Retrieval Time Research Articles

Guideline No. 315: Prevention of Ovarian Hyperstimulation Syndrome

Summary Statements1.The particular follicle-stimulating hormone formulation used for ovarian stimulation does not affect the incidence of ovarian hyperstimulation syndrome. (I)2.Coasting may reduce the incidence of severe ovarian hyperstimulation syndrome. (III)3.Coasting for longer than 3 days reduces in vitro fertilization pregnancy rates. (II-2)4.The use of either luteinizing hormone or human chorionic gonadotropin for final oocyte maturation does not influence the incidence of ovarian hyperstimulation syndrome. (I)5.There is no clear published evidence that lowering the human chorionic gonadotropin dose will result in a decrease in the rate of ovarian hyperstimulation syndrome. (III)6.Cabergoline starting from the day of human chorionic gonadotropin reduces the incidence of ovarian hyperstimulation syndrome in patients at higher risk and does not appear to lower in vitro fertilization pregnancy rates. (II-2)7.Avoiding pregnancy by freezing all embryos will prevent severe prolonged ovarian hyperstimulation syndrome in patients at high risk. (II-2)8.Pregnancy rates are not affected when using gonadotropin-releasing hormone (GnRH) agonists in GnRH antagonist protocols for final egg maturation when embryos are frozen by vitrification for later transfer. (II-2) Recommendations1.The addition of metformin should be considered in patients with polycystic ovarian syndrome who are undergoing in vitro fertilization because it may reduce the incidence of ovarian hyperstimulation syndrome. (I-A)2.Gonadotropin dosing should be carefully individualized, taking into account the patient’s age, body mass, antral follicle count, and previous response to gonadotropins. (II-3B)3.Cycle cancellation before administration of human chorionic gonadatropin is an effective strategy for the prevention of ovarian hyperstimulation syndrome, but the emotional and financial burden it imposes on patients should be considered before the cycle is cancelled. (III-C)4.Gonadotropin-releasing hormone (GnRH) antagonist stimulation protocols are recommended in patients at high risk for ovarian hyperstimulation syndrome (OHSS). The risk of severe OHSS in patients on GnRH antagonist protocols who have a very robust ovarian stimulation response can be reduced by using a GnRH agonist as a substitute for human chorionic gonadotropin to trigger final oocyte maturation. (I-B)5.A gonadotropin-releasing hormone (GnRH) antagonist protocol with a GnRH agonist trigger for final oocyte maturation is recommended for donor oocyte and fertility preservation cycles. (III-C)6.Albumin or other plasma expanders at the time of egg retrieval are not recommended for the prevention of ovarian hyperstimulation syndrome. (I-E)7.Elective single embryo transfer is recommended in patients at high risk for ovarian hyperstimulation syndrome. (III-C)8.Progesterone, rather than human chorionic gonadotropin, should be used for luteal phase support. (I-A)9.Outpatient culdocentesis should be considered for the prevention of disease progression in severe ovarian hyperstimulation syndrome. (II-2B)

Improving Usability of the Pediatric Code Cart by Combining Lean and Human Factors Principles.

This quality improvement project used a phased approach to redesign the code cart. A multidisciplinary team used Lean and Human Factors principles to improve the efficiency and intuitiveness of the redesigned cart. Nurses and respiratory therapists participated in simulations asking for certain supplies with the original and redesigned code cart and filled out surveys for feedback on each code cart. Facilitators measured retrieval times during each simulation. We performed 10 simulations with the original code cart and 13 with the redesigned code cart. Staff could find intraosseous access equipment more quickly (23.9 versus 46.4 seconds; P = 0.003). In addition, staff reported they were less likely to open the wrong drawer or grab the wrong equipment and that the redesigned code cart was overall more well organized than the original code cart. Finally, the redesigned code cart reduced the cost by over 800 dollars per full cart restock. Revising the code cart using Lean and Human Factors improves efficiency and usability and can contribute to cost savings.

An algorithm for retrieving aerosol optical depth from Landsat 8 Operational Land Imager in Vietnam

High-resolution aerosol products offer advantages over lower spatial-resolution products for monitoring pollution in urban areas and industrial zones. Therefore, in this study we develop a Landsat 8 algorithm to retrieve aerosol optical depth (AOD) based on the MODIS Dark Target (DT) algorithm. This algorithm uses the direct surface reflectance of Landsat 8 to build a surface reflectance relationship between the visible (BLUE, RED) and short-wave infrared bands (SWIR2). AOD data from AERONET stations in the study area and AOD data from MODIS 3 km were used for validation of the estimated Landsat 8 AOD. The estimated AOD was highly correlated at most AERONET AOD, with =0.98, (RMSE = 0.3), except Bac Lieu, but only had a moderate correlation with MODIS AOD which was attributed to the difference in data retrieval time and associated changes in climate conditions. This is the first high-resolution AOD retrieval in Vietnam, leading to more practical applications for air quality monitoring.

