Result Of Note Research Articles

Effects of shenling baizhu powder herbal formula on intestinal microbiota in high-fat diet-induced NAFLD rats

BackgroundWorldwide, non-alcoholic fatty liver disease (NAFLD) is a common chronic liver disease closely associated with obesity, diabetes and other metabolic diseases. Shenling Baizhu powder (SLBZP), a formulation of a variety of natural medicinal plants, has hepatoprotective properties and clinical efficacy in treating non-infectious intestinal disease. SLBZP has improved NAFLD symptoms; however, its mechanism of action is unknown. MethodsWe established an NAFLD model in rats given a high-fat diet (HFD), administered different interventions and measured serum biochemical indices and inflammatory factors. Liver tissues were stained with hematoxylin and eosin (HE) and oil red O, and colon tissues were analyzed by immunohistochemistry. The expression profiles of liver TLR4 pathway related protein was confirmed by western blotting. Changes in intestinal microbiota composition were analyzed using a 16S rDNA sequencing technique. ResultsOf note, SLBZP effectively reduced body weight in HFD-fed rats (p < 0.05). Serum biochemical analysis indicated that SLBZP decreased the serum level of total cholesterol (TC) and improved liver function. Additionally, SLBZP decreased the serum level of endotoxin, tumor necrosis factor α (TNF-α), interleukin-1β (IL-β) (p < 0.05), and decreased the expression of TLR4 pathway related protein. Pathological examination showed that SLBZP alleviates hepatic steatosis and repairs colon mucosa. Microbiome analysis revealed that SLBZP improved the abundance of intestinal microbiota. In taxonomy-based analysis, compared with control rats, SLBZP-treated rats showed obvious changes in intestinal microbiota composition. Moreover, SLBZP increased the relative abundance of short-chain fatty acid (SCFA)-producing bacteria, including Bifidobacterium and Anaerostipes. ConclusionTaken together, these results suggest that the effects of SLBZP against NAFLD may be related to the increased abundance of beneficial gut microbiota and decreased levels of LPS in the portal vein.

THE ANALYSIS OF TEACHER AND STUDENTS TALK IN INDONESIAN EFL CLASSROOM INTERACTION

This research analyzes teacher and students talk in Indonesian EFL classroom interaction in University of Kuningan in second semester who are taking Speaking 2 subject. This qualitative data was from observation, note taking, and interview. The result of classroom observation found the content cross as the most dominant characteristic in teacher and students talk, it means that most of the teaching learning process devoted to asking questions and lecturing by the lecturer. The proportation of content cross was 65.55% in the first meeting, 95.88% in the second meeting, and 97.44% in the third meeting. While, in the additional data, the most dominant category found was teacher talk. It means that all of teacher talk categories appear in each meeting. The proportation of teacher talk is 38.16% in the first meeting, 55.11% in the second meeting, and 54.83% in the third meeting. In addition, the result of note taking and interview indicated that the interaction always happened in teaching learning process among students although the lecturer�s role is still dominant.Keywords: teacher and students talk, FIAC analysis system, speaking skill

Effectiveness and Advantages of On-Site Pathology Services in the Care of Patients With Nonmelanoma Skin Cancer.

On-site pathology services are an integral part of many dermatology and surgical dermatology practices in the United States. Assess the effectiveness and advantages of on-site pathology services. Biopsy data from 7 practices with on-site pathology services were reviewed to determine the diagnostic accuracy of malignancies from all lesional biopsies. Patient preference and convenience were queried and measured with satisfaction surveys. Of note, 1,052/1,379 (76.3%) of biopsies demonstrated a malignancy. Most patients underwent treatment of malignant lesions on a different day than the biopsy. Of the patients who scheduled a return visit for surgery on a later date, 42/246 (17.1%) reported incurring additional costs and 44/249 (17.7%) had a relative/friend who was inconvenienced. On-site pathology services provide efficient, effective, and convenient care for skin cancer patients. Fellowship-trained dermatologic surgeons use on-site pathology services to diagnose and treat clinically relevant nonmelanoma skin cancer.

