Results Of Validation Tests Research Articles

Pengaruh Kepemimpinan, Motivasi dan Pelatihan terhadap Kinerja Pegawai PT. Bank Rakyat Indonesia (Persero) Kantor Cabang Kendal

This research analyzes the influence of leadership, motivation, and training on team member performance. The population in this study was all PT employees. Bank Rakyat Indonesia (Persero) Kendal Branch Office with 94 respondents. The research method used is quantitative research. Data was collected using a Google form questionnaire with four variables: leadership, motivation, training, and team member performance. Data processing results are in the form of respondent descriptions, variable descriptions, validity test results, reliability test results, F test results, coefficient of determination test results (R2), and hypothesis test results. The results of this study show that leadership does not affect team member performance, motivation has a positive and significant effect on team member performance, and training has a positive and significant impact on team member performance. Conclusion: There is a significant influence between motivation and training on team member performance. However, leadership does not affect team member performance. Keywords: Employee Performance, Leadership, Motivation, Training

Development of an Interactive E-Module Based On Flipbook Protista Material To Improve Student Biology Learning Outcomes

The development of a flipbook-based interactive e-module is an innovative step in increasing the effectiveness of biology learning, especially Protista material. Protista is a group of eukaryotic organisms that includes various microorganisms such as protozoa, unicellular algae, and others. This research aims to develop an interactive e-module based on flipbook material on protists that is valid, practical and effective. The research method refers to the analysis, design, development, implementation, and evaluation development model. The subjects of this research were class X students at Oikomene Manokwari High School, consisting of 24 students. Data collection procedures in the form of a questionnaire to determine validator and student responses to interactive e-modules as well as providing multiple choice questions to measure learning outcomes. Descriptive data analysis technique by calculating validation results and student learning outcomes. The research results showed that the media and material expert validation test results obtained a percentage of 96.67% with a very valid category. The results of the assessment of student responses in large group trials obtained an average percentage of 83.61% in the very practical category. The test results show that the average student learning outcome is 82.21 in the very high category. This research can be concluded that the flipbook-based interactive e-module on protist material meets the criteria of being valid, practical and effective in improving student learning outcomes.

Analisis Risiko Rantai Pasok Material dalam Pelaksanaan Proyek Konstruksi Gedung Di Aceh

The material supply chain is a material distribution flow that varies from various sources or suppliers, until the material arrives at the project site. This study aimed to analyze material supply chain risk factors that arise in the implementation of building construction projects in Aceh Province, as well as identify solutions to prevent material supply chain risk factors that arise in the implementation of building construction projects in Aceh Province. The methods developed in this research are validity test, reliability test, quantitative descriptive, and multiple regression analysis through SPSS software version 25. From the validity test results obtained, the value of Rcount ≥ Rtable. This shows that the validity test performed on all questions is valid. Furthermore, the results of the reliability test obtained the average value of each variable of 0.708, then the reliability test was said to be reliable. Because the value of a variable is said to be reliable (reliable) if Cronbach Alpha value exceeds 0.6. Then from the results of the descriptive analysis, there are indicators that are often questioned as risk factors, namely the delay of the main contractor in paying subcontractors (X2.8) with a mean value of 3.39. This shows that the majority of respondents stated that X2.8 has a high influence on the occurrence of material supply chains in the implementation of construction projects. From the results of the correlation analysis, the R value of 0.382 (low/weak), then the two variables have a unidirectional relationship. This means that if the value of the X variable is high, then the value of the Y variable will also be high or if it means that all X variables are related to material supply chain risk, and the regression model obtained is: Ŷ=7.408+0.096X1-0.006.X2+ 0.132X3+0.112X4. From the results of the coefficient of determination, the value of R2 = 14.6%, which means that the risk of the material supply chain is influenced by supply factors, control factors, demand factors, process factors, amounting to 14.6%, the remaining 85.4% is influenced by other factors variables which are not included in this study.