O-120 Predicting Embryo Ploidy Status Using Time-lapse Images

Abstract Study question Can deep learning models using time-lapse images of embryo development be used to predict embryo ploidy and provide supplemental information to embryologists for clinical decision-making? Summary answer We developed a general MDBS-Ploidy model that uses time-lapse images and maternal age to predict embryo quality scores and ploidy status. What is known already Ploidy status, or the presence or lack of chromosomal abnormalities, is an important factor in a successful pregnancy. Embryos with abnormalities are classified as aneuploid, whereas those without are euploid. With the advent of artificial intelligence in computer vision and the collection of large IVF-related datasets combining images, videos, and clinical outcomes, a variety of methods have been developed to automatically assess embryo quality and other characteristics using images from time-lapse sequences. To our knowledge, a video classification model validated by heterogeneous data to predict both embryo quality score and ploidy is lacking. Study design, size, duration The training dataset for the model consisted of 1,998 time-lapse sequences captured by the Embryoscope®. Time-lapse image sequences consisted of around 360–420 frames captured during 5 days of development. PGT-A results were used as ground truth labels for all ploidy prediction tasks, with embryos classified as euploid or aneuploid. The dataset also included clinical information such as blastocyst score (BS) and maternal age at the time of oocyte retrieval. Participants/materials, setting, methods The MDBS-Ploidy consists of two steps. The first step is quality score prediction from day-5 time-lapse video input using a Bidirectional Long Short-Term Memory architecture with added output layers for multitasking. In the second step, the predicted score, in addition to maternal age, is used to predict the ploidy status of the embryo using a logistic regression model. We evaluated the performance of the MDBS-Ploidy using area under the receiver-operating-characteristic (AUROC) on a validation dataset. Main results and the role of chance For the MDBS-Ploidy quality score prediction module, the Pearson correlation between scores predicted by the MDBS-Ploidy and ground truth quality scores is 0.70 on the validation dataset, suggesting moderate correlation strength. As for the aneuploidy prediction module, the MDBS-Ploidy can discriminate between euploidy and aneuploidy with an AUROC of 0.76 ± 0.002. The MDBS-Ploidy performs comparably with a model trained on the embryologist-annotated blastocyst score. We replicate these comparative results in external validation datasets as well, namely the Embryoscope+® dataset with 1,000 embryos and the IVI Valencia Spain dataset with 543 embryos. Moreover, the MDBS-Ploidy is completely automated, requiring only time-lapse images from 96 to 112 hpi and maternal age to predict embryo ploidy status. This allows the MDBS-Ploidy to be adapted clinically without interrupting ongoing workflows. The MDBS-Ploidy also provides a certain level of explainability; embryologists can use the intermediate quality score (from the first module) to determine why an embryo is classified as a certain ploidy status. With a recall of 0.84 ± 0.004 for the validation dataset, the MDBS-Ploidy shows promise for successfully selecting euploid embryos. We believe that the MDBS-Ploidy can provide supplemental information for selecting the most viable embryo. Limitations, reasons for caution Our model primarily uses data from time-lapse microscopy. Clinics without access to this technology will be unable to use our model. Wider implications of the findings This model is clinically relevant for making decisions as to whether an embryo may be chromosomally normal. Automated quality score prediction is instrumental to embryologists who are currently annotating embryos manually. Future iterations of the model can theoretically be adopted into clinical practice because it is end-to-end and fully automated. Trial registration number not applicable

P-120 Seasonal effects at the time of oocyte collection on the success of frozen embryo transfers

