Autobiographical Memory Retrieval Research Articles

Computerized Memory Specificity Training (c-MeST) for major depression: A randomised controlled trial

Given modest response and high relapse after treatment for Major Depressive Episodes (MDE), the development and refinement of treatments to target cognitive vulnerabilities is indicated. Memory Specificity Training (MeST) remediates deficits in recalling detailed memories of past experiences through repeated practice of autobiographical memory retrieval. This randomised controlled trial aimed to assess the efficacy of an online, computerized version of MeST (c-MeST) for MDE. Adults (N = 245, 88.4% female; M age = 46.4) with a current MDE were randomised to the c-MeST program or wait-list control group. Significantly fewer participants in the c-MeST group, relative to control, met criteria for an MDE at one-month follow-up (35.7% c-MeST vs. 60.6% control), but not at other time-points. The c-MeST group, relative to the control group, scored significantly higher on memory specificity at all time-points following baseline (d = 0.53–0.93), and lower on depressive symptoms at one (d = 0.57) and three-month follow-up (d = 0.67). Changes in memory specificity mediated the effect of c-MeST on depressive symptoms at follow-up. c-MeST can improve memory specificity and depressive symptoms in people with an MDE, and may speed the rate of recovery. Future studies can further examine the mechanisms through which this occurs.

Specificity and detail in autobiographical memory retrieval: a multi-site (re)investigation

ABSTRACT This investigation examined conflicting suggestions regarding the association between problems retrieving specific autobiographical memories and the tendency to retrieve the details of these memories. We also examined whether these tendencies are differentially related to depression symptoms. U.S., Belgian, Hong Kong and Japanese participants retrieved memories related to cue words. Responses were coded for if they referred to a specific event (i.e., an event lasting less than 24 h) and their details (What? Where? Who?). Across sites, and in meta-analyses, the retrieval of more specific memories was associated with retrieval of more details. Memories that were specific included more detail than non-specific memories. Across sites, retrieval of more specific memories and more detail was associated with less severe depression symptoms. Episodic specificity and detailedness are related but separable constructs. Future investigations of autobiographical memory specificity, and methods for alleviating problematic specificity, should consider measures of episodic detailedness.

Common and distinct neural systems support the generation retrieval phase of autobiographical memory and personal problem solving

Prior research has documented engagement of a common ‘core’ retrieval network during autobiographical memory retrieval and higher-order prospective tasks, such as personal problem solving. This neural overlap has overwhelmingly been documented in the context of the 'elaboration phase' of retrieval, when a single mental event is simulated in detail . However, recollective and prospective tasks are often associated with generic cues, which require the retrieval and consideration of multiple conceptually-related events. This initial ‘generation phase’ of retrieval has received comparably little attention in the literature, leaving open questions as to how and when autobiographical memory and prospective tasks overlap within the brain. Here, we compare and contrast neural activity between autobiographical memory retrieval and personal problem solving with a focus on the initial generation phase of retrieval. In the MRI scanner, young adults completed both an autobiographical memory and a personal problem solving task. Each task consisted of a generation phase, which required participants to generate multiple past personal events or problem solutions to a given cue and a subsequent elaboration phase, where a single memory or solution was simulated in detail. A multivariate Partial Least Squares analysis revealed patterns of neural overlap between memory and problem solving during the generation phase that were distinct from the elaboration phase. Among regions commonly recruited during the generation phase was the anterior hippocampus, a structure involved in initiating mental construction and integrating concepts. Subsequent analyses demonstrated that the anterior hippocampus interacted with distinct cortical regions as a function of task, in particular the ventromedial prefrontal cortex. Together, these data provide novel evidence that neural overlap between autobiographical memory and personal problem solving does not occur solely in the context of detailed simulation but, instead, is driven by common retrieval demands.