Development of Arduino Uno-Based Free Fall Motion Props to Increase Learning Motivation Towards Practicum Results of 11th Grade Students

Research has been conducted on the development of Arduino Uno-based Free Fall Motion (FFM) teaching aids to increase learning motivation towards the results of practicum for 11th grade students of MAN 1 Mataram. This study aims, (1) to design arduino-based teaching aids on free fall motion (FFM) material, (2) to determine the validity level of teaching aids to 3 media experts and 3 material experts, (3) to determine the increase in student learning motivation, (4) to determine the results of student practicum, and (5) to determine the effect of learning motivation on student practicum results. This type of tool development is Research and Development (R&D). the subject model of this research is MAN 1 MATARAM students as many as 35 students. The instrument used was a questionnaire. The development model in this study uses a 3D model. 3D development model (ThreeD). This model is a modification of the Thiagarajan model which includes 4 stages called the 4D (Four-D) model. Based on the research objectives, a student's practicum teaching aid on GJB material was made. Based on the validity test results, the teaching aids are suitable for use as learning media in class 11 MAN 1 Mataram. Furthermore, the results of motivation based on the value before applying FFM props amounted to 51.60% (pretest). While the interpretation after the practicum (posttest) was 90.44% and the N-Gain was 0.46. This means that there are changes in learning activities in students. For the results of student practicum through the satisfaction interval with a very high category of 11 students, a high category of 23 students, a low category of 1 student and very low 0 students. Meanwhile, the correlation of learning motivation to student practicum results shows rcount> table (0.450>0.344) and obtained tcount> table (2.895>2.035). From the truth value of the hypothesis it can be concluded that there is an influence between learning motivation (X) and practicum learning outcomes (Y) on GJB material.

21st Century Skills Oriented Science Learning Worksheets for Elementary Schools

The low learning outcomes of science in grade V elementary schools require educators to innovate in developing learning tools. This study aims to develop LKPD oriented toward 21st-century skills that are valid and effective. This research uses the ADDIE model, which comprises five stages: Analysis, Design, Development, Implementation, and Evaluation. This study took the subject of 21st-century skills-oriented LKPD media, while the objects of development research were media content validity, student responses, teacher responses, and media effectiveness. This study utilizes qualitative and quantitative descriptive analysis methods. The data collection methods were observation, interviews, and performance tests to assess student products. The instruments used to collect data were interview guidelines, rating scale sheets, and performance guidelines to assess student products. The results of the media validity test obtained scores from media experts of 0.90 and material experts of 0.92, student responses of 94%, and teacher responses of 98% with very good predicate/qualification. These results align with the study objectives to obtain valid and effective LKPDs. It is concluded that the 21st-century skills-oriented LKPD on science content is declared valid and effective in learning to improve the science learning outcomes of fifth-grade elementary school students.

TEST OF THE VALIDITY AND RELIABILITY OF THE SOCIAL STIGMATIZATION SCALE OF ATTITUDES TOWARDS PRISONERS (ATP) CORRECTIONAL CLIENTS

One of the challenges in the correctional system is the negative stigma associated with clients and released inmates, making it difficult for inmates to integrate positively into society. Until now, there has been no method to assess the extent of the community's attitudes towards released or parolee inmates in a specific region. This research aims to test the validity and reliability of the Attitudes Towards Prisoners (ATP) scale in the Indonesian language. Developed by Melvin, the ATP scale has been validated and demonstrated good trial reliability, with excellent consistency when tested in various countries. The adaptation of this instrument involved steps such as Forward-Backward Translation, instrument panel testing based on translation results, instrument revisions, content validity, back translation, instrument approval, data collection, and instrument reliability. For testing the validity and reliability, the scale was distributed online using Google Forms to 224 respondents, including correctional groups, students, the general public, and correctional officers. The results of the ATP scale's validity test found that 35 items were valid, while 1 item was not valid, with a Cronbach's Alpha value of 0.917. The findings of this study recommend the use of the ATP as a supporting instrument in assessing the community's attitudes towards released inmates and further research in the field of inmate integration.