Abstract Study question Does season and duration of daylight hours at the time of oocyte collection impact on live birth rates following frozen embryo transfer? Summary answer Frozen embryo transfer following oocyte collection in summer had 30% increased odds of live birth compared to oocytes collected in autumn. What is known already Season and conditions at the time of fresh or frozen embryo transfer do not appear to impact live birth rates. Recent data from the northwest USA suggest increased live birth rates following frozen embryo transfer from oocytes collected in summer, independent of the season at the time of transfer. Study design, size, duration Retrospective cohort study of all frozen embryo transfers at a single centre in Western Australia from 2013 - 2021 for which oocyte collection also occurred between these dates. This study included 3,659 frozen embryo transfers with embryos generated from 2,155 IVF cycles in 1,835 patients. Data were analysed by season, temperature and recorded sunshine hours at the time of oocyte collection and embryo transfer. Participants/materials, setting, methods All transfers during the study period were included; demographics, IVF cycle characteristics, embryological data and clinical outcomes were collected from the clinic database. Weather data were recorded by the Australian Bureau of Meteorology. Statistical adjustment was performed for factors known to affect live birth rates, and we corrected for multiple cycles in the same patient and conditions at embryo transfer. Main results and the role of chance Compared to frozen embryo transfer (FET) with oocyte retrieval dates in autumn, FET with oocyte retrieval dates in summer had 30% increased odds of live birth (OR: 1.30, 95% CI: 1.04-1.62). Temperature at the time of oocyte retrieval did not affect LBR; there was a 28% increase in odds of live birth when the sunshine hours were in the highest tertile compared to the lowest on the day of oocyte retrieval (OR: 1.28, 95% CI: 1.06-1.53). These findings remained consistent when adjusted for season or sunshine hours on the day of FET respectively. Odds of livebirth were decreased by 18% when the minimum temperature on the day of transfer was high compared with low (OR: 0.82, 95% CI: 0.69−0.99). The duration of bright sunshine on the day of oocyte retrieval appeared to drive the seasonal variations, whereas ambient temperature was not associated with clinical outcomes. Limitations, reasons for caution This was a retrospective study, however study populations across seasons, temperature tertiles and sunshine tertiles were similar. We did not analyse subgroups of low prognosis patients. We also did not analyse environmental pollutants in this study, nor did we assess impacts on sperm quality. These may all affect the results. Wider implications of the findings Optimal conditions for livebirth appear to be associated with summer and increased sunshine hours on the day of oocyte retrieval. Consideration could be given to timing oocyte retrieval to optimise outcomes. The mechanisms remain to be clarified, though may involve melatonin and its impact on oocyte quality. Trial registration number 2022/ET000980

P-419 Oocytes quality in random start protocols for fertility preservation: insights from follicular steroidogenesis.

Abstract Study question Is follicular steroidogenesis impaired in women undergoing random start protocols for fertility preservation? Summary answer The phase of menstrual cycle at initiation of ovarian stimulation does not influence the endocrine microenvironment surrounding oocytes. What is known already Cryopreservation of oocytes is the gold standard for fertility preservation in women with cancer. Random start protocols have been introduced for oocytes cryopreservation in these patients to shorten the duration of ovarian stimulation. However, albeit generally reassuring, available evidence is still insufficient to rule out a sub-optimal cycle outcome of random start protocols. Study design, size, duration The present study was conducted to provide evidence on the validity of random start protocols by exploring the quality of ovarian steroidogenesis. The primary outcome was comparing levels of steroids in the follicular fluid between women initiating the random start protocol in the luteal phase and those initiating in the follicular phase (considered as controls since equivalent to the conventional protocols). We excluded those requiring concomitant letrozole assumption. Participants/materials, setting, methods Seventy-one women with cancer were prospectively recruited during a 24-month period. Thirty-three initiated in luteal phase while 38 in follicular phase. All women were stimulated with recombinant FSH and GnRH antagonists. At the time of oocytes retrieval, follicular fluids were pooled, and a sample was frozen at -80 °C. All samples were assayed concomitantly after thawing, by liquid chromatography tandem mass spectrometry. The concentration of 15 different steroid hormones was determined. Main results and the role of chance Baseline characteristics of the two groups were similar. No differences emerged in anamnestic data and ovarian reserve variables. Cycle outcome did not also differ, the two study groups being similar in terms of total dose of gonadotropins, duration of stimulation, number of developed follicles and number of oocytes retrieved. The median [interquartile range] number of frozen mature oocytes was 9 [5-14] and 10 [5-21] in women who initiated in the luteal and the follicular phase, respectively (p = 0.42). None of the 15 tested steroid hormones differed. Two subgroup secondary analyses were performed to rule out confounders. First, we excluded women who were on estroprogestins at the time of recruitment (leaving 31 women initiating in the follicular phase and 32 in the luteal phase). Levels of steroids in the follicular fluids were still mainly similar. We observed a significant difference only for androstenedione, levels being higher for women initiating stimulation in the follicular phase. Second, we compared women in the early (up to day 5) and late follicular phase (26 and 12 cases, respectively). Levels of steroids in the follicular fluids did not differ except for cortisone, the concentration being higher in the early follicular phase. Limitations, reasons for caution Our study is not randomized, inevitably exposing our results to confounders. Assessment of intraovarian steroidogenesis is an indirect evidence of oocyte quality. Multiple comparisons were done, exposing our findings to type I errors (such as, in our opinion, the differences that emerged in the secondary analyses). Wider implications of the findings Random start protocols have become the standard of care for fertility preservation in women with cancer in the absence of robust evidence. Our data supports the validity of random start protocols in terms of quality of ovarian response since none of the tested hormones differed. Trial registration number Not applicable

P-700 preimplantation genetic testing for aneuploidy failed to improve cumulative live birth rate in patients with limited good-quality embryos