Effect of Early Tracheostomy on Resource Utilization and Clinical Outcomes in Critically Ill Patients

Background Early tracheostomy may decrease the duration of mechanical ventilation, sedation exposure, and intensive care stay, possibly resulting in improved clinical outcomes, but the evidence is conflicting. Methods Systematic review and meta-analysis of randomized trials in patients allocated to tracheostomy within 10 days of start of mechanical ventilation was compared with placement of tracheostomy after 10 days if still required. Medline, EMBASE, the Cochrane Controlled Clinical Trials Register, and Google Scholar were searched for eligible trials. The co-primary outcomes were mortality within 60 days, and duration of mechanical ventilation, sedation, and intensive care unit stay. Secondary outcomes were the number of tracheostomy procedures performed, and incidence of ventilator-associated pneumonia (VAP). Outcomes are described as relative risk or weighted mean difference with 95% confidence intervals. Results Of note, 4482 publications were identified and 14 trials enrolling 2406 patients were included. Tracheostomy within 10 days was not associated with any difference in mortality [risk ratio (RR): 0.93 (0.83–1.05)]. There were no differences in duration of mechanical ventilation [−0.19 days (−1.13–0.75)], intensive care stay [−0.83 days (−2.05–0.40)], or incidence of VAP. However, duration of sedation was reduced in the early tracheostomy groups [−2.78 days (−3.68 to −1.88)]. More tracheostomies were performed in patients randomly assigned to receive early tracheostomy [RR: 2.53 (1.18–5.40)]. Conclusion We found no evidence that early (within 10 days) tracheostomy reduced mortality, duration of mechanical ventilation, intensive care stay, or VAP. Early tracheostomy leads to more procedures and a shorter duration of sedation.

A prospective comparison of the pathologic and surgical outcomes obtained after elective treatment of renal cell carcinoma by open or robot-assisted partial nephrectomy

ObjectiveTo prospectively compare surgical and pathologic outcomes obtained by elective robot-assisted (RAPN) or open partial nephrectomy (OPN) for small renal cell carcinoma (RCC). Materials and methodsBetween 2008 and 2010, after protocol design and patient consent, we prospectively collected clinical data for 100 patients who concurrently underwent either OPN (58) or RAPN (42) by an individual experienced surgeon. Clinical data included age, BMI, and past medical history. Operative data included operative time, warm ischemia time (WIT), and estimated blood loss (EBL). Postoperative outcomes included hospital stay (LOS), creatinine variation, Clavien complications, pathologic results, and survival. We stratified the complexity of the renal tumor using the R.E.N.A.L Nephrometry score. ResultsOf note, RAPN was superior to OPN in terms of EBL (median 143 mL vs. 415; P < 0.001) and LOS (median 3.8 days vs. 6.8; P < 0.0001). The median WIT for the RAPN group was 17.5 minutes (vs. 17.1 OPN; P = 0.3)) and the mean strict operative time was 134.8 minutes (vs. 128.4 OPN; P = 0.097). Regarding immediate, early, and short-term complications, variation of creatinine levels, and pathologic margins, the rates were equivalent for both groups (P > 0.05). According to the R.E.N.A.L nephrometry scores, both groups (RAPN/OPN) had similar rates (%) of low (81/72.4) and intermediate (19/20.7) complexity tumors, though there were 4 high complexity tumors in OPN group (vs. 0; P = 0.03). ConclusionWe found that RAPN is superior to the reference standard (OPN) surgical treatment of small RCCs in terms of blood loss and length of hospital stay with equivalent complications, warm ischemia time, and effect on renal function. Larger randomized trials with longer follow-up will give us further information and insight into the oncologic equivalence.

The ψ-associate X # of a flat X in PG(n, 2)

For a given hypersurface ψ in PG(n, 2), with equation Q(x) = 0, where Q is a polynomial of (reduced) degree d > 1, a definition is given of the ψ-associate X # of a flat X in PG(n, 2). The definition involves the fully polarized form of the polynomial Q; in the cubic case d = 3 it reads: X # = {zn, 2) | Tx, y, z) = 0 for all x, y}, where T(x, y, z) denotes the alternating trilinear form obtained by completely polarizing Q. Some general results, valid for any degree d and projective dimension n, are first expounded. Thereafter several choices of ψ are visited, but for each choice just a few aspects are highlighted. Despite the partial nature of the survey quite a variety of behaviours of the ψ-associate are uncovered. Many of the choices of ψ which are considered are of cubic hypersurfaces in PG(5, 2). If ψ is the Segre variety it is shown that the 48 planes external to fall into eight pairs of ordered triplets {(P 1, R 1, S 1), (P 2, R 2, S 2)} such that and . Further those lines L of PG(5, 2) which are singular, satisfying that is L # = PG(5.2), are in this case shown to form a complete spread of 21 lines. Another result of note arises in the case where ψ is the underlying 35-set of a non-maximal partial spread Σ5 of five planes in PG(5, 2), where it is shown that one plane is singled out by the property that every line is singular.