The Influence of Paylater and Affiliate Features on Consumer Buying Interest in Shopping on the Shopee Aplication

The paylater feature is a digital payment feature that uses an e- commerce platform, purchasing goods among teenagers is very lacking due to the economic conditions that are currently unstable. The method used in this research is quantitative method. The population in this study was conducted at the unswagati Cirebon campus, level 1-4 management study program as many as 147 respondents. The sampling technique used by researchers is non-probability sampling with purposive sampling technique and data analysis used in this researcher is regression and descriptive analysis then the analysis methods used in this study include validity test, cross tabulation, reliability test, normality test, multicollinearity test, hypothesis testing, path analysis fit model test using SPSS and amos Softwer analysis tools to test the effect of paylater and affiliate features on consumer buying interest. The results of this study indicate that the paylater feature has a positive effect on consumer buying interest, affiliates have an effect on consumer buying interest. Because the validity and reliability test results are less than 0.1362, the normality test is less than 0, 01, the multicoronality test is less than 10, hypothesis testing, the results show that all hypotheses are accepted, because the C.R value is more than 1.98, namely with a C.R value of 7.875 and 11.532 respectively. And the P value also shows the same result if the P value is less than 0.05 or symbolized * (below 0.01), it means that the two hypotheses have a significant effect or are accepted. path analysis fit model test is accepted because the GFT measure shows a P-value of more than 0.05, RMSE less than 0.08, CMIN less than 2.00, GFI less than 0.90, AGFI less than, 0.90, CFI more than 0.90, TLI more than 0.90. So it can be stated that the path analysis model fit test is accepted.

Translation, Cultural Adaptation, and Validation into Romanian of the Myeloproliferative Neoplasm Symptom Assessment Form-Total Symptom Score (MPN-SAF TSS or MPN-10) Questionnaire.

Background: Patients with myeloproliferative neoplasms (MPNs) experience a high disease-related symptom burden. A specific instrument to evaluate quality of life (QoL), i.e., the MPN Symptom Assessment Form Total Symptom Score (MPN-SAF TSS; MPN-10), was developed. We conducted the translation, cultural adaptation, and validation into Romanian of the MPN-10. Methods: We translated the MPN-10 and tested its psychometric properties. Results: We recruited 180 MPN patients: 66 polycythemia vera (36.67%), 61 essential thrombocythemia (33.89%), 51 primary and secondary myelofibrosis (SMF) (28.33%), and 2 MPN-unclassifiable (1.11%). The mean TSS was 19.51 ± 16.51 points. Fatigue, inactivity, and concentration problems were the most cumbersome symptoms. We detected scoring differences between MPN subtypes regarding weight loss (p < 0.001), fatigue (p = 0.006), early satiety (p = 0.007), night sweats (p = 0.047), pruritus (p = 0.05), and TSS (p = 0.021). There were strong positive associations between TSS and inactivity, fatigue, and concentration problems, and moderate negative correlations between QoL scores and all MPN-10 items. Cronbach's α internal consistency coefficient was 0.855. The Kaiser-Meyer-Olkin construct validity test result was 0.870 and the Bartlett Sphericity Test was significant (p < 0.001). Symptom scores were loaded into one single factor according to the exploratory factor analysis. Conclusions: The Romanian MPN-10 version displayed excellent psychometric properties and is a reliable instrument for assessing symptom burden and QoL in Romanian MPN patients.

The Impact of Using Idioms Card Game Media “FARMIDIOMS” in Language Art Subject to Increase Literacy in Elementary Students

The literacy problem among elementary students persists as a significant challenge in the Indonesian education system. Literacy is one of the main focuses in elementary education. In order to increase literacy skills in students, teaching aids is an good option that can be applied in the teaching learning process. This research developed card game media called FARMIDIOMS for idioms topic in Language Arts for 3rd grade students to increase student literacy skills at Tritunggal Christian Elementary School-Semarang, Indonesia. This research and development method uses the Four-D model by S. Thiagarajan, Dorothy S. Semmel, and Melvyn I. Semmel created in 1974. There are 4 main stages, namely Define, Design, Develop, and Disseminate. This research was carried until the Develop stage due to limited time. The material expert validation test results obtained an actual score of 70 from the ideal score 75 which represents 93% and is in the “Very High” category. The media expert validation test results obtained an actual score of 66 from the ideal score of 70 which represents 94% and is in the “Very High” category. The results of the teacher and student response questionnaire also showed results in the "Very High" category. The students’ results in pre-test and post-test showed a significant increase with the Paired Samples T Test result Sig. (2-tailed) gets a result of 0.001 smaller than 0.05. From this data it can be concluded that the usage of the card game FARMIDIOMS are valid, practical, and effective in increaseing literacy skills in 3rd grade students.