Abstract Study question To evaluate whether preimplantation genetic testing for aneuploidy (PGT-A) can improve pregnancy and neonatal outcomes for patients with limited good-quality embryos. Summary answer PGT-A failed to improve cumulative live birth rate or shorten time to pregnancy, but optimized pregnancy outcomes per transfer for patients with limited good-quality embryos. What is known already PGT-A is currently widely used to screen for aneuploidy with the goal of improving live birth rates. Remarkably, previous studies have focused on the effect of PGT-A on cumulative clinical outcomes in women with good pregnancy prognosis. However, it is still unclear whether PGT-A can improve the cumulative pregnancy outcomes in patients with limited good-quality embryos. Study design, size, duration A retrospective cohort study was performed among 1553 women who intended PGT-A for the first time but obtained only two or less good-quality embryos on day 3 after oocyte retrieval from March 2017 to June 2021. Participants/materials, setting, methods A total of 1553 patients were divided into two groups: 997 in the PGT-A group and 556 in the drop-out group of withdrawing PGT-A due to poor embryological outcome. Multivariable logistic regression was performed to adjust for potential confounders when comparing the clinical outcomes between two groups. Main results and the role of chance After adjusting for potential confounding factors, PGT-A group exhibited significantly lower cumulative rates of biochemical pregnancy (19.96% vs. 30.22%, P-adj < 0.001), clinical pregnancy (17.55% vs. 23.38%, P-adj < 0.001) and live birth (14.14% vs. 16.19%, P-adj = 0.005) per oocyte retrieval and longer median time to pregnancy and live birth compared with drop-out group. However, significant increases in rates of biochemical pregnancy (72.16% vs. 35.50%, P-adj < 0.001), clinical pregnancy (61.86% vs. 26.98%, P-adj < 0.001), and live birth (48.45 vs. 18.26%, P-adj < 0.001) per transfer were found in the PGT-A group. No significant differences were observed in cumulative miscarriage and ectopic pregnancy rates, number of ETs needed per live birth and neonatal outcomes. Limitations, reasons for caution This study was limited by the inherent potential bias of retrospective studies and small sample size. Thus, additional studies with larger sample sizes are needed to confirm our findings. Wider implications of the findings PGT-A failed to improve cumulative live birth rate or shorten time to pregnancy, but optimized pregnancy outcomes per transfer for patients with limited good-quality embryos. Trial registration number Not applicable

A knowledge graph-based deep learning framework for efficient content similarity search of Sustainable Development Goals data

Abstract Sustainable development denotes the enhancement of living standards in the present without compromising future generations’ resources. Sustainable Development Goals (SDGs) quantify the accomplishment of sustainable development and pave the way for a world worth living in for future generations. Scholars can contribute to the achievement of the SDGs by guiding the actions of practitioners based on the analysis of SDG data, as intended by this work. We propose a framework of algorithms based on dimensionality reduction methods with the use of Hilbert Space Filling Curves (HSFCs) in order to semantically cluster new uncategorised SDG data and novel indicators, and efficiently place them in the environment of a distributed knowledge graph store. First, a framework of algorithms for insertion of new indicators and projection on the HSFC curve based on their transformer-based similarity assessment, for retrieval of indicators and load-balancing along with an approach for data classification of entrant-indicators is described. Then, a thorough case study in a distributed knowledge graph environment experimentally evaluates our framework. The results are presented and discussed in light of theory along with the actual impact that can have for practitioners analysing SDG data, including intergovernmental organizations, government agencies and social welfare organizations. Our approach empowers SDG knowledge graphs for causal analysis, inference, and manifold interpretations of the societal implications of SDG-related actions, as data are accessed in reduced retrieval times. It facilitates quicker measurement of influence of users and communities on specific goals and serves for faster distributed knowledge matching, as semantic cohesion of data is preserved.

Efficacy and safety of Danlou tablets in traditional Chinese medicine for coronary heart disease: a systematic review and meta-analysis.

Danlou tablets exert auxiliary advantages in treating coronary heart disease (CHD), but a summary of evidence-based proof is lacking. This study aims to systematically evaluate Danlou tablets in treating CHD from two aspects, including efficacy and safety. By a thorough retrieval of the four English databases, namely, PubMed, The Cochrane Library, Embase, and Web of Science, and the four Chinese databases, namely, CNKI, Wanfang, VIP database, and China Biomedical Literature Service System, we found all randomized controlled trials (RCTs) related to Danlou tablets in treating CHD. The retrieval time was from the construction of the database to April 2022. We engaged two researchers to screen the studies, extract the required data, and assess the risk of bias. We then used RevMan5.3 and STATA.14 software to conduct a meta-analysis. The Grading of Recommendations Assessment, Development, and Evaluation (GRADE) was used to evaluate the quality of outcome indicators. Seventeen RCTs involving 1,588 patients were included. The meta-analysis results are displayed as follows: clinical treatment effect [risk ratio (RR) = 1.22, 95% confidence interval (CI): 1.16, 1.28, P < 0.00001], angina pectoris duration [MD = -0.2.15, 95% CI: -2.91, -1.04, P < 0.00001], angina pectoris frequency [standard mean difference (SMD) = -2.48, 95% CI: -3.42, -1.54, P < 0.00001], angina pectoris degree [SMD = -0.96, 95% CI: -1.39, -0.53, P < 0.0001], TC [MD = -0.71, 95% CI: -0.92, -0.51, P < 0.00001], TG [MD = -0.38, 95% CI: -0.53, -0.22, P < 0.00001], low-density lipoprotein cholesterol [MD = -0.64, 95% CI: -0.76, -0.51, P < 0.00001], high-density lipoprotein cholesterol [MD = 0.16, 95% CI: 0.11, 0.21, P < 0.00001], and adverse events [RR = 0.46, 95% CI: 0.24, 0.88, P = 0.02]. The current evidence suggests that the combination of Danlou tablets and Western medicine can enhance the efficacy of CHD and does not increase adverse events. However, because of the limited number and quality of the included studies, the results of our study should be treated with caution. Further large-scale RCTs are necessary to verify the benefits of this approach.