Isotopic discrimination of resource partitioning among ungulates in C3-dominated communities from the Miocene of Florida and California

Stable isotope analysis of mammalian tooth enamel is a valuable method for examining resource partitioning in modern and ancient environments where there is a mixture of C3 and C4 plants. However, before 7 Ma North American ecosystems were composed predominantly of C3 plants, complicating isotopic assessment of resource partitioning. Study of modern African and North American ecosystems has shown that niche partitioning among mammals may be discerned in communities dominated by C3 plants, suggesting that a similar approach may work for ancient C3 ecosystems. Here, such analyses are applied to explore resource use and niche partitioning in two ancient C3-dominated communities, one from California and one from Florida. Each locality, Black Hawk Ranch (California) and the Love Bone Bed (Florida), occurs in Miocene deposits that accumulated prior to the rapid increase in C4 ecosystems 7 Myr ago. δ13C and δ18O values were obtained from the tooth enamel of eight species from Black Hawk Ranch, and 15 species from the Love Bone Bed. Results from the 197 bulk isotope samples showed significant differences in δ13C among taxa at the Love Bone Bed, but no significant differences were observed among taxa at Black Hawk Ranch. At both localities, equids generally have more positive δ13C values than co-occurring taxa, suggesting that equids occupied more open habitats, whereas antilocaprids, camelids, and proboscideans have more negative values, implying utilization of more closed communities. One result of note is the positive δ13C values of Pediomeryx (Yumaceras) hamiltoni from the Love Bone Bed, which suggests that P. (Y.) hamiltoni incorporated abundant fiber, possibly grass, in the diet similar to the horses from this locality. The lack of significant differences among taxa at Black Hawk Ranch may indicate a relatively homogeneous flora, or presence of abundant resources permitting niche overlap, whereas the opposite is implied by the presence of significantly different isotope values among taxa at the Love Bone Bed. The results from this study highlight the utility of isotopic techniques allowing discernment of resource partitioning in C3-dominated landscapes such as those that persisted for the millions of years before the rapid increase in C4 ecosystems that occurred during the late Miocene.

Triage in a public outpatient sexual health clinic

The increasing prevalence of sexually transmissible infections in Australia, coupled with a NSW Health Department requirement to target services to those most in need, has led many services to investigate patient triage as a way of better using scarce resources. In October 1997, a Triage Nurse position was trialled that aimed to facilitate the optimal flow of patients through the Sydney Sexual Health Centre (SSHC) clinic in an efficient and patient-focussed manner. A pre and post implementation time-flow study was conducted to analyse the effect. A staff survey was also completed to ascertain staff acceptance of the Nurse Triage system. A time-flow data survey tool was developed and placed in the medical record of every person attending the SSHC in one month in 1997 and again in 1999. The staff survey was an 11-item likert scale questionnaire administered to all centre staff. Data were analysed and average visit and waiting times were generated. When comparing 1997 with 1999 data, the main results of note were that the length of consultation had been stable or decreased, the average wait time had remained stable or decreased and the wait time in the medical and nursing unbooked clinic had decreased. The average wait time for the unbooked clinic had decreased from approximately 24 minutes in 1997 to approximately 12 minutes in 1999. Since the introduction of Nurse Triage, the average overall waiting times for those who attend without an appointment has halved and the wait to see a doctor and a nurse has decreased. The majority of staff felt that the triage process had improved patient flow.

Description and simulation of an active imaging technique utilizing two speckle fields: iterative reconstructors.