Field study to determine the reliability of HIV viral load results shows minimal impact of delayed testing in South Africa.

Understanding factors that impact HIV viral load (VL) accuracy in resource-limited settings is key to quality improvement. We evaluated whether testing delay and specimen storage between 25 °C and 30 °C before testing affected results. Between November 2019 and June 2023, 249 individuals on antiretroviral therapy, or with newly diagnosed HIV, were recruited from clinics in Cape Town and Gqeberha, South Africa, and three plasma preparation tubes were collected. One tube was tested within 24 h, while the others were stored uncentrifuged at ambient temperatures before testing. Centrifugation and testing of matched samples were performed on Day 4 and Day 7 after collection. Time delay and ambient storage had minimal impact in specimens with a Day 1 VL of > 100 copies/mL. When grouped by Day 1 VL range, 96% - 100% of specimens at Day 4 and 93% - 100% at Day 7 had VLs within 0.5 log copies/mL of the first result. The greatest variability at Days 4 and 7 was observed when the Day 1 VL was < 100 copies/mL. However, there was no trend of increasing difference over time. Of Day 1 specimens with undetectable VL, or VL < 50 copies/mL, 80% had concordant results at Day 4 and 78% at Day 7. These results show that VL is stable in plasma preparation tubes for 7 days when stored at room temperature. There is significant variability in specimens with low VL, but variability is not affected by testing delay. Ideal HIV VL testing conditions are frequently unachievable in resource-limited settings. Data are needed on whether this impacts on the validity of test results. Our results provide reassurance that storage at ambient temperature for up to 7 days before testing does not substantially affect the VL result.

THE INFLUENCE OF EMOTIONAL LITERACY MATERIAL GROUP GUIDANCE SERVICES ON INCREASING SELF-EFFICACY IN CLASS X MAN 1 MEDAN STUDENTS

&lt;p&gt;This research aims to determine the magnitude of the contribution of group guidance services to increasing self-efficacy in class X MAN 1 Medan students for the 2022/2023 academic year. This research uses a quantitative approach with a quasi-experimental type by looking at changes in research data between before and after treatment. The population in this study was 384 class X students, then the sampling technique used purposive random sampling so that the sample was 8 students. The instrument used is a questionnaire instrument with a Likert scale model. The results of the instrument validity test produced 29 valid items and the reliability was 0.905. Research data was analyzed using Pearson Product Moment Correlation.&lt;/p&gt;&lt;p&gt;The research findings show that with the correlation obtained from the SPSS output model summary 26.00, the results of the hypothesis test using the Product Moment Correlation test show an output of r = 0.989 with an Asymp.Sig value. = 0.000 (2-tailed) is smaller than &amp;lt; 0.005, then Ha is accepted. Here there is a positive correlation coefficient, which means that 10 students experienced an increase in student self-efficacy scores from the Pre Test score to the Post Test score. The difference in increase in Mean Rank or average increase is 30.00, the correlation coefficient is 0.989 with an influence level of 98.9% and the rest is influenced by other variables. Thus, it can be concluded that the implementation of Group Tutoring Services can have an influence on increasing the self-efficacy of class X students at MAN 1 Medan for the 2022/2023 academic year.&lt;/p&gt;

Correlation of Character Values in the Qur'an and Hadith in Hamziyah Ahmad Syauqi Poetry Towards the Ethics of PBA College Students at UIN Walisongo

This study aims to determine the correlation of character values in the Qur'an and hadith in Hamziyah Ahmad Syauqi on the ethics of PBA UIN Walisongo College Students. The approach used to obtain data is a mix method through the technique of distributing questionnaires, observations and interviews. with the pattern "the dominant-less dominat design", Population of PBA College Students of UIN Walisongo Semarang. The samples used in this study were 50 PBA UIN Walisongo College Students, 3 lecturers and 10 College Students to conduct interviews. The data collection technique used in this needs analysis is a survey technique. The questionnaire was used as a tool that was compiled and distributed through the Google form platform. The data analysis used is descriptive statistical analysis. Based on the validity and reliability test results, it can be determined that the questionnaire used for data collection has valid and reliable items. According to the survey results, 97% of the character values contained in Hamziyah ahmad syauqi affect College Students' ethics.