Trait Mindfulness and Emotion Regulation upon Autobiographical Memory Retrieval during Depression Remission

ObjectivesDepression is associated with both emotion dysregulation upon retrieval of autobiographical memories and low trait mindfulness. The present study raised the question of whether these processes are related to each other and whether they may reflect a cognitive-affective vulnerability in individuals at risk of depression. The study examined emotion regulation in response to involuntary and voluntary autobiographical memories during depression remission and explored how trait mindfulness relates to such emotion regulation.MethodsThe study employed a naturalistic design in which individuals with remitted depression (n = 35) and individuals with no history of depression (n = 32) completed a trait mindfulness measure and a structured memory diary where they rated state use of five emotion regulation strategies upon involuntary and voluntary autobiographical memory retrieval.ResultsIndividuals with remitted depression reported heightened brooding in response to autobiographical memories when memory retrieval occurred involuntarily, and trait mindfulness was low. Depression remission and higher trait mindfulness were independently associated with greater cognitive reappraisal efforts upon involuntary retrieval of autobiographical memories. Higher trait mindfulness predicted less memory suppression, irrespective of depression history and memory retrieval mode.ConclusionsThe findings suggest a vulnerability in emotional processing of autobiographical memories during depression remission that is dependent on mindfulness skill level and how memories come to mind.

Testing the impact of emotional mood and cue characteristics on detailed autobiographical memory retrieval.

Autobiographical memory retrieval is impacted by emotion, whether from an individual's mood state or a retrieval cue. Here, we addressed two questions concerning how emotion from these two sources affects the remembering of autobiographical experiences. The first question concerns whether emotional mood and retrieval cues both reliably impact the details and content of a recalled autobiographical memory. The second question concerns to what extent distinct emotional dimensions of retrieval cues-valence and arousal-individually impact the way these memories are recalled. Across three experiments, young adult participants described the details of autobiographical experiences in response to cue words that varied in emotional valence (Experiment 1) or both emotional valence and arousal (Experiments 2 and 3) under two mood states (happy or sad). Memory descriptions were scored for the number of specific episodic (internal) and nonepisodic (external) details as well as for overall emotional tone. Experiment 1 demonstrated that cue valence more reliably predicted the number of episodic details and tone of the memories than mood. Experiment 2 and 3 further explored this reported cue effect by comparing memory recollection to cues that systematically varied in both valence and arousal. Generally, we found that highly arousing cues led to memories described with more episodic details while cue valence predicted the emotional tone of the memory. We discuss how these dimensions of emotionality (i.e., valence and arousal) bias cued autobiographical memory recall and the implications these results have on models of memory. (PsycInfo Database Record (c) 2020 APA, all rights reserved).

Eye movements of recent and remote autobiographical memories: fewer and longer lasting fixations during the retrieval of childhood memories

There is an increased interest in the study of eye movements during the retrieval of autobiographical memories. Following this trend, the aim of the current study was to evaluate eye movements during the retrieval of remote and recent autobiographical memories. We instructed 71 participants to retrieve memories of personal events from early childhood (6-10years), late childhood/early adolescence (11-14years), late adolescence (15-18years), and the last month. During the retrieval of these memories, participants wore eye-tracking glasses. Analyses showed that early childhood memories triggered fewer fixations and fixations with longer durations than memories from the last month. However, no significant differences were observed for the number of saccades, saccade durations, or total amplitude of the saccades. The fewer and longer lasting fixations during the retrieval of early childhood memories can be attributed either to the visual system reconstructing remote memories from an observer perspective or to difficulties when reconstructing remote memories.

Memory-Related Emotion Regulation and its Relation to Internalizing Symptoms

Memory-related emotion-regulation is the emotion-regulation strategies employed in response to the retrieval of specific autobiographical memories. We propose that memory-related emotion-regulation may facilitate the link between a memory’s centrality to an individual’s identity and internalizing symptoms as identified in previous work. In two studies (Ns = 229 and 199), Amazon MTurk workers reported the use of five emotion regulation strategies in relation to recent memories that were judged to be either highly central or less central to their identity. Further, participants completed different measures of depression and anxiety symptoms. Across both studies, high-centrality memories were associated with greater employment of emotion regulation strategies than low-centrality memories. Brooding over high-centrality memories (but not low-centrality memories) predicted depressive symptoms. For anxiety, in Study 1, emotion regulation for both high- and low-centrality memories was associated with higher generalized anxiety disorder symptoms (i.e. worry). In Study 2, emotion regulation of high-centrality memories (but not low-centrality memories) predicted fear and panic symptoms. Highly central memories were associated with a distinct emotional experience and emotion regulation strategies. Brooding, when remembering highly central events, was robustly associated with all types of internalizing symptoms. Other emotion regulation strategies showed less consistent patterns, and emotion regulation for low centrality memories was related only to worry. Overall, the findings underscore the importance that memory centrality has for understanding emotion regulation when experiencing elevated depressive and anxiety symptoms.