Quasi-monochromatic light will form laser speckle upon reflection from a rough object. This laser speckle provides information about the shape of the illuminated object. In a prior paper [J. Opt. Soc. Am. A 19, 444 (2002)], it was shown that two intensities of two speckle patterns and their interference are sufficient to produce an unambiguous (except for object translation) band-limited image of the object, based on a root-matching technique described therein, in the absence of measurement error and in the case of distinct roots of the field polynomials and their complex conjugates. On the other hand, algorithms based on the root-matching technique are found to be slow and sensitive to noise. So motivated, several other techniques are applied to the problem, including phase retrieval, expectation maximization, and statistical maximization. The phase-retrieval and expectation-maximization techniques proved to be most effective for reconstructions of complex objects larger than 10 pixels across, and high-quality images were formed by using three independent sets of two-field data (three frames of two-wavelength data), each comprising two speckle intensity patterns and their interference. Two additional results of note are reported. First, the expectation-maximization algorithm produced relatively good images when three or more frames each of only one speckle intensity pattern (data at just one wavelength) were used and second, the phase-retrieval algorithm when only the object autocorrelation was used also produced relatively good images for the chosen test object.

Improved Design of Queueing Simulation Experiments with Highly Heteroscedastic Responses

Simulation experiments for analysing the steady-state behaviour of queueing systems over a range of traffic intensities are considered, and a procedure is presented for improving their design. In such simulations the mean and variance of the response output can increase dramatically with traffic intensity; the design has to be able to cope with this complication. A regression metamodel of the likely mean response is used consisting of two factors, namely, a low-degree polynomial and a factor accounting for the exploding mean as the traffic intensity approaches its saturation. The best choice of traffic intensities at which to make simulation runs depends on the variability of the simulation output, and this variability is estimated using analytical heavy traffic results. The optimal numbers of customers simulated at each traffic intensity are built up using a multistage procedure. The asymptotic properties of the procedure are investigated theoretically. The procedure is shown to be robust and to be more efficient than more naive procedures. A result of note is that even when the range of interest includes high traffic intensities, the highest traffic load simulated should remain well away from its upper limit; but the number of customers simulated should be concentrated at the higher traffic intensities used. Empirical results are included for simulations of a single server queue with different priority rules and for a complicated queueing network. These results support the theoretical results, demonstrating that the proposed procedure can increase the accuracy of the estimated metamodel significantly compared with more naive methods.

Distance From Projections to Nilpotents

AbstractThe distance from an arbitrary rank-one projection to the set of nilpotent operators, in the space of k × k matrices with the usual operator norm, is shown to be sec(π/(k:+2))/2. This gives improved bounds for the distance between the set of all non-zero projections and the set of nilpotents in the space of k × k matrices. Another result of note is that the shortest distance between the set of non-zero projections and the set of nilpotents in the space of k × k matrices is .

Rehabilitation service utilization models: Changes in the opportunity structure for disabled women

The focus of this paper is the opportunity structure for rehabilitation and subsequent outcome for disabled women, in comparison with disabled men. From evidence cited in the literature the differential provision of rehabilitation and other supportive services to disabled women suggests variation in outcome, based on two analytic service utilization models of rehabilitation: medical and psychosocial. Aggregate trend data (1972 and 1978) were used in the analysis of adult disabled groups, by gender and selected disabling conditions. There are two striking results from the analysis of these data sets. One indicates that receipt of rehabilitation is greatly influenced by sociodemographic factors, particularly gender and age. A detailed examination of the combination effects of gender and other sociodemographic variables shows that there are subtleties, such as an interaction between race and gender and education and gender, as well as between age and gender, that put uneducated, younger, white women at a disadvantage in their access to rehabilitation resources. The analysis of these sociodemographic factors over two points in time, however, demonstrates what can be considered a diffusion of the distinctions of social inequality, probably due to changes in rehabilitation legislation that redefined eligibility criteria for rehabilitation services and expanded programme goals. The second result of note is that neither form of rehabilitation is associated with a positive outcome, in this case ability to work. In the earlier data set (1972), indications were that neither the medical model of rehabilitation nor the psychosocial model were effective in returning the individual to the work role. This was true for both men and women.(ABSTRACT TRUNCATED AT 250 WORDS)

A geometrical measure for entropy changes

The geometrical approach to statistical mechanics is used to discuss changes in entropy upon sequential displacements of the state of the system. An interpretation of the angle between two states in terms of entropy differences is thereby provided. A particular result of note is that any state can be resolved into a state of maximal entropy (both states having the same expectation values for the constraints) and an orthogonal component. A cosine law for the general case is also derived.