Utilization of Hotspot Network Bandwidth Management at SMK Muhammadiyah Parkan

Mikrotik is a routing activity using Wireless Local Area Network (W-LAN) technology. Mikrotik is an operating system and software used to function a computer as a router. The model used in this study refers to the PPDIOO type development model with 6 stages, namely Prepare, Plan, Design, Implement, Operate, and Optimize. Validity tests and effectiveness tests include the product being able to run optimally and successfully improving the quality of existing network bandwidth. Data collection instruments used interviews and observation. Data collection was carried out in November 2022 at Muhammadiyah Parakan Vocational School. The results of the material expert validity test were 92%, the media expert validity test was 80%, the teacher response effectiveness test was 80% and the student effectiveness test was 88%

Development of Vocational Skills for Mild Mentally Retarded Children on Making Bags from Batik Cloth at the SMALB Level

Learning the vocational skills of children with mild mental retardation today has encountered many difficulties which resulted in the limitations of children in mastering the vocational skills of making bags from batik cloth. This study aims to produce a product for developing vocational skills learning for mild mentally retarded children towards making bags from batik cloth at the SMALB level. This research method uses Research and Development (R&amp;D) research to produce a certain product, and tests the effectiveness of the product to perfect a product that is in accordance with the references and criteria of the product made so as to produce a new product through various stages, validation, and testing that includes a learning video tutorial that makes it easier for mild mentally retarded children to understand and develop vocational skills in making bags from batik cloth. The conclusion of this study is that with the development of vocational skills learning for mild mentally retarded children, it is hoped that mild mentally retarded children at the SMALB level have vocational skills to make bags from batik cloth which can be used as life skills to prepare them for entering the workforce after graduation and these vocational skills need to be trained so that the vocational skills of mild mentally retarded children can develop optimally. The results of the expert validation test are in the form of learning video tutorials and bags from batik cloth which are categorized as valid and effective. The conclusion of this study is that with the development of vocational skills learning for mild mentally retarded children, it is hoped that mild mentally retarded children at the SMALB level have vocational skills to make bags from batik cloth which can be used as life skills to prepare them for entering the workforce after graduation and these vocational skills need to be trained so that the vocational skills of mild mentally retarded children can develop optimally. The results of the expert validation test are in the form of learning video tutorials and bags from batik cloth which are categorized as valid and effective. The conclusion of this study is that with the development of vocational skills learning for mild mentally retarded children, it is hoped that mild mentally retarded children at the SMALB level have vocational skills to make bags from batik cloth which can be used as life skills to prepare them for entering

Training Materials for Elementary Schools Social Sciences Teacher Forum

Subject teacher forum activities, especially in social sciences subjects at the elementary school level, have not shown significant changes in improving teacher abilities. Based on this, this research aims to develop materials for elementary schools social sciences teacher forum. This type of research is development research (Research and Development or R&amp;D) by adapting two research and development models, namely the Borg and Gall model and the Dick and Carey model. The research subjects involved 3 experts who assessed the training materials: material experts, design experts, and language experts. The research respondents were social sciences teacher forum administrators or managers, instructors or resource persons, and 20 teachers. The techniques used in collecting data were observation, questionnaires, interviews, and documentation. The instrument used to collect data was a questionnaire sheet. The techniques used for data analysis are qualitative and quantitative descriptive analysis. The research results, namely the results of validity tests by learning material experts, obtained an average value of 3.58 (valid). The assessment by the training materials design expert was 3.75 (valid). The assessment from language experts is 3.57 (valid). The effectiveness test results obtained an average value from the calculation results, namely 4.27 (very effective). It was concluded that the social sciences teacher forum training materials were declared suitable for use. It indicates that the training materials are very effective for use in the social sciences teacher forum. The implication of this research is that the MGMP IPS training materials developed can be used to improve teacher abilities.

