Temperature Limit Research Articles

Functional suppression of a yeast maf1 deletion mutant by overdose of the N-terminal fragment of the largest RNA polymerase III subunit, C160

Maf1 is a general and global negative regulator of RNA polymerase III (Pol III) transcription. Under repressive conditions, Maf1 binds directly to the Pol III complex and sequesters Pol III elements that are involved in transcription initiation. To further understand Pol III regulation, we searched for genetic bypass suppressors of a maf1 deletion mutant (maf1Δ) of Saccharomyces cerevisiae. Strains that carried maf1Δ were temperature-sensitive on media that contained nonfermentable carbon sources and showed the antisuppressor phenotype. Suppressors allowed colonies to grow at the restrictive temperature on glycerol media and partially complemented the antisuppressor phenotype of maf1Δ. DNA plasmids that were identified as overdose suppressors encoded N-terminal fragments of the largest Pol III subunit, C160 of various lengths. The shortest fragment, 372 amino acids long, the overdose of which partially complemented the antisuppressor phenotype and temperature-sensitive respiratory growth of maf1Δ, was named C160-NTF. In this study, we showed that the expression of HA-tagged C160-NTF resulted in accumulation of approximately 40 kDa protein that was distributed throughout the yeast cell, in the cytoplasm and nucleus. The overdose of C160-NTF led to decrease of tRNA transcription in maf1Δ mutant cells, demonstrating functional suppression. Levels of newly synthesized individual tRNAs and Pol III occupancies on tRNA genes were decreased by C160-NTF in the maf1Δ mutant. Additionally, we analyzed the effect of C160-NTF overproduction and the presence of Maf1 on the associations among Pol III subunits. Previous structural analyzes of Pol III have indicated that the N-terminal region of C160 interacts with the C82-34-31 heterotrimeric Pol III subcomplex. We suggest that the negative effect of C160-NTF overdose on tRNA transcription is related to defective Pol III assembly, because overproduction of C160-NTF altered C160 interactions with C34 and C82 in the maf1Δ mutant.

ANALISIS PERBANDINGAN KINERJA SISTEM PENDINGIN PV DENGAN CAIRAN AQUADES, AIR SUMUR, DAN TANPA PENDINGIN DENGAN MONITORING IOT

Solar Power Plants are an environmentally friendly energy source that utilizes sunlight energy which is converted into electricity. However, solar panels must maintain their performance. One of the impacts is that solar panels cannot work optimally if the temperature of the solar panels exceeds the safe temperature. This research examines the factors that cause the performance of solar panels to not work optimally, when the surface temperature of the solar panels is too hot and exceeds the safe temperature limit, then tools are needed to help the solar panels so that the working temperature is not too high. The technology used to control the temperature of solar panels is by utilizing IoT by maximizing the DS18B20 sensor and voltage sensor, to read the surface temperature of the panel, which will then wet the surface of the solar panel with distilled water and well water automatically if the surface temperature of the panel exceeds the safe temperature on the solar panel. And later you can monitor the temperature of the panel with a smartphone and also observe whether distilled water and well water can reduce the temperature on the surface of the panel. When collecting data, it can be compared to when without using cooling, the temperature on the panel is above 33 degrees. Meanwhile, when using a cooler the temperature obtained decreases. The well water cooler produces a temperature of 32 degrees, while the distilled water cooler produces a temperature of 30.5 degrees. It can be concluded that distilled water can reduce the temperature of the panel, so it can make the panel work optimally. So, in order to maximize the performance of the panels to utilize solar power, in this research, distilled water is very good for lowering the temperature on the surface of the panels.

Quantum gravity of the Heisenberg algebra

We consider a simplified model of double scaled SYK (DSSYK) in which the Hamiltonian is the position operator of the Harmonic oscillator. This model captures the high temperature limit of DSSYK but could also be defined as a quantum theory in its own right. We study properties of the emergent geometry including its dynamics in response to inserting matter particles. In particular, we find that the model displays de Sitter-like properties such as that infalling matter reduces the rate of growth of geodesic slices between the two boundaries. The simplicity of the model allows us to compute the full generating functional for correlation functions of the length mode or any number of matter operators. We provide evidence that the effective action of the geodesic length between boundary points is non-local. Furthermore, we use the on-shell solution for the geodesic lengths between any two boundary points to reconstruct an effective bulk metric and reverse engineer the dilaton gravity theory that generates this metric as a solution.