Shaping the Future of Animation towards Role of 3D Simulation Technology in Animation Film and Television

The application of 3D simulation technology has revolutionized the field of animation film and television art, providing new possibilities and creative opportunities for visual storytelling. This research aims to explore the various aspects of applying 3D simulation technology in animation film and television art. It examines how 3D simulation technology enhances the creation of realistic characters, environments, and special effects, contributing to immersive and captivating storytelling experiences. The research also investigates the technical aspects of integrating 3D cloud simulation technology into the animation production pipeline, including modeling, texturing, rigging, and animation techniques. This paper explores the application of these optimization algorithms in the context of cloud-based 3D environments, focusing on enhancing the efficiency and performance of 3D simulations. Black Widow and Spider Monkey Optimization can be used to optimize the placement and distribution of 3D assets in cloud storage systems, improving data access and retrieval times. The algorithms can also optimize the scheduling of rendering tasks in cloud-based rendering pipelines, leading to more efficient and cost-effective rendering processes. The integration of 3D cloud environments and optimization algorithms enables real-time optimization and adaptation of 3D simulations. This allows for dynamic adjustments of simulation parameters based on changing conditions, resulting in improved accuracy and responsiveness. Moreover, it explores the impact of 3D cloud simulation technology on the artistic process, examining how it influences the artistic vision, aesthetics, and narrative possibilities in animation film and television. The research findings highlight the advantages and challenges of using 3D simulation technology in animation, shedding light on its potential future developments and its role in shaping the future of animation film and television art.

IS METALLOSIS AN ISSUE IN INTERNAL LENGTHENING?

IntroductionThere is no doubt that the future of limb lengthening lies with internal lengthening. Complication rates are reduced and patient satisfaction is increased. The evolution of internal lengthening peaked with the dual direction, easily inserted and externally controlled PRECICE Nail. It has excelled in performance in accuracy and satisfaction. Its versatility increased with smaller sizes and increased excursion. A field safety notice was issued was issued in October 2021 by the parent company NuVasive. The advice was monitoring of current cases and a hold on implantation until after a review of process. At the National Orthopaedic Hospital Cappagh we elected to remove all implanted nails and assess the nail integrity and physiological changes associated with implantation.Materials &amp; MethodsAll patients in who a retained Precice nail at the time of the field safety notice were identified. Patients and families were contacted to explain the issued safety notice from the company and explain that we would be scheduling them for nail removal. This was part of our standard care but we prioritised this group on our waiting list. Consent was obtained for nail removal but also for histological assessment of canal scrapings, blood ion level analysis and independent assessment of the retrieved nail by our academic collaborators at University College Dublin. Ion levels were then repeated at an interval post removal with consent.ResultsWe identified 7 Precice nails in 5 patients still implanted. All patients had consolidated after lengthening and were ready for nail removal. Elevated Titanium blood ion levels were identified at the time of retrieval. Histological abnormalities consistent with metalosis were identified. In all cases the nail was grossly intact and examination of the motor showed no evidence of wear or failure. Follow up ion levels obtained post retrieval showed persistent elevation.ConclusionsOur retrieval audit shows persistent elevation of Titanium ion levels and abnormal histology despite apparent nail integrity. These findings require further evaluation in a larger retrieval series to determine if there is a high incidence of this phenomenon and if ion levels have a clinical effect.