Attachment and autobiographical memory retrieval: Event-related potential evidence from strategic information processing.

This article presents two studies using event-related potentials combined with an autobiographical memory (AM) retrieval task and a lexical judge task to explore differences in AM retrieval among differently attached individuals and to further explore whether the source of these differences is the schematic information processing mode or strategic information processing mode. The effectiveness of the information processing mode is also studied. The results revealed that differences in the AM extraction of different attachment styles were due to the strategic information processing mode, while no differences were found in the schematic information processing used by individuals with different attachment styles. Further, the strategic information processing used by the securely attached group was more flexible and efficient than that used by the insecurely attached group; moreover, the strategic information processing mode used by the avoidantly attached group was more stable and consistent than that used by the anxiously attached group.

Emojis influence autobiographical memory retrieval from reading words: An fMRI-based study.

Advances in computer and communications technology have deeply affected the way we communicate. Social media have emerged as a major means of human communication. However, a major limitation in such media is the lack of non-verbal stimuli, which sometimes hinders the understanding of the message, and in particular the associated emotional content. In an effort to compensate for this, people started to use emoticons, which are combinations of keyboard characters that resemble facial expressions, and more recently their evolution: emojis, namely, small colorful images that resemble faces, actions and daily life objects. This paper presents evidence of the effect of emojis on memory retrieval through a functional Magnetic Resonance Imaging (fMRI) study. A total number of fifteen healthy volunteers were recruited for the experiment, during which successive stimuli were presented, containing words with intense emotional content combined with emojis, either with congruent or incongruent emotional content. Volunteers were asked to recall a memory related to the stimulus. The study of the reaction times showed that emotional incongruity among word+emoji combinations led to longer reaction times in memory retrieval compared to congruent combinations. General Linear Model (GLM) and Blind Source Separation (BSS) methods have been tested in assessing the influence of the emojis on the process of memory retrieval. The analysis of the fMRI data showed that emotional incongruity among word+emoji combinations activated the Broca's area (BA44 and BA45) in both hemispheres, the Supplementary Motor Area (SMA) and the inferior prefrontal cortex (BA47), compared to congruent combinations. Furthermore, compared to pseudowords, word+emoji combinations activated the left Broca's area (BA44 and BA45), the amygdala, the right temporal pole (BA48) and several frontal regions including the SMA and the inferior prefrontal cortex.

Eavesdropping on Autobiographical Memory: A Naturalistic Observation Study of Older Adults' Memory Sharing in Daily Conversations.

The retrieval of autobiographical memories is an integral part of everyday social interactions. Prior laboratory research has revealed that older age is associated with a reduction in the retrieval of autobiographical episodic memories, and the ability to elaborate these memories with episodic details. However, how age-related reductions in episodic specificity unfold in everyday social contexts remains largely unknown. Also, constraints of the laboratory-based approach have limited our understanding of how autobiographical semantic memory is linked to older age. To address these gaps in knowledge, we used a smartphone application known as the Electronically Activated Recorder, or “EAR,” to unobtrusively capture real-world conversations over 4 days. In a sample of 102 cognitively normal older adults, we extracted instances where memories and future thoughts were shared by the participants, and we scored the shared episodic memories and future thoughts for their make-up of episodic and semantic detail. We found that older age was associated with a reduction in real-world sharing of autobiographical episodic and semantic memories. We also found that older age was linked to less episodically and semantically detailed descriptions of autobiographical episodic memories. Frequency and level of detail of shared future thoughts yielded weaker relationships with age, which may be related to the low frequency of future thoughts in general. Similar to laboratory research, there was no correlation between autobiographical episodic detail sharing and a standard episodic memory test. However, in contrast to laboratory studies, episodic detail production while sharing autobiographical episodic memories was weakly related to episodic detail production while describing future events, unrelated to working memory, and not different between men and women. Overall, our findings provide novel evidence of how older age relates to episodic specificity when autobiographical memories are assessed unobtrusively and objectively “in the wild.”