Pengaruh Reward Dan Punishment Terhadap Kinerja Pegawai Negeri Sipil Pada Dinas Pemuda, Olahraga Dan Pariwisata Kabupaten Paser

The purpose of this research is to determine the influence of Reward (X1) and Punishment (X2) which influence jointly (simultaneously) and individually (partially) on the performance of Civil Servants at the Paser Regency Youth, Sports and Tourism Service. From the research results, it was obtained that the validity test results of the total number of questions were 22 items, all of which had a value of rcount &gt; rtable, which means that all questions were valid (feasible). From the results of the reliability test, it can be seen that the results obtained were 0.881, which means that the questionnaire items can be said to be reliable because the Cronbach's Alpha value is &gt; 0.6. From the research results of multiple linear regression analysis, the regression equation Y = 1.152 + 0.338 X1 + 0.383 X2 is obtained. The magnitude of the correlation coefficient (R) is 0.737, this shows that there is a strong relationship between the Reward variable (X1) and the Punishment variable (X2) on the Performance of Civil Servants (Y) at the Paser Regency Youth, Sports and Tourism Service. Meanwhile, the coefficient of determination (R2) is 0.543, which means that the Reward variable (X1) and Punishment variable (X2) can explain the Civil Servant Performance variable (Y) at the Paser Regency Youth, Sports and Tourism Service by 54.3% while the remaining is 45. 7% is influenced by other variables not studied. From the results of the F Test, it is obtained that Fcount is 18.432 &gt; Ftable 3.30 so it can be concluded that there is a significant influence simultaneously (simultaneously) between the Reward variable (X1) and the Punishment variable (X2) on the Civil Servant Performance variable (Y) at the Youth Service, Sports and Tourism in Paser Regency so that the first hypothesis is confirmed or Ha is accepted and H0 is rejected. From the results of the t test for the Reward variable (X1) and the Punishment variable (X2) they have a significant effect on the Performance of Civil Servants (Y) at the Paser Regency Youth, Sports and Tourism Service. Furthermore, the results of the t test show that the Punishment variable (X2) has a dominant influence on Civil Servant Performance (Y) which is strengthened by the highest t value of 2.758 and the smallest significance value of 0.010 so that the second hypothesis is proven or Ha is accepted and H0 is rejected.

Validity and Reliability of Physical Sports and Health Education's Learning Assessment of Self Defense Material for Class VII Junior High School Stud

Instruments adhering to appropriate standards are crucial in gauging the conclusive outcomes of learning activities. This ensures that student learning achievements are accurately identified, serving as evaluation benchmarks for subsequent educational programs. The present research endeavors to develop an assessment instrument for Physical Education and Health (PJOK) learning, specifically focusing on self-defense material designed for seventh-grade junior high school students. This instrument is envisaged as a valuable tool to assist educators in conducting assessments, leading to the optimization of learning skills evaluation outcomes. The research methodology employs the Research and Development approach, referencing the ADDIE development model. The analysis stage involves observation and interviews, instrument design, product development, as well as Focus Group Discussions (FGD) with learning evaluation experts. Additionally, instrument product trials are conducted to examine validity and reliability. The research involves 66 seventh-grade junior high school students as participants. The validity test was carried out using the Reproducibility Coefficient and Scalability Coefficient according to the Guttman scale test, while the reliability test used Kuder Richardson (K-R) 20. The validity test results showed that all variables had values ​​&gt; 0.90 for the reproducibility coefficient and &gt; 0.60 for the scalability coefficient so it is said to be valid. The reliability test results showed a value of &gt; 0.60 for K-R 20 so it is considered reliable. In conclusion, the PJOK learning assessment instrument for self-defense material emerges as a reliable and valid tool. Educators can confidently integrate this instrument into their assessments, leveraging its proven to be valid and reliable.

Combining enhanced spectral resolution of EMG and a deep learning approach for knee pathology diagnosis.