Oxidative stress in OPU mares can delay embryo development in vitro

The application of ovum pickup-intracytoplasmic sperm injection (OPU-ICSI) is well established for the commercial equine in vitro production (IVP). There is a marked individual mare effect on the OPU-ICSI outcome, but little is known about the influence of the mare's health conditions. This study aimed to determine a potential association between the concentrations of interleukin-6 (IL-6) and reactive oxygen metabolites (d-ROMs) in the serum of the donor mare on the efficiency of equine IVP. Just before OPU, a blood sample was collected from 28 Warmblood donor mares, that were subjected to a routine OPU-ICSI program. The serum concentrations of IL-6 and d-ROMs were photometrically assayed using the equine Nori® (Genorise Scientific, USA) and Diacron® (Diacron International, Italy) kits, respectively. The kinetics of blastocyst development and the blastocyst rate (blastocysts/injected oocytes) were recorded. For the blastocyst forming mares, Pearson's and Spearman's correlation coefficients were calculated between the blastocyst rate and the serum concentration of IL-6 and d-ROMs. The serum concentrations were also compared between mares yielding at least one and mares yielding no blastocyst or between mares with fast (at day 7-8 post ICSI) and slow (≥ day 9 post ICSI)growing blastocysts using the independent t-test or Mann-Whitney U-test. The average blastocyst formation rate was 24.68±5.16 % and the average concentrations of IL-6 and d-ROMs were 519.59±157.08 pg/mL and 171.30±4.55 carratelli units (UCARR), respectively. Serum concentrations of IL-6 and d-ROMs, respectively, were not significantly correlated with blastocyst formation rates and not markedly different between the blastocyst forming (552.68±235.18 pg/mL and 168.36±5.56 UCARR) and non-forming (468.47±179.99 pg/mL and 175.85±7.89 UCARR) mares. Serum concentrations of d-ROMs were significantly lower in mares with fast growing (148.10±8.13 UCARR) compared to those with slow growing blastocysts (179.41±4.89 UCARR; P= 0.003). Taken together, the serum concentration of IL-6 and d-ROMs are not associated with the mares’ ability to produce blastocysts after OPU-ICSI. Although it may be questioned whether a single sample is representative of the mare's health status, changes in serum metabolites related to oxidative stress at the time of oocyte retrieval may diminish the OPU-ICSI outcome via interfering with the embryonic development in mares. Funded by the Ministry of Higher Education of the Arab Republic of Egypt.

English

This Cloud environment offers users friendly services that assist them in achieving their professional and personal objectives. Any personal computer or other device with a broadband connection can access the data. The data can be an image file or a document etc. To protect such data from illegal access, proper security measures must be adopted so that the data resides safe and secure in a third party premise. The centremost node always has the lesser possibility of being hacked, leaving the data to be secure aside. Also, the central nodes have improved retrieval time. This study aims to propose an Intelligent Node Selection Model (INSM) comprising centrality measure and choosing the centre most stable nodes with less energy and security cost in the network for placing the data fragments so that the access time gets improved and node failure is significantly reduced. Improving the client success ratio gives the customer a sense of satisfaction. The cost estimation is high as it includes more parameters than the existing one. The different cost estimation at various stages of the Intelligent Node Selection Model (INSM) is compared with the existing node selection mechanism, the Optimal Selection Model. The average cost of node selection is approximately 1.1% higher than the Optimal Selection model as the cost of nodes in the INSM model is incurred for calculating the degree of centrality and node ranking to determine the success probability, security cost and energy cost. Thus, the node access time is better, and the failure of nodes also gets reduced so that the user will have safe access to data. Calculating the degree centrality of all the nodes in a network takes Θ(V²) time, and for edges, Θ(E) where V is the vertices and E are the edges.

Comparative Study ofSearch Engine Optimization Algorithms On Retrieval Time andPrecise Data Entry for Websites

A search engine is a complex software in that a finder visits numerous websites and their pages to find essential data. It is the primary source to find content on the World Wide Web. Search Engine Optimization (SEO) methods have been invented to make user searching smoother. Although search engines are intelligent, sometimes they also provide irrelevant data. As a result, researchers have found a solution to this problem by implementing SEO techniques. SEO techniques make websites more visible and produce organic search results. Thus, this study proposed the implementation of Artificial Neural Networks (ANN) and Particle Swarm Optimization (PSO) for SEO problems on online shopping websites and educational websites. These algorithms are evaluated based on retrieval time and precise data entry by using precision and recall. Moreover, PageSpeed Insights is used to check the speed index of the websites. The research outcome found that PSO outperformed ANN for both shopping and educational websites. PSO has a minimal retrieval time, which is 0.04 seconds for an online shopping website and 0.10 seconds for an educational website. As for precision and recall, online shopping websites have been proven to have the highest precision score of 0.67 and 0.63 recall score. The simulation analysis results show thatfuture researchers should concentrate more on determining the significance of each SEO approach and the best blend for various sectors.