VmPFC Drives Hippocampal Processing during Autobiographical Memory Recall Regardless of Remoteness.

Our ability to recall past experiences, autobiographical memories (AMs), is crucial to cognition, endowing us with a sense of self and underwriting our capacity for autonomy. Traditional views assume that the hippocampus orchestrates event recall, whereas recent accounts propose that the ventromedial prefrontal cortex (vmPFC) instigates and coordinates hippocampal-dependent processes. Here we sought to characterize the dynamic interplay between the hippocampus and vmPFC during AM recall to adjudicate between these perspectives. Leveraging the high temporal resolution of magnetoencephalography, we found that the left hippocampus and the vmPFC showed the greatest power changes during AM retrieval. Moreover, responses in the vmPFC preceded activity in the hippocampus during initiation of AM recall, except during retrieval of the most recent AMs. The vmPFC drove hippocampal activity during recall initiation and also as AMs unfolded over subsequent seconds, and this effect was evident regardless of AM age. These results recast the positions of the hippocampus and the vmPFC in the AM retrieval hierarchy, with implications for theoretical accounts of memory processing and systems-level consolidation.

Response styles to sad mood and self-esteem as predictors of autobiographical memory: Distinctions between memory specificity and detail

Past studies have found that ruminative responses to sad mood contribute to impaired autobiographical memory (AM) retrieval. We tested the theoretical proposition that generalized negative beliefs about the self increase the impact of rumination, and examined both memory specificity (recall of single unique events occurring in one day) and memory detail (number of unique units of information in specific memories). Results indicated that memory specificity and detail were weakly correlated. Greater distraction was associated with poorer memory specificity, whereas greater distraction and lower ruminative questioning were associated with less memory detail, but only among individuals with low self-esteem. The study suggests that ruminative questioning and distraction play a stronger role in AM detail among individuals with generalized negative beliefs about the self, and supports the role of functional avoidance in impaired retrieval of specific memories and the distinction between AM specificity and detail.

Effect of the NMDA receptor partial agonist, d-cycloserine, on emotional processing and autobiographical memory.

Studies suggest that d-cycloserine (DCS) may have antidepressant potential through its interaction with the glycine site of the N-methyl-D-aspartate receptor; however, clinical evidence of DCS's efficacy as a treatment for depression is limited. Other evidence suggests that DCS affects emotional learning which may also be relevant for the treatment of depression and anxiety. The aim of the present investigation was to assess the effect of DCS on emotional processing in healthy volunteers and to further characterise its effects on emotional and autobiographical memory. Forty healthy volunteers were randomly allocated to a single dose of 250 mg DCS or placebo in a double-blind design. Three hours later, participants performed an Emotional Test Battery [including Facial Expression Recognition Task (FERT), Emotional Categorisation Task (ECAT), Emotional Recall Task (EREC), Facial Dot-Probe Task (FDOT) and Emotional Recognition Memory Task (EMEM)] and an Autobiographical Memory Test (AMT). Also, participants performed the FERT, EREC and AMT tasks again after 24 h in order to assess longer lasting effects of a single dose of DCS. DCS did not significantly affect the FERT, EMEM and FDOT performance but significantly increased emotional memory and classification for positive words v. negative words. Also, DCS enhanced the retrieval of more specific autobiographical memories, and this effect persisted at 24 h. These findings support the suggestion that low-dose DCS increases specific autobiographical memory retrieval and positive emotional memory. Such effects make it an intriguing agent for further investigation in clinical depression, which is characterised by decreased autobiographical memory specificity and increased negative bias in memory recall. It also underscores the potential role of DCS as an adjunct to cognitive behavioural therapy in depression.