Knee osteoarthritis (OA) is a prevalent, debilitating joint condition primarily affecting the elderly. This investigation aims to develop an electromyography (EMG)-based method for diagnosing knee pathologies. EMG signals of the muscles surrounding the knee joint were examined and recorded. The principal components of the proposed method were preprocessing, high-order spectral analysis (HOSA), and diagnosis/recognition through deep learning. EMG signals from individuals with normal and OA knees while walking were extracted from a publicly available database. This examination focused on the quadriceps femoris, the medial gastrocnemius, the rectus femoris, the semitendinosus, and the vastus medialis. Filtration and rectification were utilized beforehand to eradicate noise and smooth EMG signals. Signals' higher-order spectra were analyzed with HOSA to obtain information about nonlinear interactions and phase coupling. Initially, the bicoherence representation of EMG signals was devised. The resulting images were fed into a deep-learning system for identification and analysis. A deep learning algorithm using adapted ResNet101 CNN model examined the images to determine whether the EMG signals were conventional or indicative of knee osteoarthritis. The validated test results demonstrated high accuracy and robust metrics, indicating that the proposed method is effective. The medial gastrocnemius (MG) muscle was able to distinguish Knee osteoarthritis (KOA) patients from normal with 96.3±1.7% accuracy and 0.994±0.008 AUC. MG has the highest prediction accuracy of KOA and can be used as the muscle of interest in future analysis. Despite the proposed method's superiority, some limitations still require special consideration and will be addressed in future research.

Optimizing the Role of User and Maintainer Groups (Kpp) in the Settlement Quality Improvement Program (Case Study of Klasabi Slum Settlement, Sorong City)

The purpose of this research is to optimize the role of the user and maintainer group (KPP) in the Klasabi slum quality improvement program of Sorong City. In this case, the environmental conditions in this settlement are reviewed, the role of KPP is evaluated, and optimization strategies are also formulated that can be used for the environmental management of Klasabi slums in Sorong City. This research is quantitative with the method used in this research, namely the descriptive method with a case study technique through data collection from the results of distributing questionnaires, interview results, direct observation, and using other official documents analyzed using validity test analysis and reliability tests. Based on the results of the data validity test and the data reliability test, it was found that the research data or questionnaire data used in the study was valid and reliable. research data or questionnaire data used in this study is valid or reliable. The results showed that environmental conditions, seen from several perspectives, including ecological, economic, social, and cultural, can be considered good. However, when viewed in ecological conditions, especially in road and drainage conditions, it is still considered adequate by the community because there is no equal distribution of facility development. Also, the role of the user and maintainer group (KPP) is assessed as not optimal in carrying out its duties and responsibilities; this is supported by the results of the conducted interviews and observations made by researchers. In addition, optimization strategies can be carried out, such as structuring the Klasabi area around Deo Airport in Sorong City, handling slum houses by the government to support the development of water tourism, optimizing the use of water hyacinth plants that can be developed by community members using SIKIM and BLK facilities, and providing capital loans to support the business of making traditional snacks, traditional Papuan handicrafts, and Papuan craftsmen certification training in Sorong City.

Abstract PO2-17-06: Real world treatment patterns and clinical outcomes by germline BRCA (gBRCA) mutation status in patients with HER2-negative early breast cancer in the US community oncology setting: a retrospective observational chart-review study

