Asphalt mixtures for road pavements are produced and laid at high temperatures, producing gaseous emissions that contain polycyclic aromatic hydrocarbons and volatile organic compounds that paving workers are exposed to. This paper aims to combine the effects of gaseous emissions on human health with the life cycle impacts of wearing courses. The results of sanitary-environmental risk analysis and life cycle assessment were combined in an integrated approach, the life cycle risk analysis, to evaluate the environmental performance of road pavements and local cancer and toxicological effects on workers. Two asphalt mixtures modified with crumb rubber (CR) from end-of-life tires (gap and dense graded) were compared to standard, unmodified asphalt mix. Air samples were collected at the screed and the driver’s seat of a paver during the construction of a full-scale trial section in Turin, Italy. The CR wearing course with a higher asphalt binder content (gap-graded) had a cancer effect on workers 3.5 and 2.9 times higher than the CR mixture with a lower asphalt binder percentage (dense-graded) and the standard mixture, respectively. Instead, the toxicological effects were 1.3 and 1.2 times higher for the gap-graded mixture than the dense-graded and the standard mix, respectively.