To understand the physical condition and change rule of undergraduate students of different nationalities in Guangxi in their four-year life, and to provide basis for Han and minority students to formulate measures to enhance their physical condition and prevent physical decline. By using the methods of literature review and mathematical statistics, the monitoring data of 3314 students of Grade 2015 from Guangxi University of Science and Technology with complete 4-year physical fitness test results were analyzed. 14.45% of the freshmen had normal BMI and the seniors did not meet the standard. 21.03% of the freshmen and seniors did not meet the BMI standard. 10.29% of freshmen whose BMI is not up to standard and seniors are normal; 54.22% of the freshmen and seniors had normal BMI. The differences in height, weight and vital capacity between Han students and minority students are statistically significant. On the whole, the physique of Han students is better than that of minority students. The physical changes of Han students and minority students in 4 years have their own characteristics. It is an effective way to promote the physical health of college students of different nationalities to continuously study and improve the methods and means of physical health monitoring, strengthen the exchange and mutual learning of national cultures, and advocate a healthy campus cultural atmosphere.