An individualized adaptive distributed approach for fast energy-carbon coordination in transactive multi-community integrated energy systems considering power transformer loading capacity

The optimization of multi-community integrated energy systems (MCIES), as a proficient means of integrating distributed energy resources and diverse loads, poses a compelling challenge. This challenge revolves around strategically harnessing the energy-carbon synergy advantages within these systems, while factoring in the heterogeneity among different communities and the constraints imposed by electrical connectivity devices. Facing the challenge, this paper proposes an individualized adaptive distributed approach for energy-carbon coordination in MCIES with power transformers (PT-MCIES). Firstly, a feasible region is constructed based on current and temperature limits to assess the loading capacity of power transformers. Based on this, a transactive energy (TE) based co-optimization model for PT-MCIES considering energy sharing and carbon trading is developed, where rolling horizon optimization is adopted to cope with the randomness from renewable energy and loads. For the TE problem, the alternating direction method of multipliers (ADMM) algorithm is employed to achieve distributed optimization. Uncertain renewable energy and loads, along with variable rolling horizons, make it difficult for the traditional ADMM to ensure convergence speed in the co-optimization of PT-MCIES. Accordingly, an individualized adaptive ADMM (IAADMM) embedded a spectral penalty parameter selection rule is adopted. Simulation results show that the proposed scheduling model can effectively guarantee the safe operation of power transformers with the suggestion of a feasible region, and achieve higher economic and environmental benefits than the reference one that ignores energy-carbon coordination. Furthermore, the proposed IAADMM exhibits superior performance in terms of convergence speed and robustness to the initial penalty parameter when compared to ADMM and its various variants.

Non-chemical stresses do not strongly induce male offspring in Daphnia magna ascertained using the short-term juvenile hormone activity screening assay.

Juvenile hormone (JH), together with ecdysone, regulates molting, metamorphosis, growth, and reproduction in arthropods. The effects of its analogs used as insecticides on nontarget species are of concern. Since JH and JH analogs (JHAs) induce male offspring in daphnids, which generally reproduce by parthenogenesis, short-term JH activity screening assay (JHASA) using the male offspring ratio as an endpoint has been developed as a detection method for JHA. However, the production of male offspring is also induced by environmental stresses such as temperature, short-day length, overcrowding, and food limitation. Thus, it is vital to prevent non-chemical stresses from inducing male offspring during the test to detect chemicals with potential JH activity accurately. Therefore, we investigated the effects of temperature (low and high), hardness, high density with low feeding, and day length on male production utilizing JHASA. Male offspring were not strongly induced by any stresses in JHASA, although the male ratios of 4-12% were observed in the preculture under high density (≥70 daphnid/L) and constant darkness. The Clone A strain was relatively more sensitive to high density and day length compared with the strain from National Institute for Environmental Studies (NIES). The selection of strains that rarely produce males under non-chemical stresses and finding the culturing conditions for each strain appropriate for not-inducing male offspring are recommended to control and prevent male offspring induction during JHASA.

Buckling prediction based on joint opening and safe temperature estimation in jointed plain concrete pavements

Concrete pavement buckling is a significant distress that disrupts traffic flow and results in costly repairs, issues that are increasingly exacerbated by global warming. Addressing these issues, this study develops a systematic framework for assessing jointed plain concrete pavement (JPCP) by integrating temperature and moisture gradients, pavement structures, and material properties into mechanical-based models for predicting buckling potential. Specifically, a two-stage analysis is developed to analyze buckling development based on the slab deformation and the slab-base interface, including joint closure assessment and upheaval buckling prediction. Through the established model, parametric studies are conducted to quantitatively identify key factors influencing buckling. Moreover, the developed models are applied to pavement sections in various climate regions and validated through comparative analysis with field data from the Long-Term Pavement Performance (LTPP) database to confirm model accuracy. Additionally, a case study using pavement buckling data from Wisconsin between 2014 and 2020 demonstrates the model's practical application. As the results, it is found that temperature increase, the percentage of incompressible materials, and the coefficient of thermal expansion are critical for joint opening changes, while the coefficient of thermal expansion, elastic modulus, and slab thickness are crucial to post-buckling performance. Regression equations are provided to estimate safe temperature increases as a recommended buckling temperature limit. Furthermore, the predicted joint opening shows reasonable alignment with joint gauge measurement in the field recordings from the LTPP database. Finally, the predicted buckling events are reasonably compared with field recordings for a Wisconsin pavement section from 2014 to 2020. In summary, by considering pavement structural parameters, material properties, and weather conditions, this comprehensive model provides a reasonable tool for predicting and mitigating JPCP buckling in different climate conditions.