I like you better when you are coherent. Narrating autobiographical memories in a coherent manner has a positive impact on listeners' social evaluations.

We all have stories to tell. The stories that prevail in our conversations frequently concern significant past personal experiences and are accordingly based on autobiographical memory retrieval and sharing. This is in line with the social function of autobiographical memory, which embodies the idea that we share memories with others to develop and maintain social relationships. However, the successful fulfilment of this social function is dependent on phenomenological properties of the memory, which are highly inter-individually different. One important individual difference is memory coherence, operationalized as narrative coherence. The objective of this study was to investigate the impact of memory coherence on the social evaluations of listeners. We hypothesized that being incoherent in the sharing of autobiographical memories, would evoke more negative social evaluations from listeners, in comparison to coherently sharing autobiographical memories. In a within-subject experimental study, 96 participants listened to four pre-recorded audio clips in which the speaker narrated about an autobiographical experience, in either a coherent or an incoherent manner. Results were in line with our hypotheses. Participants showed more willingness to interact, more instrumental support, more positive feelings, more empathy and more trust towards those narrators who talked in a coherent manner about their autobiographical memories, as compared to those that talked in an incoherent manner. Negative feelings in the listener were evoked when the speaker talked incoherently, but especially when it concerned a positive memory. Results can be explained in terms of a reduction in the attraction effect when effortful processing is increased, which is in line with the dual processing theory of impression formation. Another explanation involves the idea that coherence is necessary to establish truthfulness in communication. The clinical relevance of these findings is further illustrated in light of the relation between social support and psychological well-being.

Interindividual Differences in Cognitive Functioning Are Associated with Autobiographical Memory Retrieval Specificity in Older Adults

Abstract. We examined whether interindividual differences in cognitive functioning among older adults are related to episodic memory engagement during autobiographical memory retrieval. Older adults ( n = 49, 24 males; mean age = 69.93; mean education = 15.45) with different levels of cognitive functioning, estimated using the Montreal Cognitive Assessment (MoCA), retrieved multiple memories (generation task) and the details of a single memory (elaboration task) to cues representing thematic or event-specific autobiographical knowledge. We found that the MoCA score positively predicted the proportion of specific memories for generation and episodic details for elaboration, but only to cues that represented event-specific information. The results demonstrate that individuals with healthy, but not unhealthy, cognitive status can leverage contextual support from retrieval cues to improve autobiographical specificity.

Remembering the past to live better in the future: A feasibility randomised controlled trial of memory specificity training for motivation in psychosis

Background and objectivesPeople with a diagnosis of psychosis often experience low motivation and reduced activity levels. Autobiographical memory deficits have been identified in people with psychosis and this may limit the role of memory retrieval in supporting motivation. This pilot study adapted a recently developed protocol, Memflex, which aims to enhance autobiographical memory and has shown promise in depression. Our brief intervention targets experiential negative symptoms of psychosis using supported autobiographical memory retrieval. MethodA sample of 31 participants with psychosis were recruited from inpatient and community settings and randomised in a 2:1 ratio to either a basic recall control or an enhanced recall intervention group. Participants were asked to generate positive autobiographical memories linked to activities they wish to repeat in the future. The enhanced recall condition received additional prompts from the Memflex protocol, and the basic recall condition received no additional support. ResultsThe intervention delivered was acceptable (rated >80%) and feasible (94% adherence) to those who took part. Participants were able to generate positive autobiographical memories linked to their goals and experienced appropriate emotions linked to these. The controlled preliminary effect sizes (0.2–0.34) showed encouraging signals for self-efficacy, motivation and a reduction in negative mood. LimitationsAs this was a pilot study with a small sample size between-group tests of statistical significance were not conducted, and therefore findings should be interpreted with caution. ConclusionsThese findings suggest that guided autobiographical memory retrieval may be an effective way tool for targeting motivation in people with psychosis.