Abstract Background: Women with early-stage breast cancer (eBC) who have inherited BRCA1 or BRCA2 mutations (gBRCAm) are typically diagnosed at a younger age and often require more intensive treatment. In the randomized, double-blind OlympiA trial of HER2-negative (HER2–) gBRCAm patients, olaparib, a targeted poly (ADP-ribose) polymerase inhibitor (PARPi), significantly improved invasive disease free survival (IDFS), distant disease free survival (DDFS) and overall survival (OS) and was subsequently approved for adjuvant treatment of gBRCAm HER2– high-risk eBC patients. This study examined the real-world patient characteristics, treatment patterns and clinical outcomes by gBRCA status among patients with HER2– eBC in a US community oncology setting prior to olaparib US approval for treatment of eBC. Methods: This retrospective observational study used chart review data from The US Oncology Network's iKnowMed database to examine adult patients diagnosed with HER2– eBC (stage I-III) initiating systemic neoadjuvant or adjuvant therapy with chemotherapy and/or endocrine therapy between January 1, 2012 and December 31, 2018. Patients with valid gBRCAm test results (all gBRCAm and randomly selected BRCAwt patients) were included and followed through December 31, 2021. Patients were excluded if they had HER2+ tumors and progressed to stage IV within 6 months after initiation of neoadjuvant therapy or were diagnosed with another primary cancer. Descriptive analyses assessed patient characteristics. Kaplan Meier methods and multivariate Cox proportional hazard models (CPHM) were used to evaluate IDFS, DDFS and OS by gBRCA status and by HR+/HER2– or TNBC eBC subsets. Results: Among 298 BC patients meeting initial criteria, 42% had gBRCAm (n=124, 43% hormone receptor positive [HR+], 56% triple-negative BC [TNBC], 1% unknown), and 58% had gBRCAwt (n=174, 74% HR+, 22% TNBC). Median (interquartile) age at surgery was numerically lower in gBRCAm (45 [36,55] years) than gBRCAwt (48 [41,55] years) patients. A numerically higher proportion of gBRCAm patients received neoadjuvant therapy compared with gBRCAwt (Neoadj: gBRCAm 37.1% vs gBRCAwt 12.6%) but the reverse was true for adjuvant (Adj: gBRCAm 42.7% vs gBRCAwt 65.5%) and neoadjuvant + adjuvant use was numerically similar (Neoadj+Adj: gBRCAm 20.1% vs gBRCAwt 21.8%). The majority of TNBC patients received neoadjuvant therapy while the majority of HR+ patients received adjuvant therapy (Neoadj: TNBC 51.4% vs HR+ 6.6%, Adj: TNBC 29.0% vs HR+ 71.4%, Neoadj+Adj: TNBC 19.6% vs HR+ 22.0%). Median IDFS, DDFS, and OS in both study cohorts were not reached. Median follow-up from surgery was &amp;lt; 5 years (overall 59.0 months; gBRCAm 50.6 months; gBRCAwt 61.3 months). At 60 months, in gBRCAm and gBRCAwt respectively, estimated IDFS were 85.5% and 90.9%, estimated DDFS 88.1% and 92.2%, and estimated survival 91.9% and 95.2%. At 60 months, in HR+/HER2– and TNBC respectively, estimated IDFS were 92.4% and 81.2%, estimated DDFS 93.9% and 85.7%, and estimated survival 96.3% and 90.9%. CPHM results showed that risks of invasive disease (HR 1.74; 95% CI 0.83-3.64; p=0.15), distant disease (HR 1.24; 95% CI 0.50-3.07; p=0.65) and death (HR 1.79; 95% CI 0.52-6.13; p=0.353) were similar between gBRCAm and gBRCAwt patients. Between HR+/HER2– and TNBC patients, risks of invasive disease (HR=0.63; 95% CI 0.21-1.89; p=0.41), distant disease (HR=0.42; 95% CI 0.11-1.67; p=0.22) and death (HR 0.48; 95% CI 0.09-2.70; p=0.41) were similar. Conclusions: This real-world chart review study of data through 2021 (before PARPi approval for eBC) with limited follow up of 5 years found that gBRCAm patients had a numerically shorter survival (IDFS, DDFS and OS) than gBRCAwt, but this difference was not statistically significantly different. Given that the follow-up period was too short to draw conclusions, further studies examining clinical outcomes over a longer follow-up period after approval of PARPi may be of interest. Citation Format: Jay Andersen, Jagadeswara Earla, Nicole Fulcher, Juliet Ndukum, Nicholas J Robert, Mark Robson, Weiyan Li, Jaime Mejia. Real world treatment patterns and clinical outcomes by germline BRCA (gBRCA) mutation status in patients with HER2-negative early breast cancer in the US community oncology setting: a retrospective observational chart-review study [abstract]. In: Proceedings of the 2023 San Antonio Breast Cancer Symposium; 2023 Dec 5-9; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2024;84(9 Suppl):Abstract nr PO2-17-06.