Image retargeting aims to obtain high visual quality of target images for human vision. Through semantic segmentation and understanding of input images, we can better preserve the important semantic regions, so as to effectively improve the performance of image retargeting. Benefit from the successful application of deep neural network in the field of semantic segmentation, in this paper, we propose a novel image retargeting approach using semantic segmentation and pixel fusion. Compared with existing image retargeting methods, our approach can effectively reduce geometric distortion during image retargeting by finely reallocating scaling factors for each region based on the semantic segmentation results. Experimental results demonstrate that the proposed approach can well preserve important semantic regions while leaving less unnatural geometric distortion. Our approach also shows the important role of semantic segmentation and understanding of scenes in image retargeting in detail.