Breaking the Temperature Limit of Lithium-Ion Batteries With Carbon Nanotube-Based Electrodes and "Constructive Alliance" Electrolyte Strategy.

Lithium-ion batteries (LIBs) are paramount in energy storage in consumer electronics and electric vehicles. However, a narrow operating temperature range severely constrains their evolution. In this study, a wide-temperature operating LIB system is constructed utilizing carbon nanotube (CNT)-based electrodes and a "constructive alliance" electrolyte. The unique microstructure of the CNT current collector, with high electrical and thermal conductivity, accelerates the reaction kinetics of active materials at subzero temperatures and optimizes the thermal management of the entire electrode at elevated temperatures. Furthermore, a strategy employing the "constructive alliance" electrolyte is proposed, demonstrating that a simple combination of commercially available electrolytes can enhance resilience to harsh thermal conditions. Molecular dynamics simulations and density functional theory calculations reveal that the hybrid electrolyte predominantly adopts aggregate solvation structures and possesses low Li+ desolvation barriers regardless of thermal variations. Consequently, the assembled Li4Ti5O12//LiCoO2 full cell, with a negative/positive electrode material ratio of 1.2, exhibits outstanding electrochemical performance in the wide temperature range of -40 and 60°C. This innovative strategy overcomes challenges in wide-temperature electrolyte research and offers promise for next-generation wide-temperature LIBs.

Reflected entropy and timelike entanglement in TT¯ -deformed CFT2s

We develop a covariant formalism to investigate the mixed state entanglement between time-dependent boosted subsystems in TT¯-deformed CFT2s through the reflected entropy. To this end we utilize a conformal perturbation theory to obtain the Rényi reflected entropy through the partition function on the replica manifold. The correction to the reflected entropy to the first order in the deformation parameter μ is then obtained in the replica limit for finite temperature and finite-sized systems. We further perform an analytic continuation of our results to obtain the reflected entropy for timelike subsystems in such TT¯-deformed CFT2s. We verify our field theoretic computations for both spacelike and timelike subsystems by obtaining the dual EWCS in the corresponding bulk cutoff AdS3 geometries and find perfect agreement between the two. Published by the American Physical Society 2024

Vaporization thermodynamics of normal alkyl azides

Two n-alkyl azides, n-tetradecyl- and n-octadecyl azides, were synthesized and characterized by differential scanning calorimetry and fast scanning calorimetry. Based on the experiments performed, the enthalpies and temperatures of solid-solid transitions and fusion, condensed phase heat capacities, vapor pressures above the liquids, and vaporization enthalpies were obtained, and temperature limits of stability were determined. Combining the newly obtained and existing literature data on the vaporization characteristics of n-alkyl azides, the linear dependences of the vaporization enthalpy and the natural logarithm of vapor pressure on the chain length were derived at 298.15 K and the p-T properties of unstudied members of homologous series were predicted.

Gambaran Tingkat Pengetahuan Swamedikasi Demam pada Balita di Posyandu Desa Karanganyar Kecamatan Tamansari Kabupaten Boyolali

Fever is a condition where the body temperature is above the normal temperature limit, namely ≥ 38°C. If fever is not treated immediately, seizures can occur in toddlers which endangers the toddler's safety. In Indonesia, it was reported that the incidence of febrile seizures was 3-5% of children aged 5-6 months in 2017-2018. This figure continues to increase to 6% in 2019. Fever is one of the symptoms that can be treated with self-medication. The Indonesian Ministry of Health explains that self-medication is a person's attempt to treat the symptoms of a disease without consulting a doctor. The aim of this study was to determine the level of knowledge about fever self-medication among toddlers at posyandu. This research method is descriptive. The sample in this study was mothers of toddlers who were active members of the posyandu with a total of 93 respondents. Sample selection used purposive sampling. The instrument in this research used a questionnaire distributed to 93 respondents. The results of this study show that of the 93 respondents with characteristics aged 26-30 years 69.9%, high school education 86.0%, private employment 80.6% and the level of knowledge of fever self-medication at posyandu in the good category 86.0%, moderate category 11.8% and the less than 2.2% category. The conclusion is that the level of knowledge about fever self-medication in toddlers at the posyandu in Karanganyar Village, Tamansari District, Boyolali Regency is included in the good category, namely 86.0%.