Time-conserving deduplicated data retrieval framework for the cloud computing environment

Cloud computing technology is quite inevitable in today’s smart world. The excessive utilization of data mandates updated storage space, which is highly expensive and cloud storage is the best solution to it. As charges are levied for the utilized space, data redundancy must be avoided for the effective exploitation of cloud space. Data deduplication is a technique, which removes redundant data and conserves storage, bandwidth and charges. However, data retrieval upon deduplicated data is not well explored in the existing literature. This work attempts to present an effective retrieval framework for deduplicated data in a cloud environment by presenting two protocols namely Data Outsourcing Protocol (DOP) and Data Retrieval Protocol (DRP). The retrieval performance of the proposed approach is tested and compared with the existing approaches in terms of standard performance measures. The work performance of the proposed Deduplicated Data Retrieval (DDR) framework performs better in terms of retrieval precision, recall and time conservation rates. The average precision and recall rates attained by the proposed work are 97.9% and 95.75% respectively.

Relationship Between Language Spoken and Inferior Vena Cava Filter Retrieval Rates at a Single Center

The majority of inferior vena cava (IVC) filters placed are intended to be retrievable after the patient’s risk of pulmonary embolism has decreased. However, studies have shown that there are many factors that play into whether these filters are actually removed. Even socioeconomic factors such as insurance status, age, and race can influence retrieval rates. No study to date has identified a link between IVC retrieval rates and patient language although without proper interpretive services patient language may be a barrier to effective communication and may decrease the likelihood that patients have their filter removed. We performed a retrospective chart review of all patients who underwent IVC filter placement at our institution from January 1, 2017, to July 1, 2022. This time frame intentionally excluded the six most recent months to allow appropriate time for filter retrieval. Demographic, procedural, and comorbidity information was collected through the electronic medical record review. Patients who either had their filter removed or who died with the filter in place were counted as a retrieved filter, and those who did not have their filter removed and remained living were coded as filter remaining in place. The Pearson χ2 analysis was used to compare the groups. From January 1, 2017, to July 1, 2022, 150 patients underwent placement of an IVC filter. The overall filter modified (accounting for patient death) retrieval rate was 83%. There was a significantly decreased filter retrieval rate in patients who were listed as speaking a language other than English (61.5%) when compared with English speakers (85.4%, P < .05). Cantonese was the language with the lowest retrieval rate with just 20% of the filters retrieved in patients who spoke Cantonese. In patients whose filter was removed, there was no difference in average days the filter remained in place based on language. In our single institution study, patients who spoke a language other than English had a decreased rate of IVC filter retrieval. The identification of this difference is imperative to creating and implementing programs to ensure equal care across all socioeconomic backgrounds.

Traditional Chinese therapy in the treatment of ICU-acquired weakness: a Meta-analysis

To systematically assess the efficacy of traditional Chinese therapy in the treatment of ICU-acquired weakness (ICU-AW). PubMed, Cochrane Library, Embase, Web of Science, CNKI, Wanfang, VIP were retrieved by computer and were used to collect a randomized controlled trials (RCT) of traditional Chinese therapy for ICU-AW. The retrieval time was from databases establishment to December 2021. After 2 researchers independently screened the literature, extracted data and evaluated the risk of bias included in the study, and RevMan 5.4 software was used for Meta-analysis. 334 articles were selected, totally 13 clinical studies and 982 patients were included, including 562 in the trial group and 420 in the control group. Meta-analysis results showed that traditional Chinese therapy could improve clinical efficacy of ICU-AW patients [relative risk (RR) = 1.35, 95% confidence interval (95%CI) was 1.20 to 1.52, P < 0.000 01], improve the muscle strength [Medical Research Council score (MRC score); standardized mean difference (SMD) = 1.00, 95%CI was 0.67 to 1.33, P < 0.000 01], improve daily life ability [modified Barthel index score (MBI score); SMD = 1.67, 95%CI was 1.20 to 2.14, P < 0.000 01], shorten mechanical ventilation time (SMD = -1.47, 95%CI was -1.84 to -1.09, P < 0.000 01), reduce the length of intensive care unit (ICU) stay [mean difference (MD) = -3.28, 95%CI was -3.89 to -2.68, P < 0.000 01], reduce the total hospitalization time (MD = -4.71, 95%CI was -5.90 to -3.53, P < 0.000 01), reduce tumor necrosis factor-α (TNF-α; MD = -4.55, 95%CI was -6.39 to -2.70, P < 0.000 01) and interleukin-6 (IL-6; MD = -5.07, 95%CI was -6.36 to -3.77, P < 0.000 01). There was no obvious advantage in reducing the severity of the disease [acute physiology and chronic health evaluation II (APACHE II; SMD = -0.45, 95%CI was -0.92 to 0.03, P = 0.07). Based on the current research, traditional Chinese therapy can improve the clinical efficacy of ICU-AW, improve muscle strength and daily life ability, shorten mechanical ventilation, the length of ICU stay and total hospitalization time, reduce TNF-α and IL-6. But traditional Chinese therapy can not reduce the overall disease severity.

