cerebral palsy (CP) will have a life expectancy similar to that of the general population, international research has primarily focused on childhood and adolescence; and knowledge about the quality of life (QoL) of young adults with CP, its trajectories, and associated factors remains scarce.Methods: This longitudinal study included young adults with CP living in five European regions and who had previously participated in the SPARCLE cohort as children and/or adolescents. Their QoL in the psychological well-being and social relationships domains was estimated using age-appropriate validated instruments (KIDSCREEN-52 in childhood/adolescence and WHOQOL-Bref in young adulthood). We used generalized linear mixed-effect models with random intercept to estimate long-term trajectories of QoL in both domains and to investigate whether severity of impairment, pain, and seizure influenced these trajectories. We sought to identify potentially different trajectories of QoL from childhood to adulthood using a shape-based clustering method.Results: In total, 164 young adults with CP aged 22–27 years participated in the study. Psychological well-being linearly decreased by 0.78 points (scale 0–100) per year (95% confidence interval (CI) −0.99 to −0.56) from childhood to young adulthood, whereas QoL in the social relationships domain increased (β coefficient 1.24, 95% CI 0.92–1.55). Severity of impairment was associated with reduced QoL in all life periods of the study (childhood, adolescence, and young adulthood): motor impairment with social relationships, and more nuancedly intellectual disability with psychological well-being and social relationships. At all periods, frequent pain significantly reduced psychological well-being, and seizures were associated with lower QoL in the social relationships domain. In both domains, we identified a group of individuals with CP who presented a reverse trajectory compared with the general QoL trajectory.Conclusion: Identification of QoL trajectories and their associated factors yields improved knowledge about the experience of individuals with CP until young adulthood. Further studies are needed to better understand the determinants that have the greatest influence on the different shapes of long-term trajectories of QoL.

Position control with zero residual vibration for two degrees-of-freedom flexible systems based on motion trajectory optimization

Zero residual vibration (RV) in the position control of a flexible system is difficult to achieve because this system has low stiffness and underactuated feature. In this paper, we present a position control strategy to achieve zero RV in the position control of two degrees-of-freedom (DOF) flexible systems. First, a general dynamic model for two-DOF flexible systems is established. Next, we transform the position control with zero RV to motion planning and tracking control. Based on the position control objective with zero RV, three constraints for the desired system trajectory are given. To make the desired system trajectory satisfy these three constraints, we propose a motion trajectory optimization method. Specifically, we plan a forward system trajectory and a reverse system trajectory based on bidirectional trajectory planning method. Then, the rewinding strategy and the trajectory optimization based on genetic algorithm are used to connect these two system trajectories and to obtain a complete desired system trajectory. Finally, a sliding mode tracking controller is designed to make the system track this desired system trajectory. In this way, the system can reach its target-rest-position with zero RV. The effectiveness and superiority of the proposed control strategy are demonstrated in simulations.

Common Muscle Metabolic Signatures Highlight Arginine and Lysine Metabolism as Potential Therapeutic Targets to Combat Unhealthy Aging.

Biological aging research is expected to reveal modifiable molecular mechanisms that can be harnessed to slow or possibly reverse unhealthy trajectories. However, there is first an urgent need to define consensus molecular markers of healthy and unhealthy aging. Established aging hallmarks are all linked to metabolism, and a ‘rewired’ metabolic circuitry has been shown to accelerate or delay biological aging. To identify metabolic signatures distinguishing healthy from unhealthy aging trajectories, we performed nontargeted metabolomics on skeletal muscles from 2-month-old and 21-month-old mice, and after dietary and lifestyle interventions known to impact biological aging. We hypothesized that common metabolic signatures would highlight specific pathways and processes promoting healthy aging, while revealing the molecular underpinnings of unhealthy aging. Here, we report 50 metabolites that commonly distinguished aging trajectories in all cohorts, including 18 commonly reduced under unhealthy aging and 32 increased. We stratified these metabolites according to known relationships with various aging hallmarks and found the greatest associations with oxidative stress and nutrient sensing. Collectively, our data suggest interventions aimed at maintaining skeletal muscle arginine and lysine may be useful therapeutic strategies to minimize biological aging and maintain skeletal muscle health, function, and regenerative capacity in old age.