The aim of this study is to create and validate a fast, easy-to-use, affordable, sensitive, and accurate method for measuring Siponimod and Ponesimod in bulk and pharmaceutical products using Reversed-Phase Ultra-Performance Liquid Chromatography (RP-UPLC). A Luna C18 column was used with a running phase composed of 0.1% trifluoroacetic acid: acetonitrile (30:70 v/v) at a flow rate of 1.0 ml/min. UV detection was used at a wavelength of 230 nm. Ponesimod and Siponimod correlation coefficients were found to be 0.999 over a concentration range of 5-75 µg/ml and 0.5-7.5 µg/ml, respectively. Ponesimod and Siponimod have respective retention times of 1.751 and 3.203 minutes. The run time for separating Ponesimod and Siponimod peaks was 5 minutes. The validation results agreed with what's acceptable and had good limits. This method, proposed as a regular analysis and quality control tool for medications that contain these active drugs either individually or in combination, was evident to be a suitable one.