A Retrieval Algorithm for Time-constrained Heterogeneous Data Items in Wireless Networks

&lt;p&gt;Homogeneous and heterogeneous data retrieval problem refers that these requested data items are retrieved on the basis of data items broadcast at some channels such that the access latency of all requested data items is minimized. The problem has an important study significance in MIMO (Multiple Input and Multiple Output) wireless communication. Almost researches are focused on proposing some schemes for solving signal antenna or multiple antennae data retrieval based on homogeneous data items, but these schemes are not suitable for heterogeneous data retrieval problem. So in this paper, we describe a SPR (Shortest Paths Retrieval) algorithm that is suitable for solving homogeneous and heterogeneous data retrieval problem at the same time. Moreover, for avoiding the retrieval time too long, when the each requested data item is set a constrained condition-deadline, we propose another DKPR (Deadline-based Key Path Retrieval) algorithm that finds the critical path with the largest number of requested data items in a broadcast cycle, so as to complete the retrieval operation of data items within the deadline of requesting data items as much as possible. Through experiments, the proposed scheme has good efficiency. &lt;/p&gt; &lt;p&gt;&amp;nbsp;&lt;/p&gt;

Deep muscle stimulator in the treatment of post-stroke spasticity: A protocol for systematic review and meta-analysis.

Spasticity is one of the most common complications and sequelae of stroke, with the main clinical manifestations being increased muscle tension, pain, stiffness, and other disorders. It not only increases the length of hospitalization and medical costs but also affects the quality of daily life and the stress of returning to society, increasing the burden on patients and their families. At present, 2 driver types of deep muscle stimulator (DMS) have been used in the clinical treatment of post-stroke spasticity (PSS) with good clinical results, but there is no evidence of clinical efficacy and safety. Therefore, this study aims to integrate direct and indirect comparative clinical evidence through a systematic review and network meta-analysis (NMA). According to the data, different driver types for DMS with the same body of evidence will be collected, analyzed, and sequenced in a quantitative and comprehensive manner and then screened for the optimal driver type of DMS device for PSS treatment. The study also aims to provide reference value and an evidence-based theoretical basis for the clinical optimization of DMS equipment selection. A comprehensive retrieval of China National Knowledge Infrastructure, Chinese scientific journal database, China biological feature database, Wanfang Chinese databases and the Cochrane Library, PubMed, Web of Science, and Embase foreign databases will be conducted. Randomized controlled trials of these 2 driver types of DMS devices combined with conventional rehabilitation training of PSS will be searched and published. The retrieval time is from the establishment of the database to December 20, 2022. The 2 first authors will screen references that meet the inclusion criteria, independently extract data according to predesigned rules, and assess the quality of the included studies and the risk of bias according to the Cochrane 5.1 Handbook criteria. R programming and Aggregate Data Drug Information System software will be used to perform a combined NMA of the data and to evaluate the probability of ranking for all interventions. The NMA and probability ranking will determine the best driver type of DMS device for PSS. This study will offer a comprehensive evidence-based approach to DMS therapy and assist doctors, PSS patients, and decision-makers in selecting a more efficient, secure, and cost-effective treatment option.

Meta-analysis of Ac-SDKP inhibition of Pulmonary fibrosis in animal models

Objective: To systematically study the anti-fibrotic effect of N-acetyl-seryl-as partyl-lysyl-proline (Ac-SDKP) on pulmonary fibrosis. Methods: In May 2021, a computer search was performed on CNKI, Wanfang Knowledge Service Platform, VIP.com, China Biomedical Literature Database, Pubmed, OVID and other databases. The retrieval time was from January 2008 to May 2021. Randomized controlled experiments on the inhibition of pulmonary fibrosis by Ac-SDKP were screened. The control group was the pulmonary fibrosis model group and the experimental group was the Ac-SDKP treatment group. The quality of the literature was assessed using the syrcle risk of bias assessment tool, and data were extracted. Data analysis was Performed using revman 5.4 software. Results: 18 papers were included, with a total of 428 animal models. The results of meta analysis showed that the contents of α-smooth muscle actin (α-SMA), type I collagen, type Ⅲ collagen, transforming growth factor-β (TGF-β) and Nodule area in the exPerimental group were lower than those in the control grouP. [SMD=-2.44, 95%CI (-3.71--1.17), P=0.000][SMD=-5.36, 95%CI (-7.13--3.59), P=0.000] [SMD=-3.07, 95%CI (-4.13--2.02), P<0.000][SMD=-2.88, 95%CI (-3.63--2.14), P=0.000] [SMD=-1.80, 95%CI (-2.42--1.18), P=0.000], the content of hydroxy proline in the experimental group was higher than that in the control group [SMD=7.62, 95%CI (4.90-10.33), P=0.000], all indexes included in the literature were statistically significant. Conclusion: Ac-SDKP has obvious inhibitory effect on the process of pulmonary fibrosis, and may become a new clinical drug for the treatment of pulmonary fibrosis.