Emotional cue effects on accessing and elaborating upon autobiographical memories

If remembering the past requires a cue to stimulate mental reactivation of an experience (i.e., a memory), then the nature of the retrieval cue should bias how that experience is recalled. Based on the established link between emotion and memory, we tested how two emotional properties of a cue - valence (positive and negative) and arousal (high and low) - influence different phases of autobiographical memory retrieval: searching/accessing an autobiographical episode, and then elaborating on the associated memory representation. Young, healthy participants completed two experimental sessions that were separated by 24 to 48 h. In session one, participants used musical retrieval cues that varied in emotional valence and arousal to access autobiographical memories. Cue-evoked physiological arousal and valence responses were measured via skin conductance and facial electromyography, respectively, as were the reaction times to access each memory. In session two, participants reactivated and then described (elaborated) the details of the memories that were accessed in session one. The resultant descriptions were scored for the number of specific episodic (internal) and non-episodic (external) details. While arousal and valence levels of the retrieval cues, as well as the evoked physiological responses, significantly predicted the reaction time to access a memory, only cue arousal predicted how detailed the representations were constructed. Memories that were initially accessed to high-arousing cues were later described with more episodic details than memories accessed to low-arousing cues. These data provide new insights into how emotional valence and arousal levels of retrieval cues distinctly bias the accessibility and detailed elaboration of autobiographical memories.

Precuneus stimulation alters the neural dynamics of autobiographical memory retrieval

Autobiographical memory (AM) unfolds over time, but little is known about the dynamics of its retrieval. Space-based models of memory implicate the hippocampus, retrosplenial cortex, and precuneus in early memory computations. Here we used transcranial magnetic stimulation (TMS) and magnetoencephalography (MEG) to investigate the causal role of the precuneus in the dynamics of AM retrieval. During early memory search and construction, precuneus stimulation compared to vertex stimulation led to delayed evoked neural activity within 1000 ​ms after cue presentation. During later memory elaboration, stimulation led to decreased sustained positivity. We further identified a parietal late positive component during memory elaboration, the amplitude of which was associated with spatial perspective during recollection. This association was disrupted following precuneus stimulation, suggesting that this region plays an important role in the neural representation of spatial perspective during AM. These findings demonstrate a causal role for the precuneus in early AM retrieval, during memory search before a specific memory is accessed, and in spatial context reinstatement during the initial stages of memory elaboration and re-experiencing. By utilizing the high temporal resolution of MEG and the causality of TMS, this study helps clarify the neural correlates of early naturalistic memory retrieval.

The architecture of neural networks for enhanced autobiographical memory access: a functional MRI study

Abstract The paper reports results of the first neuroimaging study of a peculiar phenomenon of autobiographical human memory (AM) - a state of “enhanced memory access”. The objective of this work was to determine the AM network and the AM gate, i.e. the brain structures responsible for access to the entire memory network. In the framework of the experiment, fMRI images of the volunteers’ brains were obtained during normal and enhanced autobiographical memory retrieval, then pre-processing and processing of these data were performed, the areas involved in actualization of the AM on the individual and group levels were identified, after that the connections between these areas were exposed and visualized, and a meta-analysis of the data received at individual level were performed. The areas that were identified in the state of enhanced memory retrieval significantly overlap with the already known AM network, but activations were also detected in areas not mentioned earlier in the papers on AM. Also we report evidence, that achievement of the “enhanced memory access” has individual threshold for each subject.

Autobiographical Memory Increases Pupil Dilation.

BackgroundPupil activity has been widely considered as a “summed index” of physiological activities during cognitive processing.MethodologyWe investigated pupil dilation during retrieval of autobiographical memory and compared pupil diameter with a control condition in which participants had to count aloud. We also measured pupil diameters retrieval of free (i.e., first memory that comes to mind), positive, and negative memories (memories associated, respectively, with the words “happy” and “sad”).ResultsAnalyses demonstrated larger pupil diameters during the free, positive, and negative autobiographical memory retrieval than during the control task. Analyses also demonstrated no significant differences in pupil diameters across the three autobiographical memory conditions.ConclusionThese outcomes demonstrate that, compared with counting, autobiographical retrieval results in a larger pupil size. However, the emotional valence of memories yields non-significant effect on pupil diameters. Our findings demonstrate how autobiographical memory retrieval yields pupil dilation.