Objective: This study aims to identify the main barriers to implementing reverse logistics for construction and demolition waste (RCD), focusing on challenges faced by both small and large waste generators. Theoretical Framework: The research is grounded in reverse logistics theories, addressing sustainability and waste management frameworks. These concepts provide a basis for understanding the diverse challenges different generator profiles encounter. Method: A systematic literature review was conducted over nine months (October 2023 to July 2024) following the PRISMA method. Seven databases were consulted—Web of Science, Scopus, MDPI, Emerald, ScienceDirect, Taylor and Francis, and Wiley—resulting in 119 relevant articles. The study identifies and categorizes barriers for small and large generators. Results and Discussion: The results revealed 20 barriers for large generators and 7 for small generators, with 4 common barriers between both groups. These barriers highlight the complexity of RCD management and suggest specific policy and strategy needs. In the discussion, these barriers are analyzed in the context of the theoretical framework, revealing practical implications for improving reverse logistics systems. Research Implications: The findings provide valuable insights for both academic research and practical applications in waste management, contributing to the development of more effective strategies for RCD handling and disposal. This research has the potential to influence public policy and industry practices in waste logistics. Originality/Value: This study fills a gap in the literature by providing a comprehensive overview of barriers specific to different waste generator profiles. It advances theoretical knowledge and offers practical recommendations for improving RCD reverse logistics.