Utilizing screen printing technology to fabricate tungsten-rhenium thick film thermocouples with a maximum temperature limit of 1600 °C

Tungsten-rhenium thick film thermocouples (TFTCs) show excellent potential for in-situ high-temperature monitoring due to their high-temperature resistance. However, the only reported method for preparing tungsten-rhenium thin film thermocouples is magnetron sputtering. The upper limit of temperature resistance of thetungsten-rhenium thin film thermocouples prepared by this method is low because the thickness is reduced by continuous thermal ablation at high temperatures. In this work, screen printing technology is used to prepare tungsten-rhenium TFTCs. The tungsten-rhenium TFTCs’ temperature accuracy is better than ±1.5 %, repeatability is better than 0.9 %, and drift is only 0.26 %/h at 1600 °C. Finally, the tungsten-rhenium TFTC temperature ring array is installed in a tubular furnace for high-temperature monitoring, and the tungsten-rhenium TFTC is heated in the air using a high-temperature flame gun at approximately 1000 °C for up to 30 s. This method to fabricate tungsten-rhenium TFTCs has the potential for temperature measurement in extremely harsh environments.

Effect of linear antenna chemical vapor deposition process parameters on the growth of nanocrystalline diamond-on-GaN films

The present work will systematically study the effect of different linear antenna microwave plasma enhanced chemical vapor deposition (LACVD) processing parameters on the optimal deposition of the diamond films. The low pressure and low temperatures of LACVD growth conditions is expected to deposit diamond films on otherwise reactive gallium nitride (GaN) surfaces, without any intermediate nitride buffer layer. First, the distances between the quartz tube and the samples put on the stage are varied (3–15 cm), which has a direct impact on the substrate temperature (415°–300 °C). Thereafter, the microwave input power was also altered (1.5–2.8 kW) to attain low substrate temperatures. It was found that 300 °C is the temperature limit, which can be attained by heating only with microwave plasma when the substrates are kept farthest (15 cm) away from the liner antenna quartz tube. An additional heater was used under the stage for rapidly achieving such minimum substrate temperature of 300 °C. Substrate heater was used for efficient growth of the diamond phase while using pulse mode frequency of microwave power input for optimization of the diamond films. The microstructure (plate-like and cauliflower-like) of the deposited nanocrystalline diamond (NCD) films and the cross-sectional images for thickness measurements was observed under the scanning electron microscope and the elemental analysis of the film surfaces was done by electron diffraction spectroscopy. Moreover, the diamond film quality and crystallinity were evaluated by Raman spectroscopy with 488 nm laser light. Diamond-on-GaN film results were compared with conventional Si substrate. Different LACVD reactor parameters like, antenna to stage distances, microwave input power in continuous wave mode, and growth temperatures have significant impacts on the grown films, both in terms of their quality and microstructure. It was found that the optimum deposition of nanocrystalline diamond film on GaN substrates without its surface etching was possible, under pulse mode (20 kHz, 45 % duty cycle) with 2 kW average input microwave power.

Complex partition function of 1-dimensional Dirac particle confined in Woods-Saxon interaction

We present the bound state solutions of one-dimensional Schrödinger and Dirac equations for a particle confined in Woods-Saxon potential. In each case the wavefunctions and the energy eigenvalues have been obtained in terms of the Jacobi polynomials by using the Nikiforov-Uvarov method. The complex eigenenergy obtained from the Dirac equation is explicitly shown to contain the nonrelativistic energies plus complex relativistic correction terms The quantum partition functions obtained using the relativistic and the nonrelativistic energies have been used to generate important thermodynamic properties of the system in the high temperature limit. In particular, the complex partition function obtained in the relativistic regime is taken to indicate some important physical effects in the system.

Thermodynamic formulation of vacuum energy density in flat spacetime and potential implications for the cosmological constant

We propose a thermodynamical definition of the vacuum energy density ρvac, defined as 〈vac|Tμν|vac〉 = − ρvacgμν, in quantum field theory in flat Minkowski space in D spacetime dimensions, which can be computed in the limit of high temperature, namely in the limit β = 1/T → 0. It takes the form ρvac = const ∙ mD where m is a fundamental mass scale and “const” is a computable constant which can be positive or negative depending on interaction couplings. Due to modular invariance ρvac can also be computed in a different non-thermodynamic channel where one spatial dimension is compactifed on a circle of circumference β and we confirm this modularity for free massive theories for both bosons and fermions for D = 2, 3, 4. We list various properties of ρvac that are generally required, for instance ρvac = 0 for conformal field theories, and others, such as the constraint that ρvac has opposite signs for free bosons verses fermions of the same mass, which is related to constraints from supersymmetry. Using the Thermodynamic Bethe Ansatz we compute ρvac exactly for 2 classes of integrable QFT’s in 2D and interpreting some previously known results. We apply our definition of ρvac to Lattice QCD data with two light quarks (up and down) and one additional massive flavor (the strange quark), and find it is negative, ρvac ≈ − (200 MeV)4. Finally we make some remarks on the Cosmological Constant Problem since ρvac is central to any discussion of it.

Fabrication, Modeling, and Testing of a Prototype Thermal Energy Storage Containment

Abstract Increasing penetration of variable renewable energy resources requires the deployment of energy storage at a range of durations. Long-duration energy storage (LDES) technologies will fulfill the need to firm variable renewable energy resource output year round; lithium-ion batteries are uneconomical at these durations. Thermal energy storage (TES) is one promising technology for LDES applications because of its siting flexibility and ease of scaling. Particle-based TES systems use low-cost solid particles that have higher temperature limits than the molten salts used in traditional concentrated solar power systems. A key component in particle-based TES systems is the containment silo for the high-temperature (>1100 ∘C) particles. This study combined experimental testing and computational modeling methods to design and characterize the performance of a particle containment silo for LDES applications. A laboratory-scale silo prototype was built and validated the congruent transient finite element analysis (FEA) model. The performance of a commercial-scale silo was then characterized using the validated model. The commercial-scale model predicted a storage efficiency above 95% after 5 days of storage with a design storage temperature of 1200 ∘C. Insulation material and concrete temperature limits were considered as well. The validation of the methodology means the FEA model can simulate a range of scenarios for future applications. This work supports the development of a promising LDES technology with implications for grid-scale electrical energy storage, but also for thermal energy storage for industrial process heating applications.

Сравнительное изучение сохранности антоцианов в гранатовых соках-заготовках горячего розлива

Abstract. Taking into account the biological and antioxidant activity of anthocyanins and their responsiveness to various technological factors, the purpose of this work was to identify a balance between the total losses of anthocyanins and anthocyanins of sediment in experimental samples of pomegranate juice-semi-finished product. The juice of pomegranates of the Guleisha pink variety from Geokchai (Azerbaijan), obtained from their grains using a laboratory press, was used as the starting material. The freshly squeezed juices were filtered through a multilayer gauze filter, additives were introduced into some of them to stabilize the color, after which they were stabilized by hot filling (heated to 85 оC in 15 minutes), using preservatives (sorbic acid, sodium benzoate) or by instant heating and cooling in tubular heat exchangers. The juices were stored in a regular warehouse at a lower temperature limit of 5 оC and an upper temperature limit of 18 оC. Cold storage of one of the hot filling juices and juice from instant heating to 85 оC and cooling to 15-20 оC (both in 10 seconds) at a temperature of 0...+ 1 оC was also tested. Changes in anthocyanins were judged by the optical density of the tested solutions at a wavelength of 520 nm before and after treatment with hydrogen peroxide, which discolors anthocyanins and does not act on newly formed dark-colored pigments. It was found that at the end of the specified shelf life, the total color intensity of semi-finished juices increased by 6.2...10.2 % was determined by dark-colored products of the melanoidin formation process and other processes that took place without the participation of anthocyanins; the percentage of preservation of anthocyanins proper in semi-finished juices with and without various additives, such as vitamin B1, vitamin E, etc., varied from 40.31 to 60.84, and the total loss of anthocyanins was almost 100 % associated with loss they are precipitated. Keywords: pomegranate juice purchases of long-term storage, glass cylinders, hot filling, anthocyanins of settled juice, anthocyanins of sediment, dark-colored pigments

Upper Limit for the Superconducting Transition Temperature in Eliashberg–McMillan Theory

We present simple qualitative estimates for the maximal superconducting transition temperature, which may be achieved due to electron–phonon coupling in Eliashberg–McMillan theory. It is shown that in the limit of very strong coupling the upper limit for transition temperature is determined in fact by a combination of atomic constants and density of conduction electrons.

Effects of structure parameter and material property on thermal performance of on-board hydrogen storage tanks during fast refueling

As a power generation fuel, high-pressure hydrogen gas is widely used in transportation, and significantly contributed to development of hydrogen fuel cell electric vehicles. However, obvious temperature rise generated during fast refueling causes serious safety risk to reliable operation of fuel cell stacks. Therefore, it is necessary to conduct in-depth research on fast filling process. Based on safety reasons, the SAE J2601/ISO 15869 strictly regulates the maximum temperature limit of 85 °C in specifications for refueling hydrogen gas tanks. In this study, a 70 MPa, Type IV on-board hydrogen storage tank is adopted as the research object, and a 2-dimensional axisymmetric numerical model is established to study the temperature rise of the vapor within storage tanks during fast refueling. The Realizable k-ε turbulence model is employed to simulate high intensity turbulent fluctuation during fast filling. Considering the compressibility of vapor, the state of equation for real hydrogen gas is used by obtaining fluid thermodynamic properties from the National Institute of Standards and Technology database. Three groups of fast filling experiments are selected to validate the developed numerical model. The comparison result shows that the numerical model has good prediction ability on hydrogen fast refueling. The final mass average temperature differences between numerical results and experimental data are 2.6 K, 4.3 K, and 0.03 K, respectively. Based on the developed numerical model, the influences of structure parameters and material properties on the temperature rise of hydrogen storage tanks are investigated. The results indicate that the inlet diameter and wall thickness of the inner and outer layers of the storage tank have weaken impacts on the temperature rise during rapid charging, with the maximum temperature differences of 1.8 K, 0.74 K, and 0.54 K, respectively. Due to the influence of heat capacity, the material properties of different layers exhibit a similar variation trend. This work can deepen researchers' understanding of the temperature rise of on-board hydrogen storage tanks during fast filling, and provide technical references for the structural optimal design of tanks and rapid refueling at hydrogen stations.

An in situ exsolution strategy to prepare metallic Sn modified SnO2 with oxygen vacancies for ppb-level NO2 detection

The practical applications of SnO2 materials for NO2 detection in the field of indoor air quality monitoring are strongly plagued by low sensitivity toward ppb-level NO2. Herein, an in situ exsolution strategy was developed to prepare Sn-containing materials with abundant oxygen vacancy defects and Sn/SnO2 heterojunctions (designated as Sn/SnO2-x), which were obtained by annealing mixture of commercial SnO2 and NaBH4 in Ar atmosphere. Compared to commercial SnO2, the optimal Sn/SnO2-x-3 displays the obvious advantages of low operating temperature (110 °C), high sensitivity (response value of 4.65 toward 80 ppb NO2), and low limit of detection (10 ppb NO2 with response value of 1.17). The improvement of NO2 sensing performances is attributed to the synergistic effect of introducing oxygen vacancy defects and constructing Sn/SnO2 heterojunctions. Theoretically, the former leads to increasing the active sites for adsorption of NO2 and the latter reduces the band gap for improvement of carrier concentration. Additionally, this NO2 sensor shows excellent sensing performances for monitoring NO2 concentration in simulated indoor environment. This work not only provides an effective and large-scale approach to prepare novel sensing materials from commercial metal oxides by exsolution method, but also opens the way to fabricate high-performance gas sensors for detection of NO2 with low concentrations.

Emergence of lake conditions that exceed natural temperature variability

Lake surface temperatures are projected to increase under climate change, which could trigger shifts in the future distribution of thermally sensitive aquatic species. Of particular concern for lake ecosystems are when temperatures increase outside the range of natural variability, without analogue either today or in the past. However, our knowledge of when such no-analogue conditions will appear remains uncertain. Here, using daily outputs from a large ensemble of SSP3-7.0 Earth system model projections, we show that these conditions will emerge at the surface of many northern lakes under a global warming of 4.0 °C above pre-industrial conditions. No-analogue conditions will occur sooner, under 2.4 °C of warming, at lower latitudes, primarily due to a weaker range of natural variability, which increases the likelihood of the upper natural limit of lake temperature being exceeded. Similar patterns are also projected in subsurface water, with no-analogue conditions occurring first at low latitudes and occurring last, if at all, at higher latitudes. Our study suggests that global warming will induce changes across the water column, particularly at low latitudes, leading to the emergence of unparalleled climates with no modern counterparts, probably affecting their habitability and leading to rearrangements of freshwater habitats this century.